AutismKB 2.0

Annotation Detail for TSHZ2


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Basic Information Top
Gene Symbol:TSHZ2 ( C20orf17,DKFZp686K2480,FLJ33887,OVC10-2,TSH2,ZABC2,ZNF218 )
Gene Full Name: teashirt zinc finger homeobox 2
Band: 20q13.2
Quick LinksEntrez ID:128553; OMIM: NA; Uniprot ID:TSH2_HUMAN; ENSEMBL ID: ENSG00000182463,ENSG00000227164; HGNC ID: 13010
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
hemoglobin
Desease Name
Hemoglobin
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TSHZ2 mRNAincreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of TSHZ2 mRNAincreases expression 20406850
D000968 Antimycin A Antimycin A results in decreased expression of TSHZ2 mRNAdecreases expression 19304788
D001104 Arbutin Arbutin results in decreased expression of TSHZ2 mRNAdecreases expression 17103032
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TSHZ2 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TSHZ2 mRNAaffects expression 17484886
D008345 Manganese Manganese results in increased expression of TSHZ2 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of TSHZ2 mRNAincreases expression 17175027
D010100 Oxygen Oxygen deficiency results in increased expression of TSHZ2 mRNAincreases expression 17175027
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TSHZ2 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of TSHZ2 mRNAdecreases expression 19482888
D012402 Rotenone Rotenone results in decreased expression of TSHZ2 mRNAdecreases expression 19304788
D043343 Testosterone Propionate Testosterone Propionate results in decreased expression of TSHZ2 mRNAdecreases expression 15601916
D014635 Valproic Acid Valproic Acid results in increased expression of TSHZ2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.926195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.928875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D055371 Acute Lung Injury Oxygen 4.6216759491
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.0917620307
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000756 Anemia, Sideroblastic Manganese 11.3016910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.3016910769
MESH:D000860 Anoxia Oxygen 5.1720872349
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D050197 Atherosclerosis Oxygen 3.8516391483
MESH:D001321 Autistic Disorder Valproic Acid 2.0018316065 15238991 17688650 16609825 17157402 18396377 18775368 18558336 18985861 18940202 20603192 18177632 19232924 17507914 19460635
MESH:D001714 Bipolar Disorder Valproic Acid 3.1120046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.458888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4520146248 17474063
MESH:D001943 Breast Neoplasms Oxygen 2.4517263869
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8816097048 3786805 16011737 10355542 18705752 16227642 16124888 16050911 16192424 15721981 15700767 15673190
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6616705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6618788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.6620007298 6705139 1701930 17173139 20935162
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0720419170
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.826135515
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.364080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.3921278145 4309450 15027814 3732212 10092053 15968718 6884620 6623471 7179309 9327722 2869522 16227642 19085960 19336974 11566570 10915739 17522070 15998439 7440962 7120509 3786805 16177239
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.391733752 19641884
MESH:D004417 Dyspnea Oxygen 4.9720016425
MESH:D004421 Dystonia Phenobarbital 10.731851702
MESH:D004421 Dystonia Valproic Acid 10.731851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 11.153659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.153659116 17275665
MESH:D004828 Epilepsies, Partial Phenobarbital 10.4311558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 10.4316628512 3922381
MESH:D004827 Epilepsy Phenobarbital 6.8020417680
MESH:D004827 Epilepsy Valproic Acid 6.8020417680 18234410
MESH:D004832 Epilepsy, Absence Phenobarbital 9.106401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.106426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.657750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.657750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.883659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.883659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1461145 16239168 19224547 17595544 16045604 15959796 12795759 12631006
MESH:D005234 Fatty Liver Valproic Acid 8.1419224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.238888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5618705752
MESH:D005739 Gas Poisoning Oxygen 5.3520016425
MESH:D005909 Glioblastoma Manganese 3.9717043766
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6920471113
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 3.5916109766
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0416705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1616294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7811903743 16221502 17157831 11408273 17334410 16943688 17174718 16239168 21278145
MESH:D008103 Liver Cirrhosis Phenobarbital 6.7821047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7516033810 15893842 18205269 18472332 14724832 16015684 18395914 14748882 18156304 12445418 10355542 18472094 12586293 14512876 17721639 18054572 15362042 12389079 13678700 15931870 18420326 12666154 12445421 15650968 17631135 18277467 18187930 15052691 18339082 17698563 12546737 17823541 12632514 16011737 15876570 16136751 18376398 18263696 18279442 16638106 17900296 14716496 17708605 15370692 15673190 17922224 18481824 17869086 17766677 17481882 17761835 15959796 15338365 15925388 12898905 17976157 15123356 18006644 18166357 12649538 17565644 17557913 15818738 14620537 16027843 12667390 16097048 17714472 18705752 15057751 16116963 17525996 18418968 18317297 12632512 17944888 17805973 16248980 15730626 18210741 18395095 20821823 12609069 11481614 15996030 18251166 12958196 18412020 17640975 16192424 12741479 18429990 14716833
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1617285989 15830285 16964402 16246199 15720792
MESH:D008107 Liver Diseases Phenobarbital 4.1619363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7716899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.957678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.9520195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.9519294768
MESH:D008113 Liver Neoplasms Phenobarbital 10.9515975961 21047994 19812893 19073162 19482888 8742319
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.152876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.1512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.151399818 18308698 17172636 2563599 6150874
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D055370 Lung Injury Oxygen 4.6118339021
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5620064080 18520028 20135361 17053015 18569708 20869020 18816296 20464547 6695378
MESH:D020149 Manganese Poisoning Manganese 5.6519453300 16551646 16568477
MESH:D008881 Migraine Disorders Valproic Acid 3.2518765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009069 Movement Disorders Manganese 5.1016551646
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2017596541
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5917484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9818551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2011141357
MESH:D009410 Nerve Degeneration Manganese 9.0616551646
MESH:D009410 Nerve Degeneration Rotenone 9.0618619942 15790535 17356569
MESH:D009436 Neural Tube Defects Valproic Acid 3.188888407 16359493
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5116049721
MESH:D010018 Osteomalacia Phenobarbital 4.4817016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5216965848
MESH:D010300 Parkinson Disease Manganese 5.8811181820
MESH:D010300 Parkinson Disease Rotenone 5.8811445065 18191903 18619942 16412576 19232380 19114014 15451049 11535288 16140633
MESH:D020734 Parkinsonian Disorders Manganese 9.7616140633
MESH:D020734 Parkinsonian Disorders Rotenone 9.7615795934 15574749 15927086 18197244
MESH:D011230 Precancerous Conditions Phenobarbital 3.692563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9520603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9617292933
MESH:D019310 Pseudolymphoma Phenobarbital 12.6412752131
MESH:D019310 Pseudolymphoma Valproic Acid 12.6411422049 12752131
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.5917627322 18339021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 10.1618551238
MESH:D012640 Seizures Phenobarbital 10.163137016 16876388 11442880 4039156
MESH:D012640 Seizures Valproic Acid 10.1614763951 15475178 11738929 1511512 16876388 11044598 3137016 17978042
MESH:D003294 Seizures, Febrile Phenobarbital 4.946407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4010029692 19755658
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013398 Sudden Infant Death Oxygen 5.6612563064
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.111399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0717053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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