AutismKB 2.0

Annotation Detail for CLCNKA


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Basic Information Top
Gene Symbol:CLCNKA ( CLCK1,ClC-K1,MGC61490,hClC-Ka )
Gene Full Name: chloride channel Ka
Band: 1p36.13
Quick LinksEntrez ID:1187; OMIM: 602024; Uniprot ID:CLCKA_HUMAN; ENSEMBL ID: ENSG00000186510; HGNC ID: 2026
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1790Hyperaldosteronism
1862Conduct disorder
2091Hypertension
2207Deafness
No data
No data
Desease Name
Bartter syndrome, type 4b, digenic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C048213 2-(4-chlorophenoxy)propionic acid 2-(4-chlorophenoxy)propionic acid analog results in decreased activity of CLCNKA proteindecreases activity 14694153
12130677
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CLCNKA mRNAaffects expression 16483693
D017878 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid analog results in decreased activity of CLCNKA proteindecreases activity 15167890
D005665 Furosemide Furosemide results in decreased expression of CLCNKA mRNAdecreases expression 12759757
D008456 2-Methyl-4-chlorophenoxyacetic Acid 2-Methyl-4-chlorophenoxyacetic Acid analog results in decreased activity of CLCNKA proteindecreases activity 15167890
D013267 Stilbenes Stilbenes analog results in decreased activity of CLCNKA proteindecreases activity 14694153
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
OMIM:602522 BARTTER SYNDROME, TYPE 4A marker/mechanism
OMIM:613090 BARTTER SYNDROME, TYPE 4B marker/mechanism
MESH:D004417 Dyspnea Furosemide 5.4616935035
MESH:D004487 Edema Furosemide 4.3211834646
MESH:D034381 Hearing Loss Furosemide 5.1117868369
MESH:D006333 Heart Failure Furosemide 4.2416011733 12660669 16845234
MESH:D006934 Hypercalcemia Furosemide 5.4017652376
MESH:D053565 Hypercalciuria Furosemide 6.1217652376
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 6.4015086907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.7016612254
MESH:C537153 Hypomagnesemia primary Furosemide 6.1211041285
MESH:D007019 Hypoproteinemia Furosemide 6.4016096441
MESH:D007022 Hypotension Furosemide 4.9711041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.9415811171
MESH:D007674 Kidney Diseases Furosemide 3.9311041285
MESH:D009397 Nephrocalcinosis Furosemide 6.4015086907
MESH:D053206 Nocturnal Enuresis Furosemide 6.4017945291
MESH:D011141 Polyuria Furosemide 6.1217945291
MESH:D015427 Reperfusion Injury Furosemide 4.0416526316
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.9716096441 12394941 15912074
MESH:D013274 Stomach Neoplasms Furosemide 2.8617052386
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB04552 agonist Niflumic Acid Cyclooxygenase Inhibitors
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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