AutismKB 2.0

Annotation Detail for ADH1C


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Basic Information Top
Gene Symbol:ADH1C ( ADH3 )
Gene Full Name: alcohol dehydrogenase 1C (class I), gamma polypeptide
Band: 4q23
Quick LinksEntrez ID:126; OMIM: 103730; Uniprot ID:ADH1G_HUMAN; ENSEMBL ID: ENSG00000248144; HGNC ID: 251
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6342noradrenaline and adrenaline degradation
PWY-6313serotonin degradation
PWY66-21ethanol degradation II (cytosol)
PWY-5451acetone degradation I (to methylglyoxal)
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1709Parkinson disease
1870Drug abuse
1934Cancer
Desease Name
Parkinson's disease
alcohol abuse cirrhosis, alcoholic pancreatitis, chronic
Conduct disorder (interaction)
CHEMDEPENDENCY
CANCER
PSYCH
aerodigestive tract cancers
overall effect
alcohol abuse
NEUROLOGICAL
alcohol dependency
METABOLIC
diabetes, type 2
head and neck cancer
Desease Name
Conduct disorder (interaction)
Desease Name
Alcohol dependence, protection against
Parkinson disease, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000079 Acetaldehyde [ADH1C protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehydeincreases chemical synthesis|increases metabolic processing 15138216
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ADH1C proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of ADH1C mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of ADH1C mRNAdecreases expression 20106945
D000431 Ethanol ADH1C protein results in increased metabolism of Ethanolincreases metabolic processing 15138216
D000431 Ethanol [ADH1C protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehydeincreases chemical synthesis|increases metabolic processing 15138216
D009853 Omeprazole Omeprazole results in decreased expression of ADH1C mRNAdecreases expression 12040753
D012293 Rifampin Rifampin results in increased expression of ADH1C mRNAincreases expression 12040753
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ADH1C mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.6217676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6214514962 15322242 11752688
MESH:D000138 Acidosis Ethanol 4.8311192467
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.7015451039 15451040
MESH:D000437 Alcoholism marker/mechanism 16404797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000853 Anophthalmos Ethanol 5.1315513904
MESH:D001008 Anxiety Disorders Ethanol 4.2011141031
MESH:D001249 Asthma Acetaldehyde 3.729600491
MESH:D001778 Blood Coagulation Disorders Omeprazole 10.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Estradiol 1.9112948864 16675129 17289903 17261762 14630087 19861407 17018787 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D002056 Burns Ethanol 4.9616374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8512907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8516924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.8515289165 18788625 15763234
MESH:D006332 Cardiomegaly Ethanol 7.2519332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.2518850075 18670907 16120746
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 6.8610525098
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1112371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1118566989
MESH:D002637 Chest Pain Omeprazole 5.4815447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D002971 Cleft Lip Ethanol 3.6915513904
MESH:D002972 Cleft Palate Ethanol 6.2415513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.2415668235 16354765 15340226 8697196 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 2.6915513904 11198716 11873399 15451039 10194807 19302082 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6920055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.1311566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.6117151854 21218061 15991576 16613094
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.1318566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004938 Esophageal Neoplasms Ethanol 2.8016704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 8.7319224547
MESH:D005234 Fatty Liver Ethanol 8.7316409862 19236843 18620774
MESH:D005235 Fatty Liver, Alcoholic Ethanol 6.0417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.6410194807 15451040 16946407 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Cyclosporine 9.5212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5220067830
MESH:D005756 Gastritis Ethanol 5.0715046732
MESH:D020022 Genetic Predisposition to Disease marker/mechanism 16404797
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216959395 15340226 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Ethanol 3.9118783367
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.1116627594 16393666
MESH:D007569 Jaw Abnormalities Ethanol 10.9415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.9416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.3618776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.3615618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.9515610895
MESH:D007859 Learning Disorders Ethanol 4.5215451040
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.3019248655
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9817676605
MESH:D008103 Liver Cirrhosis Ethanol 3.4915289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.4318295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.6318166357
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6312878042
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.9617347304 17207112
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.7018177683 2125692 9163691 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7016984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.288603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2812151625
MESH:D008175 Lung Neoplasms Acetaldehyde 3.6917372256
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6914755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6919555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Rifampin 6.4711422169
MESH:D008180 Lupus Erythematosus, Systemic Rifampin 4.0311422169
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7016891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D008569 Memory Disorders Ethanol 4.4718411066 15451040
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms marker/mechanism 15138216
MESH:D009164 Mycobacterium Infections Rifampin 5.9218474467
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4616810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.4216427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4214600291
MESH:D010051 Ovarian Neoplasms Estradiol 2.2819401270
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0412384795
MESH:D010300 Parkinson Disease marker/mechanism
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012220 Rhinitis Acetaldehyde 4.9717050345
MESH:D012640 Seizures Ethanol 3.329754883
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013272 Stomach Diseases Omeprazole 4.9518545984
MESH:D013274 Stomach Neoplasms Ethanol 2.3118456281
MESH:D013276 Stomach Ulcer Ethanol 8.4711906479 9211565 17918041 9562338 16755016 17189318
MESH:D013276 Stomach Ulcer Omeprazole 8.4715991576 11906479 18237397 10750652 16755016 17977527
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.489754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D014376 Tuberculosis Rifampin 4.9015236969 18397238
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00071 Fatty acid metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00830 Retinol metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24572
    • Releated gene ID Related gene Name
    PA24572ADH1C
    Releated disease ID Related disease Name
    PA443309Alcoholism
    PA446879Alcohol-Related Disorders
    PA444818Lung Neoplasms
    PA444802Liver Diseases, Alcoholic
    Releated drug ID Related drug Name
    PA448073ethanol
    PA448073ethanol
    PA452604xenobiotics
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB00898 agonist Ethanol Anti-Infective Agents, Local;Solvents;Central Nervous System Depressants;Disinfectants
    DB01093 - Synotic Otic Solution Free Radical Scavengers;Analgesics, Non-Narcotic;Solvents;Cryoprotective Agents
    DB01213 antagonist Fomepizole Antidotes
    DB01711 - 2,3,4,5,6-Pentafluorobenzyl Alcohol
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB02131 - N-1-Methylheptylformamide
    DB02249 - 2-Ethoxyethanol
    DB02659 - Cholic Acid
    DB02721 - 4-Iodopyrazole
    DB02757 - Pyrazole Enzyme Inhibitors
    DB02822 - Para-Bromobenzyl Alcohol
    DB02871 - 3-Butylthiolane 1-Oxide
    DB03020 - 5-Beta-D-Ribofuranosylnicotinamide Adenine Dinucleotide
    DB03061 - (R)-N-(1-Methyl-Hexyl)-Formamide
    DB03226 - Trifluoroethanol
    DB03527 - Nicotinamide-Adenine-Dinucleotide (Acidic Form)
    DB03559 - Cyclohexylformamide
    DB03684 - 2-Methyl-2,4-Pentanediol
    DB04071 - Cpad
    DB04113 - N-Formylpiperidine
    DB04312 - 2,3-Difluorobenzyl Alcohol
    DB04448 - 2,4-Difluorobenzyl Alcohol 2,4-Difluoro-1-(Hydroxymethyl)Benzene
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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