AutismKB 2.0

Annotation Detail for CNN3


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Basic Information Top
Gene Symbol:CNN3 ( - )
Gene Full Name: calponin 3, acidic
Band: 1p21.3
Quick LinksEntrez ID:1266; OMIM: 602374; Uniprot ID:CNN3_HUMAN; ENSEMBL ID: ENSG00000117519; HGNC ID: 2157
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CNN3 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CNN3 mRNAaffects cotreatment|increases expression 18164116
C459604 candoxin candoxin results in increased expression of CNN3 mRNAincreases expression 16309724
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of CNN3 mRNAaffects cotreatment|decreases expression 18636392
D016572 Cyclosporine Cyclosporine results in decreased expression of CNN3 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of CNN3 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CNN3 mRNAaffects cotreatment|increases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CNN3 mRNAdecreases expression 17557909
15576828
D019266 Iron, Dietary Iron, Dietary affects the expression of CNN3 mRNAaffects expression 15637178
D007657 Ketone Bodies Ketone Bodies results in decreased expression of CNN3 mRNAdecreases expression 15469884
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of CNN3 mRNAincreases expression 17616710
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of CNN3 mRNAaffects cotreatment|decreases expression 18636392
C041786 palm oil palm oil results in increased expression of CNN3 mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of CNN3 mRNAdecreases expression 17426115
D012643 Selenium Selenium results in increased expression of CNN3 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CNN3 mRNAincreases expression 16054898
D015032 Zinc Zinc results in decreased expression of CNN3 mRNAdecreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of CNN3 mRNAdecreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8111752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 10.5018287403
MESH:D000138 Acidosis Zinc Sulfate 10.507265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D000169 Acrodermatitis Zinc 5.3717202136 17190629 16889938
MESH:D055371 Acute Lung Injury Chlorine 9.0120601635
MESH:D055371 Acute Lung Injury pirinixic acid 9.0118653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8014692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.8019389873
MESH:D000236 Adenoma Diethylnitrosamine 6.806695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.0819061943 19052882 16434500 17162532 18056438 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.0816835633
MESH:D000544 Alzheimer Disease Ozone 4.4215513908
MESH:D000544 Alzheimer Disease Zinc 4.4216580781 16325427 16410023 17119284
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.8616916123
MESH:D000860 Anoxia Zinc Sulfate 4.987265320
MESH:D001161 Arteriosclerosis Dietary Fats 9.7815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 5.1316373670 17854713
MESH:D001249 Asthma Zinc 5.1317085522
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.6319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001930 Brain Injuries Zinc 4.6517109824
MESH:D001943 Breast Neoplasms Dietary Fats 1.8320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8317474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6418315731 19059883 15516495 17626835 14754758 16777450 18417511
MESH:D002100 Cachexia Ozone 4.7016183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8417978847 20007298 19539802 18665156 17055752 20214788 17761372 19107877 10672840 16830150 16288022 16540662 17173139 19418558 20514400 20512989 19919837 20727157 18788625 20101231 16502159 10737359 16878318 20524982 18506893 16328049 17138121 19208518 19171122 20432363 20935162 16935385 18393292 19822196 19052882 16779866 17428255 18056438 18210153 16681979 19394651 19383236 18785209 18494052 16807293 18978308 19335982 16569478 3084413 11831363 3581430 16698587 20084675 18971187 19701751 21159647 19519916 17162532 18691550
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.8916543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.6316936243
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.502727394 21159647 17174075 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2016835633
MESH:D002779 Cholestasis Cyclosporine 13.1519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.1517333356 11677210 16919318 15861022 16105132 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 13.1519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815668235 8697196 12621046 15340226 16354765
MESH:D003092 Colitis Selenium 3.7417936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6620055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Zinc 2.6619302082
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003920 Diabetes Mellitus Zinc 4.1616479319
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1817107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.1319107877
MESH:D056486 Drug-Induced Liver Injury Selenium 6.1315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4218367378
MESH:D004417 Dyspnea Chlorine 4.6020016425
MESH:D004487 Edema pirinixic acid 6.4012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.8815150132 16510608 15547733 16805852 15878914 15547721 16704527 15264214 15623463
MESH:D004938 Esophageal Neoplasms Zinc 4.8816543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Cyclosporine 24.2219224547
MESH:D005234 Fatty Liver Dietary Fats 24.2217967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 24.2221071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.2215345470
MESH:D005234 Fatty Liver pirinixic acid 24.2220131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005355 Fibrosis Cyclosporine 14.5012639820 12168785
MESH:D005355 Fibrosis Dietary Fats 14.5018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.5020067830
MESH:D005739 Gas Poisoning Chlorine 4.9820016425
MESH:D005756 Gastritis Zinc 4.7717241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006130 Growth Disorders Zinc 3.9317217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 11.6820558911
MESH:D006333 Heart Failure Selenium 11.6817162251
MESH:D006333 Heart Failure Zinc 11.6817162251
MESH:D006335 Heart Injuries Zinc 5.7417074742
MESH:D016481 Helicobacter Infections Zinc 4.4917241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006527 Hepatolenticular Degeneration Zinc 11.1917276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 11.1917063115
MESH:D006529 Hepatomegaly pirinixic acid 8.1319176532 19772884 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1315340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0216354765 15340226 8697196 18606429 16959395
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5721332399
MESH:D006973 Hypertension Cyclosporine 4.8910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716569931 16945680
MESH:D007022 Hypotension Zinc Sulfate 4.437265320
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Dietary Fats 8.1520412841
MESH:D007249 Inflammation Diethylnitrosamine 8.1518785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1512200463 12878042
MESH:D007251 Influenza, Human Selenium 4.1716624496
MESH:D007333 Insulin Resistance Dietary Fats 7.1511836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.1516306350
MESH:D007511 Ischemia Zinc 4.5916584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.1218776723 10903974 8314463
MESH:D007674 Kidney Diseases Zinc 6.1216960431
MESH:D007676 Kidney Failure, Chronic Selenium 9.9516518626
MESH:D007676 Kidney Failure, Chronic Zinc 9.9516518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7012371664
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.2215237267
MESH:D008103 Liver Cirrhosis Dietary Fats 6.5518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.5520032147 19638242 18665156 18407596 18522880
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1212878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0917034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 10.5621295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.5610737359 19090486 20492335 19073162 18644402 19642983 19426721 19850985 18754104 19996281 20405173 20434301 19833225 15885732 21047994 20501860 19256749 16942905 9163691 19551842 19812893 19294768 12112319 19427195 20452335 18978307 18648771 18977376 20137499 20118626 12771043 20583210 19499222 15175105 19638242 19255062 21278145 2862719 20101389 19254457 19690152 21167192 21071580 2422723
MESH:D008113 Liver Neoplasms pirinixic acid 10.5620007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.5616984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 9.7018164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.7018544905 18093689 18079962 17942915 16267830 3124819 19539802 17174075 18775883 18164116 19009564 18282651 19519916 9362446 19004024 17854601 19126423 21159647 18308698 2563599 16842330 18253720
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7012151625
MESH:D008171 Lung Diseases Ozone 3.3519066396 8266340
MESH:D055370 Lung Injury Ozone 3.8120417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.396695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Ozone 3.398597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3919555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.2015318939
MESH:D008325 Mammary Neoplasms, Experimental Zinc 6.2012773700
MESH:D008654 Mesothelioma Selenium 2.7715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D008679 Metaplasia Ozone 5.0810496685
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.559029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.9317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3020387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D009765 Obesity Dietary Fats 4.4020132043 21332399 20518802 17217161 18457598 19632207 11836018 18674790 16723640
MESH:D009765 Obesity pirinixic acid 4.4020558911
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4116540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010538 Peritonitis Ozone 4.0916369182
MESH:D010954 Plasmacytoma Selenium 4.8615087411
MESH:D011014 Pneumonia Ozone 4.3618929643 18007984 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.8212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.822563599
MESH:D011225 Pre-Eclampsia Zinc 4.1417114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Zinc 3.8416517595 16700911 12429649 16606632
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012120 Respiration Disorders Chlorine 5.1818579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012162 Retinal Degeneration Zinc 4.0916584753
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6018456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6017575124 12958204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.957505956
MESH:D014062 Tongue Neoplasms Zinc 4.3616543248
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D015430 Weight Gain Dietary Fats 3.7016723640
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26667
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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