AutismKB 2.0

Annotation Detail for LTB4R


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Basic Information Top
Gene Symbol:LTB4R ( BLT1,BLTR,CMKRL1,GPR16,LTB4R1,LTBR1,P2RY7,P2Y7 )
Gene Full Name: leukotriene B4 receptor
Band: 14q12
Quick LinksEntrez ID:1241; OMIM: 601531; Uniprot ID:LT4R1_HUMAN; ENSEMBL ID: ENSG00000213903; HGNC ID: 6713
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063609 1,2-dimethyl-4-nitrobenzene 1,2-dimethyl-4-nitrobenzene results in decreased expression of LTB4R mRNAdecreases expression 19784758
C082206 7-(3-(2-(cyclopropylmethyl)-3-methoxy-4-((methylamino)carbonyl)phenoxy)propoxy)-3,4-dihydro-8-propyl-2H-1-benzopyran-2-propanoic acid 7-(3-(2-(cyclopropylmethyl)-3-methoxy-4-((methylamino)carbonyl)phenoxy)propoxy)-3,4-dihydro-8-propyl-2H-1-benzopyran-2-propanoic acid binds to and results in decreased activity of LTB4R proteinaffects binding|decreases activity 7812673
D000082 Acetaminophen Acetaminophen affects the expression of LTB4R mRNAaffects expression 19784758
D000082 Acetaminophen Acetaminophen results in decreased expression of LTB4R mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of LTB4R mRNAincreases expression 19784758
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LTB4R mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of LTB4R mRNAdecreases expression 19784758
C089698 CP 105696 CP 105696 binds to and results in decreased activity of LTB4R proteinaffects binding|decreases activity 8666909
C089698 CP 105696 CP 105696 binds to and results in decreased activity of LTB4R proteinaffects binding|decreases activity 19880577
D005419 Flavonoids Flavonoids results in decreased expression of LTB4R mRNAdecreases expression 18035473
D007975 Leukotriene B4 [SC 41930 binds to and results in decreased activity of LTB4R protein] which results in decreased abundance of Leukotriene B4affects binding|decreases abundance|decreases activity 8014878
D009578 Nitrobenzenes Nitrobenzenes analog results in decreased expression of LTB4R mRNAdecreases expression 19784758
C067523 ONO-LB 457 ONO-LB 457 binds to and results in decreased activity of LTB4R proteinaffects binding|decreases activity 11886531
C104857 PH 163 PH 163 binds to and results in decreased activity of LTB4R proteinaffects binding|decreases activity 12654629
C059950 SC 41930 SC 41930 binds to and results in decreased activity of LTB4R proteinaffects binding|decreases activity 7812673
8014878
C059950 SC 41930 [SC 41930 binds to and results in decreased activity of LTB4R protein] which results in decreased abundance of Leukotriene B4affects binding|decreases abundance|decreases activity 8014878
C059950 SC 41930 SC 41930 binds to LTB4R proteinaffects binding 7812673
D014284 Triiodothyronine [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LTB4R mRNAaffects cotreatment|decreases expression 14761676
D013749 Tetrachlorodibenzodioxin [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LTB4R mRNAaffects cotreatment|decreases expression 14761676
D013853 Thioacetamide Thioacetamide results in decreased expression of LTB4R mRNAdecreases expression 19784758
D014212 Tretinoin Tretinoin results in increased expression of LTB4R mRNAincreases expression 17218384
C062137 U 75302 U 75302 binds to and results in decreased activity of LTB4R proteinaffects binding|decreases activity 16313356
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3716835633
MESH:D011125 Adenomatous Polyposis Coli Leukotriene B4 5.4217942926
MESH:D000505 Alopecia Tretinoin 3.6015955085
MESH:D000707 Anaphylaxis marker/mechanism 10934231
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001168 Arthritis Leukotriene B4 6.1411006272
MESH:D001169 Arthritis, Experimental Tretinoin 3.0616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Leukotriene B4 5.4619667530 11006272
MESH:D001249 Asthma Tretinoin 5.4616456186
MESH:D001250 Asthma, Exercise-Induced Leukotriene B4 5.9219667531
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3916935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.3112125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 15.3119483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.3116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9916443354 16166294 16873071
MESH:D016535 Bronchial Hyperreactivity Leukotriene B4 9.8212654629 12794006
MESH:D016535 Bronchial Hyperreactivity PH 163 9.8212654629
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5816813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7715673190 16097048 15700767 16124888 15721981 16011737 16227642 3786805 18705752 10355542 16192424 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1616168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.563084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.5618788625
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 6.5617997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.561917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2816096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.1810977129
MESH:D002386 Cataract Tretinoin 7.1817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.4918291259
MESH:D002822 Choriocarcinoma Tretinoin 5.1616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7412621046 15668235 16354765 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 5.749407595
MESH:D003092 Colitis Tretinoin 3.6917035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.449224671 10589399 9211117 9664655 9142499 17551590 9125849 14991402 16925845 8800419
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9319420014 12153990 16781746 16485898 19416960 16393943 17906064 14550746 11461765 12392966 16177239 15619225 16227642 10663392 12958197 11529661 15968718 11739529 19085960 12540782 11421492 11743745 19739265 12594235 11834606 19923254 17522070 19164858 14986274 12705907 16081117 2444490 16109766 18713872 14725611 17562736 10915739 19370779 18071297 10774834 11287661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.937120509 16227642 6884620 7440962 6623471 21278145 10092053 4309450 3732212 15027814 3786805 17522070 15998439 7179309 19085960 10915739 11566570 9327722 16177239 15968718 19336974 2869522
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9320420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 8.9312963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004487 Edema 7-(3-(2-(cyclopropylmethyl)-3-methoxy-4-((methylamino)carbonyl)phenoxy)propoxy)-3,4-dihydro-8-propyl-2H-1-benzopyran-2-propanoic acid 12.127812673
MESH:D004487 Edema SC 41930 12.127812673
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.1211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.9516714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.9518230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.7816938888 9664655
MESH:D005218 Fat Necrosis Thioacetamide 5.7216456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.1512631006 19224547 15959796 16045604 12795759 17595544 16239168 61145
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005355 Fibrosis Carbon Tetrachloride 14.6918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.6920067830
MESH:D005355 Fibrosis Tretinoin 14.6917994277
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005909 Glioblastoma Tretinoin 2.9917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.5014991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.5518665440 15929193 17276928
MESH:D006505 Hepatitis Carbon Tetrachloride 9.4319110552 19900420
MESH:D006505 Hepatitis Thioacetamide 9.4316456712
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8815340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.058697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.5716870215
MESH:D006930 Hyperalgesia Tretinoin 7.5716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5216899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5516778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0715338365
MESH:D007249 Inflammation marker/mechanism 10934231
MESH:D007249 Inflammation Flavonoids 4.9617296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9612878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Leukotriene B4 4.4611006272
MESH:D007410 Intestinal Diseases Tretinoin 3.7517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8716580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8715992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.1912587719 15629191
MESH:D007938 Leukemia Tretinoin 2.7617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6819285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0719850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1416823087 16788101 17301526 17361223 17506722 19642359 17368321 19075265 17294898 15748426 19029980 16891316 17217047 16766008 12679006 16331271 17649720 17339181 16140955 9834237 19225113 17712046 16935935 19035177 17107899
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.299224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8016943688 16239168 11408273 17157831 16221502 17334410 21278145 11903743 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9515362042 18006644 15123356 15925388 18339082 18205269 12632512 16015684 18418968 18054572 12649538 14748882 17976157 12666154 12667390 16248980 17525996 16136751 18472094 10355542 14716833 15931870 17640975 15370692 12445421 12445418 18420326 18251166 12741479 16638106 20821823 18472332 12958196 14512876 11481614 16027843 15052691 15673190 15893842 12546737 18277467 18412020 15650968 14620537 15876570 17721639 17631135 15730626 16011737 15338365 17900296 17823541 16033810 17481882 14724832 17761835 15996030 15818738 18263696 18429990 16116963 17714472 15057751 18376398 18705752 12389079 17766677 17805973 17944888 17869086 18317297 18210741 18156304 17557913 18395095 17708605 17565644 17698563 18187930 17922224 13678700 18395914 16192424 12898905 12609069 18279442 15959796 12632514 18166357 14716496 18481824 16097048 12586293
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9512878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.9517050028 15316131 15095483 16343077 16098781 15474484 18416461 16126171 11481614 15158331 15334695 17292413 12891558 16248980 12531686 15288472 15288473 17629604 18395095 16489207 15075984 18032466 12085344 15078482 10677585 12557150 16097051 17355460 18263696 18458672 18606216 11682029 17127702 11172339 14739098 18031379 12679928 15716488 12175628 18380797 15362042 18615449 16511523 18295389 15465738
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.9518397230 16248980
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases Acetaminophen 6.5211587558 19784758 12587719 12969438 16610002 19014921 16611625 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.5216964402 17285989 15720792 16246199 15830285
MESH:D008107 Liver Diseases Thioacetamide 6.5218374380 16337175 15158337
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 16.1516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 16.1514706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 16.1515313186 12479984 15633222 17276928
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.3719294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3716984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.7112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7112151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2319555203 11884234
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Tretinoin 1.9416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008591 Meningomyelocele Tretinoin 4.4116940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D009369 Neoplasms Tretinoin 2.4016594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4614600291
MESH:D009421 Nervous System Malformations Tretinoin 9.469125849
MESH:D009436 Neural Tube Defects Tretinoin 3.049142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D009503 Neutropenia Leukotriene B4 5.318305713
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3416936753
MESH:D010146 Pain Acetaminophen 6.5316870215
MESH:D010146 Pain Tretinoin 6.5316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4515976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811896295 11118676 11222880 11399792
MESH:D011507 Proteinuria Tretinoin 3.5916636307
MESH:D011537 Pruritus ONO-LB 457 6.8619657356
MESH:D011565 Psoriasis Leukotriene B4 4.3211006272
MESH:D011625 Pterygium Tretinoin 4.7816723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0816283617 16116481
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5316192470
MESH:D012878 Skin Neoplasms Tretinoin 5.5316467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7716051514
MESH:D014376 Tuberculosis Tretinoin 3.2116040207
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6616129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6116752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D014820 Vitiligo Tretinoin 4.0416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D009396 Wilms Tumor Tretinoin 3.9516287080
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30476
    • No data
    Releated disease ID Related disease Name
    PA447279Rhinitis, Allergic, Seasonal
    PA445558Rhinitis, Allergic, Perennial
    No data
    Drug Bank Top

    Simple Query:


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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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