AutismKB 2.0

Annotation Detail for ADH5


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Basic Information Top
Gene Symbol:ADH5 ( ADH-3,ADHX,FDH,GSNOR )
Gene Full Name: alcohol dehydrogenase 5 (class III), chi polypeptide
Band: 4q23
Quick LinksEntrez ID:128; OMIM: 103710; Uniprot ID:ADHX_HUMAN; ENSEMBL ID: ENSG00000197894; HGNC ID: 253
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-21ethanol degradation II (cytosol)
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00071Fatty acid metabolism
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No data
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
2066Lung cancer
2074Asthma
2106Pancreas cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ADH5 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ADH5 mRNAaffects expression 17562736
C004984 apocarotenal apocarotenal results in increased expression of ADH5 mRNAincreases expression 17034753
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ADH5 mRNAdecreases expression 20064835
D019207 beta Carotene beta Carotene results in increased expression of ADH5 mRNAincreases expression 17034753
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ADH5 mRNAdecreases expression 16872691
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADH5 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADH5 mRNAaffects cotreatment|increases expression 17942748
D011374 Progesterone [Progesterone results in increased activity of PGR protein] which results in increased expression of ADH5 mRNAincreases activity|increases expression 15845616
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADH5 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3520464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.023712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.026695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7117868700
MESH:D001930 Brain Injuries Progesterone 4.5615665606 15380490 15845082
MESH:D002545 Brain Ischemia beta Carotene 5.4316157235
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8317474063 20146248
MESH:D001943 Breast Neoplasms Progesterone 1.8315562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.917296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.917505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.459022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4516919318 17110522 11677210 17681005 16105132 17333356 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 15668235 12621046 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.102524372 18759878 14531868 11298694 11906362 8970840 8156756 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.8017187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.471440618 18692083 9328219 18289764 16192314 8291058 7440962 9653073 6679447 9022650 18648102 6482804 11289319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4718071297 10774834 10915739 15968718 12705907 16081117 12540782 14986274 16781746 19085960 19739265 17562736 14550746 16109766 17906064 12958197 11529661 12392966 14725611 16393943 11461765 16177239 11287661 17522070 10663392 16227642 12153990 16485898 19420014 19416960 11739529 19370779 11743745 11421492 12594235 11834606 19164858 15619225 18713872 2444490 19923254
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.9917692515
MESH:D004715 Endometriosis Progesterone 9.7016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.7010568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.533581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8210048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2012621046 15340226 16120746
MESH:D015658 HIV Infections beta Carotene 4.1516960176
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Progesterone 5.3515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3512878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.176582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.339327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719784758 11587558 19460945 16611625 12969438 12587719 19014921 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5920195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.796587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 10.7917113696
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7912151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6418816296 20869020 18569708 18520028 20464547 6695378 20135361 20064080 17053015
MESH:D008175 Lung Neoplasms beta Carotene 3.6416401635
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0111408345 17203775
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.8011141357
MESH:D009369 Neoplasms beta Carotene 5.8017051425
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.656482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010051 Ovarian Neoplasms Progesterone 2.5816525653 17393432
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9218045962
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.6216503802 15862959
MESH:D013272 Stomach Diseases beta Carotene 5.4317638125
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer beta Carotene 4.5012500499
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.066582329 6587162 7505956 3712494 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.248074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00071 Fatty acid metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00830 Retinol metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24574
    • Releated gene ID Related gene Name
    PA39ADRB2
    Releated disease ID Related disease Name
    PA443450Asthma
    PA446879Alcohol-Related Disorders
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA448068salbutamol
    PA448073ethanol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB03017 - Lauric Acid
    DB03704 - 12-Hydroxydodecanoic Acid
    DB04153 - S-Hydroxymethyl Glutathione
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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