Gene Symbol:	ADSSL1 ( FLJ38602 )
Gene Full Name:	adenylosuccinate synthase like 1
Band:	14q32.33
Quick Links	Entrez ID:122622; OMIM: 612498; Uniprot ID:PURA1_HUMAN; ENSEMBL ID: ENSG00000185100; HGNC ID: 20093
Relate to Another Database:	SFARIGene; denovo-db

Pathway ID	Pathway Name
hsa00250	Alanine, aspartate and glutamate metabolism
hsa00230	Purine metabolism
hsa01100	Metabolic pathways

Pathway ID	Pathway Name
P02738	De novo purine biosynthesis
P00057	Wnt signaling pathway

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
D000082	Acetaminophen	Acetaminophen affects the expression of ADSSL1 mRNA	affects expression	17562736
D016572	Cyclosporine	Cyclosporine results in decreased expression of ADSSL1 mRNA	decreases expression	20106945
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ADSSL1 mRNA]	affects reaction\|increases expression	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of ADSSL1 mRNA	increases expression	19270015 19482888

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced	Phenobarbital	4.18	6195326
MESH:D018248	Adenoma, Liver Cell	Phenobarbital	4.71	17620307
MESH:D000799	Angioedema	Acetaminophen	4.71	10982225
MESH:D001321	Autistic Disorder	Acetaminophen	1.39	18445737
MESH:D006528	Carcinoma, Hepatocellular	Acetaminophen	3.03	3084413
MESH:D006528	Carcinoma, Hepatocellular	Phenobarbital	3.03	20007298 20935162 17173139 1701930 6705139
MESH:D002386	Cataract	Acetaminophen	2.81	10977129
MESH:D002471	Cell Transformation, Neoplastic	Cyclosporine	2.82	12371664
MESH:D002493	Central Nervous System Diseases	Phenobarbital	4.90	4080065
MESH:D002779	Cholestasis	Cyclosporine	3.24	19486331
MESH:D056486	Drug-Induced Liver Injury	Acetaminophen	1.68	18713872 12153990 19416960 12540782 11739529 19420014 12705907 14550746 10915739 10774834 15968718 10663392 14725611 12392966 11461765 11529661 18071297 15619225 16781746 2444490 19739265 19370779 11287661 12958197 17906064 19923254 16177239 11834606 19085960 17562736 11743745 16109766 16485898 17522070 16081117 16393943 11421492 12594235 19164858 16227642 14986274
MESH:D056487	Drug-Induced Liver Injury, Chronic	Acetaminophen	4.96	19426721
MESH:D004421	Dystonia	Phenobarbital	4.53	1851702
MESH:D004831	Epilepsies, Myoclonic	Phenobarbital	4.76	3659116
MESH:D004828	Epilepsies, Partial	Phenobarbital	4.74	11558140 3922381
MESH:D004827	Epilepsy	Phenobarbital	3.08	20417680
MESH:D004832	Epilepsy, Absence	Phenobarbital	3.96	6401628
MESH:D017029	Epilepsy, Complex Partial	Phenobarbital	4.90	7750514
MESH:D004830	Epilepsy, Tonic-Clonic	Phenobarbital	4.76	3659116
MESH:D005234	Fatty Liver	Cyclosporine	3.34	19224547
MESH:D005355	Fibrosis	Cyclosporine	3.79	12639820 12168785
MESH:D005756	Gastritis	Acetaminophen	4.54	16983495
MESH:D005885	Gingival Hyperplasia	Cyclosporine	4.96	8708960
MESH:D006457	Hemoglobinuria, Paroxysmal	Cyclosporine	5.16	15720958
MESH:D006529	Hepatomegaly	Phenobarbital	4.13	16109766
MESH:D006930	Hyperalgesia	Acetaminophen	3.06	16870215
MESH:D006973	Hypertension	Cyclosporine	2.23	10903974
MESH:D007638	Keratoconjunctivitis Sicca	Cyclosporine	5.31	15604871
MESH:D007674	Kidney Diseases	Acetaminophen	6.55	15629191 12587719
MESH:D007674	Kidney Diseases	Cyclosporine	6.55	10903974 8314463 18776723
MESH:D007680	Kidney Neoplasms	Cyclosporine	3.12	12371664
MESH:D008103	Liver Cirrhosis	Phenobarbital	3.10	21047994
MESH:D008107	Liver Diseases	Acetaminophen	4.22	11587558 16611625 19014921 12969438 19784758 19460945 12587719 16610002
MESH:D008107	Liver Diseases	Phenobarbital	4.22	19363144
MESH:D017114	Liver Failure, Acute	Acetaminophen	3.68	17185352 16871587
MESH:D008113	Liver Neoplasms	Phenobarbital	2.43	19073162 19482888 15975961 21047994 8742319 19812893
MESH:D008114	Liver Neoplasms, Experimental	Phenobarbital	2.95	1399818 6150874 17172636 2563599 18308698
MESH:D008546	Melanoma, Experimental	Acetaminophen	4.22	19513568
MESH:D008664	Metal Metabolism, Inborn Errors	Cyclosporine	5.65	16801185
MESH:D020191	Myoclonic Epilepsies, Progressive	Phenobarbital	5.22	17484760
MESH:D009402	Nephrosis, Lipoid	Cyclosporine	5.31	17954296
MESH:D009404	Nephrotic Syndrome	Cyclosporine	3.70	19348381 18481113
MESH:D019636	Neurodegenerative Diseases	Acetaminophen	3.26	18514411
MESH:D010018	Osteomalacia	Phenobarbital	5.11	17016548
MESH:D010146	Pain	Acetaminophen	2.77	16870215
MESH:D010190	Pancreatic Neoplasms	Phenobarbital	2.61	16965848
MESH:D011230	Precancerous Conditions	Cyclosporine	10.38	12371664
MESH:D011230	Precancerous Conditions	Phenobarbital	10.38	2563599
MESH:D019310	Pseudolymphoma	Phenobarbital	5.36	12752131
MESH:D011565	Psoriasis	Cyclosporine	2.34	16882103
MESH:D012640	Seizures	Phenobarbital	2.97	16876388 4039156 3137016 11442880
MESH:D003294	Seizures, Febrile	Phenobarbital	5.56	6407741
MESH:D013964	Thyroid Neoplasms	Phenobarbital	3.39	1399818
MESH:D014581	Urticaria	Acetaminophen	3.50	10982225
MESH:D014605	Uveitis	Cyclosporine	4.85	1336536
MESH:D014985	Xerophthalmia	Cyclosporine	5.31	17120751

Pathway ID	Pathway Name
KEGG:00250	Alanine, aspartate and glutamate metabolism
KEGG:01100	Metabolic pathways
REACT:1698	Metabolism of nucleotides
KEGG:00230	Purine metabolism

Drugbank ID	Action	Drug Name	Description
DB00128	-	L-Aspartic Acid	Dietary supplement;Micronutrient;Non-Essential Amino Acids
DB02109	-	Hadacidin	Antibiotics, Antineoplastic;Teratogens
DB03510	-	6-O-Phosphoryl Inosine Monophosphate
DB04137	-	Guanosine-5'-Triphosphate
DB04184	-	Acetate Ion	Indicators and Reagents
DB04315	-	Guanosine-5'-Diphosphate
DB04418	-	Adenylosuccinic Acid
DB04566	-	Inosinic Acid

AutismKB 2.0

Annotation Detail for ADSSL1

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics