AutismKB 2.0

Annotation Detail for ADD3


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Basic Information Top
Gene Symbol:ADD3 ( ADDL )
Gene Full Name: adducin 3 (gamma)
Band: 10q25.1-q25.2
Quick LinksEntrez ID:120; OMIM: 601568; Uniprot ID:ADDG_HUMAN; ENSEMBL ID: ENSG00000148700; HGNC ID: 245
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
hypertension
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002029 17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol 17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol results in increased expression of ADD3 mRNAincreases expression 17275934
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ADD3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of ADD3 mRNAincreases expression 20406850
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADD3 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ADD3 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ADD3 mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ADD3 mRNAincreases expression 19150397
C095105 bexarotene bexarotene results in increased expression of ADD3 mRNAincreases expression 17178900
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ADD3 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ADD3 mRNAdecreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of ADD3 mRNAdecreases expression 20106945
D004317 Doxorubicin ADD3 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADD3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADD3 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ADD3 mRNAdecreases expression 15576828
17557909
D005419 Flavonoids Flavonoids results in decreased expression of ADD3 mRNAdecreases expression 18035473
D005472 Fluorouracil ADD3 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C051890 irinotecan irinotecan metabolite results in decreased expression of ADD3 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of ADD3 mRNAdecreases expression 15956246
D001556 Lindane Lindane affects the expression of ADD3 mRNAaffects expression 17785943
D008294 Malathion Malathion results in increased expression of ADD3 mRNAincreases expression 19784758
D008743 Methyl Parathion Methyl Parathion affects the expression of ADD3 mRNAaffects expression 19784758
D008743 Methyl Parathion Methyl Parathion results in decreased expression of ADD3 mRNAdecreases expression 19784758
D008743 Methyl Parathion Methyl Parathion results in increased expression of ADD3 mRNAincreases expression 19784758
C008493 methylselenic acid methylselenic acid results in increased expression of ADD3 mRNAincreases expression 12517777
D017239 Paclitaxel ADD3 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
D010278 Parathion Parathion results in increased expression of ADD3 mRNAincreases expression 19784758
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ADD3 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of ADD3 mRNAincreases expression 18301758
D012643 Selenium Selenium results in decreased expression of ADD3 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of ADD3 mRNA]affects reaction|increases expression 19465110
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADD3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ADD3 mRNAincreases expression 19465110
D019772 Topotecan ADD3 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014212 Tretinoin Tretinoin results in increased expression of ADD3 mRNAincreases expression 16140955
16054129
D014747 Vinblastine ADD3 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
C025643 vinclozolin vinclozolin affects the expression of ADD3 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of ADD3 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.6020127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 9.6017418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.6014692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.6017638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.506695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.0216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0216835633
MESH:D000382 Agricultural Workers' Diseases Lindane 13.2912661182
MESH:D000382 Agricultural Workers' Diseases Malathion 13.2911874814 17119214
MESH:D000382 Agricultural Workers' Diseases Parathion 13.2917119214 11874814
MESH:D000419 Albuminuria Doxorubicin 4.2921441931
MESH:D000505 Alopecia Tretinoin 3.4115955085
MESH:D000740 Anemia Fluorouracil 7.9316511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9311748828
MESH:D001008 Anxiety Disorders vinclozolin 3.4319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8219183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.6715885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.6716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2016292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001471 Barrett Esophagus Tretinoin 4.1516935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.9119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.9112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.9116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4314601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.3215867366
MESH:D001932 Brain Neoplasms Doxorubicin 3.5817150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.7220146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 6.7216818667 16344269
MESH:D001943 Breast Neoplasms Doxorubicin 6.7217426702 18234424 15136595 15993339 18382427 16826403 15567936 16322301 18695136 15634643 16935488 15994142 16264153 16595493 15939500 15692762 17983394 11325840 17369602 19526202 16096432 16115903 18628466 15668708
MESH:D001943 Breast Neoplasms Fluorouracil 6.7218357371 15136595 18608205 19217205 16595493 16557594 16110121
MESH:D001943 Breast Neoplasms Lindane 6.7214688026
MESH:D001943 Breast Neoplasms Malathion 6.7212762645
MESH:D001943 Breast Neoplasms Paclitaxel 6.7215136595 16244791 11325840 16273361 16115903 18234424 18223236 18323546
MESH:D001943 Breast Neoplasms Parathion 6.7212762645
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.7220435547
MESH:D001943 Breast Neoplasms Tretinoin 6.7216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3316813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.0816192424 16011737 10355542 16124888 15700767 18705752 15673190 16097048 15721981 16050911 16227642 3786805
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.0816050911
MESH:D002276 Carcinoid Tumor Doxorubicin 11.4616051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.4616051944
MESH:D002277 Carcinoma Fluorouracil 7.5017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.3916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.3916705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.3918788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.3916234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.3916799960 16332177 18930000 17045692 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 13.3916313753
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.391917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1416247446
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.211485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.2118695887
MESH:D002292 Carcinoma, Renal Cell Vinblastine 10.211485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.1420419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.146189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.1418986760 16280240 16757204 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.1416051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2216120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.3617974986 17007740 17928571 16242529 17924179 16455267 16952015 16612575 15792986 17519947 16731534 15476868 16651473 17351982 15811867 15505089 17382496 16109756 16278810 16364871 17329180 17131338 18627295 16269455 17308081
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8617334414 16243910
MESH:D002386 Cataract Tretinoin 2.9417460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.106135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.1020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.1012371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9416835633
MESH:D002779 Cholestasis Cyclosporine 12.2319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.2317110522 16919318 15861022 16105132 17333356 11677210 17681005
MESH:D002779 Cholestasis pirinixic acid 12.2319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4015340226 8697196 12621046 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 5.409407595
MESH:D003092 Colitis Selenium 8.6417936198
MESH:D003092 Colitis Tretinoin 8.6417035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7918772588 16510598 17725105 15001691 17018589 16340194 17016597 17172411 17287894 17169374
MESH:D003110 Colonic Neoplasms irinotecan 3.7917725105 17287894
MESH:D015179 Colorectal Neoplasms Doxorubicin 6.2118259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 6.2115289873 18802399 16303861 18448328 17454858 16331619 18509181 16282729 15148649 17401013 18383874 16524972 14970324 17695437 17594712 16391804 17094418 20501625 18949393 17016601 17255274 18288408
MESH:D015179 Colorectal Neoplasms irinotecan 6.2116391804 17454858 18259882 15273666 17159606 18509181 16303861
MESH:D015179 Colorectal Neoplasms Paclitaxel 6.2118802399
MESH:D015179 Colorectal Neoplasms Vinblastine 6.2118802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5920055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.5917551590 9125849 8800419 9211117 10589399 14991402 16925845 9664655 9142499 9224671
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.5919769572
MESH:D003456 Cryptorchidism vinclozolin 4.0914966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.0318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.0318551238
MESH:D007644 Darier Disease Fluorouracil 4.5316733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.1918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 14.1918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.1916177239 4309450 10915739 16227642 7440962 7120509 2869522 3786805 21278145 15027814 19085960 7179309 15968718 17522070 10092053 15998439 6884620 11566570 6623471 19336974 9327722 3732212
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 14.1917416283
MESH:D056486 Drug-Induced Liver Injury Selenium 14.1915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.1920420201
MESH:D004362 Drug Toxicity Doxorubicin 7.4718602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.4711462148
MESH:C538011 Eales disease Vitamin E 4.449068938
MESH:D004487 Edema pirinixic acid 5.7712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.7712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.0515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.0518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9412538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.0217359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.0216569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8010568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8918037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.8320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.8316530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.8315173087 16481741 17638652 16785472 16337965
MESH:D004938 Esophageal Neoplasms Paclitaxel 9.8316481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1911564622
MESH:D005124 Eye Abnormalities Tretinoin 8.199664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.8015959796 16239168 12795759 17595544 12631006 16045604 61145 19224547
MESH:D005234 Fatty Liver Cyclosporine 16.8019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.8015345470
MESH:D005234 Fatty Liver pirinixic acid 16.8019236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.3219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 19.0118705752
MESH:D005355 Fibrosis Cyclosporine 19.0112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.0120067830
MESH:D005355 Fibrosis Tretinoin 19.0117994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0316417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D005909 Glioblastoma Doxorubicin 6.6817150277
MESH:D005909 Glioblastoma Tretinoin 6.6817312396
MESH:D005910 Glioma Fluorouracil 2.7716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 11.9615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.9615162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 11.9616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 14.8320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.8310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 14.8314991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 14.8316080930
MESH:D006331 Heart Diseases Doxorubicin 3.3118006777 16144979 16879835 17888722 14766674 16707910 16495754 18674790 16244372 16330681 17875725 12587719 16244371
MESH:D006333 Heart Failure Doxorubicin 10.8717481944
MESH:D006333 Heart Failure pirinixic acid 10.8720558911
MESH:D006333 Heart Failure Selenium 10.8717162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6715692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3519900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.4119176532 19772884 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.4112621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6116490937 16863852
MESH:D006689 Hodgkin Disease Doxorubicin 7.0817606976 18501091 15147373
MESH:D006689 Hodgkin Disease Vinblastine 7.0818501091 18180244
MESH:D019584 Hot Flashes Vitamin E 3.7114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.788697196 15340226 16354765 18606429 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.0116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2716899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3116778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9620558911
MESH:D006973 Hypertension Cyclosporine 4.6110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.4017937319
MESH:D007248 Infertility, Male Parathion 10.4016029889
MESH:D007248 Infertility, Male vinclozolin 10.4016467254
MESH:D007249 Inflammation Flavonoids 4.5517296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.5512200463 12878042
MESH:D007251 Influenza, Human Selenium 10.0716624496
MESH:D007251 Influenza, Human Vitamin E 10.0716624496
MESH:D007333 Insulin Resistance pirinixic acid 2.4616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5117994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.1515992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D007674 Kidney Diseases Cyclosporine 9.248314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 9.2415699352 15369732 16775033
MESH:D007674 Kidney Diseases Vitamin E 9.2412488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.2016707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.2016518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.0216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.0216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 16.0212371664
MESH:D007680 Kidney Neoplasms Fluorouracil 16.0216985049
MESH:D007938 Leukemia Tretinoin 2.6417143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8916085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4616932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0316294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9816891316 16788101 17361223 12679006 17294898 17301526 16823087 16766008 17107899 15748426 17712046 19075265 19642359 19029980 17649720 19225113 17339181 16935935 16140955 17506722 17368321 16331271 17217047 9834237 19035177
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.129224671
MESH:D008080 Liposarcoma Paclitaxel 4.5817353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6717157831 17334410 16943688 17174718 16221502 16239168 21278145 11903743 11408273
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.2816033810 18251166 18054572 15123356 14620537 18472332 16015684 12632514 14724832 12586293 15370692 18395914 18472094 17481882 18166357 16136751 17944888 15818738 12666154 17557913 15057751 17708605 15925388 12546737 17823541 18277467 17922224 12632512 14716496 17761835 15931870 17766677 18006644 17631135 20821823 16248980 18481824 17869086 16638106 18339082 12389079 12741479 14512876 12958196 11481614 14748882 18705752 12898905 16097048 18187930 12445418 17714472 17900296 15338365 17698563 18376398 16116963 15996030 18420326 18210741 17640975 18412020 12445421 15730626 16011737 17805973 15876570 15673190 17976157 12649538 18418968 16192424 17525996 18317297 12667390 18429990 15959796 18156304 16027843 14716833 18263696 15362042 17565644 10355542 15052691 17721639 18279442 15650968 15893842 12609069 18395095 18205269 13678700
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.2816439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.2815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.2818397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.2816169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2015830285 17285989 16964402 16246199 15720792
MESH:D008107 Liver Diseases Lindane 4.201715830
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4614706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 16.657678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.6521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.6519294768
MESH:D008113 Liver Neoplasms Fluorouracil 16.6518383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 16.6515890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.6516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.782876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.7815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 12.7817085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.7812151625
MESH:D008171 Lung Diseases Vitamin E 3.0016863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.1120135361 18569708 6695378 18816296 20064080 20464547 18520028 17053015 20869020
MESH:D008175 Lung Neoplasms bexarotene 8.1117849452
MESH:D008175 Lung Neoplasms Doxorubicin 8.116189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 8.1115246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1119555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 8.1111062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5315086387
MESH:D008223 Lymphoma Doxorubicin 3.2816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.2617654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 8.2614749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3115621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.8911161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.1615591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.1615458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.1615318939
MESH:D008527 Medulloblastoma Tretinoin 2.6817453147
MESH:D008545 Melanoma Doxorubicin 6.9716827129
MESH:D008545 Melanoma Paclitaxel 6.9716342250 12040289 12025231
MESH:D008545 Melanoma Tretinoin 6.9716752155
MESH:D008545 Melanoma Vinblastine 6.9712374674 17761969 16248763 16809738 18332650 18505091 15577320 16432458 18176117 15577323
MESH:D008591 Meningomyelocele Tretinoin 4.1716940565
MESH:D008654 Mesothelioma Doxorubicin 5.9417638057
MESH:D008654 Mesothelioma Selenium 5.9415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2615792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.8716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.8718986760 16757204
MESH:D052016 Mucositis Doxorubicin 11.5417415656
MESH:D052016 Mucositis irinotecan 11.5417159606
MESH:D009101 Multiple Myeloma Paclitaxel 3.5014749477
MESH:D009135 Muscular Diseases pirinixic acid 3.2516239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9317596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.3419429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.3419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.4718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.477678174 18551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.0818259882
MESH:D009362 Neoplasm Metastasis irinotecan 9.0818259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 9.0815867366
MESH:D009369 Neoplasms Benzo(a)pyrene 14.3411141357
MESH:D009369 Neoplasms Fluorouracil 14.3418600527 16928823 18239605
MESH:D009369 Neoplasms Lindane 14.3416818664 12807735
MESH:D009369 Neoplasms pirinixic acid 14.3417405874
MESH:D009369 Neoplasms Tretinoin 14.3416594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.5219196722
MESH:D009401 Nephrosis Doxorubicin 4.5116899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.5618481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.5615640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.689125849
MESH:D009436 Neural Tube Defects Tretinoin 2.899142499
MESH:D009447 Neuroblastoma Doxorubicin 10.8015555623
MESH:D009447 Neuroblastoma irinotecan 10.808761367
MESH:D009447 Neuroblastoma Topotecan 10.8015176712
MESH:D017599 Neuroectodermal Tumors irinotecan 4.478761367
MESH:D020258 Neurotoxicity Syndromes marker/mechanism 19784758
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 12.6516436463
MESH:D020258 Neurotoxicity Syndromes Malathion 12.6515081274
MESH:D020258 Neurotoxicity Syndromes Methyl Parathion 12.6519784758
MESH:D009503 Neutropenia Vinblastine 4.3317378895
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.1312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.1316049721
MESH:D010014 Osteolysis Paclitaxel 4.7215867366
MESH:D012516 Osteosarcoma Doxorubicin 3.9115930896
MESH:D010051 Ovarian Neoplasms Paclitaxel 4.8111161223
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8116936753
MESH:D010146 Pain Tretinoin 2.7016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.0215113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.0215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8917983394
MESH:D010954 Plasmacytoma Selenium 4.6215087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8917638057
MESH:D011041 Poisoning Methyl Parathion 4.8017603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6111896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.6118042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.6718220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0616729912 15749863 18437689 16868541 15897917 16888761
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0618626508 19082440
MESH:D011471 Prostatic Neoplasms Lindane 2.0612661182 14688026
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.0616205645
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.0616356831 17136230 17172428 16729912
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0615084515
MESH:D011472 Prostatitis vinclozolin 4.6718629315
MESH:D011507 Proteinuria Tretinoin 3.3616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011625 Pterygium Tretinoin 4.5316723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7916160472 18286688 18722050 15538739
MESH:D051437 Renal Insufficiency Doxorubicin 3.9617922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2619058328
MESH:D012135 Respiratory Sounds Malathion 9.7717119214 11874814
MESH:D012135 Respiratory Sounds Parathion 9.7711874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012140 Respiratory Tract Diseases Malathion 10.6217119214
MESH:D012140 Respiratory Tract Diseases Parathion 10.6217119214
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8616283617 16116481
MESH:D012509 Sarcoma Doxorubicin 3.7615675481 17203757 18313854 17710206 15625365 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.9916326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5317846226
MESH:D012640 Seizures 2,4-dinitrotoluene 8.9118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.9118551238
MESH:D012640 Seizures Lindane 8.917539098 15475178 12842176
MESH:D012871 Skin Diseases Vitamin E 2.3718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.6010029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 16.6015692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.608532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.6016192470
MESH:D012878 Skin Neoplasms Tretinoin 16.6016467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3115625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6816709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.1120155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 6.1118567086 17522103 15786421 16424979 17172411 19015929 19084572 18396642 17498489 16951190
MESH:D013274 Stomach Neoplasms irinotecan 6.1115723263
MESH:D013274 Stomach Neoplasms Paclitaxel 6.1118396642 18506536
MESH:D013274 Stomach Neoplasms Tretinoin 6.1117261132
MESH:D020521 Stroke Vitamin E 3.3216517955
MESH:D024801 Tauopathies Paclitaxel 4.5516930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.6616010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6617045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 9.0716280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.0716051514
MESH:D014376 Tuberculosis Tretinoin 3.0716040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.0616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.0616049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.0617053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.0617653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.1110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.1110091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.7016803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.7016129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0514692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3416752155
MESH:D014605 Uveitis Cyclosporine 3.721336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.7915577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9617638931 16364871 17334414 17678736
MESH:D014820 Vitiligo Tretinoin 3.8116761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D009396 Wilms Tumor Tretinoin 3.7516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24567
    • No data
    Releated disease ID Related disease Name
    PA444552Hypertension
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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