AutismKB 2.0

Annotation Detail for ADH1A


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Basic Information Top
Gene Symbol:ADH1A ( ADH1 )
Gene Full Name: alcohol dehydrogenase 1A (class I), alpha polypeptide
Band: 4q23
Quick LinksEntrez ID:124; OMIM: 103700; Uniprot ID:ADH1A_HUMAN; ENSEMBL ID: ENSG00000187758; HGNC ID: 249
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C047519 2,2'-thiodiethanol ADH1A protein affects the metabolism of 2,2'-thiodiethanolaffects metabolic processing 16417912
C043958 2-butanol ADH1A protein binds to and results in increased metabolism of 2-butanolaffects binding|increases metabolic processing 1618764
C106538 abacavir [ADH1A protein binds to ADH1A protein] which results in increased metabolism of abacaviraffects binding|increases metabolic processing 12399160
C004984 apocarotenal apocarotenal results in increased expression of ADH1A mRNAincreases expression 17034753
C006632 arsenic trioxide arsenic trioxide results in increased expression of ADH1A mRNAincreases expression 20458559
D019207 beta Carotene beta Carotene results in increased expression of ADH1A mRNAincreases expression 17034753
D003511 Cyclohexanols ADH1A protein binds to and results in increased metabolism of Cyclohexanolsaffects binding|increases metabolic processing 1618764
D016572 Cyclosporine Cyclosporine results in decreased expression of ADH1A mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of ADH1A mRNAdecreases expression 20106945
D000431 Ethanol ADH1A protein binds to and results in increased metabolism of Ethanolaffects binding|increases metabolic processing 1618764
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ADH1A mRNAdecreases expression 11489354
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.1218926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1215322242 14514962 11752688
MESH:D000138 Acidosis Ethanol 4.6911192467
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5011798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 4.5011473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.5415451040 15451039
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000853 Anophthalmos Ethanol 5.0015513904
MESH:D001008 Anxiety Disorders Ethanol 4.1211141031
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.4316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D002545 Brain Ischemia beta Carotene 5.2816157235
MESH:D001943 Breast Neoplasms Estradiol 1.9216675129 17289903 18497071 12948864 17261762 19861407 17018787 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002056 Burns Ethanol 4.8316374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7816217749 15073043 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7816924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.7815763234 18788625 15289165
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D006332 Cardiomegaly Ethanol 7.0919332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0918850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases abacavir 5.2218753925
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8918566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D002971 Cleft Lip Ethanol 3.6515513904
MESH:D002972 Cleft Palate Ethanol 6.1315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1312621046 8697196 15340226 16354765 15668235
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9010525206
MESH:D019465 Craniofacial Abnormalities Ethanol 3.9015451039 11873399 19302082 15451040 15513904 10194807 11198716
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9015322242 10048152 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D004342 Drug Hypersensitivity abacavir 5.4315024131 15867870
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.0511566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.0719148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.8212903497
MESH:D004938 Esophageal Neoplasms Ethanol 4.8216704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver arsenic trioxide 14.0315073043
MESH:D005234 Fatty Liver Cyclosporine 14.0319224547
MESH:D005234 Fatty Liver Ethanol 14.0319236843 16409862 18620774
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4916946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 9.0712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005756 Gastritis Ethanol 4.9115046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0716120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D015658 HIV Infections abacavir 7.9011141242 12891065 17457083
MESH:D015658 HIV Infections beta Carotene 7.9016960176
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Ethanol 3.8318783367
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.0516627594 16393666
MESH:D007569 Jaw Abnormalities Ethanol 10.5915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.5916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.198314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 6.1915618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6712371664
MESH:D007680 Kidney Neoplasms Estradiol 7.6715610895
MESH:D007859 Learning Disorders Ethanol 4.3915451040
MESH:D007938 Leukemia arsenic trioxide 2.8915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1617050201 16968895 19850784 16467208 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3016112521 19225113 11468182 17217047 16330433 12018890 17107899 16966277 19642359 15748426 12712474 16331271 17712046 11161223 19035177 15336539 9834237 15213294 16823087 17649720 16891316 19075265 12679006 17869043 15622746
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9117676605
MESH:D008103 Liver Cirrhosis Ethanol 3.4415289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2918295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.5918166357
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5912878042
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.8317347304 17207112
MESH:D008113 Liver Neoplasms arsenic trioxide 4.6014682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6016984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.4820377131
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 10.4817113696
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6311798837 19825857
MESH:D008175 Lung Neoplasms beta Carotene 3.6316401635
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6311884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6411807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008569 Memory Disorders Ethanol 4.3515451040 18411066
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2019417148 11468182 15949261 19549372 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2216105982 16882451
MESH:D009203 Myocardial Infarction abacavir 4.7318753925
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009369 Neoplasms beta Carotene 3.7017051425
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.0116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0114600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2010525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9616624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 4.9619401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6215580305
MESH:D010190 Pancreatic Neoplasms Ethanol 5.6212384795
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1819131511
MESH:D011471 Prostatic Neoplasms Estradiol 3.1816740699
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012640 Seizures Ethanol 3.269754883
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013272 Stomach Diseases beta Carotene 5.2817638125
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6717007042
MESH:D013274 Stomach Neoplasms Ethanol 2.6718456281
MESH:D013276 Stomach Ulcer beta Carotene 8.3012500499
MESH:D013276 Stomach Ulcer Ethanol 8.3016755016 17918041 17189318 11906479 9211565 9562338
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.399754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1919014326
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5312973940 12845720 20435036 11780464
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00071 Fatty acid metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00830 Retinol metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24570
    • No data
    Releated disease ID Related disease Name
    PA446879Alcohol-Related Disorders
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA448073ethanol
    PA448073ethanol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB00898 agonist Ethanol Anti-Infective Agents, Local;Solvents;Central Nervous System Depressants;Disinfectants
    DB01213 antagonist Fomepizole Antidotes
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB02721 - 4-Iodopyrazole
    DB04065 - N-Cyclopentyl-N-Cyclobutylformamide
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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