AutismKB 2.0

Annotation Detail for ADH1B


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Basic Information Top
Gene Symbol:ADH1B ( ADH2,DKFZp686C06125 )
Gene Full Name: alcohol dehydrogenase 1B (class I), beta polypeptide
Band: 4q23
Quick LinksEntrez ID:125; OMIM: 103720; Uniprot ID:ADH1B_HUMAN; ENSEMBL ID: ENSG00000196616; HGNC ID: 250
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1789Movement disorder
1870Drug abuse
1918Atherosclerosis
1932Pancreatitis
1934Cancer
1954Stroke
Desease Name
atherosclerosis, coronary
cerebral infarct
alcohol abuse cirrhosis, alcoholic pancreatitis, chronic
CARDIOVASCULAR
CHEMDEPENDENCY
CANCER
stroke, lacunar
alcoholism
esophageal cancer
overall effect
alcohol abuse
fetal alcohol syndrome
No data
Desease Name
Alcoholism, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031390 9-cis-retinal ADH1B protein results in increased metabolism of 9-cis-retinalincreases metabolic processing 17279314
D000079 Acetaldehyde [ADH1B protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehydeincreases chemical synthesis|increases metabolic processing 15499379
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ADH1B proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of ADH1B mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of ADH1B mRNAdecreases expression 20106945
D000431 Ethanol ADH1B protein results in increased metabolism of Ethanolincreases metabolic processing 15499379
D000431 Ethanol [ADH1B protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehydeincreases chemical synthesis|increases metabolic processing 15499379
D012172 Retinaldehyde ADH1B protein results in increased metabolism of Retinaldehydeincreases metabolic processing 17279314
D012643 Selenium Selenium results in decreased expression of ADH1B mRNAdecreases expression 19244175
D012643 Selenium Selenium results in increased expression of ADH1B mRNAincreases expression 18583539
D014284 Triiodothyronine Triiodothyronine results in decreased expression of ADH1B mRNAdecreases expression 15507505
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ADH1B mRNAdecreases expression 20106945
D014212 Tretinoin ADH1B protein results in increased metabolism of Tretinoinincreases metabolic processing 17279314
D014752 Vinyl Chloride ADH1B gene polymorphism results in increased susceptibility to Vinyl Chlorideincreases response to substance 16270392
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.9917676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9915322242 11752688 14514962
MESH:D000138 Acidosis Ethanol 4.6511192467
MESH:D000230 Adenocarcinoma Estradiol 2.1211473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4915451039 15451040
MESH:D000437 Alcoholism marker/mechanism 16404797 17590986
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000853 Anophthalmos Ethanol 4.9615513904
MESH:D001008 Anxiety Disorders Ethanol 4.0911141031
MESH:D001169 Arthritis, Experimental Tretinoin 3.1416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Acetaldehyde 5.439600491
MESH:D001249 Asthma Tretinoin 5.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001661 Biliary Tract Neoplasms Vinyl Chloride 7.0411024202
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.3116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001932 Brain Neoplasms Vinyl Chloride 5.2712562636
MESH:D001943 Breast Neoplasms Estradiol 1.8217018787 16675129 19861407 12948864 18497071 17261762 17289903 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8220435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002056 Burns Ethanol 4.7916374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.0912907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.0916924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 9.0918788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.091917145
MESH:D006528 Carcinoma, Hepatocellular Vinyl Chloride 9.0912958735 15289165 12828392 10699891
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3216051514 16096774
MESH:D006332 Cardiomegaly Ethanol 7.0419332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0416120746 18850075 18670907
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 6.6510525098
MESH:D002386 Cataract Tretinoin 3.1517460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8218566989
MESH:D002544 Cerebral Infarction marker/mechanism 15534263
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002971 Cleft Lip Ethanol 3.6415513904
MESH:D002972 Cleft Palate Ethanol 10.0915513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 10.0915340226 8697196 15668235 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 10.099407595
MESH:D003092 Colitis Selenium 9.9717936198
MESH:D003092 Colitis Tretinoin 9.9717035595
MESH:D015179 Colorectal Neoplasms marker/mechanism 16332725
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 3.8811198716 10194807 19302082 15451040 15451039 15513904 11873399
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8820055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.889224671 10589399 9142499 8800419 9211117 9125849 16925845 9664655 17551590 14991402
MESH:D009783 Dermatitis, Occupational Vinyl Chloride 5.8910870345
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury Ethanol 6.4511566570
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.5318230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.5318230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.6519148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004938 Esophageal Neoplasms marker/mechanism 18500343
MESH:D004938 Esophageal Neoplasms Ethanol 2.7816704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.119664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 14.0719224547
MESH:D005234 Fatty Liver Ethanol 14.0719236843 16409862 18620774
MESH:D005234 Fatty Liver Vinyl Chloride 14.0712197357
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4516946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 15.5612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.5620067830
MESH:D005355 Fibrosis Tretinoin 15.5617994277
MESH:D005756 Gastritis Ethanol 4.8715046732
MESH:D020022 Genetic Predisposition to Disease marker/mechanism 16404797 17590986
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Tretinoin 3.0717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.7214991402 9664655
MESH:D006333 Heart Failure Selenium 3.1417162251
MESH:D006390 Hemangioendothelioma Vinyl Chloride 6.3515380572
MESH:D006393 Hemangiopericytoma Vinyl Chloride 7.0410964802
MESH:D006394 Hemangiosarcoma Vinyl Chloride 5.3712211074 15989139 11217710 15999577 12762079 12828392 12958735
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216354765 15340226 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Ethanol 8.2918783367
MESH:D006930 Hyperalgesia Tretinoin 8.2916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112878042 12200463
MESH:D007251 Influenza, Human Selenium 4.3716624496
MESH:D007333 Insulin Resistance Estradiol 3.0316393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007569 Jaw Abnormalities Ethanol 17.8415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 17.8416580747
MESH:D007569 Jaw Abnormalities Tretinoin 17.8417551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.1418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.1415618244
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms Cyclosporine 13.1612371664
MESH:D007680 Kidney Neoplasms Estradiol 13.1615610895
MESH:D007680 Kidney Neoplasms Vinyl Chloride 13.1612562636
MESH:D007822 Laryngeal Neoplasms marker/mechanism 18500343
MESH:D007859 Learning Disorders Ethanol 4.3515451040
MESH:D007938 Leukemia Tretinoin 2.8217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8116932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0916294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2216140955 9834237 17368321 16823087 16935935 12679006 19029980 17506722 17301526 19075265 19225113 16788101 19642359 16891316 17217047 17361223 19035177 17649720 17107899 17294898 17339181 17712046 16766008 16331271 15748426
MESH:D017880 Limb Deformities, Congenital Ethanol 8.5817676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.589224671
MESH:D008103 Liver Cirrhosis Ethanol 7.6515289165
MESH:D008103 Liver Cirrhosis Vinyl Chloride 7.6511679801 15354062 15289165 12958735 12499459
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2518295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.9014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.9018166357
MESH:D008106 Liver Cirrhosis, Experimental Retinaldehyde 6.9016248980
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.9012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.9016248980 18397230
MESH:D008107 Liver Diseases Vinyl Chloride 3.8716270392 15211785
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7917347304 17207112
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.8715890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8716984957
MESH:D008113 Liver Neoplasms Vinyl Chloride 7.8711024202 15999577 12762079 12211074 10964802 10629081 11679801
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.448603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4412151625
MESH:D008114 Liver Neoplasms, Experimental Vinyl Chloride 10.4412562636
MESH:D008175 Lung Neoplasms Acetaldehyde 5.0817372256
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0814755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0819555203 11884234
MESH:D008175 Lung Neoplasms Vinyl Chloride 5.0812958735 12562636
MESH:D015674 Mammary Neoplasms, Animal Vinyl Chloride 5.6812562636
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.2517203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.2515318939
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008569 Memory Disorders Ethanol 4.3115451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms marker/mechanism 18500343
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3616810080
MESH:D009369 Neoplasms Tretinoin 5.8716594593 16946489
MESH:D009369 Neoplasms Vinyl Chloride 5.8711911487
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 17.1011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.1014600291
MESH:D009421 Nervous System Malformations Tretinoin 17.109125849
MESH:D009436 Neural Tube Defects Tretinoin 3.129142499
MESH:D009784 Occupational Diseases Vinyl Chloride 5.3712061072
MESH:D010051 Ovarian Neoplasms Estradiol 4.9119401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9116936753
MESH:D010146 Pain Tretinoin 2.9916870215
MESH:D010190 Pancreatic Neoplasms Ethanol 5.5712384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.5715976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010610 Pharyngeal Neoplasms marker/mechanism 18500343
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D017285 Polymyositis Vinyl Chloride 7.0411642524
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0716740699
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D011928 Raynaud Disease Vinyl Chloride 6.2716977343
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration 9-cis-retinal 6.0817003450
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216283617 16116481
MESH:D012220 Rhinitis Acetaldehyde 4.8517050345
MESH:D012509 Sarcoma Vinyl Chloride 5.4512828392
MESH:D012595 Scleroderma, Systemic Vinyl Chloride 5.9214979077
MESH:D012640 Seizures Ethanol 3.249754883
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D012878 Skin Neoplasms Tretinoin 5.7216467112
MESH:D013274 Stomach Neoplasms Ethanol 3.7218456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.7217261132
MESH:D013274 Stomach Neoplasms Vinyl Chloride 3.7212562636
MESH:D013276 Stomach Ulcer Ethanol 3.649562338 11906479 17189318 17918041 9211565 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.369754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1117045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.8916051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00071 Fatty acid metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00830 Retinol metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24571
    • Releated gene ID Related gene Name
    PA24571ADH1B
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    PA443309Alcoholism
    PA446879Alcohol-Related Disorders
    PA444802Liver Diseases, Alcoholic
    Releated drug ID Related drug Name
    PA448073ethanol
    PA448073ethanol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB00898 agonist Ethanol Anti-Infective Agents, Local;Solvents;Central Nervous System Depressants;Disinfectants
    DB01213 antagonist Fomepizole Antidotes
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB02481 - N-Benzylformamide
    DB02721 - 4-Iodopyrazole
    DB03461 - 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB03703 - Cyclohexanol
    DB04077 - Glycerol Solvents;Cryoprotective Agents
    DB04105 - N-Heptylformamide
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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