AutismKB 2.0

Annotation Detail for ARHGEF19


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Basic Information Top
Gene Symbol:ARHGEF19 ( FLJ33962,RP4-733M16.1,WGEF )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 19
Band: 1p36.13
Quick LinksEntrez ID:128272; OMIM: 612496; Uniprot ID:ARHGJ_HUMAN; ENSEMBL ID: ENSG00000142632; HGNC ID: 26604
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ARHGEF19 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ARHGEF19 mRNAaffects expression 17562736
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ARHGEF19 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ARHGEF19 mRNA]decreases reaction|increases expression 17942915
D010634 Phenobarbital Phenobarbital results in decreased expression of ARHGEF19 mRNAdecreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARHGEF19 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.986195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000236 Adenoma Diethylnitrosamine 3.036695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.7818056438 19061943 17620307 19052882 17162532 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.7817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.7816434500
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1917474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.923084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.9220935162 16878318 17761372 17138121 16807293 16698587 19394651 19539802 20524982 20214788 19519916 19171122 18506893 16569478 19052882 19919837 17428255 17978847 18210153 17055752 18785209 16502159 20084675 16328049 18393292 16540662 19701751 17173139 3084413 16288022 18056438 16830150 18691550 20727157 21159647 18788625 16681979 10672840 19335982 19208518 3581430 20514400 18971187 18978308 16779866 16935385 11831363 18665156 10737359 19418558 19822196 20512989 20007298 17162532 20101231 19107877 19383236 20432363 18494052
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.9217173139 1701930 6705139 20007298 20935162
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.092727394 21159647 17174075 7505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 4.0119052882
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6916177239 11529661 19085960 19739265 14986274 11743745 19416960 19164858 11461765 12153990 18071297 12540782 16227642 10663392 11834606 17906064 16781746 19420014 14725611 18713872 16081117 11287661 16109766 10915739 12958197 12594235 12705907 11739529 2444490 14550746 16393943 17562736 15619225 15968718 19370779 10774834 19923254 17522070 12392966 16485898 11421492
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6919107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.483922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.7316302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.9520387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 8.9520131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly Phenobarbital 10.1416109766
MESH:D006529 Hepatomegaly pirinixic acid 10.1418467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007249 Inflammation Diethylnitrosamine 2.5318785209
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2816705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.2218665156 18522880 18407596 20032147 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 7.2221047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 6.9212969438 12587719 19014921 16611625 19460945 11587558 16610002 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 6.9217034775
MESH:D008107 Liver Diseases Phenobarbital 6.9219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0719638242 2422723 20452335 19090486 19426721 19073162 9163691 20434301 21278145 19850985 18644402 19833225 10737359 19551842 19812893 16942905 20492335 20501860 19499222 19427195 18754104 18978307 19256749 20118626 20405173 21047994 19996281 15885732 21071580 19690152 19642983 20583210 2862719 21167192 20137499 18977376 12112319 19255062 12771043 19254457 18648771 19294768 15175105 20101389
MESH:D008113 Liver Neoplasms Phenobarbital 8.0719073162 19812893 8742319 19482888 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 8.0716377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.6717942915 19004024 18544905 18093689 18079962 17854601 18164116 2563599 18775883 19126423 18253720 21159647 16842330 17174075 19539802 3124819 19009564 19519916 18282651 18308698 16267830 9362446
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.671399818 18308698 17172636 6150874 2563599
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 21163286 20512841
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.689029167 3581430
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.2218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 9.2220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.7320387270
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7816049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.6116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.6116965848
MESH:D011230 Precancerous Conditions Diethylnitrosamine 10.192563599
MESH:D011230 Precancerous Conditions Phenobarbital 10.192563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012640 Seizures 2,4-dinitrotoluene 6.7118551238
MESH:D012640 Seizures Phenobarbital 6.713137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 8.107505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.101399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
MESH:D014581 Urticaria Acetaminophen 3.3810982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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