AutismKB 2.0

Annotation Detail for RXFP2


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Basic Information Top
Gene Symbol:RXFP2 ( GPR106,GREAT,INSL3R,LGR8,LGR8.1,RXFPR2 )
Gene Full Name: relaxin/insulin-like family peptide receptor 2
Band: 13q13.1
Quick LinksEntrez ID:122042; OMIM: 606655; Uniprot ID:RXFP2_HUMAN; ENSEMBL ID: ENSG00000133105; HGNC ID: 17318
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500411Relaxin receptors
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Cryptorchidism, bilateral
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RXFP2 mRNAaffects expression 17562736
C006253 pirinixic acid NCF1 protein inhibits the reaction [pirinixic acid results in decreased expression of RXFP2 mRNA]decreases expression|decreases reaction 17950772
C006253 pirinixic acid pirinixic acid results in decreased expression of RXFP2 mRNAdecreases expression 17950772
D014212 Tretinoin Tretinoin results in increased expression of RXFP2 mRNAincreases expression 16010410
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D000505 Alopecia Tretinoin 3.9815955085
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.3216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3416292516
MESH:D001249 Asthma Tretinoin 2.4416456186
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001471 Barrett Esophagus Tretinoin 4.9916935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.6319483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.6316206674 16197459
MESH:D001943 Breast Neoplasms Tretinoin 2.2316443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.3316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 6.0316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.023084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.021917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3816051514 16096774
MESH:D002386 Cataract Acetaminophen 7.9910977129
MESH:D002386 Cataract Tretinoin 7.9917460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.3316129372
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D002822 Choriocarcinoma Tretinoin 6.0316461808
MESH:D002972 Cleft Palate Tretinoin 2.819407595
MESH:D003092 Colitis Tretinoin 4.3517035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8316925845 8800419 9224671 9125849 14991402 10589399 9211117 9664655 9142499 17551590
OMIM:219050 CRYPTORCHIDISM, UNILATERAL OR BILATERAL marker/mechanism
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6812392966 11461765 12958197 14725611 16177239 10663392 19923254 11287661 11743745 12705907 12153990 17906064 11739529 18713872 10774834 18071297 15619225 10915739 19420014 19416960 11421492 19739265 17522070 16781746 14550746 16081117 2444490 16109766 16227642 19164858 15968718 16485898 19370779 11529661 17562736 11834606 16393943 12540782 12594235 19085960 14986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D004489 Edema, Cardiac Tretinoin 5.3318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3716569247
MESH:D005124 Eye Abnormalities Tretinoin 3.9016938888 9664655
MESH:D005234 Fatty Liver pirinixic acid 3.2519236843 20131406
MESH:D005355 Fibrosis Tretinoin 4.1617994277
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D005909 Glioblastoma Tretinoin 3.2717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 6.0316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0914991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.6416221962 18467677 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 8.8616870215
MESH:D006930 Hyperalgesia Tretinoin 8.8616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.2216778211
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D007410 Intestinal Diseases Tretinoin 4.4217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3915992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D007938 Leukemia Tretinoin 2.9517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1816932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1317596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.4216823087 12679006 17294898 16766008 17361223 19642359 17301526 19225113 17107899 9834237 16891316 16140955 17339181 19035177 16788101 19029980 19075265 16331271 16935935 15748426 17649720 17368321 17712046 17506722 17217047
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.629224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.7119014921 12969438 12587719 16611625 16610002 11587558 19784758 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6816871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9420007298 16377806 15890375
MESH:D008527 Medulloblastoma Tretinoin 2.9217453147
MESH:D008545 Melanoma Tretinoin 1.9916752155
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D008591 Meningomyelocele Tretinoin 5.0816940565
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.3017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009369 Neoplasms pirinixic acid 5.5317405874
MESH:D009369 Neoplasms Tretinoin 5.5316594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.369125849
MESH:D009436 Neural Tube Defects Tretinoin 3.329142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4516936753
MESH:D010146 Pain Acetaminophen 7.8916870215
MESH:D010146 Pain Tretinoin 7.8916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5815976015
MESH:D011507 Proteinuria Tretinoin 4.1316636307
MESH:D011625 Pterygium Tretinoin 5.5416723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.6316283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7816467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.3617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.2416051514
MESH:D014376 Tuberculosis Tretinoin 3.4716040207
MESH:D014581 Urticaria Acetaminophen 3.5010982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.1216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.4816752155
MESH:D014820 Vitiligo Tretinoin 4.6416761959
MESH:D009396 Wilms Tumor Tretinoin 4.3916287080
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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