AutismKB 2.0

Annotation Detail for SEZ6


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Basic Information Top
Gene Symbol:SEZ6 ( - )
Gene Full Name: seizure related 6 homolog (mouse)
Band: 17q11.2
Quick LinksEntrez ID:124925; OMIM: NA; Uniprot ID:SEZ6_HUMAN; ENSEMBL ID: ENSG00000063015; HGNC ID: 15955
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SEZ6 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SEZ6 mRNAaffects expression 21346803
C006632 arsenic trioxide arsenic trioxide results in increased expression of SEZ6 mRNAincreases expression 20458559
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of SEZ6 mRNAdecreases expression 19638242
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of SEZ6 mRNAincreases expression 17010207
D004958 Estradiol Estradiol results in increased expression of SEZ6 mRNAincreases expression 17010207
D005419 Flavonoids Flavonoids results in decreased expression of SEZ6 mRNAdecreases expression 18035473
C474055 octylphenol octylphenol results in increased expression of SEZ6 mRNAincreases expression 17010207
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5611798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 4.5611473722
MESH:D000236 Adenoma Diethylnitrosamine 2.9810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2417162532 19061943 18056438 19052882 17620307 16434500
MESH:D000686 Amyloidosis Diethylstilbestrol 4.7615469931
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9116206674
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9417129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 1.9414630087 18497071 17018787 12948864 19861407 16675129 17261762 17289903
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.8316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.8316705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.8315553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.8319418558 19519916 18788625 11831363 16935385 16779866 17173139 3581430 16288022 19822196 20214788 19335982 3084413 16807293 20727157 18978308 16698587 19539802 17055752 19701751 18665156 17428255 20101231 20084675 10672840 20007298 16878318 20935162 10737359 21159647 16830150 18393292 20514400 20524982 17978847 16540662 16681979 18785209 18210153 19394651 16502159 19107877 20512989 18971187 16328049 19171122 19383236 18494052 17761372 20432363 18506893 17138121 19919837 19052882 18056438 16569478 17162532 19208518 18691550
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 11.8316924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.8316924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.136135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.137505956 17174075 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.1318566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8412952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.5919107877
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.0316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 8.0415700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 8.0411473722 18566989 19148513
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005234 Fatty Liver arsenic trioxide 8.6915073043
MESH:D005234 Fatty Liver Diethylnitrosamine 8.6920387270 21071580
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7915751030 16534752 16002989 16611131 16513791
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.2816452187
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7412960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 4.8916002989
MESH:D007246 Infertility Diethylstilbestrol 4.6415036965
MESH:D007249 Inflammation Diethylnitrosamine 5.5618785209
MESH:D007249 Inflammation Flavonoids 5.5617296493
MESH:D007333 Insulin Resistance Estradiol 3.1116393666 16627594
MESH:D007674 Kidney Diseases Estradiol 2.7115618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.5216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.5216705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 19.5214681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 19.5215610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.3717184923
MESH:D007938 Leukemia arsenic trioxide 2.9315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1716467208 17050201 19850784 16968895 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3619035177 12679006 12018890 17869043 12712474 15622746 16891316 19225113 17649720 16966277 11468182 15748426 17217047 16331271 16823087 19075265 15213294 11161223 19642359 16330433 15336539 17107899 17712046 16112521 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9418407596 18665156 19638242 20032147 18522880
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.407678174
MESH:D008113 Liver Neoplasms arsenic trioxide 11.4014682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.4010737359 20118626 2862719 19254457 9163691 2422723 21047994 15885732 20405173 18978307 19690152 20434301 19426721 19294768 20492335 19499222 19427195 12771043 16942905 20583210 19256749 20137499 21167192 19850985 21071580 19255062 19642983 19996281 19073162 21278145 19833225 19551842 20452335 19812893 19090486 12112319 20101389 18648771 18977376 20501860 15175105 19638242 18644402 18754104
MESH:D008113 Liver Neoplasms Diethylstilbestrol 11.4015890375 16712894
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.702876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.7020377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.7018308698 18775883 16842330 17174075 19519916 21159647 18164116 19539802 3124819 18079962 18253720 19009564 9362446 18544905 17942915 18282651 18093689 19004024 19126423 17854601 16267830 2563599
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5419825857 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5421163286 20970405 6695378 20512841
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.4915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6415700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.8916002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7011807958 16891317 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2719417148 15949261 11468182 19549372 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616105982 16882451
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4616810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.5018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.659029167 3581430
MESH:D009369 Neoplasms Diethylstilbestrol 2.8715313581
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.7611399458
MESH:D009421 Nervous System Malformations Estradiol 10.7616427766 11399458
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2610525206
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0412452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 5.0419401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5215580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5216540662
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.5514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.9815687265 16977796
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.4517184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5619131511
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.5615046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.5616740699
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D013088 Spermatocele Diethylstilbestrol 5.0916709447 16002989
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4917007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4918456281
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.8119014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.817505956
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.6216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.6216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.6212973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 12.6216712894 16452187 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.2616175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.5514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.3515809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7416513791 16002989
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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