AutismKB 2.0

Annotation Detail for CNGA3


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Basic Information Top
Gene Symbol:CNGA3 ( ACHM2,CCNC1,CCNCa,CCNCalpha,CNCG3,CNG3 )
Gene Full Name: cyclic nucleotide gated channel alpha 3
Band: 2q11.2
Quick LinksEntrez ID:1261; OMIM: 600053; Uniprot ID:CNGA3_HUMAN; ENSEMBL ID: ENSG00000144191; HGNC ID: 2150
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04740Olfactory transduction
No data
Pathway IDPathway Name
200078Visual signal transduction: Cones
Pathway IDPathway Name
P00028Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of CNGA3 mRNAincreases expression 20406850
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CNGA3 mRNAaffects expression 16483693
C006253 pirinixic acid pirinixic acid results in increased expression of CNGA3 mRNAincreases expression 12832660
C025299 polyphenols polyphenols results in decreased expression of CNGA3 mRNAdecreases expression 16293270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:C536128 Achromatopsia 2 marker/mechanism
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7916705839
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.036135515
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003110 Colonic Neoplasms polyphenols 2.7216293270
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.4518551238 21346803
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.4519370779
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D005234 Fatty Liver pirinixic acid 3.1919236843 20131406
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly pirinixic acid 3.5519772884 16221962 19176532 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D007249 Inflammation polyphenols 3.2316366677
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.3216705839
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases polyphenols 2.8516698588
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.817678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.8120007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.776135515 2876784 2876786
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.497678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.8316049721
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7918551238
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.9717997062
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4116049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.9510091137
Pathway ID Pathway Name
KEGG:04740 Olfactory transduction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26660
    • No data
    No data
    Releated drug ID Related drug Name
    PA450191lecithin
    PA450626nicotine
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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