AutismKB 2.0

Annotation Detail for HSPB6


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Basic Information Top
Gene Symbol:HSPB6 ( FLJ32389,Hsp20 )
Gene Full Name: heat shock protein, alpha-crystallin-related, B6
Band: 19q13.12
Quick LinksEntrez ID:126393; OMIM: 610695; Uniprot ID:HSPB6_HUMAN; ENSEMBL ID: ENSG00000004776; HGNC ID: 26511
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031285 3-xylene 3-xylene results in decreased expression of HSPB6 mRNAdecreases expression 12815608
C041594 4-nonylphenol 4-nonylphenol results in increased expression of HSPB6 mRNAincreases expression 16688536
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of HSPB6 mRNAincreases expression 16688536
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HSPB6 mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of HSPB6 mRNAincreases expression 18191166
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HSPB6 mRNAdecreases expression 16688536
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of HSPB6 mRNAaffects expression 17484886
D003345 Corticosterone Corticosterone results in increased expression of HSPB6 mRNAincreases expression 15755911
D000431 Ethanol Ethanol results in decreased expression of HSPB6 mRNAdecreases expression 17920746
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HSPB6 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of HSPB6 mRNAincreases expression 18301758
D012402 Rotenone Rotenone results in increased expression of HSPB6 mRNAincreases expression 19013527
D014415 Tunicamycin Tunicamycin results in increased expression of HSPB6 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 4.0717676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 10.9918287403
MESH:D000138 Acidosis Ethanol 10.9911192467
MESH:D055371 Acute Lung Injury 3-xylene 9.9115204773
MESH:D055371 Acute Lung Injury pirinixic acid 9.9118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4915451040 15451039
MESH:D000853 Anophthalmos Ethanol 4.9615513904
MESH:D001008 Anxiety Disorders Ethanol 4.0911141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0220146248 17474063
MESH:D002056 Burns Ethanol 4.7916374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9215721981 10355542 15673190 18705752 15700767 16097048 16227642 16192424 16011737 3786805 16124888 16050911
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.2618788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 3.2615289165 15763234 18788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Ethanol 3.4919332462
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D002971 Cleft Lip Ethanol 3.6415513904
MESH:D002972 Cleft Palate Ethanol 3.2115513904
MESH:D003110 Colonic Neoplasms arsenite 2.6015037631
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3310194807 19302082 11198716 15451039 15513904 15451040 11873399
MESH:D003872 Dermatitis 3-xylene 6.0315902427 12717741
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.2111566570 9327722 6623471 17522070 19336974 15968718 15998439 2869522 6884620 3786805 3732212 16227642 7179309 10915739 7120509 19085960 15027814 7440962 10092053 16177239 4309450 21278145
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.2111566570
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6816530937
MESH:D004938 Esophageal Neoplasms Ethanol 4.6816704527
MESH:D005234 Fatty Liver arsenite 19.7718296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.7712631006 17595544 12795759 16045604 15959796 16239168 19224547 61145
MESH:D005234 Fatty Liver Ethanol 19.7719236843 16409862 18620774
MESH:D005234 Fatty Liver pirinixic acid 19.7719236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4516946407 10194807 15451040 15513904
MESH:D005355 Fibrosis arsenite 9.4818296743
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4818705752
MESH:D005756 Gastritis Ethanol 4.8715046732
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.1318467677 16221962 19176532 19772884
MESH:D006930 Hyperalgesia Ethanol 3.8018783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007569 Jaw Abnormalities Ethanol 4.5215513904
MESH:D007859 Learning Disorders Ethanol 4.3515451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8917676605
MESH:D008103 Liver Cirrhosis arsenite 11.5018296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.5016239168 11408273 21278145 16943688 16221502 17157831 11903743 17174718 17334410
MESH:D008103 Liver Cirrhosis Ethanol 11.5015289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2518295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5917823541 10355542 18395914 17565644 18472094 18187930 16015684 17631135 15730626 15123356 12546737 18339082 12649538 15959796 15673190 18418968 17761835 16116963 17557913 15052691 18472332 15650968 17708605 17900296 17481882 12741479 12632514 18429990 14748882 16011737 16136751 13678700 14716496 16033810 12898905 12609069 17805973 12958196 15338365 15876570 18412020 18156304 15818738 17640975 18376398 18395095 18251166 14716833 16248980 16097048 18210741 18481824 17869086 15057751 12666154 17944888 18277467 17525996 18054572 18205269 12445418 12632512 12389079 17721639 15931870 12445421 14512876 20821823 18006644 17766677 15925388 12667390 16638106 11481614 17698563 18705752 15370692 15893842 17922224 16027843 14620537 18420326 18279442 15362042 18317297 14724832 15996030 17714472 17976157 12586293 16192424 18263696 18166357
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.5918166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5915474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1015830285 16964402 15720792 17285989 16246199
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7917207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7914706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6020195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.6019294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.6015890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6815583823 12014681
MESH:D008175 Lung Neoplasms arsenite 2.6216809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.6218569708 20869020 18816296 6695378 20464547 20135361 20064080 18520028 17053015
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 3.6912807724
MESH:D008569 Memory Disorders Ethanol 4.3118411066 15451040
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.5715738583
MESH:D009410 Nerve Degeneration Rotenone 3.9618619942 15790535 17356569
MESH:D020258 Neurotoxicity Syndromes 3-xylene 5.058907413 7820390
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0012384795
MESH:D010300 Parkinson Disease Rotenone 3.0115451049 16412576 19114014 18191903 11445065 16140633 11535288 19232380 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 4.1815795934 15574749 15927086 18197244
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9517292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012640 Seizures 3-xylene 7.036431079 8907413
MESH:D012640 Seizures Ethanol 7.039754883
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4119755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.562093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 2.5618456281
MESH:D013276 Stomach Ulcer Ethanol 3.649562338 16755016 17189318 11906479 9211565 17918041
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.369754883
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2117053015
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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