Annotation Detail for CNR1
Basic Information Top
| Gene Symbol: | CNR1 ( CANN6,CB-R,CB1,CB1A,CB1K5,CB1R,CNR ) |
|---|---|
| Gene Full Name: | cannabinoid receptor 1 (brain) |
| Band: | 6q15 |
| Quick Links | Entrez ID:1268; OMIM: 114610; Uniprot ID:CNR1_HUMAN; ENSEMBL ID: ENSG00000118432; HGNC ID: 2159 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| No data |
| Desease Name |
|---|
| Osteoporosis |
| CHEMDEPENDENCY |
| PSYCH |
| Dyslipidemias |
| alcoholism |
| alcohol abuse drug dependence |
| high neuroticism and low agreeableness |
| alcohol dependence |
| schizophrenia |
| METABOLIC |
| obesity |
| schizophrenia substance abuse |
| P300 event-related potential |
| Insulin Resistance |
| No data |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C094503 | 2-arachidonylglycerol | Nitroglycerin affects the reaction [2-arachidonylglycerol affects the activity of CNR1 protein] | affects activity|affects reaction | 16775503 |
| C505559 | 2-iodophenyl-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone | 2-iodophenyl-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 16438957 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 16438957 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP | affects binding|increases abundance|increases activity | 11730719 10422789 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP] | affects binding|decreases reaction|increases abundance|increases activity | 10422789 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 18582849 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | AM 251 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] | affects binding|decreases reaction|increases activity | 18582849 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | LY 320135 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] | affects binding|decreases reaction|increases activity | 18582849 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the expression of CNR1 protein | affects expression | 15107186 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 16148442 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 12560108 18536748 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide] | affects binding|decreases reaction|increases abundance|increases activity | 11891798 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which affects the expression of FOS protein | affects binding|affects expression|increases activity | 15280883 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased expression of FOS protein | affects binding|increases activity|increases expression | 12560108 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein | affects binding | 16113085 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA] | affects reaction|increases expression | 17540007 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] | affects binding|decreases reaction|increases activity | 18536748 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | affects binding|decreases reaction|increases activity|increases transport | 11891798 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the expression of CNR1 mRNA | affects expression | 10461028 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 17953657 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium] | affects binding|affects reaction|increases activity|increases transport | 12421626 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]] | affects binding|affects reaction|decreases reaction|increases abundance|increases activity | 11727767 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium] | affects binding|decreases reaction|increases activity|increases transport | 14973253 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP | affects binding|increases abundance|increases activity | 17953657 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased phosphorylation of PPP1R1B protein | affects binding|increases activity|increases phosphorylation | 17953657 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein | affects binding | 17397826 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects reaction|decreases reaction|increases transport | 12421626 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased abundance of Nitric Oxide] | affects reaction|decreases abundance | 10027878 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | Ibuprofen analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein] | affects binding|decreases reaction | 17397826 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium]] | affects binding|decreases reaction|increases activity|increases transport | 14973253 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]] | affects binding|affects reaction|decreases reaction|increases abundance|increases activity | 11727767 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects binding|decreases reaction|increases activity|increases transport | 12421626 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Nitric Oxide] | affects binding|decreases abundance|decreases reaction|increases activity | 10027878 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 17220914 |
| D000242 | Cyclic AMP | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP | affects binding|increases abundance|increases activity | 11730719 10422789 |
| D000242 | Cyclic AMP | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP] | affects binding|decreases reaction|increases abundance|increases activity | 10422789 |
| D000242 | Cyclic AMP | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP | affects binding|increases abundance|increases activity | 17953657 |
| C103505 | AM 251 | AM 251 binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 18582849 |
| C103505 | AM 251 | AM 251 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] | affects binding|decreases reaction|increases activity | 18582849 |
| C103505 | AM 251 | AM 251 binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 12509806 |
| C103505 | AM 251 | AM 251 binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 16100529 16775503 16500647 18987195 |
| C109925 | AM 281 | AM 281 binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 17678736 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of CNR1 mRNA | affects expression | 16483693 |
| C078814 | anandamide | anandamide affects the activity of CNR1 protein | affects activity | 19147270 |
| C078814 | anandamide | [anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide] | affects binding|decreases reaction|increases abundance|increases activity | 11891798 |
| C078814 | anandamide | rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | affects binding|decreases reaction|increases activity|increases transport | 11891798 |
| C078814 | anandamide | SR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | affects binding|decreases reaction|increases activity|increases transport | 11891798 |
| C078814 | anandamide | anandamide binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 17459108 |
| C078814 | anandamide | anandamide results in increased activity of CNR1 protein | increases activity | 14504685 17557913 |
| C078814 | anandamide | anandamide binds to CNR1 protein | affects binding | 19403796 |
| C119325 | arachidonyl-2-chloroethylamide | CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK1 protein] | affects reaction|increases activity|increases phosphorylation | 12734338 |
| C119325 | arachidonyl-2-chloroethylamide | CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK3 protein] | affects reaction|increases activity|increases phosphorylation | 12734338 |
| C474941 | arachidonyl dopamine | arachidonyl dopamine binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 17459108 |
| C121153 | arvanil | arvanil binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 17459108 |
| D001761 | Bleomycin | Bleomycin results in decreased expression of CNR1 mRNA | decreases expression | 15808516 |
| C006863 | butyl phosphorotrithioate | butyl phosphorotrithioate inhibits the reaction [CP 55244 binds to CNR1 protein] | affects binding|decreases reaction | 12243867 |
| C006863 | butyl phosphorotrithioate | butyl phosphorotrithioate results in decreased activity of CNR1 protein | decreases activity | 12243867 |
| D002118 | Calcium | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium] | affects binding|affects reaction|increases activity|increases transport | 12421626 |
| D002118 | Calcium | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium] | affects binding|decreases reaction|increases activity|increases transport | 14973253 |
| D002118 | Calcium | Calcium affects the reaction [Potassium Chloride results in decreased expression of CNR1 mRNA] | affects reaction|decreases expression | 16412482 |
| D002118 | Calcium | Calcium affects the reaction [Potassium Chloride results in decreased expression of CNR1 protein] | affects reaction|decreases expression | 16412482 |
| D002118 | Calcium | CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects reaction|decreases reaction|increases transport | 12421626 |
| D002118 | Calcium | CNR1 protein affects the reaction [Win 55212-2 inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects reaction|decreases reaction|increases transport | 12421626 |
| D002118 | Calcium | Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium]] | affects binding|decreases reaction|increases activity|increases transport | 14973253 |
| D002118 | Calcium | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects binding|decreases reaction|increases activity|increases transport | 12421626 |
| D002118 | Calcium | rimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects binding|decreases reaction|increases activity|increases transport | 12421626 |
| D002118 | Calcium | [Win 55212-2 binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium] | affects binding|affects reaction|increases activity|increases transport | 12421626 |
| D002211 | Capsaicin | CNR1 protein affects the reaction [Capsaicin results in increased secretion of CALCA protein] | affects reaction|increases secretion | 18987195 |
| D002211 | Capsaicin | CNR1 protein affects the susceptibility to Capsaicin | affects response to substance | 18987195 |
| D002713 | Chlorine | [Ozone co-treated with Chlorine] affects the expression of CNR1 mRNA | affects cotreatment|affects expression | 18636392 |
| C007031 | chlorpyrifos-methyl | chlorpyrifos-methyl inhibits the reaction [CP 55244 binds to CNR1 protein] | affects binding|decreases reaction | 12243867 |
| C007031 | chlorpyrifos-methyl | chlorpyrifos-methyl results in decreased activity of CNR1 protein | decreases activity | 12243867 |
| C065365 | CP 55244 | butyl phosphorotrithioate inhibits the reaction [CP 55244 binds to CNR1 protein] | affects binding|decreases reaction | 12243867 |
| C065365 | CP 55244 | chlorpyrifos-methyl inhibits the reaction [CP 55244 binds to CNR1 protein] | affects binding|decreases reaction | 12243867 |
| C065365 | CP 55244 | CP 55244 binds to CNR1 protein | affects binding | 12243867 |
| C065365 | CP 55244 | diazoxon inhibits the reaction [CP 55244 binds to CNR1 protein] | affects binding|decreases reaction | 12243867 |
| C065365 | CP 55244 | Dichlorvos inhibits the reaction [CP 55244 binds to CNR1 protein] | affects binding|decreases reaction | 12243867 |
| C065365 | CP 55244 | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate inhibits the reaction [CP 55244 binds to CNR1 protein] | affects binding|decreases reaction | 12243867 |
| C065365 | CP 55244 | Paraoxon inhibits the reaction [CP 55244 binds to CNR1 protein] | affects binding|decreases reaction | 12243867 |
| D013759 | Tetrahydrocannabinol | CNR1 protein affects the susceptibility to Tetrahydrocannabinol | affects response to substance | 10318961 |
| D013759 | Tetrahydrocannabinol | Tetrahydrocannabinol affects the expression of CNR1 mRNA | affects expression | 10461028 |
| D003975 | Diazepam | CNR1 protein affects the susceptibility to Diazepam | affects response to substance | 17442049 |
| C000912 | diazoxon | diazoxon inhibits the reaction [CP 55244 binds to CNR1 protein] | affects binding|decreases reaction | 12243867 |
| C000912 | diazoxon | diazoxon results in decreased activity of CNR1 protein | decreases activity | 12243867 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in decreased expression of CNR1 mRNA | decreases expression | 15620428 |
| D004006 | Dichlorvos | Dichlorvos inhibits the reaction [CP 55244 binds to CNR1 protein] | affects binding|decreases reaction | 12243867 |
| D004006 | Dichlorvos | Dichlorvos results in decreased activity of CNR1 protein | decreases activity | 12243867 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of CNR1 mRNA | decreases expression | 18721800 |
| D019422 | Dietary Sucrose | Dietary Sucrose results in increased expression of CNR1 mRNA | increases expression | 18627777 |
| D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate results in decreased expression of CNR1 mRNA | decreases expression | 15620428 |
| D016291 | Dizocilpine Maleate | CNR1 protein affects the susceptibility to Dizocilpine Maleate | affects response to substance | 17442049 |
| D004837 | Epinephrine | rimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Epinephrine] | affects binding|decreases abundance|decreases reaction|increases activity | 11704653 |
| D004837 | Epinephrine | [Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Epinephrine | affects binding|decreases abundance|increases activity | 11704653 |
| D004958 | Estradiol | [Progesterone co-treated with Estradiol] results in increased expression of CNR1 mRNA | affects cotreatment|increases expression | 17404688 |
| D000431 | Ethanol | CNR1 protein affects the susceptibility to Ethanol | affects response to substance | 17442049 |
| D000431 | Ethanol | Ethanol results in decreased expression of CNR1 mRNA | decreases expression | 18713641 |
| D005632 | Fructose | Fructose results in increased expression of CNR1 mRNA | increases expression | 18627777 |
| C062018 | HU 211 | HU 211 binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 16438957 |
| C062018 | HU 211 | CNR1 protein affects the reaction [HU 211 results in decreased expression of TH mRNA] | affects reaction|decreases expression | 17540007 |
| C062018 | HU 211 | HU 211 binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 18536748 |
| C062018 | HU 211 | rimonabant inhibits the reaction [HU 211 binds to and results in increased activity of CNR1 protein] | affects binding|decreases reaction|increases activity | 18536748 |
| D007052 | Ibuprofen | Ibuprofen analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein] | affects binding|decreases reaction | 17397826 |
| D008070 | Lipopolysaccharides | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide] | affects binding|decreases reaction|increases abundance|increases activity | 11891798 |
| D008070 | Lipopolysaccharides | [anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide] | affects binding|decreases reaction|increases abundance|increases activity | 11891798 |
| D008070 | Lipopolysaccharides | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | affects binding|decreases reaction|increases activity|increases transport | 11891798 |
| D008070 | Lipopolysaccharides | rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | affects binding|decreases reaction|increases activity|increases transport | 11891798 |
| D008070 | Lipopolysaccharides | SR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | affects binding|decreases reaction|increases activity|increases transport | 11891798 |
| D008070 | Lipopolysaccharides | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]] | affects binding|affects reaction|decreases reaction|increases abundance|increases activity | 11727767 |
| D008070 | Lipopolysaccharides | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]] | affects binding|affects reaction|decreases reaction|increases abundance|increases activity | 11727767 |
| C110158 | LY 320135 | LY 320135 binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 18582849 |
| C110158 | LY 320135 | LY 320135 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] | affects binding|decreases reaction|increases activity | 18582849 |
| D008694 | Methamphetamine | CNR1 protein affects the susceptibility to Methamphetamine | affects response to substance | 17953657 |
| C088155 | methanandamide | CNR1 protein affects the reaction [methanandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein] | affects reaction|increases activity|increases phosphorylation | 12734338 |
| C088155 | methanandamide | CNR1 protein affects the reaction [methanandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein] | affects reaction|increases activity|increases phosphorylation | 12734338 |
| C088155 | methanandamide | methanandamide binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 18247126 |
| C521311 | N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide | N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 17327489 |
| C521311 | N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide | N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide binds to CNR1 protein | affects binding | 17327489 |
| C521311 | N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide | N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 19046740 |
| C107594 | N-(4-hydroxyphenyl)arachidonylamide | [N-(4-hydroxyphenyl)arachidonylamide binds to and results in increased activity of CNR1 protein] which affects the expression of FOS protein | affects binding|affects expression|increases activity | 15280883 |
| D009569 | Nitric Oxide | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide] | affects binding|decreases reaction|increases abundance|increases activity | 11891798 |
| D009569 | Nitric Oxide | [anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide] | affects binding|decreases reaction|increases abundance|increases activity | 11891798 |
| D009569 | Nitric Oxide | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | affects binding|decreases reaction|increases activity|increases transport | 11891798 |
| D009569 | Nitric Oxide | rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | affects binding|decreases reaction|increases activity|increases transport | 11891798 |
| D009569 | Nitric Oxide | SR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | affects binding|decreases reaction|increases activity|increases transport | 11891798 |
| D009569 | Nitric Oxide | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]] | affects binding|affects reaction|decreases reaction|increases abundance|increases activity | 11727767 |
| D009569 | Nitric Oxide | CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased abundance of Nitric Oxide] | affects reaction|decreases abundance | 10027878 |
| D009569 | Nitric Oxide | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]] | affects binding|affects reaction|decreases reaction|increases abundance|increases activity | 11727767 |
| D009569 | Nitric Oxide | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Nitric Oxide] | affects binding|decreases abundance|decreases reaction|increases activity | 10027878 |
| D005996 | Nitroglycerin | Nitroglycerin affects the reaction [2-arachidonylglycerol affects the activity of CNR1 protein] | affects activity|affects reaction | 16775503 |
| C025256 | nonylphenol | nonylphenol results in decreased expression of CNR1 mRNA | decreases expression | 15620428 |
| C009618 | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate inhibits the reaction [CP 55244 binds to CNR1 protein] | affects binding|decreases reaction | 12243867 |
| C009618 | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased activity of CNR1 protein | decreases activity | 12243867 |
| D010126 | Ozone | [Ozone co-treated with Chlorine] affects the expression of CNR1 mRNA | affects cotreatment|affects expression | 18636392 |
| D010261 | Paraoxon | Paraoxon inhibits the reaction [CP 55244 binds to CNR1 protein] | affects binding|decreases reaction | 12243867 |
| D010261 | Paraoxon | Paraoxon results in decreased activity of CNR1 protein | decreases activity | 12243867 |
| D010424 | Pentobarbital | CNR1 protein affects the susceptibility to Pentobarbital | affects response to substance | 17442049 |
| D037342 | Pertussis Toxin | Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium]] | affects binding|decreases reaction|increases activity|increases transport | 14973253 |
| D011188 | Potassium | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium] | affects binding|decreases reaction|increases activity|increases transport | 14973253 |
| D011188 | Potassium | Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium]] | affects binding|decreases reaction|increases activity|increases transport | 14973253 |
| D011189 | Potassium Chloride | [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium] | affects binding|affects reaction|increases activity|increases transport | 12421626 |
| D011189 | Potassium Chloride | Calcium affects the reaction [Potassium Chloride results in decreased expression of CNR1 mRNA] | affects reaction|decreases expression | 16412482 |
| D011189 | Potassium Chloride | Calcium affects the reaction [Potassium Chloride results in decreased expression of CNR1 protein] | affects reaction|decreases expression | 16412482 |
| D011189 | Potassium Chloride | CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects reaction|decreases reaction|increases transport | 12421626 |
| D011189 | Potassium Chloride | CNR1 protein affects the reaction [Win 55212-2 inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects reaction|decreases reaction|increases transport | 12421626 |
| D011189 | Potassium Chloride | Potassium Chloride results in decreased expression of CNR1 mRNA | decreases expression | 16412482 |
| D011189 | Potassium Chloride | Potassium Chloride results in decreased expression of CNR1 protein | decreases expression | 16412482 |
| D011189 | Potassium Chloride | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects binding|decreases reaction|increases activity|increases transport | 12421626 |
| D011189 | Potassium Chloride | rimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects binding|decreases reaction|increases activity|increases transport | 12421626 |
| D011189 | Potassium Chloride | [Win 55212-2 binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium] | affects binding|affects reaction|increases activity|increases transport | 12421626 |
| D011374 | Progesterone | [Progesterone co-treated with Estradiol] results in increased expression of CNR1 mRNA | affects cotreatment|increases expression | 17404688 |
| D011374 | Progesterone | Progesterone results in increased expression of CNR1 mRNA | increases expression | 17404688 |
| C089032 | rimonabant | rimonabant binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 17592669 |
| C089032 | rimonabant | rimonabant binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 20107430 11730719 |
| C089032 | rimonabant | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP] | affects binding|decreases reaction|increases abundance|increases activity | 10422789 |
| C089032 | rimonabant | rimonabant binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 12560108 16148442 |
| C089032 | rimonabant | [rimonabant binds to and results in decreased activity of CNR1 protein] which affects the expression of FOS protein | affects binding|affects expression|decreases activity | 15280883 |
| C089032 | rimonabant | rimonabant binds to CNR1 protein | affects binding | 16113085 |
| C089032 | rimonabant | rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] | affects binding|decreases reaction|increases activity | 18536748 |
| C089032 | rimonabant | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | affects binding|decreases reaction|increases activity|increases transport | 11891798 |
| C089032 | rimonabant | rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | affects binding|decreases reaction|increases activity|increases transport | 11891798 |
| C089032 | rimonabant | rimonabant inhibits the reaction [HU 211 binds to and results in increased activity of CNR1 protein] | affects binding|decreases reaction|increases activity | 18536748 |
| C089032 | rimonabant | rimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Epinephrine] | affects binding|decreases abundance|decreases reaction|increases activity | 11704653 |
| C089032 | rimonabant | rimonabant binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 12509806 16554168 17018694 |
| C089032 | rimonabant | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]] | affects binding|affects reaction|decreases reaction|increases abundance|increases activity | 11727767 |
| C089032 | rimonabant | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects binding|decreases reaction|increases activity|increases transport | 12421626 |
| C089032 | rimonabant | rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Nitric Oxide] | affects binding|decreases abundance|decreases reaction|increases activity | 10027878 |
| C089032 | rimonabant | rimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects binding|decreases reaction|increases activity|increases transport | 12421626 |
| C089032 | rimonabant | rimonabant binds to and results in decreased activity of CNR1 protein | affects binding|decreases activity | 17678736 18987195 16100529 19046740 15748152 16775503 14741435 20553815 |
| C110630 | SR 144528 | SR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | affects binding|decreases reaction|increases activity|increases transport | 11891798 |
| D013549 | Sweetening Agents | Sweetening Agents results in increased expression of CNR1 mRNA | increases expression | 18627777 |
| D014212 | Tretinoin | Tretinoin results in increased expression of CNR1 mRNA | increases expression | 16477621 |
| D014212 | Tretinoin | Tretinoin results in increased expression of CNR1 protein | increases expression | 16477621 |
| C070417 | Win 55212-2 | Win 55212-2 binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 16438957 |
| C070417 | Win 55212-2 | Win 55212-2 binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 12560108 |
| C070417 | Win 55212-2 | [Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in increased expression of FOS protein | affects binding|increases activity|increases expression | 12560108 |
| C070417 | Win 55212-2 | rimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Epinephrine] | affects binding|decreases abundance|decreases reaction|increases activity | 11704653 |
| C070417 | Win 55212-2 | [Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Epinephrine | affects binding|decreases abundance|increases activity | 11704653 |
| C070417 | Win 55212-2 | CNR1 protein affects the reaction [Win 55212-2 inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects reaction|decreases reaction|increases transport | 12421626 |
| C070417 | Win 55212-2 | rimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]] | affects binding|decreases reaction|increases activity|increases transport | 12421626 |
| C070417 | Win 55212-2 | [Win 55212-2 binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium] | affects binding|affects reaction|increases activity|increases transport | 12421626 |
| C070417 | Win 55212-2 | Win 55212-2 binds to and results in increased activity of CNR1 protein | affects binding|increases activity | 17220914 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000014 | Abnormalities, Drug-Induced | Capsaicin | 11.34 | 18926900 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Diethylhexyl Phthalate | 11.34 | 6734493 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Ethanol | 11.34 | 18926900 17676605 | |
| MESH:D000138 | Acidosis | Ammonium Chloride | 8.56 | 18287403 | |
| MESH:D000138 | Acidosis | Ethanol | 8.56 | 11192467 | |
| MESH:D058186 | Acute Kidney Injury | Capsaicin | 7.62 | 18460982 | |
| MESH:D058186 | Acute Kidney Injury | Ibuprofen | 7.62 | 6375363 | |
| MESH:D055371 | Acute Lung Injury | Bleomycin | 12.51 | 17118201 | |
| MESH:D055371 | Acute Lung Injury | Chlorine | 12.51 | 20601635 | |
| MESH:D055371 | Acute Lung Injury | Lipopolysaccharides | 12.51 | 18653653 11850527 | |
| MESH:D000230 | Adenocarcinoma | Estradiol | 4.15 | 11473722 | |
| MESH:D000230 | Adenocarcinoma | Ibuprofen | 4.15 | 10697514 | |
| MESH:D000382 | Agricultural Workers' Diseases | Dichlorvos | 4.38 | 17119214 16611668 12661182 | |
| MESH:D020268 | Alcohol-Induced Disorders, Nervous System | Ethanol | 4.73 | 15451039 15451040 | |
| MESH:D000505 | Alopecia | Capsaicin | 8.04 | 17569567 | |
| MESH:D000505 | Alopecia | Tretinoin | 8.04 | 15955085 | |
| MESH:D000544 | Alzheimer Disease | Ibuprofen | 5.91 | 18351690 | |
| MESH:D000544 | Alzheimer Disease | Nitric Oxide | 5.91 | 17556102 | |
| MESH:D000544 | Alzheimer Disease | Ozone | 5.91 | 15513908 | |
| MESH:D000690 | Amyotrophic Lateral Sclerosis | Tetrahydrocannabinol | 4.45 | 15204022 | |
| MESH:D000707 | Anaphylaxis | Ibuprofen | 4.68 | 9532969 | |
| MESH:D000853 | Anophthalmos | Ethanol | 4.26 | 15513904 | |
| MESH:D000860 | Anoxia | Bleomycin | 4.83 | 15782499 | |
| MESH:D001008 | Anxiety Disorders | Diazepam | 12.55 | 16284244 18313124 | |
| MESH:D001008 | Anxiety Disorders | Ethanol | 12.55 | 11141031 | |
| MESH:D001008 | Anxiety Disorders | Pentobarbital | 12.55 | 18313124 11141031 | |
| MESH:D001161 | Arteriosclerosis | Dietary Fats | 3.33 | 15238619 | |
| MESH:D001169 | Arthritis, Experimental | Tretinoin | 2.70 | 16412693 | |
| MESH:D001172 | Arthritis, Rheumatoid | Ozone | 4.09 | 15570426 | |
| MESH:D001172 | Arthritis, Rheumatoid | Tretinoin | 4.09 | 16292516 | |
| MESH:D001249 | Asthma | Ozone | 4.24 | 17854713 16373670 | |
| MESH:D001249 | Asthma | Tretinoin | 4.24 | 16456186 | |
| MESH:D050197 | Atherosclerosis | Paraoxon | 6.77 | 16391483 | |
| MESH:D050197 | Atherosclerosis | Tetrahydrocannabinol | 6.77 | 15815632 | |
| MESH:D001471 | Barrett Esophagus | Tretinoin | 3.85 | 16935849 | |
| MESH:D001480 | Basal Ganglia Diseases | Dichlorvos | 5.40 | 15303389 | |
| MESH:D001778 | Blood Coagulation Disorders | Tretinoin | 3.10 | 16206674 16197459 | |
| MESH:D001919 | Bradycardia | Capsaicin | 4.48 | 18207255 | |
| MESH:D020201 | Brain Hemorrhage, Traumatic | Progesterone | 4.75 | 17868700 | |
| MESH:D001930 | Brain Injuries | Progesterone | 3.70 | 15665606 15845082 15380490 | |
| MESH:D002545 | Brain Ischemia | Capsaicin | 8.88 | 19211983 | |
| MESH:D002545 | Brain Ischemia | Ibuprofen | 8.88 | 15837124 | |
| MESH:D001943 | Breast Neoplasms | Dietary Fats | 2.13 | 20435547 | |
| MESH:D001943 | Breast Neoplasms | Estradiol | 2.13 | 16675129 17289903 18497071 19861407 17018787 17261762 14630087 12948864 | |
| MESH:D001943 | Breast Neoplasms | Nitric Oxide | 2.13 | 15631943 | |
| MESH:D001943 | Breast Neoplasms | Progesterone | 2.13 | 15562024 16175315 17614352 | |
| MESH:D001943 | Breast Neoplasms | Tretinoin | 2.13 | 16873071 16166294 16443354 | |
| MESH:D016535 | Bronchial Hyperreactivity | Ozone | 3.22 | 19059883 14754758 16777450 17626835 15516495 18417511 18315731 | |
| MESH:D001997 | Bronchopulmonary Dysplasia | Tretinoin | 4.01 | 16813970 | |
| MESH:D002056 | Burns | Ethanol | 4.09 | 16374292 | |
| MESH:D002100 | Cachexia | Ibuprofen | 10.66 | 15141370 | |
| MESH:D002100 | Cachexia | Ozone | 10.66 | 16183385 | |
| MESH:D002181 | Candidiasis, Vulvovaginal | Estradiol | 3.89 | 16111702 | |
| MESH:D018236 | Carcinoma, Embryonal | Tretinoin | 4.57 | 16168501 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Estradiol | 3.98 | 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Ethanol | 3.98 | 15289165 15763234 18788625 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Tretinoin | 3.98 | 1917145 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Bleomycin | 4.46 | 6189445 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Tretinoin | 4.46 | 16096774 16051514 | |
| MESH:D006332 | Cardiomegaly | Ethanol | 3.10 | 19332462 | |
| MESH:D002375 | Catalepsy | marker/mechanism | 10318961 | ||
| MESH:D002375 | Catalepsy | Tetrahydrocannabinol | 5.15 | 10318961 | |
| MESH:D002386 | Cataract | Tretinoin | 2.73 | 17460283 | |
| MESH:D002418 | Cattle Diseases | Dichlorvos | 5.07 | 14651886 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Estradiol | 2.37 | 18566989 | |
| MESH:D002493 | Central Nervous System Diseases | Dichlorvos | 5.19 | 12670839 | |
| MESH:D018290 | Cervical Intraepithelial Neoplasia | Tretinoin | 4.01 | 16129372 | |
| MESH:D002779 | Cholestasis | Nitric Oxide | 4.02 | 16919318 | |
| MESH:D002822 | Choriocarcinoma | Tretinoin | 4.57 | 16461808 | |
| MESH:D002971 | Cleft Lip | Ethanol | 3.26 | 15513904 | |
| MESH:D002972 | Cleft Palate | Diazepam | 8.54 | 3629520 | |
| MESH:D002972 | Cleft Palate | Ethanol | 8.54 | 15513904 | |
| MESH:D002972 | Cleft Palate | Tretinoin | 8.54 | 9407595 | |
| MESH:D003092 | Colitis | Tretinoin | 3.15 | 17035595 | |
| MESH:D003128 | Coma | Dichlorvos | 5.41 | 15303389 | |
| MESH:D003327 | Coronary Disease | Fructose | 4.09 | 18504504 | |
| MESH:D003371 | Cough | Capsaicin | 4.59 | 10350223 | |
| MESH:D019465 | Craniofacial Abnormalities | Ethanol | 2.62 | 15451039 10194807 19302082 15513904 15451040 11198716 11873399 | |
| MESH:D019465 | Craniofacial Abnormalities | Tretinoin | 2.62 | 16925845 8800419 9142499 14991402 17551590 9211117 9664655 9224671 10589399 9125849 | |
| MESH:D003456 | Cryptorchidism | Dibutyl Phthalate | 4.90 | 16037377 | |
| MESH:D015140 | Dementia, Vascular | Nitric Oxide | 5.38 | 17556102 | |
| MESH:D003876 | Dermatitis, Atopic | Diethylhexyl Phthalate | 3.75 | 16882537 | |
| MESH:D003921 | Diabetes Mellitus, Experimental | Fructose | 4.02 | 18603373 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Fructose | 3.22 | 18603373 | |
| MESH:D003928 | Diabetic Nephropathies | Estradiol | 2.93 | 19279558 | |
| MESH:D003929 | Diabetic Neuropathies | Progesterone | 3.93 | 17187935 | |
| MESH:D003967 | Diarrhea | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | 4.36 | 10611417 | |
| MESH:D056486 | Drug-Induced Liver Injury | Ethanol | 2.45 | 11566570 | |
| MESH:D004374 | Ductus Arteriosus, Patent | Ibuprofen | 5.04 | 18446180 16133044 18450898 | |
| MESH:D004381 | Duodenal Ulcer | Capsaicin | 4.15 | 10671773 11535926 | |
| MESH:D050171 | Dyslipidemias | Dietary Fats | 3.03 | 18367378 | |
| MESH:D004417 | Dyspnea | Chlorine | 4.04 | 20016425 | |
| MESH:D004421 | Dystonia | Diazepam | 5.14 | 1851702 | |
| MESH:D004487 | Edema | Bleomycin | 3.76 | 17118201 | |
| MESH:D004489 | Edema, Cardiac | Tretinoin | 3.88 | 18230668 | |
| MESH:D004660 | Encephalitis | 2-arachidonylglycerol | 6.36 | 16364651 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Progesterone | 3.24 | 17692515 | |
| MESH:D016889 | Endometrial Neoplasms | Estradiol | 6.10 | 19148513 18566989 11473722 | |
| MESH:D016889 | Endometrial Neoplasms | Tretinoin | 6.10 | 16569247 | |
| MESH:D004715 | Endometriosis | Ibuprofen | 7.85 | 15652904 | |
| MESH:D004715 | Endometriosis | Progesterone | 7.85 | 16134523 | |
| MESH:D019446 | Endotoxemia | Ibuprofen | 8.92 | 11545620 | |
| MESH:D019446 | Endotoxemia | Lipopolysaccharides | 8.92 | 17637181 15821434 15328337 | |
| MESH:D004828 | Epilepsies, Partial | Diazepam | 4.96 | 3922381 | |
| MESH:D004827 | Epilepsy | Diazepam | 9.79 | 821787 | |
| MESH:D004827 | Epilepsy | Epinephrine | 9.79 | 821787 | |
| MESH:D004827 | Epilepsy | Tetrahydrocannabinol | 9.79 | 821787 | |
| MESH:D004832 | Epilepsy, Absence | Diazepam | 4.72 | 6401628 6426943 | |
| MESH:D004935 | Esophageal Diseases | Capsaicin | 5.13 | 19566590 | |
| MESH:D004938 | Esophageal Neoplasms | Ethanol | 2.59 | 16704527 | |
| MESH:D005124 | Eye Abnormalities | Tretinoin | 3.14 | 16938888 9664655 | |
| MESH:D005234 | Fatty Liver | Dietary Fats | 14.78 | 17967931 19551842 18296743 19004024 | |
| MESH:D005234 | Fatty Liver | Dietary Sucrose | 14.78 | 17967931 | |
| MESH:D005234 | Fatty Liver | Ethanol | 14.78 | 19236843 18620774 16409862 | |
| MESH:D005234 | Fatty Liver | Fructose | 14.78 | 18395287 18641190 19196556 | |
| MESH:D005235 | Fatty Liver, Alcoholic | Ethanol | 5.08 | 17920746 | |
| MESH:D005310 | Fetal Alcohol Syndrome | Ethanol | 4.72 | 16946407 15451040 10194807 15513904 | |
| MESH:D005334 | Fever | Ibuprofen | 7.86 | 16997862 | |
| MESH:D005334 | Fever | Lipopolysaccharides | 7.86 | 11852909 9205823 | |
| MESH:D005355 | Fibrosis | Dietary Fats | 11.77 | 18296743 | |
| MESH:D005355 | Fibrosis | Fructose | 11.77 | 18504504 | |
| MESH:D005355 | Fibrosis | Tretinoin | 11.77 | 17994277 | |
| MESH:D005739 | Gas Poisoning | Chlorine | 4.42 | 20016425 | |
| MESH:D005756 | Gastritis | Ethanol | 4.11 | 15046732 | |
| MESH:D005909 | Glioblastoma | Capsaicin | 6.22 | 18405923 | |
| MESH:D005909 | Glioblastoma | Tretinoin | 6.22 | 17312396 | |
| MESH:D018149 | Glucose Intolerance | Fructose | 4.79 | 19165636 | |
| MESH:D006261 | Headache | Nitric Oxide | 9.43 | 11554966 11284996 | |
| MESH:D006261 | Headache | Nitroglycerin | 9.43 | 11554966 11284996 | |
| MESH:D006258 | Head and Neck Neoplasms | Tretinoin | 2.78 | 16096774 | |
| MESH:D016489 | Head Injuries, Closed | 2-arachidonylglycerol | 6.36 | 16364651 | |
| MESH:D006317 | Hearing Loss, Noise-Induced | Tretinoin | 4.57 | 16084493 | |
| MESH:D006356 | Heartburn | Capsaicin | 5.13 | 19566590 | |
| MESH:D006330 | Heart Defects, Congenital | Tretinoin | 2.57 | 14991402 9664655 | |
| MESH:D006463 | Hemolytic-Uremic Syndrome | Lipopolysaccharides | 3.88 | 16366002 | |
| MESH:D006558 | Herpes Genitalis | Estradiol | 4.44 | 15709030 | |
| MESH:D006689 | Hodgkin Disease | Bleomycin | 3.90 | 17606976 18501091 15147373 | |
| MESH:D006734 | Horse Diseases | Dichlorvos | 5.41 | 16402567 | |
| MESH:D019584 | Hot Flashes | Estradiol | 3.17 | 17088409 | |
| MESH:D006930 | Hyperalgesia | Capsaicin | 10.63 | 17043245 17434803 | |
| MESH:D006930 | Hyperalgesia | Ethanol | 10.63 | 18783367 | |
| MESH:D006930 | Hyperalgesia | Tretinoin | 10.63 | 16870215 | |
| MESH:D006937 | Hypercholesterolemia | Dietary Fats | 3.08 | 21332399 | |
| MESH:D006940 | Hyperemia | Nitric Oxide | 5.04 | 11156591 | |
| MESH:D017681 | Hypereosinophilic Syndrome | Tretinoin | 4.01 | 16778211 | |
| MESH:D006941 | Hyperesthesia | Dichlorvos | 6.10 | 12563396 | |
| MESH:D006946 | Hyperinsulinism | Fructose | 4.42 | 18360027 19008412 15752949 14757778 18563319 | |
| MESH:D006948 | Hyperkinesis | Methamphetamine | 4.93 | 17658665 | |
| MESH:D006949 | Hyperlipidemias | Dietary Fats | 7.80 | 21332399 | |
| MESH:D006949 | Hyperlipidemias | Fructose | 7.80 | 15752949 | |
| MESH:D006973 | Hypertension | Fructose | 3.38 | 14568997 14633139 14573337 16843071 19008412 | |
| MESH:D006976 | Hypertension, Pulmonary | Nitric Oxide | 4.00 | 15838368 | |
| MESH:D015228 | Hypertriglyceridemia | Fructose | 4.57 | 19799862 19342510 | |
| MESH:D006984 | Hypertrophy | Ibuprofen | 4.46 | 16672835 | |
| MESH:D020514 | Hypokalemic Periodic Paralysis | Potassium | 5.29 | 19822448 | |
| MESH:D007022 | Hypotension | anandamide | 12.92 | 14504685 | |
| MESH:D007022 | Hypotension | Epinephrine | 12.92 | 6740701 | |
| MESH:D007022 | Hypotension | methanandamide | 12.92 | 14504685 | |
| MESH:D007035 | Hypothermia | Tetrahydrocannabinol | 5.37 | 10318961 | |
| MESH:D007235 | Infant, Premature, Diseases | Ibuprofen | 5.25 | 16133044 | |
| MESH:D020244 | Infarction, Middle Cerebral Artery | Progesterone | 3.84 | 15869954 | |
| MESH:D007249 | Inflammation | Bleomycin | 15.72 | 17118201 | |
| MESH:D007249 | Inflammation | Capsaicin | 15.72 | 16956363 | |
| MESH:D007249 | Inflammation | Dietary Fats | 15.72 | 20412841 | |
| MESH:D007249 | Inflammation | Ibuprofen | 15.72 | 3291741 | |
| MESH:D007249 | Inflammation | Lipopolysaccharides | 15.72 | 12878042 17963957 17237260 17255318 9205823 | |
| MESH:D007249 | Inflammation | Progesterone | 15.72 | 15869954 | |
| MESH:D007333 | Insulin Resistance | Dietary Fats | 10.22 | 18457598 11836018 | |
| MESH:D007333 | Insulin Resistance | Estradiol | 10.22 | 16393666 16627594 | |
| MESH:D007333 | Insulin Resistance | Fructose | 10.22 | 19586609 17133782 14633139 18057795 14573337 19342510 18981581 19799862 18563319 14757778 19008412 | |
| MESH:D007410 | Intestinal Diseases | Nitric Oxide | 8.25 | 10210152 11574821 11713966 | |
| MESH:D007410 | Intestinal Diseases | Tretinoin | 8.25 | 17994277 | |
| MESH:D019189 | Iron Metabolism Disorders | Lipopolysaccharides | 4.10 | 17255318 | |
| MESH:D007569 | Jaw Abnormalities | Ethanol | 8.61 | 15513904 | |
| MESH:D007569 | Jaw Abnormalities | Tretinoin | 8.61 | 15992940 17551590 | |
| MESH:D007674 | Kidney Diseases | Dichlorvos | 5.46 | 16798900 | |
| MESH:D007674 | Kidney Diseases | Estradiol | 5.46 | 15618244 | |
| MESH:D007680 | Kidney Neoplasms | Estradiol | 2.52 | 15610895 | |
| MESH:D007683 | Kidney Tubular Necrosis, Acute | Calcium | 4.46 | 16316344 | |
| MESH:D007859 | Learning Disorders | Ethanol | 3.66 | 15451040 | |
| MESH:D007896 | Leishmaniasis | Nitric Oxide | 4.17 | 17218153 | |
| MESH:D007938 | Leukemia | Tretinoin | 2.46 | 17143497 | |
| MESH:D007951 | Leukemia, Myeloid | Tretinoin | 3.18 | 19285840 16482212 16932348 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | Tretinoin | 1.96 | 17596541 16294345 19850784 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | Tretinoin | 2.76 | 16140955 17339181 17217047 19075265 16891316 17107899 19225113 16788101 16935935 16823087 12679006 17712046 17301526 17294898 19029980 19642359 17361223 16766008 17506722 16331271 17649720 15748426 9834237 17368321 19035177 | |
| MESH:D007970 | Leukopenia | Lipopolysaccharides | 4.12 | 15821434 | |
| MESH:D017880 | Limb Deformities, Congenital | Ethanol | 6.90 | 17676605 | |
| MESH:D017880 | Limb Deformities, Congenital | Tretinoin | 6.90 | 9224671 | |
| MESH:D008103 | Liver Cirrhosis | Dietary Fats | 5.69 | 18296743 | |
| MESH:D008103 | Liver Cirrhosis | Ethanol | 5.69 | 15289165 | |
| MESH:D008104 | Liver Cirrhosis, Alcoholic | Ethanol | 4.52 | 18295389 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | marker/mechanism | 17043671 | ||
| MESH:D008106 | Liver Cirrhosis, Experimental | Estradiol | 4.26 | 14716833 14659978 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Ethanol | 4.26 | 18166357 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Lipopolysaccharides | 4.26 | 12878042 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tretinoin | 4.26 | 16248980 18397230 | |
| MESH:D008107 | Liver Diseases | Capsaicin | 3.10 | 16956363 | |
| MESH:D008108 | Liver Diseases, Alcoholic | Ethanol | 4.09 | 17207112 17347304 | |
| MESH:D008113 | Liver Neoplasms | Diethylhexyl Phthalate | 3.22 | 11940454 | |
| MESH:D008171 | Lung Diseases | Ozone | 2.98 | 19066396 8266340 | |
| MESH:D055370 | Lung Injury | Lipopolysaccharides | 12.12 | 21114838 | |
| MESH:D055370 | Lung Injury | Nitric Oxide | 12.12 | 11395602 | |
| MESH:D055370 | Lung Injury | Ozone | 12.12 | 20417186 | |
| MESH:D008175 | Lung Neoplasms | Bleomycin | 2.86 | 6189445 | |
| MESH:D008175 | Lung Neoplasms | Ozone | 2.86 | 7614698 8597069 | |
| MESH:D008223 | Lymphoma | Nitric Oxide | 3.86 | 16166326 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Estradiol | 7.87 | 11807958 11408345 17203775 16891317 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Ibuprofen | 7.87 | 10697514 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Progesterone | 7.87 | 11408345 17203775 | |
| MESH:D020149 | Manganese Poisoning | Estradiol | 3.90 | 19453300 | |
| MESH:D008527 | Medulloblastoma | Tretinoin | 2.53 | 17453147 | |
| MESH:D008545 | Melanoma | Bleomycin | 3.38 | 15577320 | |
| MESH:D008545 | Melanoma | Tretinoin | 3.38 | 16752155 | |
| MESH:D008569 | Memory Disorders | Ethanol | 3.65 | 15451040 18411066 | |
| MESH:D008591 | Meningomyelocele | Tretinoin | 3.86 | 16940565 | |
| MESH:D024821 | Metabolic Syndrome X | Fructose | 4.34 | 18497449 16815490 19165636 17261469 17098227 | |
| MESH:D008679 | Metaplasia | Ozone | 4.52 | 10496685 | |
| MESH:D008708 | Methemoglobinemia | Nitroglycerin | 4.21 | 3537620 | |
| MESH:D008881 | Migraine Disorders | Nitric Oxide | 3.86 | 11701602 | |
| MESH:D020326 | Migraine without Aura | Cyclic AMP | 14.78 | 11304026 | |
| MESH:D020326 | Migraine without Aura | Nitric Oxide | 14.78 | 11304026 14659530 | |
| MESH:D020326 | Migraine without Aura | Nitroglycerin | 14.78 | 14659530 | |
| MESH:D016472 | Motor Neuron Disease | Dichlorvos | 5.75 | 11282359 | |
| MESH:D009101 | Multiple Myeloma | Capsaicin | 3.74 | 17505005 | |
| MESH:D009103 | Multiple Sclerosis | therapeutic | 12876144 | ||
| MESH:D009128 | Muscle Spasticity | marker/mechanism | 17220914 | ||
| MESH:D009128 | Muscle Spasticity | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | 11.67 | 17220914 | |
| MESH:D009128 | Muscle Spasticity | Win 55212-2 | 11.67 | 17220914 | |
| MESH:D009190 | Myelodysplastic Syndromes | Tretinoin | 2.73 | 17596541 | |
| MESH:D009203 | Myocardial Infarction | Nitroglycerin | 3.52 | 14729435 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Estradiol | 2.83 | 16810080 | |
| MESH:D009349 | Nematode Infections | Dichlorvos | 5.56 | 16402567 | |
| MESH:D009369 | Neoplasms | Tretinoin | 2.13 | 16946489 16594593 | |
| MESH:D009389 | Neovascularization, Pathologic | Estradiol | 3.16 | 17289903 | |
| MESH:D009395 | Nephritis, Interstitial | Ibuprofen | 4.40 | 6375363 | |
| MESH:D009410 | Nerve Degeneration | Dichlorvos | 7.77 | 11282359 17850875 | |
| MESH:D009410 | Nerve Degeneration | Ibuprofen | 7.77 | 10961664 | |
| MESH:D009421 | Nervous System Malformations | Estradiol | 7.86 | 16427766 11399458 | |
| MESH:D009421 | Nervous System Malformations | Tretinoin | 7.86 | 9125849 | |
| MESH:D009436 | Neural Tube Defects | Tetrahydrocannabinol | 6.57 | 19040278 | |
| MESH:D009436 | Neural Tube Defects | Tretinoin | 6.57 | 9142499 | |
| MESH:D019636 | Neurodegenerative Diseases | Dichlorvos | 4.45 | 16635102 | |
| MESH:D020078 | Neurogenic Inflammation | Capsaicin | 4.56 | 17961222 | |
| MESH:D020258 | Neurotoxicity Syndromes | Dichlorvos | 4.37 | 12186780 | |
| MESH:D009765 | Obesity | Capsaicin | 12.33 | 19056576 | |
| MESH:D009765 | Obesity | Dietary Fats | 12.33 | 20518802 21332399 18457598 17217161 16723640 20132043 19632207 11836018 18674790 | |
| MESH:D009765 | Obesity | Fructose | 12.33 | 18585860 17707055 | |
| MESH:D009765 | Obesity | N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide | 12.33 | 17327489 19046740 | |
| MESH:D009765 | Obesity | rimonabant | 12.33 | 18773755 20518802 19046740 | |
| MESH:D010003 | Osteoarthritis | Ibuprofen | 3.76 | 7009135 | |
| MESH:D010024 | Osteoporosis | Calcium | 3.41 | 17882678 | |
| MESH:D010051 | Ovarian Neoplasms | Estradiol | 6.61 | 19401270 | |
| MESH:D010051 | Ovarian Neoplasms | Progesterone | 6.61 | 17393432 16525653 | |
| MESH:D010051 | Ovarian Neoplasms | Tretinoin | 6.61 | 16936753 | |
| MESH:D010146 | Pain | AM 251 | 16.33 | 18987195 | |
| MESH:D010146 | Pain | Capsaicin | 16.33 | 18987195 17434803 17084039 16996476 19081190 17043245 | |
| MESH:D010146 | Pain | Ibuprofen | 16.33 | 3291741 | |
| MESH:D010146 | Pain | rimonabant | 16.33 | 18987195 | |
| MESH:D010146 | Pain | Tretinoin | 16.33 | 16870215 | |
| MESH:D010149 | Pain, Postoperative | Ibuprofen | 4.56 | 16678543 | |
| MESH:D010190 | Pancreatic Neoplasms | AM 251 | 10.45 | 16500647 | |
| MESH:D010190 | Pancreatic Neoplasms | Ethanol | 10.45 | 12384795 | |
| MESH:D010190 | Pancreatic Neoplasms | Ibuprofen | 10.45 | 12384795 | |
| MESH:D010190 | Pancreatic Neoplasms | Tretinoin | 10.45 | 15976015 | |
| MESH:D010195 | Pancreatitis | Dichlorvos | 4.37 | 16258382 | |
| MESH:D010302 | Parkinson Disease, Secondary | Dichlorvos | 5.05 | 12645970 | |
| MESH:D010538 | Peritonitis | Ozone | 3.57 | 16369182 | |
| MESH:D011014 | Pneumonia | Bleomycin | 15.39 | 18024389 17071938 16317386 | |
| MESH:D011014 | Pneumonia | Lipopolysaccharides | 15.39 | 12224865 11605937 | |
| MESH:D011014 | Pneumonia | Ozone | 15.39 | 18381685 18929643 18007984 | |
| MESH:D011015 | Pneumonia, Aspiration | Nitric Oxide | 4.76 | 18573544 | |
| MESH:D011041 | Poisoning | Dichlorvos | 4.44 | 17603234 12460839 17157343 16036766 18072136 15303389 | |
| MESH:D011115 | Polyneuropathies | Dichlorvos | 5.06 | 12563396 | |
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | Estradiol | 3.37 | 20887781 | |
| MESH:D011471 | Prostatic Neoplasms | Dichlorvos | 3.13 | 12661182 | |
| MESH:D011471 | Prostatic Neoplasms | Estradiol | 3.13 | 16740699 | |
| MESH:D011471 | Prostatic Neoplasms | Ibuprofen | 3.13 | 17409433 | |
| MESH:D011507 | Proteinuria | Ibuprofen | 7.75 | 6375363 | |
| MESH:D011507 | Proteinuria | Tretinoin | 7.75 | 16636307 | |
| MESH:D011625 | Pterygium | Tretinoin | 4.22 | 16723453 | |
| MESH:D011654 | Pulmonary Edema | Bleomycin | 4.73 | 15808516 | |
| MESH:D011658 | Pulmonary Fibrosis | Bleomycin | 3.62 | 12624602 18162602 18008008 17177178 12574379 15322207 11554783 17434272 16115399 21435439 14609568 15541506 17241526 16314464 | |
| MESH:D012021 | Reflex, Abnormal | Pentobarbital | 5.45 | 10930210 | |
| MESH:D015427 | Reperfusion Injury | Capsaicin | 3.65 | 18460982 19211983 | |
| MESH:D012120 | Respiration Disorders | Chlorine | 4.63 | 18579056 | |
| MESH:D012130 | Respiratory Hypersensitivity | Lipopolysaccharides | 3.34 | 10835634 | |
| MESH:D012131 | Respiratory Insufficiency | Dichlorvos | 5.10 | 15303389 17350689 | |
| MESH:D012135 | Respiratory Sounds | Dichlorvos | 4.68 | 17119214 16611668 | |
| MESH:D012140 | Respiratory Tract Diseases | Dichlorvos | 4.91 | 16611668 17119214 | |
| MESH:D012208 | Rhabdomyosarcoma | Tretinoin | 3.57 | 16283617 16116481 | |
| MESH:D012468 | Salivary Gland Neoplasms | Progesterone | 2.62 | 18045962 | |
| MESH:D012555 | Schistosomiasis mansoni | Nitric Oxide | 4.90 | 9673227 | |
| MESH:D012640 | Seizures | Diazepam | 14.40 | 15946322 10087439 9754883 | |
| MESH:D012640 | Seizures | Dichlorvos | 14.40 | 12660363 17157343 | |
| MESH:D012640 | Seizures | Dizocilpine Maleate | 14.40 | 12660363 17157343 11218047 | |
| MESH:D012640 | Seizures | Ethanol | 14.40 | 9754883 | |
| MESH:D012640 | Seizures | Pentobarbital | 14.40 | 9754883 10087439 | |
| MESH:D012878 | Skin Neoplasms | Tretinoin | 2.32 | 16467112 | |
| MESH:D013119 | Spinal Cord Injuries | Progesterone | 3.71 | 15862959 16503802 | |
| MESH:D013274 | Stomach Neoplasms | Dichlorvos | 3.23 | 11397402 | |
| MESH:D013274 | Stomach Neoplasms | Ethanol | 3.23 | 18456281 | |
| MESH:D013274 | Stomach Neoplasms | Tretinoin | 3.23 | 17261132 | |
| MESH:D013276 | Stomach Ulcer | Ethanol | 6.13 | 16755016 17189318 17918041 9562338 11906479 9211565 | |
| MESH:D013276 | Stomach Ulcer | Nitric Oxide | 6.13 | 15138204 | |
| MESH:D013322 | Strongyloidiasis | Dichlorvos | 5.56 | 14651886 | |
| MESH:D013375 | Substance Withdrawal Syndrome | Diazepam | 13.82 | 9754883 | |
| MESH:D013375 | Substance Withdrawal Syndrome | Ethanol | 13.82 | 9754883 | |
| MESH:D013375 | Substance Withdrawal Syndrome | Pentobarbital | 13.82 | 11529278 9754883 | |
| MESH:D013705 | Temporomandibular Joint Disorders | Capsaicin | 5.14 | 17997062 | |
| MESH:D013921 | Thrombocytopenia | Lipopolysaccharides | 3.66 | 15821434 | |
| MESH:D013964 | Thyroid Neoplasms | Tretinoin | 2.59 | 17045167 16026305 | |
| MESH:D013978 | Tibial Fractures | Estradiol | 4.10 | 19048282 | |
| MESH:D014062 | Tongue Neoplasms | Tretinoin | 3.29 | 16051514 | |
| MESH:D014376 | Tuberculosis | Tretinoin | 2.85 | 16040207 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Tretinoin | 3.18 | 16129372 | |
| MESH:D014604 | Uveal Neoplasms | Tretinoin | 4.02 | 16752155 | |
| MESH:D020301 | Vasospasm, Intracranial | Ibuprofen | 4.62 | 19057314 | |
| MESH:D018487 | Ventricular Dysfunction, Left | AM 281 | 14.78 | 17678736 | |
| MESH:D018487 | Ventricular Dysfunction, Left | Dietary Sucrose | 14.78 | 18551017 | |
| MESH:D018487 | Ventricular Dysfunction, Left | rimonabant | 14.78 | 17678736 | |
| MESH:D014820 | Vitiligo | Tretinoin | 3.51 | 16761959 | |
| MESH:D015430 | Weight Gain | marker/mechanism | 20107430 | ||
| MESH:D015430 | Weight Gain | Dietary Fats | 3.25 | 16723640 | |
| MESH:D015431 | Weight Loss | Bleomycin | 11.05 | 12624602 | |
| MESH:D015431 | Weight Loss | rimonabant | 11.05 | 20107430 | |
| MESH:D009396 | Wilms Tumor | Tretinoin | 3.48 | 16287080 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04080 | Neuroactive ligand-receptor interaction |
| REACT:14797 | Signaling by GPCR |
| No data |
| Releated disease ID | Related disease Name |
|---|---|
| PA447216 | Schizophrenia |
| PA447268 | tardive dyskinesia |
| PA444460 | Heroin Dependence |
| PA447197 | Attention Deficit Disorder with Hyperactivity |
| PA447207 | Depressive Disorder |
| PA445131 | Obesity |
| PA445190 | Osteoporosis |
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| PA446488 | Dermatitis, Allergic Contact |
| PA446878 | Cocaine-Related Disorders |
| Releated drug ID | Related drug Name |
|---|---|
| PA452233 | antipsychotics |
| PA452619 | heroin |
| PA152407999 | rimonabant |
| PA152408000 | SR144528 |
| PA449072 | cocaine |