AutismKB 2.0

Annotation Detail for ADD2


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Basic Information Top
Gene Symbol:ADD2 ( ADDB )
Gene Full Name: adducin 2 (beta)
Band: 2p13.3
Quick LinksEntrez ID:119; OMIM: 102681; Uniprot ID:ADDB_HUMAN; ENSEMBL ID: ENSG00000075340; HGNC ID: 244
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
hypertension
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADD2 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ADD2 mRNAincreases expression 15336504
C004742 daidzein [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ADD2 mRNAaffects cotreatment|decreases expression 16963248
D019833 Genistein [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ADD2 mRNAaffects cotreatment|decreases expression 16963248
C086566 glycitein [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ADD2 mRNAaffects cotreatment|decreases expression 16963248
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of ADD2 mRNAdecreases expression 18087596
D014635 Valproic Acid Valproic Acid results in increased expression of ADD2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000230 Adenocarcinoma daidzein 5.1411473722
MESH:D000230 Adenocarcinoma Genistein 5.1411473722
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.9715814487
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2319898480
MESH:D001321 Autistic Disorder Valproic Acid 1.9920603192 18985861 18316065 15238991 17507914 18558336 17688650 19460635 18940202 19232924 17157402 18396377 18775368 16609825 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 3.2017594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D001943 Breast Neoplasms Genistein 2.5017200150 16541309 16873071
MESH:D006528 Carcinoma, Hepatocellular Genistein 2.1616924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.5011212258
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 3.2711212258
MESH:D002318 Cardiovascular Diseases daidzein 8.4216332659
MESH:D002318 Cardiovascular Diseases Genistein 8.4216332659
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 5.1616647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 5.1616647724
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2319641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004714 Endometrial Hyperplasia Genistein 4.9916402032
MESH:D016889 Endometrial Neoplasms daidzein 8.5611473722
MESH:D016889 Endometrial Neoplasms Genistein 8.5611473722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.363922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D007172 Erectile Dysfunction daidzein 5.3414972507
MESH:D005234 Fatty Liver Valproic Acid 3.5819224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.468888407 18558336
MESH:D005909 Glioblastoma Genistein 3.4316598420
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006973 Hypertension daidzein 3.7517169123
MESH:D007249 Inflammation Tobacco Smoke Pollution 3.4618590791
MESH:D007938 Leukemia Genistein 3.1418980019 17468513
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 2.7216288123 11091918 12111688 3440675
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.1012929590 14578162
MESH:D008881 Migraine Disorders Valproic Acid 3.3818803445 18765137
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.5615006635
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D009203 Myocardial Infarction Genistein 2.9517141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8717141266
MESH:D009421 Nervous System Malformations Genistein 4.3616427766
MESH:D009436 Neural Tube Defects Valproic Acid 3.308888407 16359493
MESH:D010024 Osteoporosis Genistein 3.4119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3916169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6719005980
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D011471 Prostatic Neoplasms Genistein 3.4216925846 15256057 15378649
MESH:D019310 Pseudolymphoma Valproic Acid 4.9811422049 12752131
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.9818410779
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9116876388 15475178 1511512 11738929 3137016 17978042 14763951 11044598
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.528532709
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 6.5218590791
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 3.4212846360
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24566
    • No data
    Releated disease ID Related disease Name
    PA444552Hypertension
    No data
    Drug Bank Top

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    Syndromic Genes

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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