AutismKB 2.0

Annotation Detail for CLCN4


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Basic Information Top
Gene Symbol:CLCN4 ( CLC4,ClC-4,ClC-4A,MGC163150 )
Gene Full Name: chloride channel 4
Band: Xp22.2
Quick LinksEntrez ID:1183; OMIM: 302910; Uniprot ID:CLCN4_HUMAN; ENSEMBL ID: ENSG00000073464; HGNC ID: 2022
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of CLCN4 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of CLCN4 mRNAaffects cotreatment|increases expression 17404688
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of CLCN4 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CLCN4 mRNAaffects cotreatment|decreases expression 19059307
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.2714745880
MESH:D000230 Adenocarcinoma Estradiol 2.1711473722
MESH:D000419 Albuminuria Raloxifene 5.1017451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.6015800139
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.0617868700
MESH:D001930 Brain Injuries Progesterone 12.9115665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 12.9116580743
MESH:D001943 Breast Neoplasms Estradiol 2.0312948864 17261762 17018787 19861407 17289903 16675129 14630087 18497071
MESH:D001943 Breast Neoplasms Progesterone 2.0316175315 15562024 17614352
MESH:D001943 Breast Neoplasms Raloxifene 2.0317893378 15758505 15572757 16912660 17952589 17049068 15775269 17440819 17261762 16837676 17242785 17595753
MESH:D001943 Breast Neoplasms Tamoxifen 2.0319011961 11161223 19288272 19142967 19189210 18425577 21138602 20005174 19189212 16202921 18815881 20135344 17261762 15565566 17893378 19289846 19221464 15668708 20390343 18629630 19084267 19155303 19410462 18984771 20065188 18855134 18821012 19115204 18997820 18351453 19244106 20544844 16818667 19066611 17440819 16873071 21152245 19487384 20859285 19200415 17049068 17242785 19059307 19103187 16273361
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 5.0719066611
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1316924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1316924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.8417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.8417572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.7115775269
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0318566989
MESH:D003072 Cognition Disorders Raloxifene 5.1815800139
MESH:D003711 Demyelinating Diseases Tamoxifen 4.9219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.5317474826
MESH:D003928 Diabetic Nephropathies Estradiol 17.2519279558
MESH:D003928 Diabetic Nephropathies Raloxifene 17.2517451421 15920148 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 17.2519279558
MESH:D003929 Diabetic Neuropathies Progesterone 5.0517187935
MESH:D004487 Edema Raloxifene 3.7615860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 18.5917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 18.5915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 18.5919031437
MESH:D016889 Endometrial Neoplasms Estradiol 8.2018566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.2017893378 16202921 19155303 20544844
MESH:D004715 Endometriosis Progesterone 4.1616134523
MESH:D005234 Fatty Liver Raloxifene 9.4317473493
MESH:D005234 Fatty Liver Tamoxifen 9.4319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.1614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.8119069698
MESH:D006331 Heart Diseases Raloxifene 3.8011110106
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D006973 Hypertension Raloxifene 2.9817577099 15787275
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.9615869954
MESH:D007249 Inflammation Progesterone 5.7615869954
MESH:D007249 Inflammation Tamoxifen 5.7619457130
MESH:D007333 Insulin Resistance Estradiol 3.2116627594 16393666
MESH:D007674 Kidney Diseases Estradiol 2.7815618244
MESH:D007680 Kidney Neoplasms Estradiol 8.5515610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.5518625569
MESH:D007889 Leiomyoma Raloxifene 4.9616973256
MESH:D008064 Lipidoses Tamoxifen 3.4317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5318564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3316684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3919428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.3916891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 11.3911408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 11.3916827153 14580682 19196723 11731420 19196722
MESH:D020149 Manganese Poisoning Estradiol 15.2019453300
MESH:D020149 Manganese Poisoning Tamoxifen 15.2019453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.8115990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.2815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.7116497877
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5916810080
MESH:D009232 Myxoma Raloxifene 6.2816343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6119410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.7219189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 4.3617289903
MESH:D009421 Nervous System Malformations Estradiol 4.1616427766 11399458
MESH:D010024 Osteoporosis Raloxifene 3.6115775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.6917823083 15579764 15758505 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 5.2019401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.2017393432 16525653
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3120887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5216740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5216536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5215067354
MESH:D011693 Purpura Raloxifene 6.2815770314
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9618045962
MESH:D013088 Spermatocele Tamoxifen 5.0216709447
MESH:D013119 Spinal Cord Injuries Progesterone 13.0715862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 13.0719457130
MESH:D020521 Stroke Raloxifene 4.1516837676
MESH:D013978 Tibial Fractures Estradiol 16.2619048282
MESH:D013978 Tibial Fractures Raloxifene 16.2619048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.6517572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.658653321 16712894 17572228
MESH:D054556 Venous Thromboembolism Raloxifene 5.9316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.2816343187
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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