AutismKB 2.0

Annotation Detail for CLPTM1


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Basic Information Top
Gene Symbol:CLPTM1 ( - )
Gene Full Name: cleft lip and palate associated transmembrane protein 1
Band: 19q13.32
Quick LinksEntrez ID:1209; OMIM: 604783; Uniprot ID:CLPT1_HUMAN; ENSEMBL ID: ENSG00000104853; HGNC ID: 2087
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
No data
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CLPTM1 mRNAdecreases expression 17547211
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CLPTM1 mRNAaffects expression 21346803
D000965 Antimony Antimony results in decreased expression of CLPTM1 mRNAdecreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in decreased expression of CLPTM1 mRNAdecreases expression 17547211
D002857 Chromium Chromium results in decreased expression of CLPTM1 mRNAdecreases expression 17547211
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of CLPTM1 mRNAdecreases expression 17547211
D004317 Doxorubicin CLPTM1 mRNA affects the susceptibility to Doxorubicinaffects response to substance 16243817
D004958 Estradiol Estradiol results in decreased expression of CLPTM1 mRNAdecreases expression 16705744
D019833 Genistein Genistein results in decreased expression of CLPTM1 mRNAdecreases expression 16705744
D008628 Mercury Mercury results in decreased expression of CLPTM1 mRNAdecreases expression 17547211
D008628 Mercury Mercury results in increased expression of CLPTM1 mRNAincreases expression 16823088
D008727 Methotrexate CLPTM1 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C022838 nickel chloride nickel chloride results in decreased expression of CLPTM1 mRNAdecreases expression 17547211
D011192 Potassium Dichromate Potassium Dichromate results in decreased expression of CLPTM1 mRNAdecreases expression 17547211
D012643 Selenium Selenium results in increased expression of CLPTM1 mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in decreased expression of CLPTM1 mRNAdecreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.3012039119
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 10.3116033868
MESH:D000230 Adenocarcinoma Doxorubicin 10.3117418594
MESH:D000230 Adenocarcinoma Estradiol 10.3111473722
MESH:D000230 Adenocarcinoma Genistein 10.3111473722
MESH:D000236 Adenoma Dimethylnitrosamine 3.5719555203
MESH:D000419 Albuminuria Doxorubicin 4.5821441931
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1017286800
MESH:D001321 Autistic Disorder Mercury 2.7817497416
MESH:D001327 Autoimmune Diseases Mercury 4.9116634805
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.7614601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.8417150277
MESH:D001943 Breast Neoplasms Chromium 2.3915986119
MESH:D001943 Breast Neoplasms Doxorubicin 2.3915634643 15939500 18695136 15136595 16935488 19526202 17426702 18628466 15567936 15994142 16322301 17983394 16264153 18382427 16595493 16826403 15668708 18234424 15993339 16115903 15692762 16096432 11325840 17369602
MESH:D001943 Breast Neoplasms Estradiol 2.3912948864 17261762 17018787 14630087 16675129 19861407 18497071 17289903
MESH:D001943 Breast Neoplasms Genistein 2.3917200150 16541309 16873071
MESH:D001943 Breast Neoplasms Methotrexate 2.3916978400
MESH:D001991 Bronchitis Antimony 6.208768112
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.8716051944
MESH:D002277 Carcinoma Dimethylnitrosamine 4.0419555203
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6416705839
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.6417876044 16234567 16023760 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6416924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6416924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.171485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 5.0516033868
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.056189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.5516731534 16612575 16109756 17974986 16651473 16242529 17131338 16952015 17351982 15811867 15505089 17382496 16269455 16455267 16364871 17924179 17928571 16278810 17329180 17007740 15792986 15476868 18627295 17519947 17308081
MESH:D002311 Cardiomyopathy, Dilated Antimony 9.8410334427
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 9.8416243910 17334414
MESH:D002311 Cardiomyopathy, Dilated Mercury 9.8410334427
MESH:D002318 Cardiovascular Diseases Genistein 3.3216332659
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.736135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7318566989
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D003092 Colitis Selenium 3.8217936198
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.659562676 12039119
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0618551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.2619747007
MESH:D017449 Dermatitis, Allergic Contact Mercury 7.8816823706
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 7.8816823706
MESH:D003882 Dermatomyositis Methotrexate 5.1620191521
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8016285004
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4916647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D004283 Dog Diseases Antimony 5.7112019027
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.1418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 12.148172417
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 12.1417416283
MESH:D056486 Drug-Induced Liver Injury Selenium 12.1415131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.1415131321
MESH:D004362 Drug Toxicity Doxorubicin 3.6918602426
MESH:D004714 Endometrial Hyperplasia Genistein 4.6416402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.6217359293
MESH:D016889 Endometrial Neoplasms Estradiol 12.6219148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 12.6211473722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2218037988
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 2.9117016578
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.6419069698
MESH:D005909 Glioblastoma Doxorubicin 7.3917150277
MESH:D005909 Glioblastoma Genistein 7.3916598420
MESH:D006086 Graft vs Host Disease Methotrexate 5.1916518429
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5515692506
MESH:D006331 Heart Diseases Doxorubicin 3.5016244371 16879835 16144979 14766674 18674790 17875725 16707910 16244372 17888722 18006777 12587719 16495754 16330681
MESH:D006333 Heart Failure Doxorubicin 7.3017481944
MESH:D006333 Heart Failure Selenium 7.3017162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9315692506
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.4315147373 18501091 17606976
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D007251 Influenza, Human Selenium 4.2616624496
MESH:D007333 Insulin Resistance Estradiol 7.4916627594 16393666
MESH:D007333 Insulin Resistance Sodium Selenite 7.4914714311
MESH:D007674 Kidney Diseases Chromium 19.3017934191
MESH:D007674 Kidney Diseases Doxorubicin 19.3015369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 19.3015618244
MESH:D007674 Kidney Diseases Mercury 19.3017934191
MESH:D007674 Kidney Diseases Potassium Dichromate 19.3019665454
MESH:D007676 Kidney Failure, Chronic Doxorubicin 10.0816707910
MESH:D007676 Kidney Failure, Chronic Selenium 10.0816518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.4416705839
MESH:D007680 Kidney Neoplasms Estradiol 7.4415610895
MESH:D007805 Language Development Disorders Methotrexate 5.139562676
MESH:D007896 Leishmaniasis Antimony 4.8321182181 15220340 21063981 10953559 12019027
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.698889330 19141829 11475954
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.5411370249 7854095 10651420 10881086 9643325
MESH:D007898 Leishmaniasis, Visceral Antimony 8.817875148 7854095 20495762 7554475 1899875 11105143 8142506
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 8.8112707265
MESH:D007938 Leukemia Genistein 3.0417468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2216085563
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 4.539834237
MESH:D008103 Liver Cirrhosis Methotrexate 3.7114986274
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 5.0615504291 15369754 18210741 16009107 15591649 17348192 16570917 15577212 16603200 17198567 15793283 14709902 15723089 17534399 15744066 17465448 14659978 15864749 18237412 14726149 15086199 16169303 18629640 15798949 17203207 17724770 17881167 15571005 15138612 18672772 15842777 14568256 15099470 15479170 12918455 18239293 12925901 18567088 16544323 18637143 17036385 17201889 17666798 16627068 15733078 15161499 15492853 14643895 15942678 15383259 18371158 15366600 15339415 15298665 18095165 17719030 15067225 16270385 15081153 18364076 17640959 16042886 17196135 17432682 15763062
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 5.0616595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.0617823541
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.4317457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.857678174
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 4.8515890375 3113478
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.102876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 10.1015603536 1848544 6150874
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.1017085340 16842330
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.0818516814
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 2.8516061637 11884234 19555203
MESH:D008175 Lung Neoplasms Doxorubicin 2.8517418594 6189445
MESH:D008223 Lymphoma Doxorubicin 7.9916098063
MESH:D008223 Lymphoma Methotrexate 7.9917352296
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8117654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6115621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 14.4515458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.4511807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 14.4514578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 14.4515318939
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008545 Melanoma Doxorubicin 2.2916827129
MESH:D008654 Mesothelioma Doxorubicin 6.3217638057
MESH:D008654 Mesothelioma Selenium 6.3215107826
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5315792986
MESH:D052016 Mucositis Doxorubicin 12.6917415656
MESH:D052016 Mucositis Methotrexate 12.6917488658
MESH:D009203 Myocardial Infarction Doxorubicin 6.0115857846 19429709
MESH:D009203 Myocardial Infarction Genistein 6.0117141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.5817141266
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9118551238 7678174
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9618259882
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009401 Nephrosis Doxorubicin 4.8116899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.0216889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 9.8911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 9.8916427766
MESH:D009447 Neuroblastoma Doxorubicin 3.2715555623
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4616049721
MESH:D010024 Osteoporosis Genistein 3.2719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1216169203
MESH:D012516 Osteosarcoma Doxorubicin 4.1315930896
MESH:D010051 Ovarian Neoplasms Estradiol 4.9319401270
MESH:D010051 Ovarian Neoplasms Genistein 4.9319005980
MESH:D010409 Penile Diseases Antimony 5.769643325
MESH:D010493 Pericarditis Antimony 6.1620465667
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2217983394
MESH:D010954 Plasmacytoma Selenium 4.9515087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2217638057
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1016868541 15897917 16729912 16888761 18437689 15749863
MESH:D011471 Prostatic Neoplasms Estradiol 2.1016740699
MESH:D011471 Prostatic Neoplasms Genistein 2.1015256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1018760546
MESH:D011565 Psoriasis Methotrexate 3.4417410198
MESH:D051437 Renal Insufficiency Doxorubicin 10.6317922066
MESH:D051437 Renal Insufficiency Methotrexate 10.6317352296
MESH:D012509 Sarcoma Doxorubicin 4.0116767912 18313854 17203757 15675481 17710206 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8417846226
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5518551238
MESH:D012878 Skin Neoplasms Doxorubicin 2.9615692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6116767912 17203757 15625365
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.3312587719
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.4616033868
MESH:D013576 Syndactyly Methotrexate 5.079562676
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.3917909728 16010429
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D014352 Trypanosomiasis Antimony 5.9915220340
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2216049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.2217653716
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3710091137
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2617678736 17638931 17334414 16364871
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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