AutismKB 2.0

Annotation Detail for IQCK


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Basic Information Top
Gene Symbol:IQCK ( FLJ20115,FLJ36575,MGC35048 )
Gene Full Name: IQ motif containing K
Band: 16p12.3
Quick LinksEntrez ID:124152; OMIM: NA; Uniprot ID:IQCK_HUMAN; ENSEMBL ID: ENSG00000174628; HGNC ID: 28556
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of IQCK mRNAdecreases expression 20064835
D016572 Cyclosporine Cyclosporine results in increased expression of IQCK mRNAincreases expression 20106945
C059514 resveratrol resveratrol results in decreased expression of IQCK mRNAdecreases expression 19371625
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of IQCK mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of IQCK mRNAdecreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of IQCK mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of IQCK mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 4.2216538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 7.426695378
MESH:D000236 Adenoma resveratrol 7.4215688382
MESH:D000544 Alzheimer Disease resveratrol 2.6316162502 16183991
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001169 Arthritis, Experimental resveratrol 3.7017115116
MESH:D050197 Atherosclerosis resveratrol 3.4617967414 16873680
MESH:D002545 Brain Ischemia resveratrol 4.8217600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2320146248 17474063
MESH:D001943 Breast Neoplasms resveratrol 2.2317651959 16393696 17534123
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4116050911
MESH:D006528 Carcinoma, Hepatocellular resveratrol 2.3416227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 5.1316675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.0020419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 5.0016227395
MESH:D002318 Cardiovascular Diseases resveratrol 3.7115458977
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D003092 Colitis resveratrol 11.3216474422
MESH:D003092 Colitis Selenium 11.3217936198
MESH:D003110 Colonic Neoplasms resveratrol 2.5016338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2316550006
MESH:D003327 Coronary Disease resveratrol 3.9616507316
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 4.0716873680
MESH:D003928 Diabetic Nephropathies resveratrol 4.2916286809
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2515131321
MESH:C538011 Eales disease Vitamin E 5.329068938
MESH:D004487 Edema resveratrol 3.738985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.4617872969
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.3317923197
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.2320471113
MESH:D006330 Heart Defects, Congenital Vitamin E 7.2316080930
MESH:D006333 Heart Failure Selenium 3.2717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8016863852 16490937
MESH:D006561 Herpes Simplex resveratrol 4.7216876885
MESH:D019584 Hot Flashes Vitamin E 4.5814716179
MESH:D006937 Hypercholesterolemia resveratrol 4.3817188708
MESH:D006949 Hyperlipidemias resveratrol 4.4316873680
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.6517488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 5.1317600658
MESH:D007249 Inflammation resveratrol 3.0016366677
MESH:D007251 Influenza, Human resveratrol 22.5716624496
MESH:D007251 Influenza, Human Selenium 22.5716624496
MESH:D007251 Influenza, Human Vitamin E 22.5716624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 6.6318776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 6.6312488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7916087638
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 5.0621137059 20195826
MESH:D008113 Liver Neoplasms resveratrol 5.0619812893 19073162 20405173 19321006
MESH:D008171 Lung Diseases Vitamin E 3.4016863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5017053015 20869020 18520028 20464547 6695378 18569708 20135361 18816296 20064080
MESH:D008175 Lung Neoplasms Vitamin E 2.5011062179
MESH:D016393 Lymphoma, B-Cell resveratrol 4.7017088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.1714749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.7815688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.9411606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.9415318939
MESH:D008545 Melanoma resveratrol 2.4017992120
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D008659 Metabolic Diseases resveratrol 4.7517112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009101 Multiple Myeloma resveratrol 3.7116490592 16267019 17049120 17935668 14749477 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.4117962980
MESH:D009203 Myocardial Infarction resveratrol 3.1517015251 17188708 16317513 16525036 17125593 16456233
MESH:D017202 Myocardial Ischemia resveratrol 4.3017125593 17015251
MESH:D009205 Myocarditis resveratrol 5.3017322642
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009374 Neoplasms, Experimental resveratrol 4.488985016
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6118481113 19348381
MESH:D019636 Neurodegenerative Diseases resveratrol 4.1117652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.8017929310
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.6617513867
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.7216679765
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5417292933
MESH:D011471 Prostatic Neoplasms resveratrol 2.5417804756 16731767 17636462 15767336 17675339 17718901
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5415084515
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D051436 Renal Insufficiency, Chronic resveratrol 6.1916325855
MESH:D015427 Reperfusion Injury resveratrol 3.4216314181 16317513 15827377 17520802 17058453
MESH:D012871 Skin Diseases Vitamin E 2.5118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.3119755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 6.3115837718 8985016
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.8116517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.8316321402
MESH:D014062 Tongue Neoplasms resveratrol 4.5616227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.4517473185
MESH:D014594 Uterine Neoplasms resveratrol 4.5717044934
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.7817488730
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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