AutismKB 2.0

Annotation Detail for CPXM2


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Basic Information Top
Gene Symbol:CPXM2 ( UNQ676 )
Gene Full Name: carboxypeptidase X (M14 family), member 2
Band: 10q26.13
Quick LinksEntrez ID:119587; OMIM: NA; Uniprot ID:CPXM2_HUMAN; ENSEMBL ID: ENSG00000121898; HGNC ID: 26977
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CPXM2 mRNAdecreases expression 18648102
D004041 Dietary Fats Dietary Fats results in increased expression of CPXM2 mRNAincreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of CPXM2 mRNAdecreases expression 15289156
D004958 Estradiol Estradiol results in decreased expression of CPXM2 mRNAdecreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CPXM2 mRNAdecreases expression 17557909
17351261
D019833 Genistein Genistein results in decreased expression of CPXM2 mRNAdecreases expression 15289156
C041786 palm oil palm oil results in increased expression of CPXM2 mRNAincreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Estradiol 7.4111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.4114692618
MESH:D000230 Adenocarcinoma Genistein 7.4111473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8115469931
MESH:D001161 Arteriosclerosis Dietary Fats 11.1315238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 11.1311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4611289319 1440618
MESH:D001943 Breast Neoplasms Dietary Fats 2.0220435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0215324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 2.0217018787 12948864 14630087 16675129 18497071 19861407 17261762 17289903
MESH:D001943 Breast Neoplasms Genistein 2.0216541309 16873071 17200150
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.903581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.9015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.9016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.9016924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002318 Cardiovascular Diseases Genistein 3.4816332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.277505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.2718566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.549022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5417110522 15861022 11677210 16919318 17681005 16105132 17333356
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8912952375 16002989
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.158156756 8970840 2524372 11906362 14531868 11298694 18759878 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5416647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.029653073 7440962 6679447 18289764 11289319 16192314 6482804 18648102 9022650 18692083 9328219 8291058 1440618
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 13.2516402032
MESH:D004714 Endometrial Hyperplasia Genistein 13.2516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 13.5215700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 13.5219148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 13.5211473722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.163581430
MESH:D005234 Fatty Liver Dietary Fats 8.6719551842 19004024 17967931 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6715345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8115751030 16611131 16002989 16534752 16513791
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005355 Fibrosis Dietary Fats 3.8818296743
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.3416452187
MESH:D005909 Glioblastoma Genistein 3.4316598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 12.0615034207
MESH:D006965 Hyperplasia Diethylstilbestrol 12.0614722030 12960047
MESH:D007021 Hypospadias Diethylstilbestrol 12.4716002989
MESH:D007021 Hypospadias Ethinyl Estradiol 12.4716569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.6815036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Dietary Fats 2.5520412841
MESH:D007333 Insulin Resistance Dietary Fats 7.9411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.9416393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.469022650 8074119
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.866582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 13.8616762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 13.8615610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4217184923
MESH:D007938 Leukemia Genistein 3.1418980019 17468513
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0118296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.6314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.6317823541
MESH:D008113 Liver Neoplasms Diethylstilbestrol 2.7216712894 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.693712494 598648 6587162 1399818
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.5515166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6615700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.9616002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6511408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.6512929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D009203 Myocardial Infarction Genistein 2.9517141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.2316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.2317141266
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms Diethylstilbestrol 2.8815313581
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 18.5011399458
MESH:D009421 Nervous System Malformations Estradiol 18.5016427766 11399458
MESH:D009421 Nervous System Malformations Genistein 18.5016427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009765 Obesity Dietary Fats 2.3411836018 20518802 20132043 18674790 17217161 19632207 18457598 21332399 16723640
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.684026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010024 Osteoporosis Genistein 3.4119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3916169203
MESH:D010051 Ovarian Neoplasms Estradiol 5.1419401270
MESH:D010051 Ovarian Neoplasms Genistein 5.1419005980
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0315687265 16977796
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.5117184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.5815846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.5816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.5816925846 15256057 15378649
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D013088 Spermatocele Diethylstilbestrol 13.2416002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 13.2416709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.096582329 7505956 1399818 3712494 6587162
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.498074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.4917306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.3016175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.6114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.5915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.5914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7916513791 16002989
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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