AutismKB 2.0

Annotation Detail for CLCN6


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Basic Information Top
Gene Symbol:CLCN6 ( CLC-6,KIAA0046 )
Gene Full Name: chloride channel 6
Band: 1p36.22
Quick LinksEntrez ID:1185; OMIM: 602726; Uniprot ID:CLCN6_HUMAN; ENSEMBL ID: ENSG00000011021; HGNC ID: 2024
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
CARDIOVASCULAR
systolic blood pressure
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CLCN6 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CLCN6 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of CLCN6 mRNAaffects expression 18648102
D000638 Amiodarone Amiodarone results in increased expression of CLCN6 mRNAincreases expression 19774075
D003474 Curcumin Curcumin results in decreased expression of CLCN6 mRNAdecreases expression 17198877
C494474 perchlorate perchlorate results in increased expression of CLCN6 mRNAincreases expression 17403546
D020849 Raloxifene Raloxifene results in increased expression of CLCN6 mRNAincreases expression 16497877
D018038 Sodium Selenite Sodium Selenite results in decreased expression of CLCN6 mRNAdecreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D000419 Albuminuria Raloxifene 4.8817451421 17308373
MESH:D019973 Alcohol-Related Disorders Curcumin 5.4617887948
MESH:D000544 Alzheimer Disease Curcumin 4.5915590663
MESH:D000544 Alzheimer Disease Raloxifene 4.5915800139
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0318218290 20041841 18057881
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7816807698
MESH:D050197 Atherosclerosis Curcumin 3.4518704882
MESH:D001281 Atrial Fibrillation Amiodarone 4.0818651412 19698954
MESH:D001327 Autoimmune Diseases Curcumin 4.8019761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.1419483382
MESH:D001930 Brain Injuries Raloxifene 4.7816580743
MESH:D002545 Brain Ischemia Curcumin 4.6716770732
MESH:D001932 Brain Neoplasms Curcumin 4.1617596214
MESH:D001943 Breast Neoplasms Curcumin 2.4916243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms Raloxifene 2.4915758505 17440819 17893378 17595753 17261762 17049068 16912660 17952589 15775269 16837676 15572757 17242785
MESH:D002277 Carcinoma Curcumin 4.0318593918
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.747296757 3581430
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0418414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8218462866
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.3017572228
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9619225199 15710769
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6015775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4218974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.196135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.197505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.329022650 19486331
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D003072 Cognition Disorders Raloxifene 4.9215800139
MESH:D003092 Colitis Curcumin 4.4816782535 16804969 18200517
MESH:D003103 Coloboma Curcumin 4.7918809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5319359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.2018497527
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3817474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.108156756 8970840 11906362 2524372 12868966 18759878 11298694 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7518403477
MESH:D003928 Diabetic Nephropathies Curcumin 9.9518204486
MESH:D003928 Diabetic Nephropathies Raloxifene 9.9517451421 17308373 15920148
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.709653073 6679447 7440962 18692083 18648102 9328219 9022650 6482804 16192314 18289764 1440618 11289319 8291058
MESH:D056486 Drug-Induced Liver Injury Amiodarone 12.7018218290 15265979
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.7015131321
MESH:D004381 Duodenal Ulcer Curcumin 4.3317351913
MESH:D004487 Edema Raloxifene 3.5815860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.2815845917
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Amiodarone 14.7814986274
MESH:D005234 Fatty Liver Curcumin 14.7819297423
MESH:D005234 Fatty Liver Raloxifene 14.7817473493
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Curcumin 4.2918705752
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0018462866
MESH:D005909 Glioblastoma Curcumin 3.6217596214
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 12.367505956
MESH:D006042 Goiter perchlorate 12.3618801409
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8118829502 18462866
MESH:D006331 Heart Diseases Raloxifene 3.6911110106
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly Amiodarone 4.0515265979
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.3517701891
MESH:D006937 Hypercholesterolemia Amiodarone 10.169751232 8137927
MESH:D006937 Hypercholesterolemia Curcumin 10.1618704882
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Raloxifene 2.9415787275 17577099
MESH:D007037 Hypothyroidism Amiodarone 4.8217991464 18020914
MESH:D007249 Inflammation Curcumin 3.0018403477 17151092 16956363
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2918596194 18200517
MESH:D007333 Insulin Resistance Sodium Selenite 3.4214714311
MESH:D007414 Intestinal Neoplasms Curcumin 4.4510783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.6016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.6016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.606582329
MESH:D007889 Leiomyoma Curcumin 12.0418555241
MESH:D007889 Leiomyoma Raloxifene 12.0416973256
MESH:D007938 Leukemia Curcumin 3.3418462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4516106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.0416106398
MESH:D008064 Lipidoses Amiodarone 3.6817567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.339327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.2817355460 18705752 18006644
MESH:D008107 Liver Diseases Curcumin 2.6616956363
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.227678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.362876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.36598648 3712494 6587162 1399818
MESH:D008133 Long QT Syndrome Amiodarone 3.7617391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.5312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8518516814
MESH:D008175 Lung Neoplasms Curcumin 2.2818462866 19359593 16243823
MESH:D008223 Lymphoma Curcumin 3.7518462866
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0016173963
MESH:D008545 Melanoma Curcumin 2.4417885582 18462866
MESH:D008569 Memory Disorders Curcumin 4.4317263510
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.9315863610
MESH:D009101 Multiple Myeloma Curcumin 8.1219372569
MESH:D009101 Multiple Myeloma Raloxifene 8.1216497877
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.2617962980
MESH:D009181 Mycoses Amiodarone 5.2812754197 17974566
MESH:D009232 Myxoma Raloxifene 5.9316343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.5018551238 7678174
MESH:D009361 Neoplasm Invasiveness Curcumin 4.6518495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.9112497104
MESH:D009423 Nervous System Neoplasms Curcumin 6.0118462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D009765 Obesity Curcumin 2.7919297423
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.4312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.4316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.436482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010024 Osteoporosis Curcumin 7.8718719352
MESH:D010024 Osteoporosis Raloxifene 7.8715775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4915758505 15579764 17893378 17823083
MESH:D010051 Ovarian Neoplasms Curcumin 2.8819020741 18462866
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0019401701 19196508 17440100
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011471 Prostatic Neoplasms Curcumin 2.6615129424 11398177 12497104 18226269 18156803 10851300 18769126
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6615731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6618760546
MESH:D011656 Pulmonary Emphysema Curcumin 4.7619168576
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9312832656 12490602 11597910
MESH:D011693 Purpura Raloxifene 5.9315770314
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2818379247 10666014
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012509 Sarcoma Curcumin 4.3418462866
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D018805 Sepsis Curcumin 4.2818389075
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4218724381
MESH:D013276 Stomach Ulcer Amiodarone 8.2918087811
MESH:D013276 Stomach Ulcer Curcumin 8.2919188055 16631530
MESH:D020521 Stroke Raloxifene 4.0116837676
MESH:D013610 Tachycardia Amiodarone 4.5711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.1319731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.061399818 3712494 6587162 7505956 6582329
MESH:D013971 Thyrotoxicosis Amiodarone 5.1719584973 18020914
MESH:D013978 Tibial Fractures Raloxifene 5.5819048282
MESH:D016171 Torsades de Pointes Amiodarone 4.5317467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 16.7016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 16.7016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 16.708074119
MESH:D001749 Urinary Bladder Neoplasms Curcumin 16.7018593936
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 16.7017572228
MESH:D014565 Urogenital Neoplasms Curcumin 5.6018462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D054556 Venous Thromboembolism Raloxifene 5.5816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.9316343187
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26551
    • No data
    Releated disease ID Related disease Name
    PA445095Neural Tube Defects
    PA446286Spina Bifida Cystica
    PA443450Asthma
    PA443314Alopecia
    PA443434Arthritis, Rheumatoid
    PA443937Drug Toxicity
    PA445846Thrombocytopenia
    PA445742Stomach Neoplasms
    PA445105Neurologic Manifestations
    PA443560Breast Neoplasms
    PA446108Colorectal Neoplasms
    PA444368Heart Diseases
    PA445454Psychophysiologic Disorders
    PA444750Leukemia
    PA446171Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    PA134850491Transplantation
    PA446180Leukemia, Promyelocytic, Acute
    PA446166Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443635Cardiovascular Diseases
    PA447054Stroke
    PA443797Coronary Disease
    PA444320Graft vs Host Disease
    Releated drug ID Related drug Name
    PA128406956fluorouracil
    PA449692folic acid
    PA450428methotrexate
    PA448388amlodipine
    PA448970chlorthalidone
    PA449407doxazosin
    PA450242lisinopril
    PA450645nitrous oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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