AutismKB 2.0

Annotation Detail for ADH4


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Basic Information Top
Gene Symbol:ADH4 ( ADH-2 )
Gene Full Name: alcohol dehydrogenase 4 (class II), pi polypeptide
Band: 4q23
Quick LinksEntrez ID:127; OMIM: 103740; Uniprot ID:ADH4_HUMAN; ENSEMBL ID: ENSG00000198099; HGNC ID: 252
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-21ethanol degradation II (cytosol)
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1870Drug abuse
Desease Name
Parkinson's disease
CHEMDEPENDENCY
drug dependence
alcohol abuse
NEUROLOGICAL
alcohol
alcohol dependence
cocaine dependence
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000079 Acetaldehyde ADH4 promoter polymorphism affects the abundance of Acetaldehydeaffects abundance 19182438
D000079 Acetaldehyde ADH4 protein results in increased abundance of Acetaldehydeincreases abundance 19182438
D000082 Acetaminophen Acetaminophen affects the expression of ADH4 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ADH4 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of ADH4 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADH4 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of ADH4 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ADH4 mRNAincreases expression 20127859
D002994 Clofibrate Clofibrate affects the expression of ADH4 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of ADH4 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of ADH4 mRNAdecreases expression 19638242
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of ADH4 mRNAdecreases expression 17072980
D004958 Estradiol Estradiol results in decreased expression of ADH4 mRNAdecreases expression 20106945
D000431 Ethanol ADH4 promoter polymorphism affects the oxidation of Ethanolaffects oxidation 19182438
D000431 Ethanol ADH4 protein results in increased oxidation of Ethanolincreases oxidation 19182438
D005001 Ethionine Ethionine affects the expression of ADH4 mRNAaffects expression 19483382
C052017 ethylene glycol monohexyl ether ADH4 protein results in increased oxidation of ethylene glycol monohexyl etherincreases oxidation 9630456
D005026 Ethylene Glycols ADH4 protein results in increased metabolism of Ethylene Glycolsincreases metabolic processing 15551062
C010176 halofuginone halofuginone results in increased expression of ADH4 mRNAincreases expression 17180598
D008713 Methimazole Methimazole results in decreased expression of ADH4 mRNAdecreases expression 17403546
D009853 Omeprazole Omeprazole affects the expression of ADH4 mRNAaffects expression 19483382
C494474 perchlorate perchlorate results in decreased expression of ADH4 mRNAdecreases expression 17403546
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ADH4 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ADH4 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of ADH4 mRNAincreases expression 17426115
C006253 pirinixic acid pirinixic acid affects the expression of ADH4 mRNAaffects expression 19483382
C035988 procymidone procymidone results in increased expression of ADH4 mRNAincreases expression 15686871
C045950 propiconazole propiconazole results in decreased expression of ADH4 mRNAdecreases expression 19363144
D011441 Propylthiouracil Propylthiouracil affects the expression of ADH4 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil results in decreased expression of ADH4 mRNAdecreases expression 17403546
C031280 pyrazole pyrazole results in decreased activity of ADH4 proteindecreases activity 15551062
D012172 Retinaldehyde ADH4 protein results in increased metabolism of Retinaldehydeincreases metabolic processing 17279314
D012172 Retinaldehyde ADH4 protein results in increased chemical synthesis of Retinaldehydeincreases chemical synthesis 17473173
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNAdecreases expression 20106945
11489354
D013853 Thioacetamide Thioacetamide affects the expression of ADH4 mRNAaffects expression 19483382
D014212 Tretinoin ADH4 protein mutant form results in increased metabolism of Tretinoinincreases metabolic processing 17279314
C032910 triadimefon triadimefon results in decreased expression of ADH4 mRNAdecreases expression 19363144
D014801 Vitamin A ADH4 protein results in increased oxidation of Vitamin Aincreases oxidation 17473173
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.4917676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4911752688 14514962 15322242
MESH:D000015 Abnormalities, Multiple Vitamin A 4.6010992263
MESH:D000138 Acidosis Ammonium Chloride 9.4918287403
MESH:D000138 Acidosis Ethanol 9.4911192467
MESH:D055371 Acute Lung Injury pirinixic acid 2.8518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6820127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 6.6816033868
MESH:D000230 Adenocarcinoma Estradiol 6.6811473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.246695378
MESH:D000236 Adenoma Diethylnitrosamine 10.246695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 10.2419555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.5619052882 19061943 17162532 17620307 16434500 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.5616835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0215451039 15451040
MESH:D000505 Alopecia Tretinoin 3.3815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1311748828
MESH:D000740 Anemia Vitamin A 8.1316960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.5416960172
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D000853 Anophthalmos Ethanol 4.5315513904
MESH:D001008 Anxiety Disorders Ethanol 3.7711141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7819183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5518218290 20041841 18057881
MESH:D001169 Arthritis, Experimental Tretinoin 2.9016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Acetaldehyde 7.629600491
MESH:D001249 Asthma Tretinoin 7.6216456186
MESH:D001249 Asthma Vitamin A 7.6216732791
MESH:D001281 Atrial Fibrillation Amiodarone 3.6918651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1216935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 60.4619483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 60.4619483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 60.4619483382
MESH:D001778 Blood Coagulation Disorders Ethionine 60.4619483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 60.4619483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 60.4619483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 60.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 60.4612125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 60.4619483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 60.4616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2217474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D001943 Breast Neoplasms Estradiol 2.2212948864 14630087 16675129 18497071 19861407 17261762 17289903 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2220435547
MESH:D001943 Breast Neoplasms Tretinoin 2.2216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 12.0316813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 12.0317377406 17426644
MESH:D002056 Burns Ethanol 4.3616374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002277 Carcinoma Dimethylnitrosamine 7.5919555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8616168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.013084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.0112907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 16.011701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.0119519916 3084413 17162532 18506893 20101231 17173139 20935162 16569478 18494052 20214788 17428255 21159647 16830150 11831363 16540662 16288022 20512989 16935385 18978308 16779866 16807293 19052882 18785209 20007298 19383236 20524982 19107877 20727157 19394651 18393292 19335982 19171122 3581430 19539802 20084675 17138121 16698587 17978847 19418558 17761372 18056438 19822196 19919837 18210153 18788625 19701751 16681979 20514400 18665156 18971187 10737359 16502159 19208518 17055752 20432363 18691550 16878318 16328049 10672840
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.0116924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 16.0115289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 16.0117997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.011917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.0520419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 7.0516033868
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.0516051514 16096774
MESH:D006332 Cardiomegaly Ethanol 6.3019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3018670907 16120746 18850075
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 6.1810525098
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7915710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7918974383
MESH:D002386 Cataract Acetaminophen 6.6510977129
MESH:D002386 Cataract Tretinoin 6.6517460283
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 14.391399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.3912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.392727394 7505956 21159647 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.3918566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2916129372
MESH:D002637 Chest Pain Omeprazole 4.8115447763
MESH:D015362 Child Nutrition Disorders Vitamin A 5.1816153327
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.6919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.6916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.6918291259
MESH:D002779 Cholestasis Cyclosporine 12.2819486331
MESH:D002779 Cholestasis pirinixic acid 12.2819176532
MESH:D002779 Cholestasis Vitamin A 12.2816175620
MESH:D002822 Choriocarcinoma Tretinoin 4.8616461808
MESH:D002971 Cleft Lip Ethanol 3.4315513904
MESH:D002972 Cleft Palate Ethanol 17.2715513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 17.2712621046 16354765 15668235 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 17.279407595
MESH:D002972 Cleft Palate triadimefon 17.2716781842
MESH:D002972 Cleft Palate Vitamin A 17.2716054864
MESH:D003092 Colitis Tretinoin 3.4217035595
MESH:D003110 Colonic Neoplasms Vitamin A 2.9917219422 16267017
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8117141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 6.9815451039 15451040 19302082 10194807 11873399 15513904 11198716
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.9815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.9814991402 16925845 9664655 17551590 9224671 10589399 9211117 8800419 9142499 9125849
MESH:D019465 Craniofacial Abnormalities triadimefon 6.9815834900 16875885
MESH:D019465 Craniofacial Abnormalities Vitamin A 6.9810992263
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4216506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1719279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 20.6111529661 15968718 19416960 19085960 11743745 16177239 19739265 17906064 11739529 18071297 18713872 10915739 14725611 16109766 10663392 11287661 16781746 12705907 11461765 16081117 19420014 14986274 19370779 12958197 19164858 19923254 16485898 12153990 17562736 12392966 17522070 2444490 11834606 16393943 12594235 16227642 12540782 14550746 15619225 10774834 11421492
MESH:D056486 Drug-Induced Liver Injury Amiodarone 20.6118218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 20.6119107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 20.618172417
MESH:D056486 Drug-Induced Liver Injury Ethanol 20.6111566570
MESH:D056486 Drug-Induced Liver Injury pyrazole 20.6112499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 20.6120420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 20.6112963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5511462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.5116146918
MESH:D004381 Duodenal Ulcer Omeprazole 4.0521218061 15991576 17151854 16613094
MESH:D050171 Dyslipidemias Clofibrate 3.8616707586
MESH:C538011 Eales disease Vitamin A 5.329068938
MESH:D004480 Ectromelia Vitamin A 5.5216054864
MESH:D004487 Edema pirinixic acid 5.6812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.6812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.9415322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.9418230668
MESH:D016889 Endometrial Neoplasms Estradiol 6.7818566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 6.7816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7710568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8216302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.9016530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 6.9017016578
MESH:D004938 Esophageal Neoplasms Ethanol 6.9016704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.119664655 16938888
MESH:D005218 Fat Necrosis Thioacetamide 5.4216456712
MESH:D005234 Fatty Liver Amiodarone 27.2914986274
MESH:D005234 Fatty Liver Clofibrate 27.2919224547
MESH:D005234 Fatty Liver Cyclosporine 27.2919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 27.2920387270 21071580
MESH:D005234 Fatty Liver Ethanol 27.2919236843 18620774 16409862
MESH:D005234 Fatty Liver pirinixic acid 27.2920131406 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3617920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0016946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005327 Fetal Resorption Vitamin A 5.0616054864
MESH:D005355 Fibrosis Cyclosporine 13.0412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.0420067830
MESH:D005355 Fibrosis Tretinoin 13.0417994277
MESH:D005756 Gastritis Acetaminophen 10.1316983495
MESH:D005756 Gastritis Ethanol 10.1315046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D005909 Glioblastoma Tretinoin 2.8217312396
MESH:D006042 Goiter perchlorate 5.0318801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8616084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 14.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.7211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 14.729664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin A 14.7210992263 16080930
MESH:D006333 Heart Failure pirinixic acid 2.3620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.3115929193 17276928 18665440
MESH:D006505 Hepatitis Thioacetamide 3.9416456712
MESH:D006529 Hepatomegaly Amiodarone 24.0815265979
MESH:D006529 Hepatomegaly pirinixic acid 24.0819772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly propiconazole 24.0817178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 24.0815340226 12621046 16120746
MESH:D006529 Hepatomegaly triadimefon 24.0817178688 17178689
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.5116877224 17436238 16292552 16863852 16490937 15707848
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D015658 HIV Infections Vitamin A 3.6716960176
MESH:D006679 HIV Seropositivity Vitamin A 5.3017209195
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7516354765 18606429 16959395 8697196 15340226
MESH:D006930 Hyperalgesia Acetaminophen 11.7416870215
MESH:D006930 Hyperalgesia Ethanol 11.7418783367
MESH:D006930 Hyperalgesia Tretinoin 11.7416870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.618137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2816778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D006965 Hyperplasia halofuginone 4.9611874485
MESH:D006973 Hypertension Cyclosporine 4.5610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5618850075 18670907
MESH:D006980 Hyperthyroidism Methimazole 5.3314678291
MESH:D006986 Hypervitaminosis A Vitamin A 5.8716054864
MESH:D007037 Hypothyroidism Amiodarone 17.8717991464 18020914
MESH:D007037 Hypothyroidism Methimazole 17.8718031379
MESH:D007037 Hypothyroidism Propylthiouracil 17.878137927 18031379
MESH:D007249 Inflammation Diethylnitrosamine 4.3918785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.3912878042 12200463
MESH:D007333 Insulin Resistance Estradiol 6.5616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.5616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4817994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.5215955940
MESH:D007569 Jaw Abnormalities Ethanol 22.4815513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 22.4816580747
MESH:D007569 Jaw Abnormalities Tretinoin 22.4815992940 17551590
MESH:D007569 Jaw Abnormalities triadimefon 22.4815992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D007674 Kidney Diseases Acetaminophen 8.9915629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 8.9918776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 8.9915618244
MESH:D007680 Kidney Neoplasms Cyclosporine 6.4912371664
MESH:D007680 Kidney Neoplasms Estradiol 6.4915610895
MESH:D007859 Learning Disorders Ethanol 3.9215451040
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.8619248655
MESH:D007938 Leukemia Tretinoin 2.6217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4416932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0319850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9616823087 17301526 19642359 17361223 19035177 19075265 17649720 16935935 16788101 19029980 17107899 16891316 17339181 19225113 17294898 16331271 16766008 17368321 17506722 15748426 9834237 17217047 16140955 12679006 17712046
MESH:D017880 Limb Deformities, Congenital Ethanol 12.6217676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 12.629224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 12.6216054864
MESH:D008064 Lipidoses Amiodarone 3.3015342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.5518407596 18522880 18665156 20032147 19638242
MESH:D008103 Liver Cirrhosis Ethanol 14.5515289165
MESH:D008103 Liver Cirrhosis halofuginone 14.5517180598
MESH:D008103 Liver Cirrhosis Vitamin A 14.5516256175
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8018295389
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 17072980
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 17.4115138612 15591649 18371158 18239293 17196135 15793283 18567088 15744066 15798949 15723089 18637143 18629640 18210741 16169303 15067225 15504291 15842777 15577212 18237412 14568256 15366600 16570917 15733078 16009107 12925901 17724770 17465448 17198567 15161499 14643895 15298665 17203207 16270385 15571005 15086199 16603200 17640959 14709902 17881167 15383259 15339415 18095165 15479170 15369754 14659978 15081153 12918455 17666798 17534399 15763062 16544323 17201889 15942678 16042886 15864749 15492853 15099470 18364076 17036385 14726149 18672772 16627068 17348192 17719030 17432682
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 17.4114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 17.4118166357
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 17.4112175628 18458672 16489207 11172339 14739098
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 17.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Retinaldehyde 17.4116248980
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 17.4112878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 17.4115288472 15316131 10677585 11682029 12085344 17629604 15158331 18032466 15716488 11172339 18031379 18395095 17292413 17355460 18606216 18380797 16248980 15078482 18458672 15474484 16097051 18263696 16343077 16126171 12891558 17050028 16511523 18295389 15288473 17127702 15075984 15095483 12531686 18615449 15334695 18416461 16098781 11481614 15362042 15465738 16489207 12679928 14739098 12175628 12557150
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 17.4116248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 17.4116248980
MESH:D008107 Liver Diseases Acetaminophen 14.8219784758 12969438 12587719 16611625 11587558 19014921 19460945 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 14.8217034775
MESH:D008107 Liver Diseases propiconazole 14.8219363144
MESH:D008107 Liver Diseases Thioacetamide 14.8218374380 15158337 16337175
MESH:D008107 Liver Diseases triadimefon 14.8219363144
MESH:D008107 Liver Diseases Vitamin A 14.8216175620
MESH:D008108 Liver Diseases, Alcoholic Ethanol 10.5817207112 17347304
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 10.5816762690
MESH:D017114 Liver Failure, Acute Acetaminophen 14.8716871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 14.8717457977
MESH:D017114 Liver Failure, Acute Thioacetamide 14.8717276928 12479984 15633222 15313186
MESH:D008113 Liver Neoplasms Aflatoxin B1 23.9318177683 15890375 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 23.9321137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 23.9315175105 20405173 2862719 15885732 19551842 20583210 20101389 19255062 18978307 19256749 18648771 19833225 21071580 19996281 20118626 9163691 19642983 21167192 19254457 20434301 20501860 21047994 2422723 19850985 19090486 10737359 18754104 20492335 12771043 19690152 19812893 20452335 12112319 20137499 21278145 19073162 16942905 19638242 19294768 19426721 19427195 18644402 18977376 19499222
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 23.9315890375 3113478
MESH:D008113 Liver Neoplasms pirinixic acid 23.9316377806 15890375 20007298
MESH:D008113 Liver Neoplasms propiconazole 23.9319028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.9316984957
MESH:D008113 Liver Neoplasms triadimefon 23.9319028983
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 25.468603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.4619126423 18282651 18253720 18093689 18079962 19519916 18164116 18308698 18775883 16842330 18544905 17854601 19009564 3124819 16267830 17942915 19004024 21159647 19539802 9362446 2563599 17174075
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 25.4615603536 6150874 1848544
MESH:D008114 Liver Neoplasms, Experimental propiconazole 25.4617178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.4612151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 25.4617178689
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 25.4617113696
MESH:D008133 Long QT Syndrome Amiodarone 3.3611989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 7.2012587719
MESH:D008171 Lung Diseases Vitamin A 7.2016863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1818516814
MESH:D008175 Lung Neoplasms Acetaldehyde 8.0417372256
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.0414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.0420464547 18520028 18569708 17053015 18816296 20869020 20135361 20064080 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.0421163286 6695378 20970405 20512841
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 8.0416061637 11884234 19555203
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.0419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.3811408345 16891317 17203775 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.1819453300
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma Tretinoin 1.9016752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D008569 Memory Disorders Ethanol 3.9118411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 4.1416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9716381670
MESH:D009101 Multiple Myeloma Vitamin A 3.8516374440
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009181 Mycoses Amiodarone 4.6012754197 17974566
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5116411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.459029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 7.3311141357
MESH:D009369 Neoplasms pirinixic acid 7.3317405874
MESH:D009369 Neoplasms Tretinoin 7.3316594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 14.7016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.7014600291
MESH:D009421 Nervous System Malformations Tretinoin 14.709125849
MESH:D009436 Neural Tube Defects Tretinoin 7.019142499
MESH:D009436 Neural Tube Defects Vitamin A 7.0117400914
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8220387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.659802331
MESH:D009765 Obesity pirinixic acid 1.7420558911
MESH:D010051 Ovarian Neoplasms Estradiol 4.4819401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.4816936753
MESH:D010146 Pain Acetaminophen 5.8116870215
MESH:D010146 Pain Tretinoin 5.8116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.0316540662
MESH:D010190 Pancreatic Neoplasms Ethanol 8.0312384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.0315976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.1212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.122563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9011118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.2216740699
MESH:D011507 Proteinuria Tretinoin 3.3316636307
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011625 Pterygium Tretinoin 4.5016723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7412490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.5116877224
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8316116481 16283617
MESH:D012220 Rhinitis Acetaldehyde 4.4917050345
MESH:D012640 Seizures Ethanol 2.989754883
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7918724381
MESH:D012871 Skin Diseases halofuginone 5.3911874485
MESH:D012871 Skin Diseases Vitamin A 5.3918709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.5610029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.5616192470
MESH:D012878 Skin Neoplasms Tretinoin 8.5616467112
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.9712587719
MESH:D013272 Stomach Diseases Omeprazole 4.3218545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.0520155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.0518456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 6.0516033868
MESH:D013274 Stomach Neoplasms Ethanol 6.0518456281
MESH:D013274 Stomach Neoplasms Tretinoin 6.0517261132
MESH:D013276 Stomach Ulcer Amiodarone 10.6918087811
MESH:D013276 Stomach Ulcer Ethanol 10.6911906479 9562338 17918041 9211565 16755016 17189318
MESH:D013276 Stomach Ulcer Omeprazole 10.6915991576 18237397 10750652 16755016 11906479 17977527
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.009754883
MESH:D013610 Tachycardia Amiodarone 4.0111238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9119225199
MESH:D013733 Testicular Diseases pyrazole 4.526499806
MESH:D013959 Thyroid Diseases Amiodarone 11.0519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.0512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.367505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 15.3615710170
MESH:D013964 Thyroid Neoplasms Tretinoin 15.3616026305 17045167
MESH:D013964 Thyroid Neoplasms triadimefon 15.3617178689
MESH:D013971 Thyrotoxicosis Amiodarone 4.5719584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5316051514
MESH:D016171 Torsades de Pointes Amiodarone 3.9011989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.0516040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.0717053015
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4216129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.3116752155
MESH:D014605 Uveitis Cyclosporine 3.681336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D014802 Vitamin A Deficiency Vitamin A 5.0016175781 16960172 16146918
MESH:D014820 Vitiligo Tretinoin 3.7816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D009396 Wilms Tumor Tretinoin 3.7216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00071 Fatty acid metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00830 Retinol metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24573
    • No data
    Releated disease ID Related disease Name
    PA446879Alcohol-Related Disorders
    Releated drug ID Related drug Name
    PA448073ethanol
    PA448073ethanol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB03559 - Cyclohexylformamide
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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