AutismKB 2.0

Annotation Detail for MSI2


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Basic Information Top
Gene Symbol:MSI2 ( FLJ36569,MGC3245,MSI2H )
Gene Full Name: musashi homolog 2 (Drosophila)
Band: 17q22
Quick LinksEntrez ID:124540; OMIM: 607897; Uniprot ID:MSI2H_HUMAN; ENSEMBL ID: ENSG00000153944; HGNC ID: 18585
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic results in decreased expression of MSI2 mRNAdecreases expression 19654921
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MSI2 mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MSI2 mRNAdecreases expression 20018196
D019833 Genistein Genistein results in decreased expression of MSI2 mRNAdecreases expression 18847459
D012402 Rotenone Rotenone results in decreased expression of MSI2 mRNAdecreases expression 19013527
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of MSI2 mRNAincreases expression 18087596
C025643 vinclozolin vinclozolin affects the expression of MSI2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6120127859 20464547
MESH:D000230 Adenocarcinoma Genistein 4.6111473722
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.9715814487
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018246 Adrenocortical Adenoma Arsenic 5.6617306315
MESH:D001008 Anxiety Disorders vinclozolin 3.8619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D020261 Arsenic Poisoning Arsenic 2.9318414634 12569548 16835338 16251483
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2319898480
MESH:D050197 Atherosclerosis Arsenic 3.4012928151 19371607
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1717474063 20146248
MESH:D001943 Breast Neoplasms Genistein 2.1716541309 16873071 17200150
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7317687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.4016507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.4016924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.5011212258
MESH:D002294 Carcinoma, Squamous Cell Arsenic 8.0715504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 8.0720419170
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 8.0711212258
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3418640142
MESH:D002318 Cardiovascular Diseases Arsenic 8.1215738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Genistein 8.1216332659
MESH:D002340 Carotid Artery Diseases Arsenic 4.5616973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5416647724
MESH:D004714 Endometrial Hyperplasia Genistein 4.9916402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5311473722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D005534 Foot Diseases Arsenic 6.006392382
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D005909 Glioblastoma Genistein 3.4316598420
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7217050553
MESH:D006973 Hypertension Arsenic 2.9516076760 9931084 11953799
MESH:D006987 Hypesthesia Arsenic 6.0016093927
MESH:D007248 Infertility, Male vinclozolin 3.2116467254
MESH:D007249 Inflammation Tobacco Smoke Pollution 3.4618590791
MESH:D007642 Keratosis Arsenic 5.3912749816 16930632
MESH:D007938 Leukemia Genistein 3.1418980019 17468513
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7217339181
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008107 Liver Diseases Arsenic 2.5911134558
MESH:D008113 Liver Neoplasms Arsenic 4.9816368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9821137059 20195826
MESH:D008175 Lung Neoplasms Arsenic 3.7419168569 17306315 17976673
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.7420869020 6695378 18569708 18520028 18816296 20135361 20064080 20464547 17053015
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 3.743440675 16288123 12111688 11091918
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.1012929590 14578162
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.5116381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 9.5115006635
MESH:D009203 Myocardial Infarction Genistein 2.9517141266
MESH:D017202 Myocardial Ischemia Arsenic 4.2115371236
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8717141266
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009410 Nerve Degeneration Rotenone 4.0915790535 18619942 17356569
MESH:D009421 Nervous System Malformations Genistein 4.3616427766
MESH:D009436 Neural Tube Defects Arsenic 3.6216620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.6817056641
MESH:D010024 Osteoporosis Genistein 3.4119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3916169203
MESH:D010051 Ovarian Neoplasms Arsenic 5.3317306315
MESH:D010051 Ovarian Neoplasms Genistein 5.3319005980
MESH:D010300 Parkinson Disease Rotenone 3.0619232380 11535288 16412576 15451049 16140633 11445065 18191903 19114014 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 4.3415927086 15574749 15795934 18197244
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3916905509 6392382 15371236
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2918220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D011471 Prostatic Neoplasms Arsenic 2.5716140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5717292933
MESH:D011471 Prostatic Neoplasms Genistein 2.5715256057 15378649 16925846
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D011507 Proteinuria Arsenic 4.3121343184
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.9818410779
MESH:D012871 Skin Diseases Arsenic 2.8019834688 17453740 15952646 17938729 16702368 18709164 6392382 16353154 16759981 17548696 17050553
MESH:D012878 Skin Neoplasms Arsenic 10.3119538983 16251483 17976673 17050553 17029826 15504454
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.3119755658 10029692
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 10.3118590791
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms Arsenic 9.0217976673 15987713 11144890 17306315 19429237 19322015 18640142
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 9.0217053015
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 9.0212846360
MESH:D014652 Vascular Diseases Arsenic 5.1317056641
Pathway ID Pathway Name
KEGG:03015 mRNA surveillance pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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