AutismKB 2.0

Annotation Detail for CCR5


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Basic Information Top
Gene Symbol:CCR5 ( CC-CKR-5,CCCKR5,CD195,CKR-5,CKR5,CMKBR5,FLJ78003,IDDM22 )
Gene Full Name: chemokine (C-C motif) receptor 5
Band: 3p21.31
Quick LinksEntrez ID:1234; OMIM: 601373; Uniprot ID:CCR5_HUMAN; ENSEMBL ID: ENSG00000160791; HGNC ID: 1606
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa05145Toxoplasmosis
hsa04062Chemokine signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Signaling by GPCR
HIV Infection
Pathway IDPathway Name
200034IL12-mediated signaling events
Pathway IDPathway Name
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1707Multiple myeloma
1713Hemophilia
1723Brucellosis
1740Alzheimer's disease
1770Melanoma
1779Cervical cancer
1804Chronic obstructive airway disease
1828Encephalitis
1831Prostate cancer
1869Behcet syndrome
1870Drug abuse
1877Multiple sclerosis
1902Kidney failure
1904Diabetes mellitus
1918Atherosclerosis
1930Graves' disease
1944Breast cancer
1979Testicular dysfunction
2008Liver disease
2022Liver cancer
2091Hypertension
2046Polymyositis
2053Colon cancer
2059Communicable disease
2066Lung cancer
2069Schizophrenia
2074Asthma
2075Heart failure
2083IGA glomerulonephritis
2093Viremia
2097Hyperlipidemia
2100Hepatitis C
2118Adenovirus infection
2146Lupus erythematosus
2167Neuritis
2174Chronic rejection of renal transplant
2219Mucocutaneous lymph node syndrome
2231Arthritis
2245Fetal disease
2256Aortic aneurysm
Desease Name
rheumatoid arthritis
Sjogren's syndrome
diabetic nephropathy
Physician diagnosed asthma
severe RSV bronchiolitis
CARDIOVASCULAR
Coronary Artery Disease
diabetes, type 1
Wegener's granulomatosis
Human Renal Transplantation
Celiac Disease
HIV-1 infection
HIV-1 disease
Renal Transplant Survival
Kidney Failure, Chronic
Asthma
nephropathy in other diseases
Inflammation
nephropathy, diabetic
RENAL
kidney transplant rejection
HCV infection
multiple sclerosis
HIV infection
IMMUNE
METABOLIC
Myocardial Infarction
Cardiovascular Diseases
HIV
hepatitis B
hepatitis C
HIV disease progression
Hepatitis C, Chronic
INFECTION
No data
Desease Name
Hepatitis C virus, resistance to
Diabetes mellitus, insulin-dependent, 22
West nile virus, susceptibility to
HIV infection, susceptibility/resistance to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C513867 2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate 2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate affects the localization of CCR5 proteinaffects localization 16920949
C513867 2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate 2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate binds to and results in increased activity of CCR5 proteinaffects binding|increases activity 16920949
C513867 2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate 2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate results in decreased expression of CCR5 proteindecreases expression 16920949
C513867 2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide inhibits the reaction [2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate affects the localization of CCR5 protein]affects localization|decreases reaction 16920949
C513867 2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide inhibits the reaction [2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate results in decreased expression of CCR5 protein]decreases expression|decreases reaction 16920949
C030682 3-chlorophenol 3-chlorophenol results in decreased expression of CCR5 mRNAdecreases expression 18486366
C438583 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide inhibits the reaction [2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate affects the localization of CCR5 protein]affects localization|decreases reaction 16920949
C438583 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide inhibits the reaction [2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate results in decreased expression of CCR5 protein]decreases expression|decreases reaction 16920949
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of CCR5 mRNAaffects expression 21346803
D015081 2-Naphthylamine 2-Naphthylamine results in increased expression of CCR5 mRNAincreases expression 18247414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CCR5 mRNAaffects expression 16483693
D019380 Anti-HIV Agents Anti-HIV Agents results in decreased expression of CCR5 mRNAdecreases expression 10202824
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CCR5 mRNAincreases expression 18247414
D001966 Bromine Bromine results in increased expression of CCR5 mRNAincreases expression 18790026
D002251 Carbon Tetrachloride PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CCR5 mRNA]affects reaction|increases expression 18038451
C105934 celecoxib celecoxib results in decreased expression of CCR5 mRNAdecreases expression 12902868
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of CCR5 mRNAincreases expression 15331540
D017373 Cyproterone Acetate [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR5 proteinaffects cotreatment|increases expression 10770211
D002945 Cisplatin Cisplatin results in increased expression of CCR5 mRNAincreases expression 15814532
D002945 Cisplatin pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCR5 mRNA]decreases reaction|increases expression 15814532
D004391 Dust Dust results in increased expression of CCR5 mRNAincreases expression 17805423
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR5 proteinaffects cotreatment|increases expression 10770211
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CCR5 mRNAdecreases expression 15885639
12538720
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CCR5 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCR5 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CCR5 mRNAincreases expression 15834898
C004809 isopentenyl pyrophosphate isopentenyl pyrophosphate results in decreased expression of CCR5 proteindecreases expression 11994442
D009151 Mustard Gas Mustard Gas results in increased expression of CCR5 mRNAincreases expression 18955075
D009538 Nicotine Nicotine results in increased expression of CCR5 mRNAincreases expression 18247414
D010416 Pentachlorophenol Pentachlorophenol results in decreased expression of CCR5 mRNAdecreases expression 18486366
C006253 pirinixic acid pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCR5 mRNA]decreases reaction|increases expression 15814532
D010936 Plant Extracts Plant Extracts results in decreased expression of CCR5 mRNAdecreases expression 12462994
C013221 proanthocyanidin proanthocyanidin results in decreased expression of CCR5 mRNAdecreases expression 12462994
D015232 Dinoprostone Dinoprostone results in decreased expression of CCR5 mRNAdecreases expression 16303787
D015232 Dinoprostone Dinoprostone results in decreased expression of CCR5 proteindecreases expression 16303787
D019311 Staurosporine Staurosporine inhibits the reaction [[IL8 protein binds to and results in increased activity of IL8RA protein] which results in increased phosphorylation of and affects the localization of CCR5 protein]affects binding|affects localization|decreases reaction|increases activity|increases phosphorylation 12594210
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCR5 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CCR5 mRNAincreases expression 18684927
C015559 trimellitic anhydride trimellitic anhydride results in increased expression of CCR5 mRNAincreases expression 16141432
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of CCR5 mRNAincreases expression 17982090
15973123
D014315 Triterpenes Triterpenes analog results in decreased activity of CCR5 proteindecreases activity 12372534
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCR5 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 7.557525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5514514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.559612607
MESH:D058186 Acute Kidney Injury Cisplatin 3.7115814532 12690470 17670903
MESH:D055371 Acute Lung Injury pirinixic acid 2.8618653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6520127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 6.6511798837 17638652
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6514692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.496695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9716835633
MESH:D011125 Adenomatous Polyposis Coli celecoxib 9.6816215675 19003578
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 9.6817942926
MESH:D000310 Adrenal Gland Neoplasms Pentachlorophenol 5.8210696769
MESH:D000544 Alzheimer Disease Nicotine 4.6316627626
MESH:D000544 Alzheimer Disease Plant Extracts 4.6316962711
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D001014 Aortic Aneurysm Dinoprostone 5.3410231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 11.0819183758
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 11.0810388637
MESH:D001161 Arteriosclerosis Cyclophosphamide 9.2615014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.9615885639
MESH:D001169 Arthritis, Experimental Plant Extracts 6.9614686799
MESH:D001249 Asthma Mustard Gas 5.2710378619
MESH:D001249 Asthma trimellitic anhydride 5.2716141432
MESH:D001477 Bartter Syndrome Dinoprostone 5.4715976003
MESH:D001768 Blister Mustard Gas 4.8819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6014601052
MESH:D002545 Brain Ischemia Plant Extracts 4.4516041641
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9420146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 1.9418382427 19526202
MESH:D001943 Breast Neoplasms Cyclophosphamide 1.9418234424 17020986 17388661 12006526 18323546 16978400 11325840 15093573 15136595
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6917687719 10378619
MESH:D002057 Burns, Chemical Plant Extracts 5.059625245
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5110355542 18705752 16097048 15700767 16124888 16227642 16011737 15721981 16050911 15673190 3786805 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5816835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.2918788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.2917982673
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 6.2919701751
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 6.2918834353
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.6116152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9416685392 12023789
MESH:D002292 Carcinoma, Renal Cell celecoxib 6.8016369983
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 6.8016201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.4820419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.4817066447 18337622 6189445
MESH:D006332 Cardiomegaly Plant Extracts 6.4717645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4718670907 18850075 16120746
MESH:D009202 Cardiomyopathies Anti-HIV Agents 5.5611706060
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.4714694615
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 4.0316192471
MESH:D002613 Cheilitis Anti-HIV Agents 7.4311488127
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.0617333356 16919318 17110522 15861022 17681005 11677210 16105132
MESH:D002779 Cholestasis pirinixic acid 7.0619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9912621046 15340226 16354765 15668235 8697196
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 4.2716867261 11698051 17991707 16474422 17936198 16782535 18200517 18023891 16804969
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3517276891
MESH:D003110 Colonic Neoplasms celecoxib 3.3616004971
MESH:D015179 Colorectal Neoplasms celecoxib 3.0818349538 11197048
MESH:D015179 Colorectal Neoplasms Cisplatin 3.0815273666
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.4115095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.4117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2410048152 20055451 15322242
MESH:D003556 Cystitis Cyclophosphamide 4.7015643279 12388444 18710439 16989017 15276878 16413132 16614059 10498854 17010015 11948286 12161096 18372110 12913760 18483878 16651033 10700343 18433785 17979934 18093676 18295254
MESH:D003876 Dermatitis, Atopic marker/mechanism 18249437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.8411751995 10990075 15331540
MESH:D003922 Diabetes Mellitus, Type 1 marker/mechanism
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1318772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6017107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 4.1719706694
MESH:D003967 Diarrhea Dinoprostone 4.2911488427 10446763 7237001
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 5.7621346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.7611566570 10092053 15998439 2869522 6623471 9327722 3732212 10915739 15968718 4309450 19085960 21278145 19336974 15027814 7120509 17522070 3786805 16227642 7440962 6884620 16177239 7179309
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.7620420201
MESH:D004362 Drug Toxicity Cisplatin 12.6412231392 12649298 19839026 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.6411462148
MESH:D004362 Drug Toxicity Zidovudine 12.6415040536
MESH:D020821 Dystonic Disorders Nicotine 5.6517881519
MESH:D004487 Edema Mustard Gas 19.049260866 11428631 11428647 11402378
MESH:D004487 Edema pirinixic acid 19.0412083418
MESH:D004487 Edema Plant Extracts 19.0412787963
MESH:D004487 Edema Staurosporine 19.048273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 19.0412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9212538720
MESH:D004715 Endometriosis celecoxib 8.5715652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.579294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.4015268973
MESH:D004802 Eosinophilia Cyclophosphamide 3.9411006010
MESH:D004827 Epilepsy Plant Extracts 3.5919700373 19439326
MESH:D004890 Erythema Mustard Gas 4.889357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3616530937
MESH:D004938 Esophageal Neoplasms Cisplatin 4.3616481741 16785472 15464296 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.0212795759 16045604 12631006 17595544 19224547 15959796 61145 16239168
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.0215345470
MESH:D005234 Fatty Liver pirinixic acid 22.0220131406 19236843
MESH:D005234 Fatty Liver Plant Extracts 22.0215975614
MESH:D005234 Fatty Liver Zidovudine 22.0218299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005334 Fever Dinoprostone 4.6416997862 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 13.2918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.2920067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 13.2917994277
MESH:D018316 Gliosarcoma Cyclophosphamide 5.2311389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.7615172196 11014644 16376943
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.5315464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.0619898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1915464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9610048152 11294989
MESH:D006333 Heart Failure pirinixic acid 6.6720558911
MESH:D006333 Heart Failure Plant Extracts 6.6718097624
MESH:D006394 Hemangiosarcoma Pentachlorophenol 4.8015200160
MESH:D006402 Hematologic Diseases Zidovudine 4.4512579204
MESH:D006467 Hemophilia A Cyclophosphamide 5.0211918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.2514986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3319110552 19900420
MESH:D006526 Hepatitis C marker/mechanism
MESH:D006529 Hepatomegaly pirinixic acid 7.3516221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3515340226 12621046 16120746
MESH:D006561 Herpes Simplex Plant Extracts 4.3510715843
MESH:D015658 HIV Infections Anti-HIV Agents 10.4111464145
MESH:D015658 HIV Infections Plant Extracts 10.4112878215
MESH:D015658 HIV Infections Zidovudine 10.4111698656 11363243 20032539 11141242 17358032
MESH:D006689 Hodgkin Disease Cisplatin 7.0116200630 16170182
MESH:D006689 Hodgkin Disease Cyclophosphamide 7.0116135485 17606976
MESH:D019584 Hot Flashes Plant Extracts 4.4717454163 16566672 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7618606429 16354765 16959395 8697196 15340226
MESH:D006930 Hyperalgesia Dinoprostone 4.3116793879
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2516899240
MESH:D006943 Hyperglycemia pirinixic acid 2.9420558911
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.2316484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.2215268973 15975614
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8115338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416569931 16945680
MESH:D007154 Immune System Diseases Cyclophosphamide 5.0516076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male Cyclophosphamide 6.2616517039 7193160
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2617937319
MESH:D007249 Inflammation Mustard Gas 7.6017524151 8975870 11402378 9357497 11428647 16001271 9260866 11428631 11428620
MESH:D007249 Inflammation Plant Extracts 7.6016366677 19332304 12787963 15997105
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6012200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.4718200517
MESH:D007333 Insulin Resistance pirinixic acid 2.4516306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.3317994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.3812628509 12351151 12584176
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0916580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.8615464296
MESH:D007674 Kidney Diseases Cisplatin 3.0912231392 18289764 12649298 15190930 19839026
MESH:D007680 Kidney Neoplasms Zidovudine 3.5612579204
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5111231351
MESH:D007938 Leukemia Cyclophosphamide 3.3510602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.3817296974 17658394 18587576 18172266 17008537 17802794
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.1620370541
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.8810373061
MESH:D007970 Leukopenia Cyclophosphamide 4.6910052129 11830472
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4316943688 16221502 11408273 17174718 11903743 21278145 17334410 16239168 17157831
MESH:D008103 Liver Cirrhosis Plant Extracts 6.4317157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.3615338365 16033810 17698563 16638106 12389079 20821823 14620537 15996030 18006644 14748882 15925388 17922224 12632514 15959796 14716496 12649538 15370692 18166357 14512876 17944888 17823541 15931870 12666154 18395095 16248980 16097048 17869086 18472094 18472332 15057751 17708605 11481614 15730626 14724832 18210741 12586293 12445418 18263696 16015684 15123356 17481882 17631135 17805973 16136751 17761835 15052691 18054572 18420326 15673190 12632512 17525996 14716833 18376398 18481824 10355542 18277467 12667390 12609069 18412020 18705752 12898905 12958196 18395914 17900296 12546737 15650968 17557913 18187930 18429990 17766677 16027843 15893842 18205269 16116963 18251166 17565644 18156304 18339082 17714472 16192424 17721639 16011737 12741479 15362042 18279442 17976157 15818738 18317297 17640975 15876570 12445421 13678700 18418968
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 6.3615816358
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 6.3615479170
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3915830285 16964402 15720792 17285989 16246199
MESH:D008107 Liver Diseases Dinoprostone 6.3915816358
MESH:D008107 Liver Diseases Plant Extracts 6.3917034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4514706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.5721137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.5719294768
MESH:D008113 Liver Neoplasms Pentachlorophenol 16.5710696769
MESH:D008113 Liver Neoplasms pirinixic acid 16.5716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Plant Extracts 16.5719168119
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.5716984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.1912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.1912151625
MESH:D008171 Lung Diseases Mustard Gas 3.2618161513 18702808
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.0820464547 18569708 17053015 18816296 18520028 20135361 6695378 20869020 20064080
MESH:D008175 Lung Neoplasms Cisplatin 8.086189445 17225452 11798837
MESH:D008175 Lung Neoplasms Mustard Gas 8.088781369 3148597
MESH:D008175 Lung Neoplasms Plant Extracts 8.0820869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.0811884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 8.0818800350
MESH:D008223 Lymphoma Cyclophosphamide 7.6512854902
MESH:D008223 Lymphoma Pentachlorophenol 7.6512669308
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.3416675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.9411911406
MESH:D008325 Mammary Neoplasms, Experimental celecoxib 3.8819196722 12104042
MESH:D008545 Melanoma Cisplatin 2.4411135225 12393984 18176117 15577323 18332650 18505091 12883367 16432458 12374674 16809738 16248763 17023156 17761969
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.4915990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.5316388313
MESH:D008654 Mesothelioma Cisplatin 3.1317638057
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.5517358032
MESH:D020326 Migraine without Aura Dinoprostone 5.0011304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9816381670
MESH:D009101 Multiple Myeloma celecoxib 4.2216123214
MESH:D009135 Muscular Diseases pirinixic acid 3.2316239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7316411023
MESH:D009369 Neoplasms Benzo(a)pyrene 14.2711141357
MESH:D009369 Neoplasms Cisplatin 14.2716773208
MESH:D009369 Neoplasms Cyclophosphamide 14.2718854779
MESH:D009369 Neoplasms Nicotine 14.2716365874
MESH:D009369 Neoplasms pirinixic acid 14.2717405874
MESH:D009376 Neoplasms, Hormone-Dependent celecoxib 5.1519196722
MESH:D018301 Neoplasms, Mesothelial Pentachlorophenol 6.3710696769
MESH:D009389 Neovascularization, Pathologic Nicotine 4.7216365874
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2115464296
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9514600291
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.9117168769
MESH:D009447 Neuroblastoma Cisplatin 6.808761367
MESH:D009447 Neuroblastoma Cyclophosphamide 6.8016115947 15176712 8761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.598761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 10.598761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 8.678291058
MESH:D009503 Neutropenia Mustard Gas 8.6716761898 7688884
MESH:D009765 Obesity pirinixic acid 4.5020558911
MESH:D009765 Obesity Plant Extracts 4.5020132043 19056576
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 3.8614694615
MESH:D009845 Oligospermia Cyclophosphamide 4.4316517039
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 6.1918500342
MESH:D010051 Ovarian Neoplasms Cisplatin 2.7919769630 6897625 15464296 17225452
MESH:D010146 Pain Cyclophosphamide 3.4112161096 18093676
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.3819003803
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.3811332152
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.9517698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010212 Papilloma Plant Extracts 4.2215173996 16517061
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.0415464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.0617638057
MESH:D011041 Poisoning Mustard Gas 3.5415727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.6521297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9111222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2617292933
MESH:D011471 Prostatic Neoplasms celecoxib 2.2615570007 17908994
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.2617136230
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.2614666653 17804756
MESH:D011537 Pruritus Ethinyl Estradiol 8.5916919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.5918058305
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.6416636934
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.6417894541 17720292 10334151 17266442 17620002
MESH:D051437 Renal Insufficiency Cisplatin 4.1315464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2519058328
MESH:D012130 Respiratory Hypersensitivity trimellitic anhydride 4.6820219652
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.1614601052
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.5616636934
MESH:D012640 Seizures Nicotine 3.6217873105
MESH:D012871 Skin Diseases Mustard Gas 2.6412880345 16961503 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.7310029692 19755658
MESH:D012878 Skin Neoplasms Plant Extracts 8.7316517061 15173996
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7316192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.0615464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6616709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.2316517039
MESH:D013160 Splenic Neoplasms Pentachlorophenol 6.0210696769
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.592093021 20155912
MESH:D013274 Stomach Neoplasms celecoxib 4.5915609394
MESH:D013274 Stomach Neoplasms Cisplatin 4.5917522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Zidovudine 4.5917696246
MESH:D013276 Stomach Ulcer Plant Extracts 3.6515255614 18237397 18193104 17135157 12787963
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.7812837982
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 5.2017997062
MESH:D013736 Testicular Neoplasms Cisplatin 4.3715464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.5316720336 11259349 16785264
MESH:D014029 Tobacco Use Disorder Nicotine 5.1718041664 15735609 17979512 18305452
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 11.1211144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.1217053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 11.1215464296 17225452 12973940
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 11.1214692829
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 3.9716803524
MESH:D014594 Uterine Neoplasms celecoxib 8.9618645019
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.9614692618
MESH:D014625 Vaginal Neoplasms Cisplatin 10.2915577323
MESH:D014625 Vaginal Neoplasms Zidovudine 10.2912579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.4718097624
MESH:D020257 Ventricular Remodeling Plant Extracts 5.0418097624
MESH:D014839 Vomiting Cisplatin 4.4311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D014901 West Nile Fever marker/mechanism
MESH:D014947 Wounds and Injuries Plant Extracts 4.0319894650 20213670
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04144 Endocytosis
REACT:6185 HIV Infection
REACT:14797 Signaling by GPCR
KEGG:05145 Toxoplasmosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26170
    • No data
    Releated disease ID Related disease Name
    PA443815Crohn Disease
    PA443250Acquired Immunodeficiency Syndrome
    PA447230HIV
    PA446213HIV Infections
    PA446070West Nile Fever
    PA446714Neoplasm, Residual
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA451365sirolimus
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04835 antagonist Maraviroc Anti-HIV Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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