AutismKB 2.0

Annotation Detail for SLC43A2


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Basic Information Top
Gene Symbol:SLC43A2 ( FLJ23848,LAT4,MGC34680 )
Gene Full Name: solute carrier family 43, member 2
Band: 17p13.3
Quick LinksEntrez ID:124935; OMIM: 610791; Uniprot ID:LAT4_HUMAN; ENSEMBL ID: ENSG00000167703; HGNC ID: 23087
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500341Amino acid transport across the plasma membrane
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C017947 sodium arsenite sodium arsenite affects the expression of SLC43A2 mRNAaffects expression 19590694
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC43A2 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.7311752688 15322242 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.2616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.7715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.9717306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.4511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.8615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.0115276417 17306315 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4818572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.6018670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.3119524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.6316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2616354765 12621046 8697196 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.5317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7517107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.1211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.9212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.9715322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.5310568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3811564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.2211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.7120067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.5716452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5511294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.6516120746 15340226 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.6212676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 5.1215340226 16354765 18606429 8697196 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0418850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 3.2912646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0612200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8916580747
MESH:D007674 Kidney Diseases sodium arsenite 3.0420008137
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms sodium arsenite 4.9315276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.9316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3812151625
MESH:D008171 Lung Diseases sodium arsenite 3.4819095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.4115276417 19931552 17077188 16712894 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4111884234 19555203
MESH:D008545 Melanoma sodium arsenite 2.0816487513 19082730
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.4312213967
MESH:D009369 Neoplasms sodium arsenite 2.6911559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.4320056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8914600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.4412854658
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5417306315 15276417
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.3212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.2318163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 4.0811896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2316039940
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.5118990726
MESH:D012878 Skin Neoplasms sodium arsenite 6.2319524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.2316192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1812854658
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.9712697716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6511723127 17306315 16712894 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.2711813266
MESH:D014652 Vascular Diseases sodium arsenite 5.3117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.3215886252
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
REACT:13 Metabolism of amino acids and derivatives
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134940765
    • No data
    No data
    Releated drug ID Related drug Name
    PA449789glycine
    PA448055l-alanine
    PA448478l-arginine
    PA449173l-cysteine
    PA450197l-leucine
    PA450280l-lysine
    PA451125l-proline
    PA451330l-serine
    PA451822l-tyrosine
    PA451843l-valine
    PA451590taurine
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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