AutismKB 2.0

Annotation Detail for AEBP2


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Basic Information Top
Gene Symbol:AEBP2 ( MGC17922 )
Gene Full Name: AE binding protein 2
Band: 12p12.3
Quick LinksEntrez ID:121536; OMIM: NA; Uniprot ID:AEBP2_HUMAN; ENSEMBL ID: ENSG00000139154; HGNC ID: 24051
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of AEBP2 mRNAaffects expression 21346803
C430898 AGN 194204 AGN 194204 results in decreased expression of AEBP2 mRNAdecreases expression 16339527
D001104 Arbutin Arbutin results in increased expression of AEBP2 mRNAincreases expression 17103032
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of AEBP2 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AEBP2 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of AEBP2 mRNAincreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of AEBP2 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of AEBP2 mRNA]decreases reaction|increases expression 17854601
D007213 Indomethacin Indomethacin results in decreased expression of AEBP2 mRNAdecreases expression 16984733
C006253 pirinixic acid pirinixic acid results in increased expression of AEBP2 mRNAincreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6820127859 20464547
MESH:D000230 Adenocarcinoma Indomethacin 4.6816537180
MESH:D000236 Adenoma Benzo(a)pyrene 11.876695378
MESH:D000236 Adenoma Diethylnitrosamine 11.876695378 10737359
MESH:D000236 Adenoma Indomethacin 11.8711497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.0619061943 17162532 16434500 17620307 19052882 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0616434500
MESH:D016301 Alveolar Bone Loss Indomethacin 5.6917225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7417627676 15579461
MESH:D001014 Aortic Aneurysm Indomethacin 5.0910231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 12.5919183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 12.5910388637
MESH:D018771 Arthralgia Indomethacin 5.492160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8611248219
MESH:D001477 Bartter Syndrome Indomethacin 5.2410684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001929 Brain Edema Indomethacin 5.3411481608
MESH:D002545 Brain Ischemia Indomethacin 4.7012524144
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9520146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Indomethacin 1.9517401462
MESH:D002056 Burns Indomethacin 4.9610459503
MESH:D002100 Cachexia Indomethacin 5.2911239499 15141370 16537180 15625704
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8216705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.8218788625 20524982 16935385 19394651 16502159 18506893 17055752 20935162 16830150 19052882 20727157 16807293 17173139 19519916 17138121 18393292 16878318 18785209 16569478 19701751 19208518 17761372 10672840 18210153 17978847 3084413 18978308 17428255 16540662 20084675 20214788 16681979 19919837 18691550 16698587 18056438 19539802 11831363 20514400 16779866 16288022 18971187 16328049 3581430 19171122 10737359 19335982 18665156 19822196 20512989 20007298 19418558 20101231 17162532 19107877 19383236 21159647 20432363 18494052
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 4.8216391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.0111053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.6418791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4617341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9420419170
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 4.9412636206 15482327
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.962727394 7505956 21159647 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D002764 Cholecystitis Indomethacin 5.4911181007
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D003110 Colonic Neoplasms Indomethacin 2.6215625704 15786552 11260862 15963497 15637740 15936596
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3612606626 11197048 18059344 17054584
MESH:D018352 Coronavirus Infections Indomethacin 6.0417302372
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D003967 Diarrhea Indomethacin 4.037237001 7907874
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.0619107877
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.4316326151 18446180 16133044 18043480 12774134 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 4.3717202747 11991626 11595431 10671773 11535926 17351913 11595415 17329845 16699067 17045617 17151854
MESH:D004487 Edema Indomethacin 7.648985016 7907874 10653021 19703484 7990266 16100529 8273558
MESH:D004487 Edema pirinixic acid 7.6412083418
MESH:D004715 Endometriosis Indomethacin 4.3415652904
MESH:D019446 Endotoxemia Indomethacin 4.7818509659
MESH:D004751 Enteritis Indomethacin 5.0616328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.2417980183
MESH:D004802 Eosinophilia Indomethacin 4.3111298111
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5520426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5516530937
MESH:D004938 Esophageal Neoplasms Indomethacin 7.5511005569
MESH:D005234 Fatty Liver Cyclosporine 14.2819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 14.2820387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 14.2820131406 19236843
MESH:D005334 Fever Indomethacin 4.3111852909 17627676 10431976
MESH:D005354 Fibrosarcoma Indomethacin 5.1810962813
MESH:D005355 Fibrosis Cyclosporine 9.7712639820 12168785
MESH:D005355 Fibrosis Indomethacin 9.7717994277
MESH:D005499 Folliculitis Indomethacin 5.4911298111
MESH:D005756 Gastritis Indomethacin 5.0615046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005909 Glioblastoma Indomethacin 3.6912870263
MESH:D005910 Glioma Indomethacin 3.2916487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.4511849393
MESH:D006073 Gout Indomethacin 5.6411248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.8715482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.7815633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.9215135802
MESH:D006529 Hepatomegaly pirinixic acid 3.2518467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia Indomethacin 3.9312727271
MESH:D034321 Hyperamylasemia Indomethacin 6.0417883296
MESH:D006940 Hyperemia Indomethacin 5.2912524144
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Indomethacin 4.3817546600
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007077 Ileal Diseases Indomethacin 5.3418306037 10574470
MESH:D007079 Ileitis Indomethacin 5.6410651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.6916133044
MESH:D007249 Inflammation Diethylnitrosamine 5.6318785209
MESH:D007249 Inflammation Indomethacin 5.633291741 7812673 12568917
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007410 Intestinal Diseases Indomethacin 4.5817994277 11713966 15610444 17329856 10210152 15831440 18236018 11855677 11686837
MESH:D019586 Intracranial Hypertension Indomethacin 5.6915241188
MESH:D007579 Jejunal Diseases Indomethacin 5.3410574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.5518776723 10903974 8314463
MESH:D007674 Kidney Diseases Indomethacin 6.5517190690
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.0710320625 11703811 12228301
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.0710785260 16572323 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6618360721
MESH:D007964 Leukocytosis Indomethacin 5.6916537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.0417980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.0411479899
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9318665156 18522880 18407596 20032147 19638242
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.6018194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.6015474484
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1417034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7820195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.7820137499 15885732 12771043 2422723 19254457 19073162 21167192 19090486 2862719 19850985 19996281 20434301 19255062 19551842 20101389 16942905 18648771 21047994 20583210 19833225 21071580 20501860 15175105 19427195 19642983 20118626 19690152 18978307 19294768 19812893 18977376 10737359 9163691 20405173 20452335 19426721 18644402 19499222 19256749 19638242 18754104 20492335 21278145 12112319
MESH:D008113 Liver Neoplasms pirinixic acid 7.7815890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7518544905 19004024 18253720 18093689 17942915 17854601 18775883 2563599 18079962 19126423 18164116 3124819 18308698 17174075 18282651 21159647 19009564 9362446 19539802 16267830 16842330 19519916
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6018569708 20869020 18816296 20135361 20464547 6695378 17053015 18520028 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.6020970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Indomethacin 3.6016537180 11497255 11053908
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D008881 Migraine Disorders Indomethacin 3.8211903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.1916381670
MESH:D009062 Mouth Neoplasms Indomethacin 9.1912636206
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.209029167 3581430
MESH:D009362 Neoplasm Metastasis Indomethacin 6.2011239499 11053908 16537180
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.3910663608 15625704
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 9.1620387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 9.1612349958
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.496374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6216049721 12819281
MESH:D010003 Osteoarthritis Indomethacin 3.787009135
MESH:D010146 Pain Indomethacin 3.6317440234 13679232 17627676 3291741
MESH:D010149 Pain, Postoperative Indomethacin 5.0012538197 18702446
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D010195 Pancreatitis Indomethacin 4.1417883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.0416537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.3112349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.0411903285
MESH:D010437 Peptic Ulcer Indomethacin 5.4311148446
MESH:D010518 Periodontitis Indomethacin 5.2317225004
MESH:D011230 Precancerous Conditions Cyclosporine 9.5612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.562563599
MESH:D047928 Premature Birth Indomethacin 5.3917000239
MESH:D011471 Prostatic Neoplasms AGN 194204 3.5016000583
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.5017292933
MESH:D011507 Proteinuria Indomethacin 4.3811849393
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013272 Stomach Diseases Indomethacin 4.7018545984 17207306 16280098 17160473 16184426 10215738 15472012 10486359 16113693 10192188 17638125 18209964 15038085
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.4920155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4918456281
MESH:D013274 Stomach Neoplasms Indomethacin 3.4915609394
MESH:D013276 Stomach Ulcer Indomethacin 3.7916252198 11523592 12500499 11145282 11595415 18181030 16397915 12467913 18543354 16934674 15104355 12498302 17627676 18087811 16755016 11729361 15138204 18299717 12077510 11595431 18431645 18209962 15255614 14567935 17135157 18237397 10423059 11906479 18193104 10878458 18726076 17657623 16631530 17654042 17895592 12787963 16150113 16169175 17918041 10750652 1323529 17977527
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.907505956
MESH:D013964 Thyroid Neoplasms Indomethacin 7.9018791128 14736730 11352223
MESH:D014456 Ulcer Indomethacin 5.1817380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2017053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014839 Vomiting Indomethacin 5.0611897121
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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