AutismKB 2.0

Annotation Detail for JDP2


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Basic Information Top
Gene Symbol:JDP2 ( JUNDM2 )
Gene Full Name: Jun dimerization protein 2
Band: 14q24.3
Quick LinksEntrez ID:122953; OMIM: 608657; Uniprot ID:JDP2_HUMAN; ENSEMBL ID: ENSG00000140044; HGNC ID: 17546
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200116ATF-2 transcription factor network
Pathway IDPathway Name
P00006Apoptosis signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of JDP2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of JDP2 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of JDP2 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of JDP2 mRNAincreases expression 20106945
D010634 Phenobarbital Phenobarbital results in decreased expression of JDP2 mRNAdecreases expression 19270015
D011374 Progesterone Progesterone results in increased expression of JDP2 mRNAincreases expression 18037150
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.906195326
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.4317620307
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.8617868700
MESH:D001930 Brain Injuries Progesterone 4.6815845082 15665606 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1420146248 17474063
MESH:D001943 Breast Neoplasms Progesterone 2.1416175315 15562024 17614352
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 20214788
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.2112907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.2120007298 17173139 1701930 6705139 20935162
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D003929 Diabetic Neuropathies Progesterone 4.9117187935
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.1617692515
MESH:D004715 Endometriosis Progesterone 4.0716134523
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.393922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006529 Hepatomegaly Phenobarbital 3.9016109766
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8215869954
MESH:D007249 Inflammation Progesterone 2.7415869954
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0012371664
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0521047994
MESH:D008107 Liver Diseases Phenobarbital 2.2319363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 8.0518177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0521137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 8.0519812893 21047994 19482888 19073162 15975961 8742319
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.648603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.6417172636 1399818 2563599 18308698 6150874
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4920464547 20869020 18816296 6695378 18569708 17053015 18520028 20064080 20135361
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0511408345 17203775
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010051 Ovarian Neoplasms Progesterone 2.6017393432 16525653
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5816965848
MESH:D011230 Precancerous Conditions Cyclosporine 9.9412371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.942563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9217292933
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9418045962
MESH:D012640 Seizures Phenobarbital 2.893137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4910029692 19755658
MESH:D013119 Spinal Cord Injuries Progesterone 4.7416503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.291399818
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2817053015
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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