AutismKB 2.0

Annotation Detail for SERPINA3


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Basic Information Top
Gene Symbol:SERPINA3 ( AACT,ACT,GIG25,MGC88254 )
Gene Full Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Band: 14q32.13
Quick LinksEntrez ID:12; OMIM: 107280; Uniprot ID:AACT_HUMAN; ENSEMBL ID: ENSG00000196136; HGNC ID: 16
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1843Metastasis to lymph nodes
1954Stroke
1997Dental plaque
2198Psychotic disorder
Desease Name
CARDIOVASCULAR
Alzheimer's disease
CANCER
Subarachnoid Hemorrhage
IMMUNE
NEUROLOGICAL
METABOLIC
osteoarthritis
Stroke
lung cancer
cerebrovascular disease
hemorrhage, intracerebral
Asthma. BHR. Total IgE. SPT
Dementia
Cerebral Hemorrhage
No data
Desease Name
Alpha-1-antichymotrypsin deficiency
Cerebrovascular disease, occlusive
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in increased expression of SERPINA3 mRNAincreases expression 15982314
C103303 alitretinoin alitretinoin results in increased expression of SERPINA3 mRNAincreases expression 15982314
D000639 Amitriptyline Amitriptyline results in increased expression of SERPINA3 mRNAincreases expression 15342952
17567588
D001241 Aspirin Aspirin results in increased expression of SERPINA3 mRNAincreases expression 11906190
C084597 chlorcyclizine chlorcyclizine results in increased expression of SERPINA3 mRNAincreases expression 15342952
D002746 Chlorpromazine Chlorpromazine results in increased expression of SERPINA3 mRNAincreases expression 15342952
D015283 Citalopram Citalopram results in increased expression of SERPINA3 mRNAincreases expression 17567588
D002997 Clomipramine Clomipramine results in increased expression of SERPINA3 mRNAincreases expression 15342952
D003024 Clozapine Clozapine results in increased expression of SERPINA3 mRNAincreases expression 15342952
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINA3 mRNA]decreases reaction|increases expression 18200517
D016572 Cyclosporine Cyclosporine results in increased expression of SERPINA3 mRNAincreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of SERPINA3 mRNAincreases expression 10811566
D004316 Doxepin Doxepin results in increased expression of SERPINA3 mRNAincreases expression 17567588
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINA3 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of SERPINA3 mRNAincreases expression 10811566
19619570
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of SERPINA3 mRNAaffects cotreatment|increases expression 17404688
D005424 Flecainide Flecainide results in increased expression of SERPINA3 mRNAincreases expression 15342952
D005473 Fluoxetine Fluoxetine results in increased expression of SERPINA3 mRNAincreases expression 17567588
15342952
D007099 Imipramine Imipramine results in increased expression of SERPINA3 mRNAincreases expression 17567588
15342952
D007654 Ketoconazole Ketoconazole results in increased expression of SERPINA3 mRNAincreases expression 15342952
D017336 Loratadine Loratadine results in increased expression of SERPINA3 mRNAincreases expression 15342952
D010419 Pentamidine Pentamidine results in increased expression of SERPINA3 mRNAincreases expression 15342952
D010480 Perhexiline Perhexiline results in increased expression of SERPINA3 mRNAincreases expression 15342952
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of SERPINA3 mRNAaffects cotreatment|increases expression 17404688
D015474 Isotretinoin Isotretinoin results in increased expression of SERPINA3 mRNAincreases expression 15982314
C116926 rofecoxib rofecoxib results in increased expression of SERPINA3 mRNAincreases expression 17070997
D020280 Sertraline Sertraline results in increased expression of SERPINA3 mRNAincreases expression 15342952
17567588
D013629 Tamoxifen Tamoxifen results in increased expression of SERPINA3 mRNAincreases expression 15342952
C004648 testosterone enanthate testosterone enanthate affects the expression of SERPINA3 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINA3 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SERPINA3 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SERPINA3 mRNAincreases expression 20106945
D013881 Thioridazine Thioridazine results in increased expression of SERPINA3 mRNAincreases expression 15342952
D001371 trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of SERPINA3 mRNAincreases expression 15342952
D014212 Tretinoin Tretinoin metabolite results in increased expression of SERPINA3 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in increased expression of SERPINA3 mRNAincreases expression 15982314
D014236 Trichlorfon Trichlorfon results in decreased expression of SERPINA3 proteindecreases expression 10599054
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINA3 mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of SERPINA3 mRNAincreases expression 18200517
D015029 Zeranol Zeranol results in increased expression of SERPINA3 mRNAincreases expression 10811566
D015031 Zimeldine Zimeldine results in increased expression of SERPINA3 mRNAincreases expression 15342952
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1914745880
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 7.5318769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5314514962 11752688 15322242
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.6618769834
MESH:D017486 Acneiform Eruptions Isotretinoin 5.9216232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.1216185265 18769834
MESH:D000230 Adenocarcinoma Estradiol 2.0111473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0216835633
MESH:D000380 Agranulocytosis Clozapine 4.7116160616 12649775 14617031
MESH:D017088 AIDS-Related Opportunistic Infections Pentamidine 5.9911806628
MESH:D019973 Alcohol-Related Disorders Curcumin 4.7217887948
OMIM:607154 ALLERGIC RHINITIS Loratadine 5.4316527031
MESH:D000505 Alopecia Tretinoin 3.3415955085
MESH:D000544 Alzheimer Disease Curcumin 4.7415590663
MESH:D000544 Alzheimer Disease Trichlorfon 4.7411419566
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6411748828
MESH:D001008 Anxiety Disorders Citalopram 13.8218083778
MESH:D001008 Anxiety Disorders Fluoxetine 13.8218083778
MESH:D001008 Anxiety Disorders Sertraline 13.8218822694
MESH:D001169 Arthritis, Experimental rofecoxib 7.0916690336
MESH:D001169 Arthritis, Experimental Tretinoin 7.0916412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.4216807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4216292516
MESH:D001249 Asthma Loratadine 5.159196086
MESH:D001249 Asthma Tretinoin 5.1516456186
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.4112372130 20485159
MESH:D050197 Atherosclerosis Curcumin 3.1118704882
MESH:D001321 Autistic Disorder Citalopram 2.7519232924 18775368
MESH:D001321 Autistic Disorder Fluoxetine 2.7519232924 18775368
MESH:D001321 Autistic Disorder Sertraline 2.7518775368
MESH:D001327 Autoimmune Diseases Curcumin 4.1519761891
MESH:D001471 Barrett Esophagus Tretinoin 4.0616935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.8912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.8916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5415746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9817868700
MESH:D001930 Brain Injuries Progesterone 3.9115665606 15845082 15380490
MESH:D002545 Brain Ischemia Curcumin 3.9816770732
MESH:D001932 Brain Neoplasms Aspirin 8.1715481559
MESH:D001932 Brain Neoplasms Curcumin 8.1717596214
MESH:D001943 Breast Neoplasms alitretinoin 5.4416344269
MESH:D001943 Breast Neoplasms Aspirin 5.4415161893
MESH:D001943 Breast Neoplasms Curcumin 5.4419250217 18462866 18593918 16243823
MESH:D001943 Breast Neoplasms Diethylstilbestrol 5.4415324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 5.4416675129 17289903 17018787 14630087 17261762 12948864 19861407 18497071
MESH:D001943 Breast Neoplasms Progesterone 5.4417614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 5.4419189212 16202921 16873071 19059307 19487384 11161223 17893378 18984771 19410462 16273361 19066611 20005174 19221464 18351453 18821012 15668708 20859285 18629630 19288272 19155303 18815881 20135344 18997820 19011961 20065188 18855134 21152245 18425577 20390343 19289846 20544844 19115204 17440819 17242785 19200415 19103187 17261762 19084267 17049068 19142967 21138602 19244106 16818667 19189210 15565566
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.4420435547
MESH:D001943 Breast Neoplasms Tretinoin 5.4416443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2416813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1116111702
MESH:D002277 Carcinoma Curcumin 7.3618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.3616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8016168501
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.0616924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.0616924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.0616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.061917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8518414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.0918462866
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 7.0911237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.0916096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1718850075 16120746 18670907
MESH:D002386 Cataract Tretinoin 2.8817460283
MESH:D002418 Cattle Diseases Trichlorfon 5.7914651886
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.7712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.7718566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2416129372
MESH:D002659 Child Development Disorders, Pervasive Citalopram 4.4215782081
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8716835633
MESH:D002779 Cholestasis Cyclosporine 2.6619486331
MESH:D002822 Choriocarcinoma Tretinoin 4.8016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2512621046 16354765 8697196 15668235 15340226
MESH:D002972 Cleft Palate Tretinoin 5.259407595
MESH:D003072 Cognition Disorders Clozapine 4.6217123785
MESH:D003092 Colitis Curcumin 14.1518200517 16804969 16782535
MESH:D003092 Colitis Tretinoin 14.1517035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 14.1516867261 16782535 11698051 18023891 17991707 16474422 18200517 16804969 17936198
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3217276891
MESH:D003103 Coloboma Curcumin 4.2318809619
MESH:D003110 Colonic Neoplasms Aspirin 5.7012411196
MESH:D003110 Colonic Neoplasms Curcumin 5.7016340194 19359593
MESH:D003110 Colonic Neoplasms rofecoxib 5.7012902858
MESH:D015179 Colorectal Neoplasms Aspirin 2.7417047198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7614669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.5518497527
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.669879862 18769834
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6620055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.669211117 10589399 9224671 17551590 9125849 16925845 9142499 9664655 8800419 14991402
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2212952375 16002989
MESH:D016757 Death, Sudden, Cardiac Thioridazine 5.5120210726
MESH:D003704 Dementia Thioridazine 5.2611575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0219031437
MESH:D003866 Depressive Disorder Amitriptyline 32.2115014590 18083778
MESH:D003866 Depressive Disorder Citalopram 32.2115014590
MESH:D003866 Depressive Disorder Clomipramine 32.2118083778
MESH:D003866 Depressive Disorder Doxepin 32.2115014590
MESH:D003866 Depressive Disorder Fluoxetine 32.2115014590
MESH:D003866 Depressive Disorder Imipramine 32.2120305041
MESH:D003866 Depressive Disorder Sertraline 32.2118822694 15014590 20305041
MESH:D003865 Depressive Disorder, Major Sertraline 5.0716968574
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.6716402076
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.6718403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.6717107852
MESH:D003928 Diabetic Nephropathies Curcumin 13.3218204486
MESH:D003928 Diabetic Nephropathies Estradiol 13.3219279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.3219279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1517187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1915331141
MESH:D056486 Drug-Induced Liver Injury Chlorpromazine 5.9311461765
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 5.9318289764
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5011462148
MESH:D004381 Duodenal Ulcer Curcumin 3.7217351913
MESH:D050171 Dyslipidemias Clozapine 3.9316402076
MESH:D004487 Edema Amitriptyline 23.0112798668
MESH:D004487 Edema Aspirin 23.0117259670
MESH:D004487 Edema Clomipramine 23.0112798668
MESH:D004487 Edema Fluoxetine 23.0112798668
MESH:D004487 Edema Imipramine 23.0112798668
MESH:D004487 Edema Tetrachlorodibenzodioxin 23.0111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.7416714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.7418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.0517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.0519031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.3416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 15.8816804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 15.8818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 15.8816202921 17893378 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 15.8816569247
MESH:D004715 Endometriosis Progesterone 13.6316134523
MESH:D004715 Endometriosis rofecoxib 13.6315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 13.639294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.969664655 16938888
MESH:D005234 Fatty Liver Curcumin 11.3519297423
MESH:D005234 Fatty Liver Cyclosporine 11.3519224547
MESH:D005234 Fatty Liver Tamoxifen 11.3514986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.4916611131 15751030 16513791 16534752 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.4916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8319069698
MESH:D005355 Fibrosis Curcumin 24.0718705752
MESH:D005355 Fibrosis Cyclosporine 24.0712168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.0720067830
MESH:D005355 Fibrosis Tretinoin 24.0717994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 24.0717994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3518462866
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.5916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.868708960
MESH:D005909 Glioblastoma Aspirin 10.7012870263
MESH:D005909 Glioblastoma Curcumin 10.7017596214
MESH:D005909 Glioblastoma Tretinoin 10.7017312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2310696789
MESH:D006261 Headache Aspirin 4.6015240983
MESH:D006258 Head and Neck Neoplasms Curcumin 7.1018462866 18829502
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.1016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8016084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 5.909664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5515340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6917701891
MESH:D006558 Herpes Genitalis Estradiol 4.6715709030
MESH:D006561 Herpes Simplex Chlorpromazine 4.941682908
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.3917440010
MESH:D019584 Hot Flashes Estradiol 9.3417088409
MESH:D019584 Hot Flashes Fluoxetine 9.3414716179
MESH:D006816 Huntington Disease Sertraline 5.6718403212
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6816959395 16354765 8697196 18606429 15340226
MESH:D012001 Hyperacusis Aspirin 5.4015240983
MESH:D006930 Hyperalgesia Tretinoin 2.9416870215
MESH:D006937 Hypercholesterolemia Curcumin 3.7418704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2216778211
MESH:D006948 Hyperkinesis Clozapine 4.5616046005
MESH:D006965 Hyperplasia Diethylstilbestrol 4.0912960047 14722030
MESH:D006973 Hypertension Cyclosporine 4.4710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.4718670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 10.9416002989
MESH:D007021 Hypospadias Loratadine 10.9416407038
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0615869954
MESH:D007246 Infertility Diethylstilbestrol 4.0215036965
MESH:D007249 Inflammation Amitriptyline 25.3412798668
MESH:D007249 Inflammation Clomipramine 25.3412798668
MESH:D007249 Inflammation Curcumin 25.3417151092 18403477 16956363
MESH:D007249 Inflammation Fluoxetine 25.3412798668
MESH:D007249 Inflammation Imipramine 25.3412798668
MESH:D007249 Inflammation Progesterone 25.3415869954
MESH:D007249 Inflammation Tamoxifen 25.3419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 25.3412878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.2018200517 18596194
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.2018200517
MESH:D007333 Insulin Resistance Estradiol 2.7416393666 16627594
MESH:D007410 Intestinal Diseases rofecoxib 14.6315831440
MESH:D007410 Intestinal Diseases Tretinoin 14.6317994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 14.6317994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.9110783313
MESH:D007417 Intestinal Polyps rofecoxib 5.0411245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8816580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.8817551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0815604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.2816144296
MESH:D007674 Kidney Diseases Cyclosporine 5.2510903974 18776723 8314463
MESH:D007674 Kidney Diseases Estradiol 5.2515618244
MESH:D007680 Kidney Neoplasms Cyclosporine 15.4212371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 15.4214681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 15.4215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 15.4218625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7217184923
MESH:D007889 Leiomyoma Curcumin 4.2518555241
MESH:D007896 Leishmaniasis Pentamidine 5.1015340016
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 8.501311351 2166429 19744259 8889330
MESH:D016773 Leishmaniasis, Cutaneous Pentamidine 8.508889330 11806628 10617787 12453009
MESH:D007897 Leishmaniasis, Mucocutaneous Pentamidine 5.7210881086
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 8.0511332679
MESH:D007898 Leishmaniasis, Visceral Pentamidine 8.051659303 10467834 16131481 7715298 12803856 7498017
MESH:D007938 Leukemia Curcumin 5.8918462866
MESH:D007938 Leukemia Tretinoin 5.8917143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.8916106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3816932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0216294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9217649720 15748426 19035177 16788101 19075265 19029980 9834237 19225113 17712046 16331271 17217047 16935935 17361223 16766008 16891316 12679006 17107899 16823087 16140955 17301526 19642359 17294898 17339181 17506722 17368321
MESH:D015458 Leukemia, T-Cell Curcumin 4.4316106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.069224671
MESH:D008064 Lipidoses marker/mechanism 15342952 16919414
MESH:D008064 Lipidoses Amitriptyline 91.4715342952 17567588
MESH:D008064 Lipidoses chlorcyclizine 91.4715342952
MESH:D008064 Lipidoses Chlorpromazine 91.4717567588 15342952
MESH:D008064 Lipidoses Citalopram 91.4717567588
MESH:D008064 Lipidoses Clomipramine 91.4715342952 17567588
MESH:D008064 Lipidoses Clozapine 91.4717567588
MESH:D008064 Lipidoses Fluoxetine 91.4715342952 17567588
MESH:D008064 Lipidoses Imipramine 91.4717567588 15342952
MESH:D008064 Lipidoses Ketoconazole 91.4717567588
MESH:D008064 Lipidoses Loratadine 91.4717567588
MESH:D008064 Lipidoses Perhexiline 91.4715342952 17567588
MESH:D008064 Lipidoses Sertraline 91.4717567588
MESH:D008064 Lipidoses Tamoxifen 91.4717567588 15342952
MESH:D008064 Lipidoses Thioridazine 91.4717567588 15342952
MESH:D008064 Lipidoses trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride 91.4715342952
MESH:D008064 Lipidoses Zimeldine 91.4715342952
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.0817355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.0814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 8.0817565644
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.0818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.0812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.0816248980 18397230
MESH:D008107 Liver Diseases Chlorpromazine 4.5214986274
MESH:D008107 Liver Diseases Curcumin 4.5216956363
MESH:D008113 Liver Neoplasms Diethylstilbestrol 6.6216712894 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 6.6216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.6216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.8912151625
MESH:D008133 Long QT Syndrome Thioridazine 4.8320210726
MESH:D008175 Lung Neoplasms alitretinoin 6.1016413115
MESH:D008175 Lung Neoplasms Curcumin 6.1019359593 16243823 18462866
MESH:D008175 Lung Neoplasms Isotretinoin 6.1015899809
MESH:D008175 Lung Neoplasms Tamoxifen 6.1018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.1011884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.7915166399
MESH:D008223 Lymphoma Curcumin 6.9618462866
MESH:D008223 Lymphoma Diethylstilbestrol 6.9615700306
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3516173963
MESH:D016778 Malaria, Falciparum Perhexiline 10.6216882315
MESH:D016778 Malaria, Falciparum Thioridazine 10.6216882315
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1516002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4119428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.6516891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.6517203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.6514580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.4419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.4419453300
MESH:D008527 Medulloblastoma Tretinoin 2.6417453147
MESH:D008545 Melanoma Curcumin 6.7718462866 17885582
MESH:D008545 Melanoma Isotretinoin 6.7717237267
MESH:D008545 Melanoma Tamoxifen 6.7712393984 19393235
MESH:D008545 Melanoma Tretinoin 6.7716752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8315990972
MESH:D008569 Memory Disorders Curcumin 9.1917263510
MESH:D008569 Memory Disorders Trichlorfon 9.1915957009
MESH:D008591 Meningomyelocele Tretinoin 4.0816940565
MESH:D001523 Mental Disorders Amitriptyline 48.3416856516
MESH:D001523 Mental Disorders Chlorpromazine 48.3416856516
MESH:D001523 Mental Disorders Citalopram 48.3416856516
MESH:D001523 Mental Disorders Clomipramine 48.3416856516
MESH:D001523 Mental Disorders Clozapine 48.3416856516
MESH:D001523 Mental Disorders Doxepin 48.3416856516
MESH:D001523 Mental Disorders Fluoxetine 48.3416856516
MESH:D001523 Mental Disorders Imipramine 48.3416856516
MESH:D001523 Mental Disorders Sertraline 48.3416856516
MESH:D001523 Mental Disorders Thioridazine 48.3416856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.1219142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4316801185
MESH:D008881 Migraine Disorders Amitriptyline 7.6218803445
MESH:D008881 Migraine Disorders Aspirin 7.6215240983
MESH:D009101 Multiple Myeloma Curcumin 3.2719372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.5617962980
MESH:D009175 Mycoplasma Infections Chlorpromazine 5.6410773494
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8817596541
MESH:D009203 Myocardial Infarction Aspirin 3.4012692751
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0116810080
MESH:D009207 Myoclonus Fluoxetine 5.528041377
MESH:D009325 Nausea Aspirin 4.8515240983
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0318495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4019410462
MESH:D009369 Neoplasms alitretinoin 7.4016946489
MESH:D009369 Neoplasms Diethylstilbestrol 7.4015313581
MESH:D009369 Neoplasms Tretinoin 7.4016946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.6412497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.6419189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3817289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9919348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 20.6711399458
MESH:D009421 Nervous System Malformations Estradiol 20.6716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.6714600291
MESH:D009421 Nervous System Malformations Tretinoin 20.679125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.2718462866
MESH:D009436 Neural Tube Defects Tretinoin 2.829142499
MESH:D009447 Neuroblastoma Isotretinoin 3.8617368321
MESH:D009765 Obesity Clozapine 4.7218515891 19142110
MESH:D009765 Obesity Curcumin 4.7219297423
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.1320418887
MESH:D010003 Osteoarthritis Aspirin 7.567009135
MESH:D010003 Osteoarthritis rofecoxib 7.5616690336
MESH:D010024 Osteoporosis Curcumin 3.2518719352
MESH:D010051 Ovarian Neoplasms Curcumin 10.3118462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 10.3119401270
MESH:D010051 Ovarian Neoplasms Progesterone 10.3116525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 10.3116936753
MESH:D010146 Pain Amitriptyline 22.8312798668
MESH:D010146 Pain Aspirin 22.836995502 6363464
MESH:D010146 Pain Clomipramine 22.8312798668
MESH:D010146 Pain Fluoxetine 22.8312798668
MESH:D010146 Pain Imipramine 22.8312798668
MESH:D010146 Pain Tretinoin 22.8316870215
MESH:D010149 Pain, Postoperative rofecoxib 5.0316678543 18165598
MESH:D010190 Pancreatic Neoplasms Curcumin 4.9917440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.9915976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.8817698068
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8912520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.1911156591
MESH:D020795 Photophobia Aspirin 5.4015240983
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.658041377
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3216977796 15687265
MESH:D011020 Pneumonia, Pneumocystis Pentamidine 6.3515340016
MESH:D017499 Porokeratosis alitretinoin 5.6416144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2218163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9312371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.3617184923
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 14.3618769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.3611222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5720887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 18383875
MESH:D011471 Prostatic Neoplasms Curcumin 1.9218226269 18156803 11398177 18769126 10851300 12497104 15129424
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9215846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 1.9216740699
MESH:D011471 Prostatic Neoplasms Ketoconazole 1.9217404083
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9215067354
MESH:D011507 Proteinuria Tretinoin 3.2816636307
MESH:D011565 Psoriasis Cyclosporine 2.1016882103
MESH:D011596 Psychomotor Disorders Isotretinoin 5.5618769834
MESH:D011618 Psychotic Disorders Clozapine 8.6815331141
MESH:D011618 Psychotic Disorders Thioridazine 8.6816882315
MESH:D011625 Pterygium Tretinoin 4.4416723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.2219168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7010666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7716283617 16116481
MESH:D012220 Rhinitis Aspirin 4.0712372130
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7318045962
MESH:D012509 Sarcoma Curcumin 3.8118462866
MESH:D012559 Schizophrenia Clozapine 2.6916141801 20580759 20168265 20521326 17667964 18806925 11151749 20452607 20521320 19369910 17123785 18855531 11763009 17726453 20107430
MESH:D018805 Sepsis Curcumin 3.7918389075
MESH:D020230 Serotonin Syndrome Fluoxetine 5.548704074
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 4.9212269725
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.9916192470
MESH:D012878 Skin Neoplasms Tretinoin 4.9916467112
MESH:D012892 Sleep Deprivation Imipramine 5.8419798453
MESH:D007319 Sleep Initiation and Maintenance Disorders Amitriptyline 9.8915341891
MESH:D007319 Sleep Initiation and Maintenance Disorders Doxepin 9.8915341891
MESH:D013088 Spermatocele Diethylstilbestrol 10.6416709447 16002989
MESH:D013088 Spermatocele Tamoxifen 10.6416709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.6916503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.6919457130
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013276 Stomach Ulcer Curcumin 3.1919188055 16631530
MESH:D020521 Stroke Aspirin 4.1016403987
MESH:D013322 Strongyloidiasis Trichlorfon 6.2714651886
MESH:D017180 Tachycardia, Ventricular Thioridazine 5.3720210726
MESH:D013927 Thrombosis Aspirin 4.2217672075
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5412697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.7617045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.3219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4816051514
MESH:D016171 Torsades de Pointes Flecainide 5.7117467628
MESH:D014352 Trypanosomiasis Pentamidine 6.1515340016
MESH:D014376 Tuberculosis Tretinoin 3.0116040207
MESH:D001749 Urinary Bladder Neoplasms Curcumin 7.5818593936
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 7.5817306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.5817572228 8653321 16712894
MESH:D014565 Urogenital Neoplasms Curcumin 4.9118462866
MESH:D014581 Urticaria Aspirin 8.7010982225 20485159
MESH:D014581 Urticaria Loratadine 8.702568013
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.4916175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.4916129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.7315809267 16690809
MESH:D014604 Uveal Neoplasms Tretinoin 4.2516752155
MESH:D014605 Uveitis Cyclosporine 3.621336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.0916513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2312125929
MESH:D014820 Vitiligo Tretinoin 3.7216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8915886252
MESH:D015430 Weight Gain Clozapine 4.1716402076 20521320 20107430 16141801 17502770 20564506
MESH:D015431 Weight Loss Clozapine 4.7217933447
MESH:D009396 Wilms Tumor Tretinoin 3.6716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.0817120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35020
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA450196letrozole
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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