AutismKB 2.0

Annotation Detail for CNR2


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Basic Information Top
Gene Symbol:CNR2 ( CB2,CX5 )
Gene Full Name: cannabinoid receptor 2 (macrophage)
Band: 1p36.11
Quick LinksEntrez ID:1269; OMIM: 605051; Uniprot ID:CNR2_HUMAN; ENSEMBL ID: ENSG00000188822; HGNC ID: 2160
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
Osteoporosis
blood pressure, arterial hypertension
bone density
METABOLIC
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C432747 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC binds to and results in increased activity of CNR2 proteinaffects binding|increases activity 15821753
C432747 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC binds to and results in increased activity of CNR2 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]affects binding|increases activity|increases reaction|increases secretion 15821753
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CNR2 mRNAaffects expression 21346803
C094503 2-arachidonylglycerol CNR2 protein affects the reaction [2-arachidonylglycerol results in increased expression of IL8 protein]affects reaction|increases expression 15115777
C094503 2-arachidonylglycerol CNR2 protein affects the reaction [2-arachidonylglycerol results in increased transport of Calcium]affects reaction|increases transport 10617657
C094503 2-arachidonylglycerol Pertussis Toxin inhibits the reaction [CNR2 protein affects the reaction [2-arachidonylglycerol results in increased transport of Calcium]]affects reaction|decreases reaction|increases transport 10617657
C094503 2-arachidonylglycerol [SR 144528 binds to and results in increased activity of CNR2 protein] inhibits the reaction [2-arachidonylglycerol results in increased expression of IL8 protein]affects binding|decreases reaction|increases activity|increases expression 15115777
C094503 2-arachidonylglycerol SR 144528 inhibits the reaction [CNR2 protein affects the reaction [2-arachidonylglycerol results in increased transport of Calcium]]affects reaction|decreases reaction|increases transport 10617657
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 proteinaffects binding|increases activity 10821843
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]affects binding|decreases reaction|increases abundance|increases activity 17558435
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] which results in increased expression of ALDOC mRNAaffects binding|increases activity|increases expression 10821843
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] which results in increased expression of BTG2 mRNAaffects binding|increases activity|increases expression 10821843
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] which results in increased expression of CCL2 mRNAaffects binding|increases activity|increases expression 10821843
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] which results in increased expression of CCL4 mRNAaffects binding|increases activity|increases expression 10821843
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] which results in increased expression of IL8 mRNAaffects binding|increases activity|increases expression 10821843
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] which results in increased expression of JUNB mRNAaffects binding|increases activity|increases expression 10821843
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] which results in increased expression of NFKBIA mRNAaffects binding|increases activity|increases expression 10821843
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] which results in increased expression of TNF mRNAaffects binding|increases activity|increases expression 10821843
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 proteinaffects binding 17397826
10688601
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol CNR2 protein promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CCL2 mRNA]increases expression|increases reaction 10218491
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol CNR2 protein promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CCL2 protein]increases expression|increases reaction 10218491
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol CNR2 protein promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of IL8 mRNA]increases expression|increases reaction 10218491
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol CNR2 protein promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of IL8 protein]increases expression|increases reaction 10218491
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol Ibuprofen analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein]affects binding|decreases reaction 17397826
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol SR 144528 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol SR 144528 inhibits the reaction [CNR2 protein promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CCL2 mRNA]]decreases reaction|increases expression|increases reaction 10218491
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol SR 144528 inhibits the reaction [CNR2 protein promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CCL2 protein]]decreases reaction|increases expression|increases reaction 10218491
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol SR 144528 inhibits the reaction [CNR2 protein promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of IL8 mRNA]]decreases reaction|increases expression|increases reaction 10218491
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol SR 144528 inhibits the reaction [CNR2 protein promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of IL8 protein]]decreases reaction|increases expression|increases reaction 10218491
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 proteinaffects binding 10688601
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 proteinaffects binding 10688601
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol CNR2 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of and results in increased activity of AKT1 protein]affects reaction|increases activity|increases phosphorylation 12734338
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol CNR2 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of and results in increased activity of MAPK1 protein]affects reaction|increases activity|increases phosphorylation 12734338
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol CNR2 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of and results in increased activity of MAPK3 protein]affects reaction|increases activity|increases phosphorylation 12734338
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 proteinaffects binding|increases activity 17220914
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CNR2 mRNAincreases expression 18648102
D000242 Cyclic AMP [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]affects binding|decreases reaction|increases abundance|increases activity 17558435
D000242 Cyclic AMP Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
D000242 Cyclic AMP Pertussis Toxin inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
D000242 Cyclic AMP SR 144528 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
D000242 Cyclic AMP SR 144528 inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
D000242 Cyclic AMP [virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]affects binding|decreases reaction|increases abundance|increases activity 17558435
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CNR2 mRNAaffects expression 16483693
C078814 anandamide anandamide affects the activity of CNR2 proteinaffects activity 19147270
C078814 anandamide anandamide binds to and results in increased activity of CNR2 proteinaffects binding|increases activity 10617657
C078814 anandamide anandamide binds to CNR2 proteinaffects binding 10688601
C078814 anandamide anandamide binds to CNR2 proteinaffects binding 10688601
C078814 anandamide anandamide binds to CNR2 proteinaffects binding 10688601
D016718 Arachidonic Acid CNR2 protein affects the reaction [Arachidonic Acid results in increased expression of IL8 protein]affects reaction|increases expression 15115777
D002118 Calcium CNR2 protein affects the reaction [2-arachidonylglycerol results in increased transport of Calcium]affects reaction|increases transport 10617657
D002118 Calcium Pertussis Toxin inhibits the reaction [CNR2 protein affects the reaction [2-arachidonylglycerol results in increased transport of Calcium]]affects reaction|decreases reaction|increases transport 10617657
D002118 Calcium SR 144528 inhibits the reaction [CNR2 protein affects the reaction [2-arachidonylglycerol results in increased transport of Calcium]]affects reaction|decreases reaction|increases transport 10617657
D002251 Carbon Tetrachloride CNR2 gene mutant form results in increased susceptibility to Carbon Tetrachlorideincreases response to substance 15765409
D013759 Tetrahydrocannabinol CNR2 protein affects the susceptibility to Tetrahydrocannabinolaffects response to substance 18247131
D013759 Tetrahydrocannabinol SR 144528 inhibits the reaction [CNR2 protein affects the susceptibility to Tetrahydrocannabinol]affects response to substance|decreases reaction 18247131
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CNR2 mRNAaffects cotreatment|increases expression 17942748
D005576 Forskolin [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]affects binding|decreases reaction|increases abundance|increases activity 17558435
D005576 Forskolin Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
D005576 Forskolin Pertussis Toxin inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
D005576 Forskolin SR 144528 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
D005576 Forskolin SR 144528 inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
D005576 Forskolin [virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]affects binding|decreases reaction|increases abundance|increases activity 17558435
D007052 Ibuprofen Ibuprofen analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein]affects binding|decreases reaction 17397826
C094023 iodopravadoline iodopravadoline binds to and results in decreased activity of CNR2 proteinaffects binding|decreases activity 17018694
C094023 iodopravadoline iodopravadoline binds to and results in decreased activity of CNR2 proteinaffects binding|decreases activity 16775503
C402944 JHW 015 JHW 015 binds to CNR2 proteinaffects binding 10688601
C402944 JHW 015 JHW 015 binds to CNR2 proteinaffects binding 10688601
C402944 JHW 015 JHW 015 binds to CNR2 proteinaffects binding 10688601
D008070 Lipopolysaccharides [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC binds to and results in increased activity of CNR2 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]affects binding|increases activity|increases reaction|increases secretion 15821753
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of CNR2 mRNAdecreases expression 11448490
C005958 palmidrol palmidrol binds to CNR2 proteinaffects binding 10688601
10617657
C005958 palmidrol palmidrol binds to CNR2 proteinaffects binding 10688601
C005958 palmidrol palmidrol binds to CNR2 proteinaffects binding 10688601
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [CNR2 protein affects the reaction [2-arachidonylglycerol results in increased transport of Calcium]]affects reaction|decreases reaction|increases transport 10617657
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
C025299 polyphenols polyphenols results in decreased expression of CNR2 mRNAdecreases expression 16293270
C110630 SR 144528 [SR 144528 binds to and results in increased activity of CNR2 protein] inhibits the reaction [2-arachidonylglycerol results in increased expression of IL8 protein]affects binding|decreases reaction|increases activity|increases expression 15115777
C110630 SR 144528 SR 144528 binds to CNR2 proteinaffects binding 10688601
C110630 SR 144528 SR 144528 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
C110630 SR 144528 SR 144528 inhibits the reaction [CNR2 protein affects the reaction [2-arachidonylglycerol results in increased transport of Calcium]]affects reaction|decreases reaction|increases transport 10617657
C110630 SR 144528 SR 144528 inhibits the reaction [CNR2 protein promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CCL2 mRNA]]decreases reaction|increases expression|increases reaction 10218491
C110630 SR 144528 SR 144528 inhibits the reaction [CNR2 protein promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CCL2 protein]]decreases reaction|increases expression|increases reaction 10218491
C110630 SR 144528 SR 144528 inhibits the reaction [CNR2 protein promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of IL8 mRNA]]decreases reaction|increases expression|increases reaction 10218491
C110630 SR 144528 SR 144528 inhibits the reaction [CNR2 protein promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of IL8 protein]]decreases reaction|increases expression|increases reaction 10218491
C110630 SR 144528 SR 144528 inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
C110630 SR 144528 SR 144528 binds to CNR2 proteinaffects binding 10688601
C110630 SR 144528 SR 144528 binds to and results in decreased activity of CNR2 proteinaffects binding|decreases activity 12509806
C110630 SR 144528 SR 144528 binds to CNR2 proteinaffects binding 10688601
C110630 SR 144528 SR 144528 inhibits the reaction [CNR2 protein affects the susceptibility to Tetrahydrocannabinol]affects response to substance|decreases reaction 18247131
C110630 SR 144528 SR 144528 binds to and results in decreased activity of CNR2 proteinaffects binding|decreases activity 16775503
15821753
16100529
15748152
14741435
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CNR2 mRNAaffects cotreatment|increases expression 17942748
C456739 virodhamine Pertussis Toxin inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
C456739 virodhamine SR 144528 inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]]affects binding|decreases reaction|increases abundance|increases activity 17558435
C456739 virodhamine [virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]affects binding|decreases reaction|increases abundance|increases activity 17558435
C070417 Win 55212-2 Win 55212-2 binds to CNR2 proteinaffects binding 10688601
C070417 Win 55212-2 Win 55212-2 binds to CNR2 proteinaffects binding 10688601
C070417 Win 55212-2 CNR2 protein affects the reaction [Win 55212-2 results in increased phosphorylation of and results in increased activity of AKT1 protein]affects reaction|increases activity|increases phosphorylation 12734338
C070417 Win 55212-2 CNR2 protein affects the reaction [Win 55212-2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]affects reaction|increases activity|increases phosphorylation 12734338
C070417 Win 55212-2 CNR2 protein affects the reaction [Win 55212-2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]affects reaction|increases activity|increases phosphorylation 12734338
C070417 Win 55212-2 Win 55212-2 binds to CNR2 proteinaffects binding 10688601
C070417 Win 55212-2 Win 55212-2 binds to and results in increased activity of CNR2 proteinaffects binding|increases activity 17220914
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D058186 Acute Kidney Injury Ibuprofen 4.286375363
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.8518653653 11850527
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4814692618
MESH:D000230 Adenocarcinoma Ibuprofen 4.4810697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.643712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1916835633
MESH:D000544 Alzheimer Disease Ibuprofen 3.1318351690
MESH:D000690 Amyotrophic Lateral Sclerosis Tetrahydrocannabinol 4.7115204022
MESH:D000707 Anaphylaxis Ibuprofen 5.069532969
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D050197 Atherosclerosis therapeutic 15815632
MESH:D050197 Atherosclerosis Tetrahydrocannabinol 4.3615815632
MESH:D001321 Autistic Disorder Arachidonic Acid 3.0418582451
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8311289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D002545 Brain Ischemia Ibuprofen 4.6915837124
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7520435547
MESH:D002100 Cachexia Ibuprofen 5.2815141370
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5915673190 10355542 15721981 16011737 15700767 16124888 16227642 16050911 3786805 16192424 16097048 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.3916705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.397296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.3918788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.597296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2618670907 18850075 16120746
MESH:D002375 Catalepsy Tetrahydrocannabinol 5.5310318961
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.637505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0016835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.399022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3917681005 16919318 11677210 16105132 15861022 17110522 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.038697196 12621046 15340226 16354765 15668235
MESH:D003110 Colonic Neoplasms polyphenols 2.6416293270
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6211906362 8970840 8156756 11298694 12868966 14531868 2524372 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.313621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003967 Diarrhea 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 4.7110611417
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.4018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.407440962 6679447 16192314 9022650 1440618 9653073 18289764 6482804 11289319 8291058 9328219 18692083 18648102
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.407120509 4309450 11566570 15027814 6623471 2869522 15998439 6884620 3786805 7179309 15968718 17522070 3732212 16227642 19085960 21278145 16177239 10092053 7440962 9327722 19336974 10915739
MESH:D056486 Drug-Induced Liver Injury polyphenols 11.4019370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.4020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.4218446180 18450898 16133044
MESH:D004487 Edema Arachidonic Acid 6.5511698051 9599246 9831321 7990266 16716910 15177302
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7115322242 16714409 18230668
MESH:D004660 Encephalitis 2-arachidonylglycerol 6.7516364651
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0112538720
MESH:D004715 Endometriosis Ibuprofen 8.6815652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.6810568697 9294722
MESH:D019446 Endotoxemia Ibuprofen 10.1811545620
MESH:D019446 Endotoxemia Lipopolysaccharides 10.1815328337 15821434 17637181
MESH:D004827 Epilepsy Tetrahydrocannabinol 4.39821787
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.063581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.1216239168 61145 15959796 12795759 17595544 12631006 19224547 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.1215345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005334 Fever Arachidonic Acid 14.5011852909
MESH:D005334 Fever Ibuprofen 14.5016997862
MESH:D005334 Fever Lipopolysaccharides 14.5011852909 9205823
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.836705139
MESH:D005355 Fibrosis Carbon Tetrachloride 7.9718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.9720067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.867505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D016489 Head Injuries, Closed 2-arachidonylglycerol 6.7516364651
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2311294989 10048152
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2216366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.616705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.6119110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8515340226 16959395 8697196 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D006984 Hypertrophy Ibuprofen 4.8016672835
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216945680 16569931
MESH:D007022 Hypotension anandamide 5.5714504685
MESH:D007035 Hypothermia Tetrahydrocannabinol 5.7310318961
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.6416133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3617937319
MESH:D007249 Inflammation Arachidonic Acid 14.8615177302 17371808 9831321
MESH:D007249 Inflammation Ibuprofen 14.863291741
MESH:D007249 Inflammation Lipopolysaccharides 14.8612878042 17237260 9205823 17255318 17963957
MESH:D007249 Inflammation polyphenols 14.8616366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.8612200463 12878042
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4517255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.839022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 6.8416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.846582329
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.8516316344
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 15039279
MESH:D007970 Leukopenia Lipopolysaccharides 4.5115821434
MESH:D008103 Liver Cirrhosis marker/mechanism 15765409
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7017174718 17334410 11903743 21278145 11408273 17157831 16943688 16239168 16221502
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.3818418968 16248980 17525996 12632514 12667390 12389079 15876570 18054572 12546737 17708605 13678700 18210741 18156304 12445418 10355542 17714472 12898905 16015684 18412020 15338365 16027843 15673190 17557913 17922224 17640975 18251166 18205269 16638106 18395914 18376398 18279442 17823541 12445421 12666154 17721639 15370692 15818738 14512876 11481614 15730626 14724832 17805973 18420326 17761835 16011737 14716496 15052691 14620537 16033810 18006644 20821823 15925388 12958196 17698563 17869086 14716833 18317297 18705752 18481824 16136751 17900296 16097048 15362042 15931870 17481882 15959796 18429990 17766677 18472332 18277467 17631135 14748882 18166357 16192424 15650968 12632512 12609069 18472094 17976157 18395095 17944888 18263696 15123356 16116963 12649538 15893842 12586293 15057751 17565644 15996030 18339082 12741479 18187930
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3812878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1616964402 17285989 15720792 16246199 15830285
MESH:D008107 Liver Diseases polyphenols 4.1616698588
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5216899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.1619294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.1616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.10598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.1012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.1012151625
MESH:D055370 Lung Injury Lipopolysaccharides 3.8221114838
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2311884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 3.5910697514
MESH:D020326 Migraine without Aura Cyclic AMP 4.9711304026
MESH:D009128 Muscle Spasticity 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 12.9417220914
MESH:D009128 Muscle Spasticity Win 55212-2 12.9417220914
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6718551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.393581430
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.796375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.2410961664
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0314600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.416679447
MESH:D009436 Neural Tube Defects Tetrahydrocannabinol 7.4119040278
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.3312819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.334026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.833988306
MESH:D010003 Osteoarthritis Ibuprofen 4.027009135
MESH:D010024 Osteoporosis Calcium 3.6617882678
MESH:D010146 Pain Ibuprofen 3.783291741
MESH:D010149 Pain, Postoperative Ibuprofen 4.9516678543
MESH:D010190 Pancreatic Neoplasms Ibuprofen 3.4212384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.307296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.286228378
MESH:D011014 Pneumonia Lipopolysaccharides 4.3611605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0011399792 11118676 11896295 11222880
MESH:D011471 Prostatic Neoplasms Ibuprofen 4.2917409433
MESH:D011507 Proteinuria Ibuprofen 4.456375363
MESH:D011537 Pruritus Ethinyl Estradiol 3.1216919318 15861022
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6110835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.233692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.4118551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7516709447
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.0617997062
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.746582329 1399818 6587162 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.7616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.768074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1210091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.0019057314
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26682
    • Releated gene ID Related gene Name
    PA26682CNR2
    Releated disease ID Related disease Name
    PA447197Attention Deficit Disorder with Hyperactivity
    PA447207Depressive Disorder
    PA445131Obesity
    PA445190Osteoporosis
    PA446488Dermatitis, Allergic Contact
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA152407999rimonabant
    PA152408000SR144528
    PA448073ethanol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00470 agonist Dronabinol Antiemetics;Analgesics;Analgesics, Non-Narcotic;Psychotropic Drugs;Hallucinogens
    DB00486 partial agonist Nabilone Anti-anxiety Agents;Antiemetics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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