AutismKB 2.0

Annotation Detail for MMP21


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Basic Information Top
Gene Symbol:MMP21 ( - )
Gene Full Name: matrix metallopeptidase 21
Band: 10q26.2
Quick LinksEntrez ID:118856; OMIM: 608416; Uniprot ID:MMP21_HUMAN; ENSEMBL ID: ENSG00000154485; HGNC ID: 14357
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D014284 Triiodothyronine Triiodothyronine results in increased expression of MMP21 mRNAincreases expression 17403546
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of MMP21 mRNAincreases expression 16984259
D014212 Tretinoin Tretinoin results in increased expression of MMP21 mRNAincreases expression 16984259
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000505 Alopecia Tretinoin 3.9815955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.3216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3416292516
MESH:D001249 Asthma Tretinoin 2.4416456186
MESH:D001471 Barrett Esophagus Tretinoin 4.9916935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0916197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2316873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.3316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 6.0316168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.921917145
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 5.2318922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.2316096774 16051514
MESH:D002386 Cataract Tretinoin 3.3217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.3316129372
MESH:D002822 Choriocarcinoma Tretinoin 6.0316461808
MESH:D002972 Cleft Palate Tretinoin 2.819407595
MESH:D003092 Colitis Tretinoin 4.3517035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8316925845 8800419 17551590 9125849 10589399 9224671 9664655 14991402 9142499 9211117
MESH:D004487 Edema Tetradecanoylphorbol Acetate 4.0915177302 16716910 8273558 11698051 9599246 7812673 8113982
MESH:D004489 Edema, Cardiac Tretinoin 5.3318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3716569247
MESH:D005124 Eye Abnormalities Tretinoin 3.909664655 16938888
MESH:D005355 Fibrosis Tretinoin 4.1617994277
MESH:D005909 Glioblastoma Tretinoin 3.2717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 6.0316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0914991402 9664655
MESH:D018219 Histiocytoma, Benign Fibrous marker/mechanism 16984259
MESH:D006930 Hyperalgesia Tretinoin 3.5716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.2216778211
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 3.287562506 7812673 15177302 8273558 11698051
MESH:D007410 Intestinal Diseases Tretinoin 4.4217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3917551590 15992940
MESH:D007938 Leukemia Tretinoin 2.9517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1319850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.4216935935 19075265 16766008 17339181 19029980 16891316 17301526 17294898 16140955 17712046 12679006 17649720 15748426 17361223 19225113 17107899 16331271 16788101 17506722 19035177 17368321 17217047 19642359 9834237 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.629224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 2.4811807781
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.618985016
MESH:D008527 Medulloblastoma Tretinoin 2.9217453147
MESH:D008545 Melanoma Tretinoin 1.9916752155
MESH:D008591 Meningomyelocele Tretinoin 5.0816940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.3017596541
MESH:D009369 Neoplasms Tretinoin 2.5916594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.369125849
MESH:D009436 Neural Tube Defects Tretinoin 3.329142499
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4516936753
MESH:D010146 Pain Tretinoin 3.2816870215
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.9315976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.9315976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.9418922899 12065085 8330346 18404319
MESH:D011507 Proteinuria Tretinoin 4.1316636307
MESH:D011625 Pterygium Tretinoin 5.5416723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.6316283617 16116481
MESH:D012871 Skin Diseases marker/mechanism 16984259
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 6.6011807781 8330346 8985016 18404319 12065085
MESH:D012878 Skin Neoplasms Tretinoin 6.6016467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.3616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.2416051514
MESH:D014376 Tuberculosis Tretinoin 3.4716040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.1216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.4816752155
MESH:D014820 Vitiligo Tretinoin 4.6416761959
MESH:D009396 Wilms Tumor Tretinoin 4.3916287080
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Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00786 antagonist Marimastat Antineoplastic Agents;Enzyme Inhibitors
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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