Annotation Detail for CNP
Basic Information Top
| Gene Symbol: | CNP ( CNP1 ) |
|---|---|
| Gene Full Name: | 2',3'-cyclic nucleotide 3' phosphodiesterase |
| Band: | 17q21.2 |
| Quick Links | Entrez ID:1267; OMIM: 123830; Uniprot ID:CN37_HUMAN; ENSEMBL ID: ENSG00000173786; HGNC ID: 2158 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C012267 | 2,4-D n-butyl ester | 2,4-D n-butyl ester results in decreased activity of CNP protein | decreases activity | 2995884 |
| D000638 | Amiodarone | Amiodarone results in increased expression of CNP mRNA | increases expression | 19774075 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of CNP mRNA | affects expression | 16483693 |
| D000643 | Ammonium Chloride | Ammonium Chloride results in decreased expression of CNP protein | decreases expression | 16483693 |
| D003024 | Clozapine | Clozapine results in decreased expression of CNP mRNA | decreases expression | 17266109 |
| D003024 | Clozapine | Clozapine results in increased expression of CNP mRNA | increases expression | 17266109 |
| D006220 | Haloperidol | Haloperidol results in decreased expression of CNP mRNA | decreases expression | 17177202 |
| D010622 | Phencyclidine | Phencyclidine results in decreased expression of CNP mRNA | decreases expression | 17266109 |
| D010622 | Phencyclidine | Phencyclidine results in increased expression of CNP mRNA | increases expression | 17266109 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000138 | Acidosis | Ammonium Chloride | 4.02 | 18287403 | |
| MESH:D000380 | Agranulocytosis | Clozapine | 5.47 | 16160616 12649775 14617031 | |
| MESH:D001145 | Arrhythmias, Cardiac | Amiodarone | 4.11 | 18057881 18218290 20041841 | |
| MESH:D001281 | Atrial Fibrillation | Amiodarone | 4.13 | 18651412 19698954 | |
| MESH:D001321 | Autistic Disorder | Haloperidol | 2.72 | 18080171 19368416 | |
| MESH:D001778 | Blood Coagulation Disorders | Amiodarone | 4.22 | 19483382 | |
| MESH:D002311 | Cardiomyopathy, Dilated | Amiodarone | 2.98 | 19225199 15710769 | |
| MESH:D002341 | Carotid Artery Thrombosis | Amiodarone | 5.55 | 18974383 | |
| MESH:D002375 | Catalepsy | Haloperidol | 5.37 | 15215559 1977408 | |
| MESH:D003072 | Cognition Disorders | Clozapine | 5.38 | 17123785 | |
| MESH:D016757 | Death, Sudden, Cardiac | Haloperidol | 5.19 | 20210726 | |
| MESH:D003704 | Dementia | Haloperidol | 4.90 | 11575062 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Clozapine | 3.03 | 16402076 | |
| MESH:D006970 | Disorders of Excessive Somnolence | Clozapine | 6.07 | 15331141 | |
| MESH:D056486 | Drug-Induced Liver Injury | Amiodarone | 2.46 | 15265979 18218290 | |
| MESH:D050171 | Dyslipidemias | Clozapine | 4.40 | 16402076 | |
| MESH:D005234 | Fatty Liver | Amiodarone | 3.84 | 14986274 | |
| MESH:D006529 | Hepatomegaly | Amiodarone | 4.16 | 15265979 | |
| MESH:D006937 | Hypercholesterolemia | Amiodarone | 4.20 | 8137927 9751232 | |
| MESH:D006948 | Hyperkinesis | Clozapine | 5.37 | 16046005 | |
| MESH:D007037 | Hypothyroidism | Amiodarone | 4.93 | 17991464 18020914 | |
| MESH:D008064 | Lipidoses | Amiodarone | 8.95 | 17567588 15342952 | |
| MESH:D008064 | Lipidoses | Clozapine | 8.95 | 17567588 | |
| MESH:D008133 | Long QT Syndrome | Amiodarone | 3.82 | 11989578 15350150 17391786 | |
| MESH:D008171 | Lung Diseases | Amiodarone | 3.57 | 12587719 | |
| MESH:D017563 | Lung Diseases, Interstitial | Amiodarone | 5.00 | 18516814 | |
| MESH:D001523 | Mental Disorders | Clozapine | 9.94 | 16856516 | |
| MESH:D001523 | Mental Disorders | Haloperidol | 9.94 | 16856516 | |
| MESH:D024821 | Metabolic Syndrome X | Clozapine | 4.68 | 19142101 | |
| MESH:D009181 | Mycoses | Amiodarone | 5.42 | 17974566 12754197 | |
| MESH:D009765 | Obesity | Clozapine | 3.07 | 18515891 19142110 | |
| MESH:D011595 | Psychomotor Agitation | Haloperidol | 5.37 | 11575062 | |
| MESH:D011618 | Psychotic Disorders | Clozapine | 9.90 | 15331141 | |
| MESH:D011618 | Psychotic Disorders | Haloperidol | 9.90 | 11575062 | |
| MESH:D011658 | Pulmonary Fibrosis | Amiodarone | 2.95 | 11597910 12832656 12490602 | |
| MESH:D012559 | Schizophrenia | Clozapine | 4.22 | 16141801 20107430 19369910 18855531 17123785 11763009 18806925 17726453 11151749 20452607 20521320 20521326 20168265 20580759 17667964 | |
| MESH:D012559 | Schizophrenia | Haloperidol | 4.22 | 20107430 1830565 19369910 18513383 | |
| OMIM:609620 | SHORT QT SYNDROME 1 | Amiodarone | 5.55 | 18724381 | |
| MESH:D013276 | Stomach Ulcer | Amiodarone | 3.64 | 18087811 | |
| MESH:D013610 | Tachycardia | Amiodarone | 4.67 | 11238279 | |
| MESH:D017180 | Tachycardia, Ventricular | Amiodarone | 11.84 | 19225199 | |
| MESH:D017180 | Tachycardia, Ventricular | Haloperidol | 11.84 | 20210726 | |
| MESH:D013959 | Thyroid Diseases | Amiodarone | 5.28 | 19731979 | |
| MESH:D013971 | Thyrotoxicosis | Amiodarone | 5.28 | 18020914 19584973 | |
| MESH:D016171 | Torsades de Pointes | Amiodarone | 4.65 | 17467628 11989578 | |
| MESH:D015430 | Weight Gain | Clozapine | 4.75 | 16402076 20107430 16141801 17502770 20564506 20521320 | |
| MESH:D015431 | Weight Loss | Clozapine | 5.54 | 17933447 |
| No data |