AutismKB 2.0

Annotation Detail for CCR7


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Basic Information Top
Gene Symbol:CCR7 ( BLR2,CD197,CDw197,CMKBR7,EBI1 )
Gene Full Name: chemokine (C-C motif) receptor 7
Band: 17q21.2
Quick LinksEntrez ID:1236; OMIM: 600242; Uniprot ID:CCR7_HUMAN; ENSEMBL ID: ENSG00000126353; HGNC ID: 1608
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00031Inflammation mediated by chemokine and cytokine signaling pathway
Pathway IDPathway Name
500406Chemokine receptors bind chemokines
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C103303 alitretinoin alitretinoin results in decreased expression of CCR7 proteindecreases expression 17475839
C103303 alitretinoin alitretinoin results in increased expression of CCR7 proteinincreases expression 17475839
D001554 Benzene Benzene results in decreased expression of CCR7decreases expression 15935813
D001554 Benzene Benzene results in decreased expression of CCR7 mRNAdecreases expression 12928149
D001554 Benzene TP53 protein promotes the reaction [Benzene results in decreased expression of CCR7]decreases expression|increases reaction 15935813
D001554 Benzene TRP53 protein affects the reaction [Benzene results in decreased expression of CCR7 mRNA]affects reaction|decreases expression 12928149
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CCR7 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of CCR7 mRNAincreases expression 20106945
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of CCR7 proteinincreases expression 15737199
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of CCR7 mRNAincreases expression 19159591
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CCR7 mRNAdecreases expression 15885639
12538720
C022838 nickel chloride nickel chloride results in increased expression of CCR7 proteinincreases expression 15737199
C029938 nickel sulfate nickel sulfate results in increased expression of CCR7 mRNAincreases expression 16780908
D015232 Dinoprostone Dinoprostone results in increased expression of CCR7 mRNAincreases expression 16303787
D015232 Dinoprostone Dinoprostone results in increased expression of CCR7 proteinincreases expression 16303787
C089730 rosiglitazone rosiglitazone results in decreased expression of CCR7 proteindecreases expression 17475839
C017947 sodium arsenite sodium arsenite results in decreased expression of CCR7 mRNAdecreases expression 12676792
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CCR7 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury nickel sulfate 4.4211954676 16100012 12718980 19131640
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2620127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2614692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 5.1317942926
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0817306315 16712894
MESH:D000544 Alzheimer Disease rosiglitazone 2.8719621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000741 Anemia, Aplastic Benzene 4.4517661222 11369114 14761424
MESH:D001014 Aortic Aneurysm Dinoprostone 5.7310231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 12.4619183758
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 12.4610388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001477 Bartter Syndrome Dinoprostone 5.8815976003
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001855 Bone Marrow Diseases Benzene 5.4016183116
MESH:D001943 Breast Neoplasms alitretinoin 2.0116344269
MESH:D001943 Breast Neoplasms Benzene 2.0117162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 1.9917306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7020419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7018572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.8112371664
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 11.8116192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.8120056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 8.0519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0517333356 16919318 17110522 11677210 17681005 16105132 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415340226 8697196 12621046 16354765 15668235
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.8917373747 19159591
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 2.7015643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7020055451 15322242 10048152
MESH:D003872 Dermatitis Benzene 4.9015902427
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 8.1115491423
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 8.1111298694 16823706 16780908
MESH:D003920 Diabetes Mellitus rosiglitazone 4.4017446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.5812642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5817107852
MESH:D003967 Diarrhea Dinoprostone 4.6810446763 7237001 11488427
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema rosiglitazone 7.3312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 13.8119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.8115345470
MESH:D005234 Fatty Liver rosiglitazone 13.8119196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005334 Fever Dinoprostone 4.9816997862 11852909
MESH:D005355 Fibrosis Cyclosporine 8.9512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6310048152 11294989
MESH:D006402 Hematologic Diseases Benzene 4.7716183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.2512676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 18606429 16959395 8697196 16354765
MESH:D006930 Hyperalgesia Dinoprostone 8.8516793879
MESH:D006930 Hyperalgesia rosiglitazone 8.8512083418
MESH:D006973 Hypertension Benzene 8.8317940673
MESH:D006973 Hypertension Cyclosporine 8.8310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.8318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8817937319
MESH:D007248 Infertility, Male sodium arsenite 6.8812646999 15346721
MESH:D007249 Inflammation rosiglitazone 5.3512083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3512878042 12200463
MESH:D007333 Insulin Resistance rosiglitazone 3.8716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.7916144296
MESH:D007674 Kidney Diseases Cyclosporine 6.2210903974 8314463 18776723
MESH:D007674 Kidney Diseases sodium arsenite 6.2220008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D007938 Leukemia Benzene 3.4414694614 15935818 18335105 17119257
MESH:D007951 Leukemia, Myeloid Benzene 4.4317506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7119478238
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 3.7915816358
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.7915980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7912878042
MESH:D008107 Liver Diseases Dinoprostone 3.4815816358
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6120195826 21137059
MESH:D008113 Liver Neoplasms sodium arsenite 7.6116712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6116984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 6.2312562636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2312151625
MESH:D008171 Lung Diseases sodium arsenite 3.2419095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.9814698565
MESH:D008175 Lung Neoplasms alitretinoin 6.7316413115
MESH:D008175 Lung Neoplasms Benzene 6.7312562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.7320464547 18569708 6695378 18816296 20135361 20064080 17053015 20869020 18520028
MESH:D008175 Lung Neoplasms sodium arsenite 6.7316712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7311884234 19555203
MESH:D008223 Lymphoma Benzene 3.8117584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.6012562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.7511921183
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 6.7516827153
MESH:D008545 Melanoma Dinitrochlorobenzene 3.8612202904 17334785
MESH:D008545 Melanoma sodium arsenite 3.8616487513 19082730
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.4717261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D020326 Migraine without Aura Dinoprostone 5.3911304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009101 Multiple Myeloma Benzene 3.7417119195
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009369 Neoplasms alitretinoin 8.6816946489
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6811141357
MESH:D009369 Neoplasms sodium arsenite 8.6811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8020056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects Benzene 7.7715643154
MESH:D009436 Neural Tube Defects sodium arsenite 7.7712854658
MESH:D009784 Occupational Diseases Benzene 4.2817479406 15935809 15576619 15913788 17178637 17119257 15727169 16737584 15612468
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 6.6518500342
MESH:D010051 Ovarian Neoplasms Benzene 5.2212562636
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.2217306315 15276417
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017499 Porokeratosis alitretinoin 6.1816144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1617292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.1616039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.6810029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 9.6819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8812854658
MESH:D013274 Stomach Neoplasms Benzene 2.6012562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.602093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013953 Thymus Neoplasms Benzene 5.1110850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1817053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.1817306315 16712894 16452187 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8711813266
MESH:D014594 Uterine Neoplasms Benzene 10.0012562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.0014692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014652 Vascular Diseases sodium arsenite 4.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04060 Cytokine-cytokine receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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