AutismKB 2.0

Annotation Detail for SP7


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Basic Information Top
Gene Symbol:SP7 ( MGC126598,OSX,osterix )
Gene Full Name: Sp7 transcription factor
Band: 12q13.13
Quick LinksEntrez ID:121340; OMIM: 606633; Uniprot ID:SP7_HUMAN; ENSEMBL ID: ENSG00000170374; HGNC ID: 17321
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Bone mineral density (spine)
METABOLIC
Desease Name
Bone mineral density (spine)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000537 Aluminum Oxide Aluminum Oxide results in increased expression of SP7 mRNAincreases expression 19464052
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SP7 mRNAaffects expression 16483693
D001374 Azacitidine Azacitidine results in increased expression of SP7 mRNAincreases expression 17085970
D004958 Estradiol Estradiol results in increased expression of SP7 mRNAincreases expression 17689939
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased expression of SP7 mRNA]decreases reaction|increases expression 17689939
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased expression of SP7 mRNA]decreases reaction|increases expression 17689939
C070081 fulvestrant fulvestrant inhibits the reaction [resveratrol results in increased expression of SP7 mRNA]decreases reaction|increases expression 17689939
C063170 Ginkgo biloba extract 761 Ginkgo biloba extract 761 results in increased expression of SP7 mRNAincreases expression 19356626
D006851 Hydrochloric Acid Hydrochloric Acid results in decreased expression of SP7 mRNAdecreases expression 17183249
D006851 Hydrochloric Acid Hydrochloric Acid results in decreased expression of SP7 proteindecreases expression 17183249
C093973 PD 98059 PD 98059 inhibits the reaction [resveratrol results in increased expression of SP7 mRNA]decreases reaction|increases expression 17689939
C093973 PD 98059 PD 98059 results in decreased expression of SP7 mRNAdecreases expression 17689939
C059514 resveratrol fulvestrant inhibits the reaction [resveratrol results in increased expression of SP7 mRNA]decreases reaction|increases expression 17689939
C059514 resveratrol PD 98059 inhibits the reaction [resveratrol results in increased expression of SP7 mRNA]decreases reaction|increases expression 17689939
C059514 resveratrol resveratrol results in increased expression of SP7 mRNAincreases expression 17689939
C009495 titanium dioxide titanium dioxide results in increased expression of SP7 mRNAincreases expression 19464052
C028541 zirconium oxide zirconium oxide results in increased expression of SP7 mRNAincreases expression 19464052
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 11.3818287403
MESH:D000138 Acidosis Hydrochloric Acid 11.3812771618 19262391 16144966 15920416 20872349 11574821
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 5.9517183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 6.0320597076
MESH:D058186 Acute Kidney Injury resveratrol 3.9916538975
MESH:D055371 Acute Lung Injury Hydrochloric Acid 4.9319760209 19060228 11850527 15970105 19094174 11953099 16759491
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D000236 Adenoma resveratrol 3.3915688382
MESH:D000544 Alzheimer Disease resveratrol 2.5916162502 16183991
MESH:D000860 Anoxia Hydrochloric Acid 5.5015090967
MESH:D001169 Arthritis, Experimental resveratrol 3.5817115116
MESH:D050197 Atherosclerosis resveratrol 3.3516873680 17967414
MESH:D001284 Atrophy fulvestrant 5.0111514358
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 4.9515920416
MESH:D001851 Bone Diseases, Metabolic Ginkgo biloba extract 761 6.5019356626
MESH:D002545 Brain Ischemia resveratrol 4.4817600658
MESH:D001943 Breast Neoplasms Estradiol 2.0712948864 17289903 16675129 18497071 17018787 19861407 14630087 17261762
MESH:D001943 Breast Neoplasms fulvestrant 2.0718984771
MESH:D001943 Breast Neoplasms resveratrol 2.0716393696 17534123 17651959
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 4.7012378975
MESH:D001986 Bronchial Spasm Hydrochloric Acid 5.6815578804
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.2216924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 3.2219321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.7816675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7516227395
MESH:D002318 Cardiovascular Diseases resveratrol 3.5715458977
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8618566989
MESH:D003092 Colitis resveratrol 4.3016474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4716338953
MESH:D015179 Colorectal Neoplasms Azacitidine 2.9719934284
MESH:D015179 Colorectal Neoplasms resveratrol 2.9716550006
MESH:D003128 Coma Ginkgo biloba extract 761 6.4410836866
MESH:D003327 Coronary Disease resveratrol 3.8416507316
MESH:D003556 Cystitis Hydrochloric Acid 5.6812599022 12853844 19279288 20719367
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 6.0317714534
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8916873680
MESH:D003928 Diabetic Nephropathies Estradiol 9.4419279558
MESH:D003928 Diabetic Nephropathies resveratrol 9.4416286809
MESH:D004487 Edema resveratrol 3.508985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.1917872969
MESH:D016889 Endometrial Neoplasms Estradiol 3.0711473722 18566989 19148513
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.0217923197
MESH:D004935 Esophageal Diseases Hydrochloric Acid 5.9919566590
MESH:D004941 Esophagitis Hydrochloric Acid 6.1912928072
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 6.2311346197 14621274 20516732
MESH:D005355 Fibrosis Hydrochloric Acid 4.8918497604
MESH:D005739 Gas Poisoning Hydrochloric Acid 5.6812378975
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 5.4919957777 20545468 20616304 20516732 12212954 19951613
MESH:D006356 Heartburn Hydrochloric Acid 5.9919566590
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D006561 Herpes Simplex resveratrol 4.3716876885
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006937 Hypercholesterolemia resveratrol 4.1417188708
MESH:D006940 Hyperemia Hydrochloric Acid 5.8412646421
MESH:D006949 Hyperlipidemias resveratrol 4.1816873680
MESH:D006975 Hypertension, Portal Hydrochloric Acid 5.5216984587
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 4.5519262391
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4317488730
MESH:D007022 Hypotension Hydrochloric Acid 4.9111574821
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.8217600658
MESH:D007248 Infertility, Male fulvestrant 3.8411514358
MESH:D007249 Inflammation Hydrochloric Acid 5.9411574821
MESH:D007249 Inflammation resveratrol 5.9416366677
MESH:D007251 Influenza, Human resveratrol 4.7616624496
MESH:D007333 Insulin Resistance Estradiol 3.0516627594 16393666
MESH:D007410 Intestinal Diseases Hydrochloric Acid 5.1411574821
MESH:D007674 Kidney Diseases Estradiol 2.6615618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0915610895
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 6.5816498863
MESH:D007826 Laryngismus Hydrochloric Acid 6.5811510729
MESH:D007938 Leukemia Azacitidine 3.7519148494
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 5.4216972261
MESH:D007951 Leukemia, Myeloid Azacitidine 4.7619077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 3.0217596541 18720364
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.3419299654
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6616087638
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 4.1416984587
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008113 Liver Neoplasms resveratrol 2.7520405173 19812893 19321006 19073162
MESH:D008171 Lung Diseases Hydrochloric Acid 4.3716784557
MESH:D055370 Lung Injury Hydrochloric Acid 4.9318497604 15090967 20597076 18339021 11395602 16129981 19262391 19644408 17627322 15044056 18573544 15607125 21311175 21114838
MESH:D008175 Lung Neoplasms Azacitidine 2.7221224363
MESH:D016393 Lymphoma, B-Cell resveratrol 4.4517088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.9914749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.4415688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4411408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.448985016 11606380
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008545 Melanoma resveratrol 2.3817992120
MESH:D008659 Metabolic Diseases resveratrol 4.5217112576
MESH:D009006 Monosomy Azacitidine 6.3019299654
MESH:D009101 Multiple Myeloma Azacitidine 8.0718443271 19549372
MESH:D009101 Multiple Myeloma resveratrol 8.0717049120 16267019 17935668 14749477 16490592 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.0617962980
MESH:D009190 Myelodysplastic Syndromes Azacitidine 4.0817596541 17611569 18720364 19805378
MESH:D009203 Myocardial Infarction Hydrochloric Acid 6.5318534312
MESH:D009203 Myocardial Infarction resveratrol 6.5317015251 17188708 16317513 17125593 16456233 16525036
MESH:D017202 Myocardial Ischemia resveratrol 4.1217015251 17125593
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009205 Myocarditis resveratrol 4.9517322642
MESH:D009374 Neoplasms, Experimental resveratrol 4.178985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009421 Nervous System Malformations Estradiol 3.8116427766 11399458
MESH:D019636 Neurodegenerative Diseases resveratrol 3.9217652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.5517929310
MESH:D009784 Occupational Diseases Hydrochloric Acid 4.8912378975
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.4117513867
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 5.5615970105 18497604 15607125 18573544
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.3716679765
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Azacitidine 2.7018324645
MESH:D011471 Prostatic Neoplasms Estradiol 2.7016740699
MESH:D011471 Prostatic Neoplasms resveratrol 2.7017718901 17636462 15767336 17804756 16731767 17675339
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 6.2320597076
MESH:D011654 Pulmonary Edema Hydrochloric Acid 5.4315090967
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.8016325855
MESH:D015427 Reperfusion Injury resveratrol 3.3316314181 17520802 15827377 17058453 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 4.9116784557 18549715 18339021 16129981 17627322
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 6.5811510729
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 5.3820516732
MESH:D012878 Skin Neoplasms resveratrol 3.0915837718 8985016
MESH:D013276 Stomach Ulcer Hydrochloric Acid 4.3617189318 16755016 15309881
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6116321402
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D014062 Tongue Neoplasms resveratrol 4.3416227395
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2317473185
MESH:D014594 Uterine Neoplasms resveratrol 4.3017044934
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.4817488730
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134917046
    • No data
    Releated disease ID Related disease Name
    PA443532Bone Diseases
    PA443536Bone Diseases, Metabolic
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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