AutismKB 2.0

Annotation Detail for COL5A2


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Basic Information Top
Gene Symbol:COL5A2 ( MGC105115 )
Gene Full Name: collagen, type V, alpha 2
Band: 2q32.2
Quick LinksEntrez ID:1290; OMIM: 120190; Uniprot ID:CO5A2_HUMAN; ENSEMBL ID: ENSG00000204262; HGNC ID: 2210
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05146Amoebiasis
hsa04974Protein digestion and absorption
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Axon guidance
Signaling by PDGF
No data
Pathway IDPathway Name
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Ehlers-Danlos syndrome, type I
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in decreased expression of COL5A2 mRNAdecreases expression 20713471
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of COL5A2 proteinaffects expression 20106945
C000188 alachlor alachlor results in increased expression of COL5A2 mRNAincreases expression 12419858
D019386 Alendronate Alendronate affects the expression of COL5A2 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of COL5A2 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of COL5A2 mRNAdecreases expression 19654921
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of COL5A2 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of COL5A2 mRNAdecreases expression 20713471
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of COL5A2 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of COL5A2 mRNAincreases expression 17484886
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNA]decreases reaction|increases expression 18200517
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of COL5A2 mRNAincreases expression 19638242
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of COL5A2 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of COL5A2 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of COL5A2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL5A2 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of COL5A2 mRNAaffects expression 16079270
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of COL5A2 mRNAincreases expression 12655037
D005419 Flavonoids Flavonoids results in increased expression of COL5A2 mRNAincreases expression 18035473
D005472 Fluorouracil COL5A2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of COL5A2 mRNAdecreases expression 20713471
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of COL5A2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of COL5A2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of COL5A2 mRNAdecreases expression 17426115
D011374 Progesterone Progesterone results in decreased expression of COL5A2 mRNAdecreases expression 18070364
D020849 Raloxifene Raloxifene affects the expression of COL5A2 mRNAaffects expression 16079270
D013467 Sulindac Sulindac results in increased expression of COL5A2 mRNAincreases expression 18499699
C004648 testosterone enanthate testosterone enanthate affects the expression of COL5A2 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of COL5A2 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of COL5A2 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL5A2 mRNAaffects cotreatment|increases expression 17942748
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNAincreases expression 18200517
C025643 vinclozolin vinclozolin affects the expression of COL5A2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.3214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6814514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D058186 Acute Kidney Injury Sulindac 4.167897758
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 13.0820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 13.0811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 13.0814692618
MESH:D000230 Adenocarcinoma Fluorouracil 13.0817638652
MESH:D000230 Adenocarcinoma Sulindac 13.0811910360
MESH:D000236 Adenoma Benzo(a)pyrene 15.236695378
MESH:D000236 Adenoma Diethylnitrosamine 15.236695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 15.2310545420 6695378
MESH:D000236 Adenoma Sulindac 15.2310223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.2819061943 17162532 17620307 18056438 19052882 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.2816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.2816835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.4519003578 11874996 15623613 11535846 16460482 17611924 12394442
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0417306315
MESH:D000382 Agricultural Workers' Diseases alachlor 4.4914769641 11874814
MESH:D000419 Albuminuria Raloxifene 4.4317308373 17451421
MESH:D019973 Alcohol-Related Disorders Curcumin 4.9117887948
MESH:D000544 Alzheimer Disease Curcumin 4.3015590663
MESH:D000544 Alzheimer Disease Raloxifene 4.3015800139
MESH:D000740 Anemia Fluorouracil 8.1815504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1811748828
MESH:D001008 Anxiety Disorders vinclozolin 3.5019015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9019183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8218414634 12569548 16835338 16251483
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5615885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7016807698
MESH:D050197 Atherosclerosis Arsenic 10.5419371607 12928151
MESH:D050197 Atherosclerosis Curcumin 10.5418704882
MESH:D050197 Atherosclerosis Methylcholanthrene 10.5411922910
MESH:D001327 Autoimmune Diseases Curcumin 4.3219761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.2519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001913 Bowen's Disease Sulindac 5.1811207687
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1717868700
MESH:D001930 Brain Injuries Progesterone 10.4015665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 10.4016580743
MESH:D002545 Brain Ischemia Curcumin 4.1616770732
MESH:D001932 Brain Neoplasms Curcumin 3.7917596214
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 8.1311921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 8.1320146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 8.1318462866 19250217 18593918 16243823
MESH:D001943 Breast Neoplasms Diethylnitrosamine 8.1317474063
MESH:D001943 Breast Neoplasms Estradiol 8.1317261762 16675129 19861407 17018787 17289903 18497071 14630087 12948864
MESH:D001943 Breast Neoplasms Fluorouracil 8.1319217205 15136595 18357371 16595493 16110121 18608205 16557594
MESH:D001943 Breast Neoplasms Methylcholanthrene 8.1317474063
MESH:D001943 Breast Neoplasms Progesterone 8.1317614352 15562024 16175315
MESH:D001943 Breast Neoplasms Raloxifene 8.1317595753 15758505 17261762 17893378 16912660 15572757 15775269 17440819 17242785 17049068 16837676 17952589
MESH:D001943 Breast Neoplasms Sulindac 8.1316642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.1320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6116192424 15700767 16050911 15673190 3786805 15721981 16011737 16227642 18705752 16097048 16124888 10355542
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5016051944
MESH:D002277 Carcinoma Curcumin 18.8418593918
MESH:D002277 Carcinoma Fluorouracil 18.8417121937
MESH:D002277 Carcinoma Methylcholanthrene 18.8410545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 18.8416835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5017687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.0312619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Arsenic 11.0316507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.0318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.0316807293 18210153 19539802 20727157 16830150 19052882 17428255 16569478 19822196 3084413 18785209 18506893 20524982 16878318 19519916 20214788 16779866 16935385 19701751 20514400 17978847 16502159 19171122 17761372 11831363 18393292 16540662 16328049 18978308 18788625 19335982 18056438 20935162 20432363 3581430 17055752 16288022 20101231 17138121 19107877 17173139 18691550 20007298 19383236 16698587 20512989 21159647 10737359 20084675 16681979 19394651 18665156 19919837 19208518 18971187 10672840 17162532 18494052 19418558
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.0316924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.0316332177 17045692 17088986 18930000 16799960 17971768
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9218414057
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9418695887
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.4115504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.4120419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 10.4118462866
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.4117066447 16757204 18986760 16280240
MESH:D002295 Carcinoma, Transitional Cell Arsenic 9.1718640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.1717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2718850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 7.1615738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases Raloxifene 7.1615775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.1616973168 18022660
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.6121159647 2727394 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.6118566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 10.6116192471
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3217110522 16105132 15861022 16919318 17333356 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 7.3219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0312621046 15668235 16354765 15340226 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.4515800139
MESH:D003092 Colitis Curcumin 9.3818200517 16804969 16782535
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 9.3811698051 18023891 16782535 17991707 16474422 17936198 16804969 18200517 16867261
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3917276891
MESH:D003103 Coloboma Curcumin 4.3918809619
MESH:D003110 Colonic Neoplasms Curcumin 5.8019359593 16340194
MESH:D003110 Colonic Neoplasms Fluorouracil 5.8017016597 15001691 17018589 16510598 16340194 17725105 17287894 17172411 18772588 17169374
MESH:D003110 Colonic Neoplasms Sulindac 5.8012902858 12458338
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8118949393 17454858 17594712 18383874 17094418 15148649 17255274 18802399 18288408 20501625 15289873 17695437 16331619 18509181 18448328 16303861 17401013 16524972 17016601 16282729 16391804 14970324
MESH:D015179 Colorectal Neoplasms Sulindac 2.8111197048 18059344 10666051 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9117141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.7318497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.1714966744
MESH:D007644 Darier Disease Fluorouracil 4.6216733453
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0217474826
MESH:D017449 Dermatitis, Allergic Contact alachlor 4.028428444
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.8818403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8817107852
MESH:D003928 Diabetic Nephropathies Curcumin 14.2518204486
MESH:D003928 Diabetic Nephropathies Estradiol 14.2519279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.2515920148 17308373 17451421
MESH:D003929 Diabetic Neuropathies Progesterone 4.3217187935
MESH:D003930 Diabetic Retinopathy Sulindac 5.0117621415 12861449
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.8916177239 10092053 7440962 21278145 11566570 9327722 15968718 15027814 19085960 10915739 6623471 6884620 7120509 16227642 19336974 7179309 3786805 17522070 15998439 4309450 3732212 2869522
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.8919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.8920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8817351913
MESH:D004487 Edema pirinixic acid 10.5312083418
MESH:D004487 Edema Raloxifene 10.5315860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.5311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7318230668 16714409 15322242
MESH:C536194 Ehlers-Danlos syndrome type 1 marker/mechanism
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.4212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.4217692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.4215845917
MESH:D016889 Endometrial Neoplasms Estradiol 2.8718566989 11473722 19148513
MESH:D004715 Endometriosis Progesterone 14.4716134523
MESH:D004715 Endometriosis Sulindac 14.4715652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.479294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9416302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.1116337965 16481741 15173087 16785472 17638652
MESH:D004938 Esophageal Neoplasms Sulindac 7.1112235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.6917595544 61145 19224547 12631006 16045604 12795759 16239168 15959796
MESH:D005234 Fatty Liver Curcumin 28.6919297423
MESH:D005234 Fatty Liver Diethylnitrosamine 28.6921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.6915345470
MESH:D005234 Fatty Liver pirinixic acid 28.6920131406 19236843
MESH:D005234 Fatty Liver Raloxifene 28.6917473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.3014745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.9619069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7714633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 19.8118705752
MESH:D005355 Fibrosis Curcumin 19.8118705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.8120067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 19.8117994277
MESH:D005534 Foot Diseases Arsenic 5.396392382
MESH:D005764 Gastroesophageal Reflux Sulindac 4.8411910360
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5218462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7616973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1316417039
MESH:D005909 Glioblastoma Curcumin 3.3717596214
MESH:D005910 Glioma Fluorouracil 2.8016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.5818462866 18829502
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.5815162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1511294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.4211110106
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.7019176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7016120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8717701891
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.5717440010
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8716959395 16354765 18606429 15340226 8697196
MESH:D006930 Hyperalgesia Alendronate 4.5816769263
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006937 Hypercholesterolemia Curcumin 3.9018704882
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3017050553
MESH:D006973 Hypertension Arsenic 8.309931084 11953799 16076760
MESH:D006973 Hypertension Raloxifene 8.3017577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.3018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D006987 Hypesthesia Arsenic 5.3916093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2315869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male alachlor 10.7116466525 17049205 12948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.7117937319
MESH:D007248 Infertility, Male vinclozolin 10.7116467254
MESH:D007249 Inflammation Curcumin 18.8317151092 18403477 16956363
MESH:D007249 Inflammation Diethylnitrosamine 18.8318785209
MESH:D007249 Inflammation Flavonoids 18.8317296493
MESH:D007249 Inflammation Progesterone 18.8315869954
MESH:D007249 Inflammation Sulindac 18.833291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.8312200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.4618596194 18200517
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.4618200517
MESH:D007333 Insulin Resistance Estradiol 6.8316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.8316306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.4417994277
MESH:D007414 Intestinal Neoplasms Curcumin 9.6210783313
MESH:D007414 Intestinal Neoplasms Sulindac 9.6212663524 12628509 12584176 12351151 10223192 10213222
MESH:D007417 Intestinal Polyps Sulindac 4.8311245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007642 Keratosis Arsenic 4.8216930632 12749816
MESH:D007674 Kidney Diseases Estradiol 2.4915618244
MESH:D007680 Kidney Neoplasms Estradiol 7.0215610895
MESH:D007680 Kidney Neoplasms Fluorouracil 7.0216985049
MESH:D007889 Leiomyoma Curcumin 10.6218555241
MESH:D007889 Leiomyoma Raloxifene 10.6216973256
MESH:D007938 Leukemia alachlor 6.6714769641
MESH:D007938 Leukemia Curcumin 6.6718462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.0516106398
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4417339181
MESH:D015458 Leukemia, T-Cell Curcumin 4.6016106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5616417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3011903743 21278145 16943688 17334410 11408273 16239168 17157831 16221502 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3018665156 19638242 18407596 18522880 20032147
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.1212468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5018187930 17761835 12586293 13678700 15650968 15338365 15996030 17805973 18420326 15876570 12609069 18210741 18317297 18156304 16136751 16027843 14716833 17708605 15123356 17721639 14748882 18429990 12741479 16248980 18395095 18279442 18472332 12667390 16011737 17525996 18277467 12632514 11481614 15730626 18481824 10355542 12649538 12445421 18472094 18205269 15057751 18418968 17944888 15673190 16116963 17640975 18339082 18006644 15362042 17557913 20821823 14620537 16097048 12898905 17481882 17922224 15893842 18054572 18705752 16015684 12632512 12445418 17976157 16638106 18166357 12546737 17766677 18376398 16033810 18251166 18263696 17714472 14724832 14716496 17631135 15818738 16192424 14512876 12958196 15370692 15931870 12666154 15052691 17823541 15959796 12389079 17565644 17698563 17869086 18412020 17900296 15925388 18395914
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.5018705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5012878042
MESH:D008107 Liver Diseases Arsenic 12.0811134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 12.0815830285 17285989 15720792 16246199 16964402
MESH:D008107 Liver Diseases Curcumin 12.0816956363
MESH:D008107 Liver Diseases Diethylnitrosamine 12.0817034775
MESH:D008107 Liver Diseases Sulindac 12.0814986274 16867024
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5416899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.849163691 15890375 18177683 2125692
MESH:D008113 Liver Neoplasms Arsenic 24.8416368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.8420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 24.8419294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.8420492335 18977376 12771043 18754104 21047994 18644402 10737359 19426721 2862719 19294768 20583210 19812893 2422723 21278145 19255062 20452335 19499222 19254457 19690152 20434301 19996281 18978307 20405173 19551842 19256749 20118626 19427195 20501860 19833225 15175105 12112319 19090486 21071580 20101389 20137499 18648771 16942905 15885732 21167192 19850985 9163691 19073162 19642983 19638242
MESH:D008113 Liver Neoplasms Fluorouracil 24.8416603448 15113037 18383874 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 24.8415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.8416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.528603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.5212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.5216842330 19539802 17942915 18775883 18308698 19009564 19126423 16267830 18253720 18544905 3124819 18079962 18164116 17854601 18282651 2563599 9362446 17174075 19519916 21159647 18093689 19004024
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 17.52598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.5212151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 15.0214755239
MESH:D008175 Lung Neoplasms Arsenic 15.0217976673 17306315 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 15.0220135361 17053015 6695378 18520028 18569708 20464547 18816296 20064080 20869020
MESH:D008175 Lung Neoplasms Curcumin 15.0218462866 19359593 16243823
MESH:D008175 Lung Neoplasms Diethylnitrosamine 15.0221163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 15.0215246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 15.026695378 11893704 1399818 21163286 9230183 10545420 20512841 20970405 7750092 16271038 17909032 16337739 15390079
MESH:D008175 Lung Neoplasms Sulindac 15.0219359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.0211884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6215086387
MESH:D008223 Lymphoma Curcumin 3.4718462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.5216173963
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 9.4711921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.4711408345 17203775 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.4711408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.3119453300
MESH:D008545 Melanoma Curcumin 3.7118462866 17885582
MESH:D008545 Melanoma Sulindac 3.7116642371
MESH:D008569 Memory Disorders Curcumin 3.9917263510
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3815863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.0916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.0916757204 18986760
MESH:D009101 Multiple Myeloma alachlor 11.6514769641
MESH:D009101 Multiple Myeloma Curcumin 11.6519372569
MESH:D009101 Multiple Myeloma Raloxifene 11.6516497877
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7517962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Arsenic 8.5515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.5512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8116411023
MESH:D009232 Myxoma Raloxifene 5.3816343187
MESH:D009361 Neoplasm Invasiveness Curcumin 4.2018495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.509029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7311141357
MESH:D009369 Neoplasms Fluorouracil 7.7318600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 7.7317405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.3612497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009421 Nervous System Malformations Estradiol 8.9116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9114600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.4618462866
MESH:D009436 Neural Tube Defects Arsenic 3.3416620997
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.2320387270
MESH:D019636 Neurodegenerative Diseases Sulindac 8.2317266991 16850258
MESH:D020078 Neurogenic Inflammation Arsenic 4.2117056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9420387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3216436463
MESH:D009669 Nose Neoplasms alachlor 4.6516178123 11127290 15580706 16698726 14563481
MESH:D009765 Obesity Curcumin 4.4619297423
MESH:D009765 Obesity pirinixic acid 4.4620558911
MESH:D010024 Osteoporosis Alendronate 11.5317882678
MESH:D010024 Osteoporosis Curcumin 11.5318719352
MESH:D010024 Osteoporosis Raloxifene 11.5317882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0717823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms Arsenic 10.8917306315
MESH:D010051 Ovarian Neoplasms Curcumin 10.8919020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 10.8919401270
MESH:D010051 Ovarian Neoplasms Progesterone 10.8916525653 17393432
MESH:D010146 Pain Sulindac 3.653291741
MESH:D010190 Pancreatic Neoplasms Curcumin 11.8919401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.8916540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.8919003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Sulindac 11.8916820089 11504793
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.0417698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.826392382 15371236 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.412563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9111399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.9119015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.7618220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7320887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8816140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Curcumin 1.8810851300 11398177 12497104 18226269 18769126 15129424 18156803
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8819082440 18626508
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8815731164 16220300 16536755
MESH:D011472 Prostatitis vinclozolin 4.7618629315
MESH:D011507 Proteinuria Arsenic 3.8421343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.1415861022 16919318
MESH:D011656 Pulmonary Emphysema Curcumin 4.3819168576
MESH:D011693 Purpura Raloxifene 5.3815770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8616160472 15538739 18286688 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8718379247 10666014
MESH:D012135 Respiratory Sounds alachlor 4.7811874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8018045962
MESH:D012509 Sarcoma Curcumin 3.9718462866
MESH:D018805 Sepsis Curcumin 3.9318389075
MESH:D012871 Skin Diseases Arsenic 2.706392382 19834688 17938729 16759981 16353154 16702368 18709164 17548696 17453740 17050553 15952646
MESH:D012878 Skin Neoplasms Arsenic 12.9117050553 15504454 16251483 19538983 17976673 17029826
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.9110029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.918532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.9116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7716709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.1115862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.262093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2618456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2619084572 17522103 16951190 18396642 19015929 18567086 16424979 17498489 17172411 15786421
MESH:D013276 Stomach Ulcer Curcumin 3.3516631530 19188055
MESH:D020521 Stroke Raloxifene 3.6916837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013964 Thyroid Neoplasms alachlor 7.208812207
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.207505956
MESH:D013978 Tibial Fractures Estradiol 13.1419048282
MESH:D013978 Tibial Fractures Raloxifene 13.1419048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8416280240
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.4311144890 19322015 17976673 15987713 19429237 17306315 18640142
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.4317053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 11.4318593936
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.4317572228
MESH:D014565 Urogenital Neoplasms Curcumin 5.0918462866
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.7316803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.1214692618
MESH:D014594 Uterine Neoplasms Sulindac 9.1218645019
MESH:D014652 Vascular Diseases Arsenic 4.5617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3814671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
REACT:18266 Axon guidance
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:04974 Protein digestion and absorption
REACT:16888 Signaling by PDGF
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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