AutismKB 2.0

Annotation Detail for CMTM3


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Basic Information Top
Gene Symbol:CMTM3 ( BNAS2,CKLFSF3,FLJ31762,MGC51956 )
Gene Full Name: CKLF-like MARVEL transmembrane domain containing 3
Band: 16q22.1
Quick LinksEntrez ID:123920; OMIM: 607886; Uniprot ID:CKLF3_HUMAN; ENSEMBL ID: ENSG00000140931; HGNC ID: 19174
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CMTM3 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CMTM3 mRNAincreases expression 17484886
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of CMTM3 mRNAdecreases expression 16636312
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CMTM3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of CMTM3 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CMTM3 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3811752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.7716835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.9215469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0817129689 15324884
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2610355542 16011737 16097048 16227642 16124888 16050911 18705752 15673190 16192424 3786805 15700767 15721981
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.833084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.8315948411 16924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5416120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.228697196 15340226 16354765 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 5.0012952375 16002989
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6312153990 12540782 11287661 11739529 10663392 19420014 17906064 11743745 19739265 12594235 10915739 19164858 18071297 16393943 12705907 12392966 17522070 11529661 14725611 15619225 16081117 14550746 19416960 19923254 16109766 2444490 10774834 18713872 16227642 12958197 19370779 16177239 15968718 11834606 17562736 19085960 11421492 16781746 14986274 16485898 11461765
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.6310092053 2869522 15027814 15968718 7179309 7440962 11566570 19085960 3786805 10915739 19336974 16177239 3732212 21278145 6884620 15998439 7120509 6623471 16227642 9327722 4309450 17522070
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema pirinixic acid 7.7912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 16714409 15322242
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.2316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.6815700306 16804899
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.9412631006 16045604 15959796 17595544 12795759 16239168 19224547 61145
MESH:D005234 Fatty Liver pirinixic acid 8.9420131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8515751030 16611131 16534752 16513791 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Carbon Tetrachloride 10.2618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.2620067830
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.4916452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4911294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 9.9219772884 19176532 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.9216120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6616354765 15340226 18606429 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.9214722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007021 Hypospadias Diethylstilbestrol 5.0616002989
MESH:D007246 Infertility Diethylstilbestrol 4.7915036965
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.7616762066 15003126 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 4.5417184923
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9816943688 16221502 17157831 11903743 16239168 21278145 11408273 17174718 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5615931870 17766677 12546737 18187930 18277467 15996030 15673190 15730626 18472094 18210741 12649538 15338365 14716496 17708605 17714472 17805973 17869086 12958196 18472332 12632512 17481882 18339082 17557913 15123356 14748882 17631135 16136751 16192424 18412020 17761835 12898905 15362042 12632514 16248980 17823541 12586293 15370692 12741479 15818738 10355542 14512876 18006644 17922224 17944888 16638106 16027843 18395914 14724832 18251166 18279442 12666154 17640975 18376398 18705752 16116963 13678700 14716833 15876570 18395095 14620537 15650968 16015684 18317297 16097048 12389079 18166357 16011737 18156304 12445418 16033810 17698563 15925388 18054572 11481614 18481824 12445421 15893842 15052691 18418968 15959796 17565644 18429990 17976157 20821823 18420326 18263696 17721639 12609069 17900296 17525996 12667390 18205269 15057751
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5612878042
MESH:D008107 Liver Diseases Acetaminophen 4.1419014921 16611625 19460945 16610002 12969438 11587558 19784758 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1415720792 17285989 15830285 16246199 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.5916871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.5914706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.6319294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 11.6315890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 11.6316377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.6316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.4515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4512151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.6915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.7215700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 6.1316002989
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms Diethylstilbestrol 5.5515313581
MESH:D009369 Neoplasms pirinixic acid 5.5517405874
MESH:D009421 Nervous System Malformations Diethylstilbestrol 11.1511399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 11.1514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.7814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.1616977796 15687265
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 11.4317184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.4311222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.5117136230 15046698 15846301
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D013088 Spermatocele Diethylstilbestrol 5.3216002989 16709447
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.8817306315 16452187 16712894
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.3816175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.7814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.5116690809 15809267
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.9216513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38813
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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