AutismKB 2.0

Annotation Detail for KLF17


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Basic Information Top
Gene Symbol:KLF17 ( FLJ40160,ZNF393,Zfp393 )
Gene Full Name: Kruppel-like factor 17
Band: 1p34.1
Quick LinksEntrez ID:128209; OMIM: 609602; Uniprot ID:KLF17_HUMAN; ENSEMBL ID: ENSG00000171872; HGNC ID: 18830
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KLF17 mRNAaffects expression 17562736
C006780 bisphenol A bisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of KLF17 mRNA]decreases expression|decreases reaction 19228888
D010634 Phenobarbital Phenobarbital affects the expression of KLF17 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of KLF17 mRNAaffects expression 19136022
D014284 Triiodothyronine bisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of KLF17 mRNA]decreases expression|decreases reaction 19228888
D014284 Triiodothyronine Triiodothyronine results in decreased expression of KLF17 mRNAdecreases expression 19228888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.986195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.9817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.9816434500
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001862 Bone Resorption bisphenol A 4.2411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.4317123778
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.013084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.0120007298 6705139 20935162 17173139 1701930
MESH:D002278 Carcinoma in Situ bisphenol A 5.5317123778
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.662444490 19085960 19164858 17906064 18713872 11461765 12540782 19416960 16485898 19420014 11743745 14725611 12153990 15968718 12594235 11421492 12392966 16177239 17562736 19739265 19923254 11834606 12705907 12958197 15619225 16781746 10774834 16227642 16393943 17522070 19370779 16081117 10663392 16109766 11739529 14986274 11529661 18071297 14550746 10915739 11287661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.483922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D005234 Fatty Liver pirinixic acid 3.1420131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly Phenobarbital 10.1416109766
MESH:D006529 Hepatomegaly pirinixic acid 10.1419772884 16221962 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007333 Insulin Resistance bisphenol A 8.0416393666
MESH:D007333 Insulin Resistance pirinixic acid 8.0416306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0721047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.1716610002 19784758 16611625 12969438 11587558 19460945 12587719 19014921
MESH:D008107 Liver Diseases Phenobarbital 4.1719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.8319812893 21047994 8742319 19073162 15975961 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 4.8320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.906150874 17172636 18308698 1399818 2563599
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009421 Nervous System Malformations bisphenol A 4.4116427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010049 Ovarian Diseases bisphenol A 5.5311985600
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5916965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.952563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.4910548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.5820887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3516740699
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D011629 Puberty, Precocious bisphenol A 5.3310548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012640 Seizures Phenobarbital 2.9211442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D019966 Substance-Related Disorders bisphenol A 4.5216684133 16045194
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.321399818
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014591 Uterine Diseases bisphenol A 5.6214652134
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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