AutismKB 2.0

Annotation Detail for CLTB


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Basic Information Top
Gene Symbol:CLTB ( LCB )
Gene Full Name: clathrin, light chain B
Band: 5q35.2
Quick LinksEntrez ID:1212; OMIM: 118970; Uniprot ID:CLCB_HUMAN; ENSEMBL ID: ENSG00000175416; HGNC ID: 2091
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
hsa04144Endocytosis
hsa05016Huntington's disease
hsa05100Bacterial invasion of epithelial cells
Pathway IDPathway Name
Membrane Trafficking
Pathway IDPathway Name
200167Arf1 pathway
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00029Huntington disease
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of CLTB mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CLTB mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CLTB mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of CLTB mRNAincreases expression 17258074
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CLTB mRNAincreases expression 20106945
C032036 bromobenzene bromobenzene results in increased expression of CLTB mRNAincreases expression 12628495
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CLTB mRNAdecreases expression 16644059
12832660
D003024 Clozapine Clozapine results in decreased expression of CLTB mRNAdecreases expression 15860345
D004958 Estradiol Estradiol affects the expression of CLTB mRNAaffects expression 14699072
D006220 Haloperidol Haloperidol results in decreased expression of CLTB mRNAdecreases expression 15860345
C029938 nickel sulfate nickel sulfate results in decreased expression of CLTB mRNAdecreases expression 16780908
D020849 Raloxifene Raloxifene affects the expression of CLTB mRNAaffects expression 14699072
D012643 Selenium Selenium results in increased expression of CLTB mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of CLTB mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CLTB proteindecreases expression 16548065
D014212 Tretinoin Tretinoin results in increased expression of CLTB mRNAincreases expression 16054129
D014810 Vitamin E Vitamin E results in increased expression of CLTB mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.457525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4514514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury nickel sulfate 4.2911954676 12718980 19131640 16100012
MESH:D000230 Adenocarcinoma arsenic trioxide 7.0419825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0420464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 7.0411473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.646695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3716835633
MESH:D000380 Agranulocytosis Clozapine 5.0416160616 14617031 12649775
MESH:D000419 Albuminuria Raloxifene 4.5817451421 17308373
MESH:D000505 Alopecia Tretinoin 3.6015955085
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.0616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001321 Autistic Disorder Acetaminophen 2.1218445737
MESH:D001321 Autistic Disorder Haloperidol 2.1219368416 18080171
MESH:D001471 Barrett Esophagus Tretinoin 4.3916935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.2416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.2412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.2416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001930 Brain Injuries Raloxifene 4.4616580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9520146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.9512948864 19861407 17289903 18497071 17261762 17018787 16675129 14630087
MESH:D001943 Breast Neoplasms Raloxifene 2.9517440819 17049068 15775269 17261762 15758505 16837676 15572757 17595753 17893378 17952589 16912660 17242785
MESH:D001943 Breast Neoplasms Tamoxifen 2.9516202921 19103187 19084267 18425577 19142967 19244106 18815881 20065188 17893378 19200415 19189212 16818667 19221464 18629630 19189210 16273361 19115204 19155303 18351453 19066611 18855134 20135344 15565566 21152245 20544844 19289846 19011961 18984771 17440819 19288272 17049068 20390343 15668708 17261762 16873071 18997820 19487384 17242785 19410462 20859285 21138602 19059307 18821012 20005174 11161223
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9520435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9516166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3111589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.8916192424 15721981 16227642 15700767 16050911 3786805 15673190 16124888 16097048 18705752 16011737 10355542
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.8916050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1616168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.363084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.3616217749 15073043 14691202 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.3618788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.3616924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.3616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.361917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1012490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5520419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5516096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.4417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.4417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3516120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4315775269
MESH:D002375 Catalepsy Haloperidol 4.9015215559 1977408
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.3014694615
MESH:D002386 Cataract Acetaminophen 12.3010977129
MESH:D002386 Cataract Tretinoin 12.3017460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.7618566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002822 Choriocarcinoma Tretinoin 5.1616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7415668235 15340226 12621046 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.749407595
MESH:D003072 Cognition Disorders Clozapine 11.6417123785
MESH:D003072 Cognition Disorders Raloxifene 11.6415800139
MESH:D003092 Colitis Selenium 9.4517936198
MESH:D003092 Colitis Tretinoin 9.4517035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.1315095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.1314669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.3810525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3810048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.389224671 10589399 8800419 17551590 14991402 16925845 9142499 9125849 9211117 9664655
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.3819769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 10.8615213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 10.8620210726
MESH:D003704 Dementia Haloperidol 4.5611575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1417474826
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.6616780908 11298694 16823706
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.4916402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4917107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.9219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.9215920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.9219279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5515331141
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.2021346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.2016485898 16781746 17562736 11743745 17522070 18713872 14550746 19416960 12540782 14725611 16227642 11461765 12594235 11739529 10774834 16177239 19164858 19739265 11421492 11287661 10663392 12705907 11834606 16081117 12392966 16109766 12958197 17906064 19923254 18071297 11529661 14986274 2444490 10915739 12153990 15968718 19370779 19085960 16393943 15619225 19420014
MESH:D056486 Drug-Induced Liver Injury bromobenzene 15.2012628495 10092053
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.2016227642 3786805 21278145 7179309 9327722 6623471 2869522 10915739 19085960 15027814 7440962 6884620 16177239 3732212 4309450 10092053 17522070 15998439 19336974 7120509 15968718 11566570
MESH:D056486 Drug-Induced Liver Injury Selenium 15.2015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.2020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D050171 Dyslipidemias Clozapine 4.1716402076
MESH:C538011 Eales disease Vitamin E 4.709068938
MESH:D004487 Edema Raloxifene 6.7915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.9518230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.9518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.1915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.1919031437
MESH:D016889 Endometrial Neoplasms Estradiol 12.3519148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.3519155303 20544844 17893378 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 12.3516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.4212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.789664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 18.6715073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.6712631006 16239168 61145 15959796 19224547 17595544 16045604 12795759
MESH:D005234 Fatty Liver Raloxifene 18.6717473493
MESH:D005234 Fatty Liver Tamoxifen 18.6714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 14.6918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.6920067830
MESH:D005355 Fibrosis Tretinoin 14.6917994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2416904648
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005909 Glioblastoma Tretinoin 2.9917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1616084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 15.8720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 15.8711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 15.8714991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 15.8716080930
MESH:D006331 Heart Diseases Raloxifene 3.5211110106
MESH:D006333 Heart Failure Selenium 3.0617162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5819900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8816120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D019584 Hot Flashes Estradiol 10.0517088409
MESH:D019584 Hot Flashes Vitamin E 10.0514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.5716870215
MESH:D006930 Hyperalgesia Tretinoin 7.5716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5216899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5516778211
MESH:D006948 Hyperkinesis Clozapine 4.9016046005
MESH:D006973 Hypertension Raloxifene 5.2015787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0715338365
MESH:D007249 Inflammation Tamoxifen 4.8519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8512200463 12878042
MESH:D007251 Influenza, Human Selenium 10.9616624496
MESH:D007251 Influenza, Human Vitamin E 10.9616624496
MESH:D007333 Insulin Resistance Estradiol 2.9516627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.7517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8716580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8715992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 9.9715629191 12587719
MESH:D007674 Kidney Diseases Estradiol 9.9715618244
MESH:D007674 Kidney Diseases Vitamin E 9.9712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8716518626
MESH:D007680 Kidney Neoplasms Estradiol 7.3315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 7.3318625569
MESH:D007889 Leiomyoma Raloxifene 4.4816973256
MESH:D007938 Leukemia arsenic trioxide 6.3115070760
MESH:D007938 Leukemia Tretinoin 6.3117143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.4119077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.4116932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8716467208 17050201 16968895 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8717596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.5915213294 16966277 9834237 16112521 17712046 12018890 12712474 15336539 17649720 19642359 16823087 19035177 16891316 17107899 19075265 16331271 17869043 17217047 12679006 15748426 15622746 11161223 16330433 11468182 19225113
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.5917301526 17368321 19029980 12679006 16891316 17506722 17361223 17712046 19225113 17217047 16935935 16766008 19075265 9834237 19642359 16140955 17339181 16331271 17649720 15748426 17294898 17107899 16823087 16788101 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3416882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.299224671
MESH:D008064 Lipidoses Clozapine 8.0317567588
MESH:D008064 Lipidoses Tamoxifen 8.0317567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8011408273 17157831 21278145 16221502 17334410 11903743 17174718 16239168 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.7112445421 16638106 13678700 18376398 17557913 14512876 15338365 18472332 18412020 16015684 17525996 15931870 16248980 12666154 12546737 14748882 18395914 17481882 17805973 17922224 18418968 17761835 18210741 17976157 15876570 15818738 12958196 17869086 12898905 16011737 18156304 18420326 12632514 15925388 15673190 14716496 12667390 15052691 17640975 17708605 15730626 16097048 15650968 18472094 10355542 17900296 15893842 12445418 14716833 18277467 17721639 12649538 17565644 15370692 17944888 18251166 18317297 17698563 15057751 14620537 18705752 16033810 16116963 12609069 18429990 12389079 17631135 18006644 12632512 18395095 16027843 17714472 16192424 18054572 15959796 17823541 18481824 16136751 18166357 15362042 18187930 12741479 18339082 15123356 12586293 17766677 11481614 20821823 15996030 18205269 18263696 14724832 18279442
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.7114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.7118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.7112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.7116248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.7116169303
MESH:D008107 Liver Diseases Acetaminophen 3.8819784758 16611625 12969438 11587558 16610002 19014921 19460945 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.8816964402 17285989 15830285 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.3516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.3514706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 14.1614682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.1621137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.1619294768
MESH:D008113 Liver Neoplasms Tamoxifen 14.1616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.1616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.7320377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.7312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3315213294
MESH:D008171 Lung Diseases Vitamin E 3.1616863852
MESH:D008175 Lung Neoplasms arsenic trioxide 6.5511798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.5520135361 18569708 18816296 20464547 6695378 18520028 17053015 20064080 20869020
MESH:D008175 Lung Neoplasms Tamoxifen 6.5518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.5511062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.8817203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.8815318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.8814580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.6519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Tamoxifen 3.2719393235 12393984
MESH:D008545 Melanoma Tretinoin 3.2716752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008591 Meningomyelocele Tretinoin 4.4116940565
MESH:D001523 Mental Disorders Clozapine 8.3416856516
MESH:D001523 Mental Disorders Haloperidol 8.3416856516
MESH:D008654 Mesothelioma Selenium 2.7815107826
MESH:D024821 Metabolic Syndrome X Clozapine 4.3919142101
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5515863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1716381670
MESH:D009101 Multiple Myeloma arsenic trioxide 7.3619417148 19549372 15949261 14977855 11468182
MESH:D009101 Multiple Myeloma Raloxifene 7.3616497877
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.3516882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.3517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2616810080
MESH:D009232 Myxoma Raloxifene 5.5516343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9416624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9611141357
MESH:D009369 Neoplasms Tretinoin 4.9616946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009421 Nervous System Malformations Estradiol 16.2411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.2414600291
MESH:D009421 Nervous System Malformations Tretinoin 16.249125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.2510525206
MESH:D009436 Neural Tube Defects Tretinoin 7.259142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D009765 Obesity Clozapine 3.0118515891 19142110
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.0814694615
MESH:D010024 Osteoporosis Raloxifene 3.3815775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2117823083 15579764 15758505 17893378
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.8316624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 7.8319401270
MESH:D010051 Ovarian Neoplasms Tretinoin 7.8316936753
MESH:D010146 Pain Acetaminophen 6.5316870215
MESH:D010146 Pain Tretinoin 6.5316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.2615580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2615976015
MESH:D010235 Paraganglioma arsenic trioxide 4.1419927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010954 Plasmacytoma Selenium 4.8915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8816536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D011507 Proteinuria Tretinoin 3.5916636307
MESH:D011595 Psychomotor Agitation Haloperidol 4.9411575062
MESH:D011618 Psychotic Disorders Clozapine 9.1115331141
MESH:D011618 Psychotic Disorders Haloperidol 9.1111575062
MESH:D011625 Pterygium Tretinoin 4.7816723453
MESH:D011693 Purpura Raloxifene 5.5515770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0816116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9416646077
MESH:D012559 Schizophrenia Clozapine 4.0920107430 16141801 20452607 11151749 20580759 20521320 18855531 19369910 20168265 18806925 17726453 20521326 17667964 17123785 11763009
MESH:D012559 Schizophrenia Haloperidol 4.091830565 19369910 18513383 20107430
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.3319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3316192470
MESH:D012878 Skin Neoplasms Tretinoin 9.3316467112
MESH:D013088 Spermatocele Tamoxifen 4.2916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3317007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3320155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 3.3317261132
MESH:D020521 Stroke Raloxifene 8.6516837676
MESH:D020521 Stroke Vitamin E 8.6516517955
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6920210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.1519014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.1517045167 16026305
MESH:D013978 Tibial Fractures Estradiol 13.7119048282
MESH:D013978 Tibial Fractures Raloxifene 13.7119048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7716051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9515213294
MESH:D014376 Tuberculosis Tretinoin 3.2116040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.8820435036 12973940 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.8817053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.8817572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.8816712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6616129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6116752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2116837676
MESH:D014820 Vitiligo Tretinoin 4.0416761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D015430 Weight Gain Clozapine 4.4516402076 17502770 20564506 16141801 20521320 20107430
MESH:D015431 Weight Loss Clozapine 5.0717933447
MESH:D009396 Wilms Tumor Tretinoin 3.9516287080
Pathway ID Pathway Name
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04144 Endocytosis
KEGG:05016 Huntington's disease
KEGG:04142 Lysosome
REACT:11123 Membrane Trafficking
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26617
    • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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