AutismKB 2.0

Annotation Detail for CNN1


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Basic Information Top
Gene Symbol:CNN1 ( SMCC,Sm-Calp )
Gene Full Name: calponin 1, basic, smooth muscle
Band: 19p13.2
Quick LinksEntrez ID:1264; OMIM: 600806; Uniprot ID:CNN1_HUMAN; ENSEMBL ID: ENSG00000130176; HGNC ID: 2155
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C477819 15-deoxyprostaglandin J2 15-deoxyprostaglandin J2 inhibits the reaction [25-hydroxycholesterol results in increased expression of CNN1 mRNA]decreases reaction|increases expression 17161435
C477819 15-deoxyprostaglandin J2 15-deoxyprostaglandin J2 inhibits the reaction [alitretinoin results in increased expression of CNN1 mRNA]decreases reaction|increases expression 17161435
C477819 15-deoxyprostaglandin J2 15-deoxyprostaglandin J2 results in decreased expression of CNN1 mRNAdecreases expression 17161435
C007997 25-hydroxycholesterol 15-deoxyprostaglandin J2 inhibits the reaction [25-hydroxycholesterol results in increased expression of CNN1 mRNA]decreases reaction|increases expression 17161435
C007997 25-hydroxycholesterol 25-hydroxycholesterol results in increased expression of CNN1 mRNAincreases expression 17161435
C007997 25-hydroxycholesterol alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of CNN1 mRNA]increases expression|increases reaction 17161435
C103303 alitretinoin 15-deoxyprostaglandin J2 inhibits the reaction [alitretinoin results in increased expression of CNN1 mRNA]decreases reaction|increases expression 17161435
C103303 alitretinoin alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of CNN1 mRNA]increases expression|increases reaction 17161435
C103303 alitretinoin alitretinoin results in increased expression of CNN1 mRNAincreases expression 17161435
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of CNN1 proteindecreases expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CNN1 mRNAincreases expression 20382639
C070515 bisindolylmaleimide I bisindolylmaleimide I results in decreased expression of CNN1 mRNAdecreases expression 15380616
C070515 bisindolylmaleimide I bisindolylmaleimide I results in decreased expression of CNN1 proteindecreases expression 15380616
C006780 bisphenol A bisphenol A results in increased expression of CNN1 mRNAincreases expression 18180321
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CNN1 mRNAincreases expression 17484886
D004041 Dietary Fats Dietary Fats results in increased expression of CNN1 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CNN1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CNN1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CNN1 mRNAincreases expression 12075121
C487498 Go 6983 Go 6983 results in decreased expression of CNN1 mRNAdecreases expression 15380616
C487498 Go 6983 Go 6983 results in decreased expression of CNN1 proteindecreases expression 15380616
C041786 palm oil palm oil results in increased expression of CNN1 mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital results in decreased expression of CNN1 mRNAdecreases expression 12807726
D010656 Phenylephrine Phenylephrine results in increased expression of CNN1 mRNAincreases expression 18158353
C017947 sodium arsenite sodium arsenite results in increased expression of CNN1 mRNAincreases expression 17350061
D013629 Tamoxifen Tamoxifen affects the expression of CNN1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CNN1 mRNAincreases expression 11489354
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CNN1 mRNAaffects cotreatment|increases expression 17942748
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased expression of CNN1 mRNAdecreases expression 15380616
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased expression of CNN1 proteindecreases expression 15380616
D014212 Tretinoin Tretinoin results in increased expression of CNN1 mRNAincreases expression 17069765
D014810 Vitamin E Vitamin E results in increased expression of CNN1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4714745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.016195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0115322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7914692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.8017620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8216712894 17306315
MESH:D000505 Alopecia Tretinoin 3.5415955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0317460149
MESH:D001161 Arteriosclerosis Dietary Fats 9.6215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.6211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.0216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.3216935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D001862 Bone Resorption bisphenol A 3.7811985600
MESH:D001919 Bradycardia Phenylephrine 4.4615306635
MESH:D001943 Breast Neoplasms alitretinoin 2.9216344269
MESH:D001943 Breast Neoplasms bisphenol A 2.9217123778
MESH:D001943 Breast Neoplasms Dietary Fats 2.9220435547
MESH:D001943 Breast Neoplasms Tamoxifen 2.9220544844 16202921 15668708 19103187 15565566 18855134 18629630 18425577 19155303 19142967 20135344 18984771 18351453 20005174 19115204 19289846 11161223 19189212 21138602 19221464 19244106 19066611 17261762 19189210 20390343 19288272 18997820 19200415 16873071 19410462 20859285 18821012 19059307 19011961 19084267 20065188 17049068 17242785 21152245 16818667 19487384 17440819 17893378 18815881 16273361
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9220435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5016813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.6416192424 16124888 15700767 16097048 3786805 16011737 16050911 15721981 10355542 16227642 18705752 15673190
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.6416050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0816168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.7318788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.7317173139 6705139 1701930 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.7316507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.7316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.731917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.9017123778
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.4818572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.4818922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.4816051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5317572228
MESH:D006332 Cardiomegaly Phenylephrine 6.7211754973 17287366 15728586 11179087 17124262 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.7216120746 18850075 18670907
MESH:D002386 Cataract Tretinoin 3.0417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.5220889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.5220056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.164080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5016129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8115861022 16919318 11677210 17681005 16105132 17333356 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.0816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6415340226 8697196 12621046 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 5.649407595
MESH:D003092 Colitis Tretinoin 3.6217035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7110048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.7114991402 10589399 9664655 16925845 8800419 17551590 9125849 9224671 9142499 9211117
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7119769572
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4019279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.642869522 3786805 16227642 15998439 21278145 7120509 7440962 10092053 10915739 19336974 19085960 4309450 15968718 15027814 16177239 9327722 11566570 6884620 3732212 7179309 6623471 17522070
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3918367378
MESH:D004421 Dystonia Phenobarbital 3.921851702
MESH:C538011 Eales disease Vitamin E 4.629068938
MESH:D004487 Edema bisindolylmaleimide I 11.258273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.2512711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 11.2511698051 15177302 16716910 7812673 9599246 8113982 8273558
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.6718230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.6718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.6612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.6619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.2420544844 17893378 19155303 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 7.2416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.023659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.793922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.466401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.167750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.933659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0520426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.619664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.1012795759 16239168 15959796 17595544 12631006 61145 16045604 19224547
MESH:D005234 Fatty Liver Dietary Fats 18.1019004024 18296743 19551842 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.1015345470
MESH:D005234 Fatty Liver Tamoxifen 18.1019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 20.4418705752
MESH:D005355 Fibrosis Dietary Fats 20.4418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.4420067830
MESH:D005355 Fibrosis Tretinoin 20.4417994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005909 Glioblastoma Tretinoin 2.9517312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.8711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.8714991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 10.8716080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5119110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 8.1516109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1512621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6716863852 16490937
MESH:D006689 Hodgkin Disease sodium arsenite 3.0812676792
MESH:D019584 Hot Flashes Vitamin E 3.8914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9615340226 8697196 18606429 16959395 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.1416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5121332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4816778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.5321332399
MESH:D006973 Hypertension Phenylephrine 5.1912717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D006984 Hypertrophy Phenylephrine 4.4718502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4417937319
MESH:D007248 Infertility, Male sodium arsenite 6.4412646999 15346721
MESH:D007249 Inflammation bisindolylmaleimide I 15.418273558
MESH:D007249 Inflammation Dietary Fats 15.4120412841
MESH:D007249 Inflammation Tamoxifen 15.4119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.4112200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 15.4115177302 8273558 11698051 7812673 7562506
MESH:D007251 Influenza, Human Vitamin E 4.1316624496
MESH:D007333 Insulin Resistance bisphenol A 7.3016393666
MESH:D007333 Insulin Resistance Dietary Fats 7.3011836018 18457598
MESH:D007410 Intestinal Diseases Tretinoin 3.6817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.6616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.6617551590 15992940
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.5516144296
MESH:D007674 Kidney Diseases sodium arsenite 6.0220008137
MESH:D007674 Kidney Diseases Vitamin E 6.0212488133
MESH:D007680 Kidney Neoplasms Tamoxifen 2.9718625569
MESH:D007938 Leukemia Tretinoin 2.7317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6216482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0616294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0916140955 17294898 17339181 16823087 17712046 19035177 19642359 17361223 17217047 19075265 17107899 9834237 17506722 16891316 19225113 17649720 16788101 16766008 17368321 15748426 17301526 19029980 16331271 16935935 12679006
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.249224671
MESH:D008064 Lipidoses Tamoxifen 3.0917567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.7511408273 17157831 16943688 21278145 11903743 16239168 17174718 17334410 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 10.7518296743
MESH:D008103 Liver Cirrhosis Phenobarbital 10.7521047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.6217761835 17698563 15730626 12666154 12958196 14620537 12898905 17565644 17805973 18006644 15123356 18054572 12649538 12445418 15673190 17823541 17869086 16015684 17481882 16116963 15362042 14512876 12546737 12389079 14748882 15925388 18339082 15370692 12741479 14716496 17922224 15893842 15931870 18317297 17766677 15650968 18277467 15052691 12632514 18481824 18187930 18166357 15818738 18429990 16136751 18705752 17557913 15057751 18472094 17631135 12586293 18156304 15996030 16027843 18472332 15876570 17714472 16192424 18412020 12632512 18251166 12445421 17708605 17640975 16638106 18420326 18395914 17525996 16248980 12667390 15338365 18418968 18210741 18395095 18376398 12609069 16033810 17976157 11481614 16097048 16011737 17900296 20821823 17944888 18205269 13678700 18279442 10355542 14724832 14716833 18263696 17721639 15959796
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.6218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6216248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.6216169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0215830285 16964402 15720792 16246199 17285989
MESH:D008107 Liver Diseases Phenobarbital 4.0219363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6116899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.8919294768
MESH:D008113 Liver Neoplasms Phenobarbital 13.8919482888 19812893 15975961 19073162 8742319 21047994
MESH:D008113 Liver Neoplasms sodium arsenite 13.8915276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 13.8916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.4812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.481399818 2563599 18308698 6150874 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.4812151625
MESH:D008171 Lung Diseases sodium arsenite 7.2419095001
MESH:D008171 Lung Diseases Vitamin E 7.2416863852
MESH:D008175 Lung Neoplasms alitretinoin 8.4316413115
MESH:D008175 Lung Neoplasms sodium arsenite 8.4319931552 16712894 17077188 17306315 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 8.4318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.4319555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 8.4311807781
MESH:D008175 Lung Neoplasms Vitamin E 8.4311062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6719428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.0719196723 11731420 14580682 16827153 19196722
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 6.078985016
MESH:D020149 Manganese Poisoning Tamoxifen 4.4719453300
MESH:D008527 Medulloblastoma Tretinoin 2.7517453147
MESH:D008545 Melanoma sodium arsenite 5.0019082730 16487513
MESH:D008545 Melanoma Tamoxifen 5.0012393984 19393235
MESH:D008545 Melanoma Tretinoin 5.0016752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1015990972
MESH:D008591 Meningomyelocele Tretinoin 4.3416940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0317596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3917484760
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms alitretinoin 8.1616946489
MESH:D009369 Neoplasms sodium arsenite 8.1611559025
MESH:D009369 Neoplasms Tretinoin 8.1616946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5820056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9219189210 19196722 19200415
MESH:D009421 Nervous System Malformations bisphenol A 15.8811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.8814600291
MESH:D009421 Nervous System Malformations Tretinoin 15.889125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.1212854658
MESH:D009436 Neural Tube Defects Tretinoin 7.129142499
MESH:D009765 Obesity Dietary Fats 2.2717217161 16723640 21332399 18457598 19632207 11836018 20518802 20132043 18674790
MESH:D010018 Osteomalacia Phenobarbital 4.2817016548
MESH:D010049 Ovarian Diseases bisphenol A 4.9011985600
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.7917306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 4.7916936753
MESH:D010146 Pain Tretinoin 2.8316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.5216965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 8.5215976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.5215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.2118404319 12065085 18922899 8330346
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D017499 Porokeratosis alitretinoin 5.9216144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.552563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.2210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.2211896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1016740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1016039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1015067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1015084515
MESH:D011507 Proteinuria Tretinoin 3.5216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2315861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.4112752131
MESH:D011625 Pterygium Tretinoin 4.7116723453
MESH:D011629 Puberty, Precocious bisphenol A 4.7010548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0216283617 16116481
MESH:D012640 Seizures Phenobarbital 2.633137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.746407741
MESH:D012852 Sinusitis Phenylephrine 4.627327846
MESH:D012871 Skin Diseases Vitamin E 2.4218709164
MESH:D012878 Skin Neoplasms sodium arsenite 13.2519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.2516192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 13.258985016 8330346 11807781 12065085 18404319
MESH:D012878 Skin Neoplasms Tretinoin 13.2516467112
MESH:D013088 Spermatocele Ethinyl Estradiol 11.2916709447
MESH:D013088 Spermatocele Tamoxifen 11.2916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7312854658
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D020521 Stroke Vitamin E 3.4516517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.9016684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.971399818
MESH:D013964 Thyroid Neoplasms Tretinoin 6.9716026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7116051514
MESH:D014376 Tuberculosis Tretinoin 3.1716040207
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.0017306315 11723127 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.0017572228 8653321 16712894
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.1511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.1516129372
MESH:D014591 Uterine Diseases bisphenol A 4.9314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5316752155
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.9716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D015430 Weight Gain Dietary Fats 3.6616723640
MESH:D009396 Wilms Tumor Tretinoin 3.8916287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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