AutismKB 2.0

Annotation Detail for IQGAP3


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Basic Information Top
Gene Symbol:IQGAP3 ( MGC10170,MGC10831,MGC1947 )
Gene Full Name: IQ motif containing GTPase activating protein 3
Band: 1q22
Quick LinksEntrez ID:128239; OMIM: NA; Uniprot ID:IQGA3_HUMAN; ENSEMBL ID: ENSG00000183856; HGNC ID: 20669
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
No data
Pathway IDPathway Name
200190RAC1 signaling pathway
200057CDC42 signaling events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of IQGAP3 mRNAincreases expression 20713471
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of IQGAP3 mRNAaffects expression 17331233
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IQGAP3 mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of IQGAP3 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of IQGAP3 mRNAaffects expression 17351261
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of IQGAP3 mRNAincreases expression 20713471
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D000236 Adenoma Methylcholanthrene 3.666695378 10545420
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6211922910
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.7111921183
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.7117474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016124888 15700767 16050911 15721981 18705752 15673190 16192424 16227642 16097048 3786805 16011737 10355542
MESH:D002277 Carcinoma Methylcholanthrene 4.2210545420
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6220889678
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.6216192471
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1017333356 17681005 17110522 16105132 15861022 16919318 11677210
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.114309450 3786805 16177239 6884620 7440962 7120509 21278145 10092053 9327722 3732212 6623471 19336974 16227642 7179309 15998439 15027814 2869522 11566570 15968718 17522070 10915739 19085960
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.7961145 15959796 19224547 12631006 16045604 12795759 17595544 16239168
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.7915345470
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.4014633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8718705752
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719900420 19110552
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9617157831 11408273 11903743 16943688 17174718 21278145 17334410 16239168 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7517708605 12649538 17761835 17823541 15673190 12389079 15730626 18395914 12632514 15931870 15650968 18412020 18339082 18376398 17565644 17557913 18420326 14620537 13678700 15338365 17900296 14716496 18205269 17922224 12632512 16638106 16011737 17714472 16097048 15818738 10355542 12666154 12445421 14512876 12667390 12898905 17944888 15925388 18481824 18472332 17721639 17869086 15057751 18006644 18156304 12445418 18187930 12546737 16116963 17481882 11481614 14748882 18166357 16136751 15996030 18054572 12609069 18277467 14724832 16015684 17766677 17805973 20821823 15370692 17976157 16248980 18418968 18472094 15893842 18251166 12586293 18210741 18279442 17698563 18317297 15959796 12741479 15123356 15876570 16027843 17631135 14716833 15362042 16033810 17640975 18705752 18429990 15052691 18395095 18263696 16192424 12958196 17525996
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1416964402 15830285 16246199 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9914706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3119294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.8012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.80598648 1399818
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.4417365036
MESH:D008175 Lung Neoplasms Methylcholanthrene 2.4116337739 11893704 20970405 17909032 16271038 10545420 15390079 20512841 1399818 6695378 9230183 21163286 7750092
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.7611921183
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2818303189 16966607 16166281
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.3110923243
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1315814490 17365031 17322281 17975199
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
Pathway ID Pathway Name
KEGG:04810 Regulation of actin cytoskeleton
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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