AutismKB 2.0

Annotation Detail for CLTC


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Basic Information Top
Gene Symbol:CLTC ( CHC,CHC17,CLH-17,CLTCL2,Hc,KIAA0034 )
Gene Full Name: clathrin, heavy chain (Hc)
Band: 17q23.1
Quick LinksEntrez ID:1213; OMIM: 118955; Uniprot ID:CLH1_HUMAN; ENSEMBL ID: ENSG00000141367; HGNC ID: 2092
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
hsa04144Endocytosis
hsa05016Huntington's disease
hsa05100Bacterial invasion of epithelial cells
Pathway IDPathway Name
Signalling by NGF
Membrane Trafficking
Axon guidance
Signaling by EGFR
Pathway IDPathway Name
200067FAS (CD95) signaling pathway
200046Arf6 trafficking events
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway IDPathway Name
500013Clathrin derived vesicle budding
500014Golgi Associated Vesicle Biogenesis
500015Lysosome Vesicle Biogenesis
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CLTC mRNAaffects expression 21346803
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of CLTC mRNAincreases expression 19643169
D000082 Acetaminophen Acetaminophen affects the expression of CLTC mRNAaffects expression 17562736
D020106 Acrylamide Acrylamide binds to and affects the metabolism of CLTC proteinaffects binding|affects metabolic processing 17698512
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CLTC mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CLTC mRNAdecreases expression 20458559
D001554 Benzene Benzene results in increased expression of CLTC mRNAincreases expression 15929907
C014347 decitabine decitabine affects the methylation of CLTC geneaffects methylation 17630775
C071192 entacapone entacapone binds to CLTC proteinaffects binding 19783845
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CLTC mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CLTC mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLTC mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil CLTC protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of CLTC mRNA]affects reaction|decreases expression 15016801
C056933 fumonisin B1 fumonisin B1 results in increased expression of CLTC mRNAincreases expression 16221962
C071834 glycidamide glycidamide results in increased expression of CLTC mRNAincreases expression 17822822
C051890 irinotecan CLTC protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
C051890 irinotecan irinotecan analog results in decreased expression of CLTC mRNAdecreases expression 18927307
D007657 Ketone Bodies Ketone Bodies results in increased expression of CLTC mRNAincreases expression 16807920
D008628 Mercury Mercury results in decreased expression of CLTC mRNAdecreases expression 16823088
C005219 methyl cellosolve methyl cellosolve results in increased expression of CLTC mRNAincreases expression 19643169
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to CLTC protein]affects binding|increases reaction 17220478
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of CLTC mRNAincreases expression 17616710
D010634 Phenobarbital Phenobarbital results in decreased expression of CLTC mRNAdecreases expression 16940010
C010327 salinomycin salinomycin results in decreased expression of CLTC mRNAdecreases expression 19682730
C017947 sodium arsenite sodium arsenite results in increased expression of CLTC proteinincreases expression 19072884
D013629 Tamoxifen Tamoxifen affects the expression of CLTC mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLTC mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CLTC mRNAincreases expression 17942748
C066340 tolcapone tolcapone binds to CLTC proteinaffects binding 19783845
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 18.867151721 6499812 6499796 6499823 6499820
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 18.866474471 6499812 3652986
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 18.866195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 18.8614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D000230 Adenocarcinoma arsenic trioxide 6.8019825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.8014692618
MESH:D000230 Adenocarcinoma Fluorouracil 6.8017638652
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.4417620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.4416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7116712894 17306315
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.1011080934
MESH:D000544 Alzheimer Disease entacapone 5.0620150427
MESH:D000544 Alzheimer Disease tolcapone 5.0620150427
MESH:D000740 Anemia Fluorouracil 8.1316511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1311748828
MESH:D000741 Anemia, Aplastic Benzene 4.2217661222 14761424 11369114
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.163699323
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 11.966499823 10689203 6499807
MESH:D053627 Asthenozoospermia methyl cellosolve 11.963987992
MESH:D001259 Ataxia 2-ethoxyethanol 5.287151721
MESH:D001284 Atrophy 2-ethoxyethanol 10.8015850284 6499799
MESH:D001284 Atrophy methyl cellosolve 10.803699323 6705890 2626667
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 4.6816634805
MESH:D053713 Azoospermia 2-ethoxyethanol 5.396499807 6492198
MESH:D001724 Birth Weight 2-ethoxyethanol 6.322884743 6499823
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.3916206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3912125929
MESH:D001836 Body Weight Changes 2-ethoxyethanol 11.387151721 6499796
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 11.3815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001855 Bone Marrow Diseases Benzene 5.0416183116
MESH:D001943 Breast Neoplasms Acrylamide 3.6516253758 18183576
MESH:D001943 Breast Neoplasms Benzene 3.6511921183 17162533
MESH:D001943 Breast Neoplasms decitabine 3.6518320071 19208741
MESH:D001943 Breast Neoplasms Fluorouracil 3.6518357371 19217205 16110121 16595493 15136595 18608205 16557594
MESH:D001943 Breast Neoplasms salinomycin 3.6519682730
MESH:D001943 Breast Neoplasms Tamoxifen 3.6517893378 19103187 20065188 19288272 19155303 19289846 18821012 18425577 18997820 20859285 19011961 16273361 19084267 18984771 19142967 17440819 19189210 20005174 20135344 19200415 18629630 21152245 18815881 16873071 19059307 17261762 18855134 20544844 19244106 15565566 18351453 19115204 19066611 17049068 19189212 15668708 17242785 20390343 11161223 19410462 16202921 19487384 19221464 21138602 16818667
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6520435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1511589617
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4816051944
MESH:D002277 Carcinoma Fluorouracil 7.6917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.6016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.603084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.6016217749 11135700 14691202 15553829 15073043
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.6017088986 16799960 17971768 17045692 18930000 16332177
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.6020935162 1701930 6705139 20007298 17173139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.6015276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.6016924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6819014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9318695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9512490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.2819215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.2816757204 17066447 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.2818572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2618850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.3910334427
MESH:D002386 Cataract Acetaminophen 2.4710977129
MESH:D002418 Cattle Diseases Acrylamide 5.2612510666
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.8619524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.064080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0016835633
MESH:D002764 Cholecystitis 2-ethoxyethanol 13.016499794
MESH:D002764 Cholecystitis methyl cellosolve 13.016499794
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7316105132 17110522 16919318 15861022 17681005 17333356 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0312621046 8697196 16354765 15668235 15340226
MESH:D003110 Colonic Neoplasms decitabine 5.7117616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.7115001691 18772588 16510598 17169374 17725105 17018589 17287894 17016597 17172411 16340194
MESH:D003110 Colonic Neoplasms irinotecan 5.7117725105 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.6720501625
MESH:D015179 Colorectal Neoplasms decitabine 4.6718981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.6715289873 20501625 16391804 16282729 18288408 18509181 14970324 18383874 17594712 17695437 17094418 16524972 17255274 15148649 17016601 18802399 17401013 17454858 16331619 16303861 18448328 18949393
MESH:D015179 Colorectal Neoplasms irinotecan 4.6717159606 15273666 18259882 17454858 16391804 16303861 18509181
MESH:D000013 Congenital Abnormalities methyl cellosolve 8.8912530607 6499821
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.8917141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7210525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.7215643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7220055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8318551238
MESH:D007644 Darier Disease Fluorouracil 4.6016733453
MESH:D003643 Death 2-ethoxyethanol 5.776499796
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003866 Depressive Disorder entacapone 8.327768276
MESH:D003866 Depressive Disorder tolcapone 8.3211224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 4.7410440460
MESH:D003872 Dermatitis Benzene 4.5815902427
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.6116823706
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.5318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.5311529661 11287661 11739529 19164858 11461765 19923254 16781746 19085960 11743745 15968718 14725611 19420014 19416960 11421492 18071297 16109766 12705907 16081117 14550746 12594235 10774834 12958197 12153990 2444490 15619225 10915739 12540782 16177239 12392966 11834606 10663392 16227642 18713872 19739265 16393943 17906064 17562736 14986274 19370779 17522070 16485898
MESH:D056486 Drug-Induced Liver Injury entacapone 14.5319783845
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 14.5316221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.5320420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 14.5319783845 16604736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.2111455177
MESH:D004421 Dystonia Phenobarbital 3.831851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7115322242 16714409 18230668
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.326499796
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.3319031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9219294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9219155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8610568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.923659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.386401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.833659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.0712903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.0716785472 16337965 16481741 17638652 15173087
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.0715264214 15547733 15878914 16805852 15547721 15150132 16510608 15623463 16704527
MESH:D054908 Extensively Drug-Resistant Tuberculosis entacapone 14.0619578428
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 14.0619578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver arsenic trioxide 12.1115073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.1115345470
MESH:D005234 Fatty Liver Tamoxifen 12.1114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death 2-ethoxyethanol 10.217151721 2884743 7198755 6499820 6499823
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 10.2111858732
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 5.236499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 12.036499812 6499820
MESH:D005327 Fetal Resorption methyl cellosolve 12.036499821 6499812 6474471 3987992
MESH:D020567 Fetal Weight 2-ethoxyethanol 13.017151721 6499820 2884743
MESH:D020567 Fetal Weight methyl cellosolve 13.016499821 6474471 6499812
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.7620067830
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.303652986
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0816904648
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4916452187
MESH:D005910 Glioma Fluorouracil 2.7916145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.4819215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.4818337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2310048152 11294989
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.596499821
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 10.7310514026 20172899
MESH:D006402 Hematologic Diseases Benzene 10.7316183116
MESH:D006461 Hemolysis 2-ethoxyethanol 11.7019051582 17874071
MESH:D006461 Hemolysis methyl cellosolve 11.7017874071
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006529 Hepatomegaly fumonisin B1 13.4616221962
MESH:D006529 Hepatomegaly Phenobarbital 13.4616109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.4616120746 15340226 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.0012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8516959395 15340226 18606429 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006973 Hypertension Benzene 5.0717940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216945680 16569931
MESH:D007247 Infertility, Female 2-ethoxyethanol 16.306499823
MESH:D007247 Infertility, Female Acrylamide 16.3011020651
MESH:D007247 Infertility, Female Ethinyl Estradiol 16.3012013081
MESH:D007248 Infertility, Male 2-ethoxyethanol 24.756499823
MESH:D007248 Infertility, Male Acrylamide 24.7515749267 15355880 11020651 12507653
MESH:D007248 Infertility, Male decitabine 24.7517581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 24.7517937319
MESH:D007248 Infertility, Male methyl cellosolve 24.753987992
MESH:D007248 Infertility, Male sodium arsenite 24.7512646999 15346721
MESH:D007249 Inflammation Tamoxifen 4.5619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.5612200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007674 Kidney Diseases Acetaminophen 9.5415629191 12587719
MESH:D007674 Kidney Diseases Mercury 9.5417934191
MESH:D007674 Kidney Diseases sodium arsenite 9.5420008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.5516705839
MESH:D007680 Kidney Neoplasms Fluorouracil 11.5516985049
MESH:D007680 Kidney Neoplasms Tamoxifen 11.5518625569
MESH:D007938 Leukemia arsenic trioxide 10.0415070760
MESH:D007938 Leukemia Benzene 10.0415935818 18335105 14694614 17119257
MESH:D007938 Leukemia decitabine 10.0418980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 15.0819077051
MESH:D007951 Leukemia, Myeloid Benzene 15.0817506065
MESH:D007951 Leukemia, Myeloid decitabine 15.0818454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.0216968895 20471514 16467208 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute Benzene 6.0219478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.0218704418 17679729 18206229 18460780 19387464 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2718055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0915336539 12679006 16331271 11161223 15748426 17869043 19225113 19075265 16966277 11468182 16330433 19642359 15622746 15213294 12712474 19035177 17107899 17649720 17712046 16891316 16823087 12018890 9834237 17217047 16112521
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1716882451
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 4.366499821
MESH:D008064 Lipidoses Tamoxifen 3.0217567588 15342952
MESH:D008103 Liver Cirrhosis Phenobarbital 2.7921047994
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.2218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2212878042
MESH:D008107 Liver Diseases Acetaminophen 3.7616611625 19784758 11587558 12969438 12587719 19014921 16610002 19460945
MESH:D008107 Liver Diseases Phenobarbital 3.7619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0716871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 17.0414682389
MESH:D008113 Liver Neoplasms Fluorouracil 17.0416603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 17.0415975961 8742319 19812893 19482888 21047994 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 17.0416712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 17.0416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.0416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.1720377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 13.1712562636
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 13.171399818 17172636 2563599 18308698 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.1712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2115213294
MESH:D008171 Lung Diseases sodium arsenite 3.0519095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.6214698565
MESH:D008175 Lung Neoplasms arsenic trioxide 8.2419825857 11798837
MESH:D008175 Lung Neoplasms Benzene 8.2412562636
MESH:D008175 Lung Neoplasms Fluorouracil 8.2415246190
MESH:D008175 Lung Neoplasms sodium arsenite 8.2416712894 17077188 15276417 17306315 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 8.2418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2411884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6015086387
MESH:D008223 Lymphoma Benzene 7.3817584886 17119257
MESH:D008223 Lymphoma decitabine 7.3819470736
MESH:D008231 Lymphopenia methyl cellosolve 5.593699323
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.4312562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.4319428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 9.4911921183
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 9.4919682730
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.4914580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.3519453300
MESH:D008545 Melanoma decitabine 4.9316505122 17785578
MESH:D008545 Melanoma sodium arsenite 4.9319082730 16487513
MESH:D008545 Melanoma Tamoxifen 4.9319393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4916757204 18986760
MESH:D052016 Mucositis irinotecan 4.8217159606
MESH:D009101 Multiple Myeloma arsenic trioxide 11.4219549372 15949261 11468182 14977855 19417148
MESH:D009101 Multiple Myeloma Benzene 11.4217119195
MESH:D009101 Multiple Myeloma decitabine 11.4218172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.1416105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 7.1419010910 19157545 18608210 16882708
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2817484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.2518551238
MESH:D009336 Necrosis 2-ethoxyethanol 10.2520172899
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7816624393
MESH:D009362 Neoplasm Metastasis irinotecan 5.7018259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms decitabine 7.8217925555 19470736 19116145
MESH:D009369 Neoplasms Fluorouracil 7.8216928823 18600527 18239605
MESH:D009369 Neoplasms sodium arsenite 7.8211559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4820056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119196722 19200415 19189210
MESH:D009410 Nerve Degeneration Acrylamide 4.5511264303 12387367 12387366
MESH:D009422 Nervous System Diseases Acrylamide 4.8212164553 12507653
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0314600291
MESH:D009436 Neural Tube Defects arsenic trioxide 11.5210525206
MESH:D009436 Neural Tube Defects Benzene 11.5215643154
MESH:D009436 Neural Tube Defects sodium arsenite 11.5212854658
MESH:D009447 Neuroblastoma irinotecan 3.388761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7218514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.548761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3116436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.6112819281 16049721
MESH:D009784 Occupational Diseases Benzene 8.6115727169 15612468 15935809 17178637 16737584 17119257 15913788 17479406 15576619
MESH:D009845 Oligospermia 2-ethoxyethanol 10.7420172899
MESH:D009845 Oligospermia methyl cellosolve 10.743987992
MESH:D010018 Osteomalacia Phenobarbital 4.1717016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.8416624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Benzene 10.8412562636
MESH:D010051 Ovarian Neoplasms decitabine 10.8419331143 19259094
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.8417306315 15276417
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.7915580305
MESH:D010190 Pancreatic Neoplasms decitabine 11.7919294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.7919003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.7916965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9819927285
MESH:D010300 Parkinson Disease entacapone 6.1219578428 17089403 20334432 11586115 19783845
MESH:D010300 Parkinson Disease tolcapone 6.1219578428 8739811 18328768 16758261 11746615 11432539 17089403 1977408 9754991 19783845 11793426 20216409 9333106 11586115 20334432 8635184 10651109 9708959 7566641 9591521 9305320
MESH:D020734 Parkinsonian Disorders entacapone 5.2318722529
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 4.9211510240
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.462563599
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 15.446499817 2884743 7198755
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 15.447974496 12530607 6499817
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.4411896295 11222880 11118676 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.5417616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1219131511
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1219082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1216039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1215067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1215861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.3012752131
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8515538739 16160472 18722050 18286688
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.2219155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7816646077
MESH:D012640 Seizures 2,4-dinitrotoluene 5.5018551238
MESH:D012640 Seizures Phenobarbital 5.5016876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.636407741
MESH:D012878 Skin Neoplasms sodium arsenite 5.3018572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9216709447
MESH:D013088 Spermatocele Tamoxifen 10.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6512854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 8.0617007042
MESH:D013274 Stomach Neoplasms Benzene 8.0612562636
MESH:D013274 Stomach Neoplasms decitabine 8.0619037991
MESH:D013274 Stomach Neoplasms Fluorouracil 8.0618567086 16951190 17522103 19015929 18396642 17172411 19084572 17498489 16424979 15786421
MESH:D013274 Stomach Neoplasms irinotecan 8.0615723263
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 8.0612958204 17575124
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 4.216499799
MESH:D013733 Testicular Diseases 2-ethoxyethanol 16.566499806 10514026 10048760
MESH:D013733 Testicular Diseases Acrylamide 16.5615864552
MESH:D013733 Testicular Diseases methyl cellosolve 16.566499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013953 Thymus Neoplasms Benzene 4.7610850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.1919014326
MESH:D013964 Thyroid Neoplasms decitabine 11.1917967635
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.191399818
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8216280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7715213294
MESH:D018088 Tuberculosis, Multidrug-Resistant entacapone 14.0619578428
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 14.0619578428
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.0116049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.0120435036 12973940 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms decitabine 15.0117616700 19087683
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.0116712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.0116712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1210091137
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.9316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.9311813266
MESH:D014594 Uterine Neoplasms Benzene 8.9612562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.9614692618
MESH:D014604 Uveal Neoplasms decitabine 4.7217785578
MESH:D014652 Vascular Diseases sodium arsenite 4.2317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3715869587 14671159
MESH:D014820 Vitiligo tolcapone 5.0110573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04144 Endocytosis
KEGG:05016 Huntington's disease
KEGG:04142 Lysosome
REACT:11123 Membrane Trafficking
REACT:9417 Signaling by EGFR
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26618
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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