Gene Symbol:	SPPL3 ( DKFZp586C1324,IMP2,MDHV1887,MGC126674,MGC126676,MGC90402,PRO4332,PSL4 )
Gene Full Name:	-
Band:	12q24.31
Quick Links	Entrez ID:121665; OMIM: 608240; Uniprot ID:PSL4_HUMAN; ENSEMBL ID: ENSG00000157837; HGNC ID: 30424
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
D000082	Acetaminophen	Acetaminophen affects the expression of SPPL3 mRNA	affects expression	17562736
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SPPL3 mRNA	decreases expression	19150397
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SPPL3 mRNA	affects binding\|increases activity\|increases expression	19710929

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D055371	Acute Lung Injury		pirinixic acid	3.64	18653653
MESH:D018248	Adenoma, Liver Cell		pirinixic acid	4.22	16434500
MESH:D000799	Angioedema		Acetaminophen	4.71	10982225
MESH:D001321	Autistic Disorder		Acetaminophen	1.39	18445737
MESH:D001778	Blood Coagulation Disorders		pirinixic acid	3.63	19483382
MESH:D006528	Carcinoma, Hepatocellular		Acetaminophen	1.41	3084413
MESH:D002386	Cataract		Acetaminophen	2.81	10977129
MESH:D002471	Cell Transformation, Neoplastic		7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	3.01	20889678
MESH:D002779	Cholestasis		pirinixic acid	3.15	19176532
MESH:D003876	Dermatitis, Atopic		pirinixic acid	2.59	18249437
MESH:D056486	Drug-Induced Liver Injury		Acetaminophen	1.68	16227642 11743745 2444490 19739265 11529661 11461765 19164858 18071297 16393943 12540782 17522070 16177239 15619225 19085960 19923254 12705907 12392966 19416960 11421492 17906064 12958197 14550746 16109766 15968718 10663392 11287661 18713872 14725611 10774834 10915739 11834606 11739529 12594235 16781746 17562736 19370779 16485898 16081117 12153990 19420014 14986274
MESH:D056487	Drug-Induced Liver Injury, Chronic		Acetaminophen	4.96	19426721
MESH:D004487	Edema		pirinixic acid	2.96	12083418
MESH:D004938	Esophageal Neoplasms		7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	2.15	20426865
MESH:D005234	Fatty Liver		pirinixic acid	3.25	19236843 20131406
MESH:D005756	Gastritis		Acetaminophen	4.54	16983495
MESH:D006333	Heart Failure		pirinixic acid	2.78	20558911
MESH:D006529	Hepatomegaly		pirinixic acid	3.64	16221962 19772884 19176532 18467677
MESH:D006930	Hyperalgesia		Acetaminophen	3.06	16870215
MESH:D006943	Hyperglycemia		pirinixic acid	3.63	20558911
MESH:D007333	Insulin Resistance		pirinixic acid	2.90	16306350
MESH:D007674	Kidney Diseases		Acetaminophen	2.42	15629191 12587719
MESH:D008106	Liver Cirrhosis, Experimental		pirinixic acid	1.35	15474484
MESH:D008107	Liver Diseases		Acetaminophen	1.71	12587719 19784758 12969438 19014921 16611625 19460945 16610002 11587558
MESH:D017114	Liver Failure, Acute		Acetaminophen	3.68	16871587 17185352
MESH:D008113	Liver Neoplasms		pirinixic acid	1.94	15890375 20007298 16377806
MESH:D008546	Melanoma, Experimental		Acetaminophen	4.22	19513568
MESH:D009135	Muscular Diseases		pirinixic acid	4.16	16239165
MESH:D009190	Myelodysplastic Syndromes	marker/mechanism			18575777
MESH:D009203	Myocardial Infarction		pirinixic acid	2.29	19151258
MESH:D015428	Myocardial Reperfusion Injury		pirinixic acid	3.29	16411023
MESH:D009369	Neoplasms		pirinixic acid	2.12	17405874
MESH:D019636	Neurodegenerative Diseases		Acetaminophen	3.26	18514411
MESH:D009765	Obesity		pirinixic acid	1.89	20558911
MESH:D010146	Pain		Acetaminophen	2.77	16870215
MESH:D015427	Reperfusion Injury		pirinixic acid	2.56	19058328
MESH:D014581	Urticaria		Acetaminophen	3.50	10982225

AutismKB 2.0

Annotation Detail for SPPL3

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics