AutismKB 2.0

Annotation Detail for BTBD11


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Basic Information Top
Gene Symbol:BTBD11 ( FLJ33957,FLJ42845 )
Gene Full Name: BTB (POZ) domain containing 11
Band: 12q23.3
Quick LinksEntrez ID:121551; OMIM: NA; Uniprot ID:BTBDB_HUMAN; ENSEMBL ID: ENSG00000151136; HGNC ID: 23844
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of BTBD11 mRNAincreases expression 19933214
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of BTBD11 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of BTBD11 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of BTBD11 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BTBD11 mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of BTBD11 mRNAdecreases expression 17484886
D010656 Phenylephrine Phenylephrine results in decreased expression of BTBD11 mRNAdecreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BTBD11 mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of BTBD11 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BTBD11 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.457525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4514514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.3017460149
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001919 Bradycardia Phenylephrine 4.8315306635
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8820146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0416227642 3786805 15721981 16192424 18705752 15700767 15673190 16050911 16011737 16097048 16124888 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1412619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1418788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Phenylephrine 7.2315728586 11754973 17124262 11179087 16170337 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.2316120746 18670907 18850075
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7414694615
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 8697196 12621046 15668235 15340226
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.8015095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.8017141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.5721346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.576623471 2869522 7120509 6884620 19336974 10092053 3786805 17522070 15998439 21278145 3732212 7179309 15968718 16227642 7440962 4309450 11566570 10915739 16177239 15027814 9327722 19085960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.3715959796 61145 16045604 12795759 16239168 19224547 17595544 12631006
MESH:D005234 Fatty Liver pirinixic acid 8.3719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.4720067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 9.1419176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1416120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 16959395 16354765 18606429 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Phenylephrine 5.538949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D006984 Hypertrophy Phenylephrine 4.7618502941 12791704
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9116239168 16943688 21278145 11903743 17334410 11408273 17157831 16221502 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5012958196 15925388 15959796 14620537 17900296 18006644 15650968 17557913 12586293 18395914 15057751 12898905 18705752 18054572 18420326 16015684 17631135 12445418 18481824 18251166 18472332 18376398 15931870 17714472 15052691 12546737 17481882 14716496 12609069 18412020 17944888 15818738 17922224 14512876 16011737 15370692 12649538 12666154 17565644 17823541 15893842 12389079 11481614 17698563 14716833 13678700 12632512 18210741 14724832 12632514 16192424 18279442 16116963 16248980 16033810 17525996 18395095 10355542 14748882 15876570 12741479 17761835 18277467 15673190 17976157 18339082 18472094 18418968 16097048 18156304 16638106 15362042 16136751 17721639 17869086 15123356 20821823 17805973 18263696 17708605 18317297 17640975 15996030 18429990 18166357 15730626 18187930 17766677 18205269 15338365 16027843 12667390 12445421
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215830285 16964402 15720792 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8814706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.9715890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.9720195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.9719294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.9716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.528603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.5212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5212151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.476695378 18520028 18816296 17053015 18569708 20464547 20135361 20064080 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4711884234 19555203
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.2914694615
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811399792 11222880 11118676 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012852 Sinusitis Phenylephrine 4.997327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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