AutismKB 2.0

Annotation Detail for TPH2


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Basic Information Top
Gene Symbol:TPH2 ( ADHD7,FLJ37295,MGC138871,MGC138872,NTPH )
Gene Full Name: tryptophan hydroxylase 2
Band: 12q21.1
Quick LinksEntrez ID:121278; OMIM: 607478; Uniprot ID:TPH2_HUMAN; ENSEMBL ID: ENSG00000139287; HGNC ID: 20692
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6030serotonin and melatonin biosynthesis
Pathway IDPathway Name
hsa00380Tryptophan metabolism
hsa01100Metabolic pathways
No data
No data
Pathway IDPathway Name
P043715-Hydroxytryptamine biosynthesis
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
personality traits
ADHD
response inhibition
PSYCH
bipolar disorder unipolar disorder
bipolar disorder depressive disorder, major
attention-deficit hyperactivity disorder
suicide
bipolar disorder suicide
attention deficit hyperactivity disorder
impulsivity
depression
panic disorder
Autism
No data
Desease Name
Unipolar depression, susceptibility to
Attention deficit-hyperactivity disorder, susceptibility to, 7
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TPH2 mRNAaffects expression 16483693
D005473 Fluoxetine Fluoxetine results in increased expression of TPH2 mRNAincreases expression 11901216
D018021 Lithium Chloride Lithium Chloride results in decreased expression of TPH2 mRNAdecreases expression 19840776
D018021 Lithium Chloride Lithium Chloride results in decreased expression of TPH2 proteindecreases expression 19840776
D008550 Melatonin TPH2 protein affects the chemical synthesis of Melatoninaffects chemical synthesis 15281067
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sertraline results in increased expression of TPH2 mRNA]decreases reaction|increases expression 11901216
D020280 Sertraline N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sertraline results in increased expression of TPH2 mRNA]decreases reaction|increases expression 11901216
D020280 Sertraline Sertraline results in increased activity of TPH2 proteinincreases activity 11901216
D020280 Sertraline Sertraline results in increased expression of TPH2 mRNAincreases expression 11901216
D020280 Sertraline Sertraline results in increased expression of TPH2 proteinincreases expression 11901216
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000236 Adenoma Melatonin 4.5317195641
MESH:D001008 Anxiety Disorders Fluoxetine 10.7518083778
MESH:D001008 Anxiety Disorders Sertraline 10.7518822694
MESH:D001289 Attention Deficit Disorder with Hyperactivity marker/mechanism
MESH:D001321 Autistic Disorder marker/mechanism 15768392
MESH:D001321 Autistic Disorder Fluoxetine 2.8118775368 19232924
MESH:D001321 Autistic Disorder Melatonin 2.8116897403 16919138
MESH:D001321 Autistic Disorder Sertraline 2.8118775368
MESH:D002252 Carbon Tetrachloride Poisoning Melatonin 5.7315700767
MESH:D003866 Depressive Disorder Fluoxetine 9.5315014590
MESH:D003866 Depressive Disorder Sertraline 9.5315014590 20305041 18822694
MESH:D003865 Depressive Disorder, Major marker/mechanism
MESH:D003865 Depressive Disorder, Major Sertraline 5.6516968574
MESH:D004487 Edema Fluoxetine 4.6912798668
MESH:D019584 Hot Flashes Fluoxetine 5.8314716179
MESH:D006816 Huntington Disease Sertraline 6.4418403212
MESH:D006869 Hydronephrosis Lithium Chloride 6.5419797860
MESH:D007249 Inflammation Fluoxetine 3.9912798668
MESH:D008064 Lipidoses Fluoxetine 9.6815342952 17567588
MESH:D008064 Lipidoses Sertraline 9.6817567588
MESH:D008106 Liver Cirrhosis, Experimental Melatonin 3.2815925388 16703270 15298665
MESH:D008175 Lung Neoplasms Melatonin 3.2817195641
MESH:D008180 Lupus Erythematosus, Systemic Melatonin 3.9816373423
MESH:D001523 Mental Disorders Fluoxetine 10.4916856516
MESH:D001523 Mental Disorders Sertraline 10.4916856516
MESH:D009207 Myoclonus Fluoxetine 6.348041377
MESH:D009336 Necrosis Melatonin 5.9312195237
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.7720418887
MESH:D010146 Pain Fluoxetine 4.6012798668
MESH:D020734 Parkinsonian Disorders Melatonin 5.3415574749
MESH:D010538 Peritonitis Melatonin 5.7315707874
MESH:D020774 Pick Disease of the Brain Fluoxetine 6.428041377
MESH:D011141 Polyuria Lithium Chloride 6.4619692487
MESH:D020230 Serotonin Syndrome Fluoxetine 6.428704074
MESH:D012893 Sleep Disorders Melatonin 5.9316919138 16897403 18182647
MESH:D020178 Sleep Disorders, Circadian Rhythm Melatonin 7.1518078449 19452292
MESH:D007319 Sleep Initiation and Maintenance Disorders Melatonin 5.7718078449
MESH:D013276 Stomach Ulcer Melatonin 4.8211523592 12500499 16150113
Pathway ID Pathway Name
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00380 Tryptophan metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128747823
    • No data
    Releated disease ID Related disease Name
    PA162370415metabolic syndrome
    PA447207Depressive Disorder
    PA447197Attention Deficit Disorder with Hyperactivity
    PA447278Depression
    Releated drug ID Related drug Name
    PA449015citalopram
    PA450522mirtazapine
    PA451866venlafaxine
    PA452229antidepressants
    PA449673fluoxetine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00150 - L-Tryptophan Dietary supplement;Micronutrient;Essential Amino Acids;Antidepressive Agents, Second-Generation
    No data
    No data
    No data

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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