AutismKB 2.0

Annotation Detail for COL6A3


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Basic Information Top
Gene Symbol:COL6A3 ( DKFZp686D23123,DKFZp686K04147,DKFZp686N0262,FLJ34702,FLJ98399 )
Gene Full Name: collagen, type VI, alpha 3
Band: 2q37.3
Quick LinksEntrez ID:1293; OMIM: 120250; Uniprot ID:CO6A3_HUMAN; ENSEMBL ID: ENSG00000163359; HGNC ID: 2213
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04974Protein digestion and absorption
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Axon guidance
Signaling by PDGF
No data
Pathway IDPathway Name
P00034Integrin signalling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Bethlem myopathy
Ullrich congenital muscular dystrophy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]affects cotreatment|decreases reaction|increases response to substance 18435905
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]decreases reaction|increases response to substance 18435905
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester [Cyclosporine co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]affects cotreatment|decreases reaction|increases response to substance 18435905
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of COL6A3 mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of COL6A3 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of COL6A3 mRNAdecreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of COL6A3 mRNAdecreases expression 20713471
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of COL6A3 mRNAincreases expression 17484886
D016572 Cyclosporine [Cyclosporine co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]affects cotreatment|decreases reaction|increases response to substance 18435905
D016572 Cyclosporine Cyclosporine inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]decreases reaction|increases response to substance 18435905
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNAaffects cotreatment|increases expression 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D004041 Dietary Fats Dietary Fats results in decreased expression of COL6A3 mRNAdecreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of COL6A3 mRNAincreases expression 15289156
D004317 Doxorubicin COL6A3 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004533 Egtazic Acid [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]affects cotreatment|decreases reaction|increases response to substance 18435905
D004533 Egtazic Acid [Cyclosporine co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]affects cotreatment|decreases reaction|increases response to substance 18435905
D004958 Estradiol Estradiol results in increased expression of COL6A3 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of COL6A3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of COL6A3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL6A3 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil COL6A3 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of COL6A3 mRNA]affects reaction|decreases expression 15016801
D019833 Genistein Genistein results in increased expression of COL6A3 mRNAincreases expression 15289156
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNAaffects cotreatment|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D007529 Isoflavones Isoflavones affects the expression of COL6A3 mRNAaffects expression 16365062
D009840 Oligomycins COL6A3 gene mutant form results in increased susceptibility to Oligomycinsincreases response to substance 18435905
D017239 Paclitaxel COL6A3 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
C041786 palm oil palm oil results in decreased expression of COL6A3 mRNAdecreases expression 18042831
D010672 Phenytoin Phenytoin results in increased expression of COL6A3 mRNAincreases expression 8224229
C006253 pirinixic acid pirinixic acid results in decreased expression of COL6A3 mRNAdecreases expression 17426115
D011794 Quercetin Quercetin results in increased expression of COL6A3 mRNAincreases expression 16455785
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNAaffects cotreatment|increases expression 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D012402 Rotenone [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]affects cotreatment|decreases reaction|increases response to substance 18435905
D012402 Rotenone 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]decreases reaction|increases response to substance 18435905
D012402 Rotenone COL6A3 gene mutant form results in increased susceptibility to Rotenoneincreases response to substance 18435905
D012402 Rotenone [Cyclosporine co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]affects cotreatment|decreases reaction|increases response to substance 18435905
D012402 Rotenone Cyclosporine inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]decreases reaction|increases response to substance 18435905
D012402 Rotenone Thapsigargin promotes the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]increases reaction|increases response to substance 18435905
C017947 sodium arsenite sodium arsenite results in decreased expression of COL6A3 mRNAdecreases expression 18812580
D013467 Sulindac Sulindac results in increased expression of COL6A3 mRNAincreases expression 18499699
D014284 Triiodothyronine Triiodothyronine results in increased expression of COL6A3 mRNAincreases expression 15507505
D013629 Tamoxifen Tamoxifen affects the expression of COL6A3 mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of COL6A3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL6A3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of COL6A3 mRNA]decreases reaction|increases expression 15667827
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of COL6A3 mRNAincreases expression 16922920
19933214
D019284 Thapsigargin Thapsigargin promotes the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]increases reaction|increases response to substance 18435905
C025643 vinclozolin vinclozolin affects the expression of COL6A3 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of COL6A3 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 11.8714745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 11.8714745880
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 7.558986270 3425630 6195326 10563481 9677735 9118846
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5511752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D058186 Acute Kidney Injury Sulindac 4.017897758
MESH:D055371 Acute Lung Injury pirinixic acid 2.8118653653
MESH:D000230 Adenocarcinoma arsenic trioxide 23.1111798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 23.1120127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 23.1117418594
MESH:D000230 Adenocarcinoma Estradiol 23.1111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 23.1114692618
MESH:D000230 Adenocarcinoma Fluorouracil 23.1117638652
MESH:D000230 Adenocarcinoma Genistein 23.1111473722
MESH:D000230 Adenocarcinoma Sulindac 23.1111910360
MESH:D000236 Adenoma Benzo(a)pyrene 6.316695378
MESH:D000236 Adenoma Sulindac 6.3110223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7716835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.3112394442 15623613 19003578 11874996 17611924 11535846 16460482
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5616712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.2221441931
MESH:D000505 Alopecia Isoflavones 4.4517569567
MESH:D000544 Alzheimer Disease rosiglitazone 2.7819621015
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1615469931
MESH:D000740 Anemia Fluorouracil 7.7115504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7111748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.9417084956
MESH:D000799 Angioedema Acetaminophen 3.5010982225
MESH:D001008 Anxiety Disorders vinclozolin 3.3719015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7419183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.8015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.8011256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.6717659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.6715885639
MESH:D001260 Ataxia Telangiectasia Quercetin 4.6415336622
MESH:D050197 Atherosclerosis Phenytoin 3.7215136057
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001327 Autoimmune Diseases Quercetin 4.0819761891
MESH:C535436 Bethlem myopathy marker/mechanism
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.5216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.5219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.5212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5515746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3514601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.2515867366
MESH:D001913 Bowen's Disease Sulindac 5.0111207687
MESH:D001932 Brain Neoplasms Doxorubicin 3.5217150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 9.1920146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 9.1920435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 9.1917129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 9.1916096432 16826403 15136595 16322301 18628466 16595493 19526202 17426702 16115903 18382427 15668708 15567936 11325840 16264153 17369602 16935488 17983394 18695136 15993339 18234424 15994142 15692762 15634643 15939500
MESH:D001943 Breast Neoplasms Estradiol 9.1918497071 16675129 17289903 17261762 14630087 19861407 17018787 12948864
MESH:D001943 Breast Neoplasms Fluorouracil 9.1916557594 15136595 16595493 18608205 18357371 19217205 16110121
MESH:D001943 Breast Neoplasms Genistein 9.1916873071 17200150 16541309
MESH:D001943 Breast Neoplasms Paclitaxel 9.1918323546 16115903 15136595 18234424 16244791 11325840 16273361 18223236
MESH:D001943 Breast Neoplasms Quercetin 9.1918628248
MESH:D001943 Breast Neoplasms Sulindac 9.1916642371
MESH:D001943 Breast Neoplasms Tamoxifen 9.1921152245 18984771 18997820 20544844 18821012 16202921 19410462 18425577 19289846 18855134 16273361 19155303 16873071 19142967 17242785 15668708 17440819 15565566 19059307 20135344 20859285 19103187 19244106 18629630 16818667 11161223 19066611 18351453 19200415 20005174 21138602 19115204 20065188 17893378 19189212 17261762 20390343 19487384 19011961 19288272 18815881 19221464 19189210 19084267 17049068
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.1920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0211589617
MESH:D002105 Cadmium Poisoning Quercetin 5.2016962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.8316192424 16097048 3786805 16124888 18705752 16011737 16050911 16227642 15673190 10355542 15700767 15721981
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.8316050911
MESH:D002276 Carcinoid Tumor Doxorubicin 11.2016051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.2016051944
MESH:D002277 Carcinoma Fluorouracil 7.3017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.3016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 27.873084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 27.8711135700 16217749 15073043 15553829 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 27.8718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 27.8716924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 27.8716023760 18059187 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 27.8716924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 27.8716332177 18930000 17045692 17088986 17971768 16799960
MESH:D006528 Carcinoma, Hepatocellular Genistein 27.8716924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 27.8716313753
MESH:D006528 Carcinoma, Hepatocellular Quercetin 27.8719519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 27.8717306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 27.8716924424
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6217234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5319014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.1316201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.1318695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.9220419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 9.926189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 9.9216757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.9218572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3217572228
MESH:D006332 Cardiomegaly Quercetin 6.1719794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.1716120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.3116731534 17131338 15811867 17329180 16651473 15476868 15792986 16269455 17974986 17351982 16612575 16364871 17382496 15505089 16278810 17519947 17924179 16242529 17928571 16109756 16952015 16455267 17007740 18627295 17308081
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8316243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 6.9816332659
MESH:D002318 Cardiovascular Diseases Isoflavones 6.9817689850
MESH:D002386 Cataract Acetaminophen 2.3810977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 9.8212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.8218566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.8219524636 20056578
MESH:D002493 Central Nervous System Diseases Phenytoin 4.974080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8816835633
MESH:D002779 Cholestasis Cyclosporine 11.8919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.8917681005 15861022 17333356 17110522 16919318 11677210 16105132
MESH:D002779 Cholestasis pirinixic acid 11.8919176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.5311748493
MESH:D002971 Cleft Lip Phenytoin 3.972227380
MESH:D002972 Cleft Palate Phenytoin 5.6710789828 6862529 1687470 2227380 3877104 6856622
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6715340226 8697196 12621046 16354765 15668235
MESH:D003103 Coloboma Phenytoin 4.859212184
MESH:D003110 Colonic Neoplasms Dexamethasone 10.3415824018
MESH:D003110 Colonic Neoplasms Fluorouracil 10.3417287894 17725105 17172411 16510598 16340194 15001691 17016597 18772588 17018589 17169374
MESH:D003110 Colonic Neoplasms Genistein 10.3417182828
MESH:D003110 Colonic Neoplasms Quercetin 10.3415741050 11134977 16640504 19440933 19056647 17148506 17191121
MESH:D003110 Colonic Neoplasms Sulindac 10.3412458338 12902858
MESH:D015179 Colorectal Neoplasms arsenic trioxide 9.9120501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 9.9118802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 9.9116524972 18509181 15148649 17594712 18383874 18288408 16282729 18448328 17401013 17255274 17695437 18949393 16331619 17094418 18802399 17454858 20501625 15289873 16391804 16303861 14970324 17016601
MESH:D015179 Colorectal Neoplasms Isoflavones 9.9117116718
MESH:D015179 Colorectal Neoplasms Paclitaxel 9.9118802399
MESH:D015179 Colorectal Neoplasms Quercetin 9.9118852136 18095365
MESH:D015179 Colorectal Neoplasms Sulindac 9.9118059344 10666051 11197048 11076880
MESH:D000013 Congenital Abnormalities Phenytoin 8.4410627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.4414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 6.8910525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.8917728286
MESH:D019465 Craniofacial Abnormalities Phenytoin 6.898986270 19952982 9212184
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.8910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 6.8919769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.2912952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 10.2914966744
MESH:D007644 Darier Disease Fluorouracil 4.4516733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0319031437
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.0912438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.0217446233
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.4619496084
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.6616647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 6.6612642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.6617107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.9019279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.9019279558
MESH:D003930 Diabetic Retinopathy Sulindac 4.8517621415 12861449
MESH:D003967 Diarrhea Dexamethasone 3.387237001
OMIM:607208 DRAVET SYNDROME Phenytoin 5.0611748493
MESH:D003875 Drug Eruptions Phenytoin 5.1715024534
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.0611743745 16109766 12540782 11834606 11287661 17562736 11739529 14725611 11529661 12958197 19739265 19370779 10915739 16485898 14550746 15968718 17906064 16177239 10663392 16081117 12594235 16781746 10774834 19085960 15619225 16227642 19923254 14986274 2444490 16393943 18713872 12392966 12153990 11461765 19420014 11421492 19164858 12705907 18071297 19416960 17522070
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.066623471 15968718 10092053 16177239 6884620 19085960 15998439 2869522 15027814 10915739 7179309 16227642 11566570 21278145 19336974 7440962 9327722 3732212 17522070 7120509 4309450 3786805
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.0617416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.0620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7519426721
MESH:D004362 Drug Toxicity Doxorubicin 7.2818602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.2811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2118367378
MESH:C538011 Eales disease Vitamin E 4.369068938
MESH:D004485 Eczema Dexamethasone 4.1412438553
MESH:D004487 Edema Dexamethasone 13.9919703484
MESH:D004487 Edema pirinixic acid 13.9912083418
MESH:D004487 Edema rosiglitazone 13.9912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.9911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5616714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.5712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 13.5717654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.5719031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.7616402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.7616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 20.9916804899 15700306
MESH:D016889 Endometrial Neoplasms Doxorubicin 20.9917359293
MESH:D016889 Endometrial Neoplasms Estradiol 20.9919148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 20.9911473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 20.9920544844 17893378 16202921 19155303
MESH:D004715 Endometriosis Sulindac 8.2215652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.2210568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8118037988
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.8720235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.891399206 6251365
MESH:D004828 Epilepsies, Partial Phenytoin 4.5711558140 17116037
MESH:D004827 Epilepsy Phenytoin 3.76821787 20417680 11434505
MESH:D017029 Epilepsy, Complex Partial Phenytoin 4.977750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 4.733659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 12.8212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.8216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.8216785472 17638652 16337965 16481741 15173087
MESH:D004938 Esophageal Neoplasms Paclitaxel 12.8216481741
MESH:D004938 Esophageal Neoplasms Sulindac 12.8212235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7611564622
MESH:D005234 Fatty Liver arsenic trioxide 38.0315073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 38.0317595544 19224547 12631006 61145 15959796 16239168 16045604 12795759
MESH:D005234 Fatty Liver Cyclosporine 38.0319224547
MESH:D005234 Fatty Liver Dietary Fats 38.0319004024 19551842 18296743 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 38.0315345470
MESH:D005234 Fatty Liver pirinixic acid 38.0319236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 38.0319196556
MESH:D005234 Fatty Liver Tamoxifen 38.0319224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.5216002989 16611131 15751030 16513791 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.5216709447
MESH:D005313 Fetal Death Phenytoin 9.6310627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.6311858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 11.8214745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 11.8214745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 17.5719069698
MESH:D018222 Fibromatosis, Aggressive Sulindac 17.5719069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 17.5719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 24.2018705752
MESH:D005355 Fibrosis Cyclosporine 24.2012168785 12639820
MESH:D005355 Fibrosis Dietary Fats 24.2018296743
MESH:D005355 Fibrosis Quercetin 24.2019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.2020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9416904648
MESH:D005756 Gastritis Acetaminophen 3.3316983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.6911910360
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5916973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9516417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.6816452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.6816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 11.778708960
MESH:D005885 Gingival Hyperplasia Phenytoin 11.779029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.8916390469 14659971
MESH:D005909 Glioblastoma Doxorubicin 10.7017150277
MESH:D005909 Glioblastoma Genistein 10.7016598420
MESH:D005909 Glioblastoma Quercetin 10.7019804834
MESH:D005910 Glioma Fluorouracil 5.7216145905
MESH:D005910 Glioma Quercetin 5.7217643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2510696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.1615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.1615162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.0420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.0410048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 10.0416080930
MESH:D006331 Heart Diseases Doxorubicin 3.2516707910 17888722 18674790 12587719 16330681 16244371 16144979 18006777 17875725 14766674 16244372 16879835 16495754
MESH:D006333 Heart Failure Doxorubicin 6.3517481944
MESH:D006333 Heart Failure pirinixic acid 6.3520558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6015692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2719110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 7.1618467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.1612621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.567520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.5616863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.6915709030
MESH:D006689 Hodgkin Disease Doxorubicin 6.5418501091 15147373 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 6.5412676792
MESH:D019584 Hot Flashes Estradiol 15.1617088409
MESH:D019584 Hot Flashes Isoflavones 15.1617290160 14716179
MESH:D019584 Hot Flashes Vitamin E 15.1614716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7016959395 8697196 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.0016870215
MESH:D006930 Hyperalgesia rosiglitazone 7.0012083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1916899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2921332399
MESH:D006943 Hyperglycemia pirinixic acid 8.2720558911
MESH:D006943 Hyperglycemia Quercetin 8.2711834736 18262572
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.3910459572
MESH:D006949 Hyperlipidemias Dietary Fats 3.3021332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1012960047 14722030
MESH:D006973 Hypertension Cyclosporine 11.2610903974
MESH:D006973 Hypertension Dexamethasone 11.2617042910
MESH:D006973 Hypertension Quercetin 11.2618356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.2618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7515338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.1416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.1416945680 16569931
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.1018306037
MESH:D007246 Infertility Diethylstilbestrol 4.0315036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.8917937319
MESH:D007248 Infertility, Male sodium arsenite 9.8912646999 15346721
MESH:D007248 Infertility, Male vinclozolin 9.8916467254
MESH:D007249 Inflammation Dexamethasone 17.628960868 11099482
MESH:D007249 Inflammation Dietary Fats 17.6220412841
MESH:D007249 Inflammation rosiglitazone 17.6212083418
MESH:D007249 Inflammation Sulindac 17.623291741
MESH:D007249 Inflammation Tamoxifen 17.6219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.6212200463 12878042
MESH:D007251 Influenza, Human Quercetin 9.9216624496
MESH:D007251 Influenza, Human Vitamin E 9.9216624496
MESH:D007333 Insulin Resistance Dietary Fats 15.8411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 15.8416627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 15.8416306350
MESH:D007333 Insulin Resistance rosiglitazone 15.8416306350
MESH:D007414 Intestinal Neoplasms Sulindac 4.3412628509 12351151 10213222 10223192 12584176 12663524
MESH:D007417 Intestinal Polyps Sulindac 4.6711245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0316580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.1018306037
MESH:D007627 Keloid Quercetin 4.6217086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0915604871
MESH:D007674 Kidney Diseases Acetaminophen 25.8115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 25.8118776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 25.8116775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 25.8115618244
MESH:D007674 Kidney Diseases Quercetin 25.8116962696
MESH:D007674 Kidney Diseases sodium arsenite 25.8120008137
MESH:D007674 Kidney Diseases Vitamin E 25.8112488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8516707910
MESH:D007680 Kidney Neoplasms Cyclosporine 20.4312371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 20.4315003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 20.4315610895
MESH:D007680 Kidney Neoplasms Fluorouracil 20.4316985049
MESH:D007680 Kidney Neoplasms Tamoxifen 20.4318625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7317184923
MESH:D007938 Leukemia arsenic trioxide 9.5415070760
MESH:D007938 Leukemia Genistein 9.5417468513 18980019
MESH:D007938 Leukemia Quercetin 9.5417468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8116085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4917077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0819850784 16467208 16968895 20471514 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.9916966277 15748426 11161223 12018890 16823087 15622746 17649720 17869043 19225113 16331271 12679006 17217047 9834237 15213294 19035177 17107899 16112521 16330433 16891316 15336539 17712046 19642359 12712474 11468182 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0316882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3916417039
MESH:D008064 Lipidoses Tamoxifen 2.9115342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.5117353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.0016943688 17157831 16221502 17334410 11408273 17174718 16239168 21278145 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 6.0018296743
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.0112468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 19.8017481882 18279442 17922224 15057751 17805973 15925388 16638106 18705752 17761835 14512876 18412020 17900296 15338365 12667390 15673190 17976157 15931870 11481614 18395914 18429990 17708605 18481824 16248980 15370692 18054572 17640975 15730626 12445421 18210741 16015684 12649538 16027843 12632514 14724832 18277467 17525996 18472094 17698563 14748882 13678700 16136751 14620537 18472332 18263696 17869086 18418968 18251166 16116963 18339082 18420326 17766677 20821823 12632512 10355542 12586293 18006644 18376398 12666154 12546737 18166357 15818738 12445418 16192424 12389079 17631135 18205269 12898905 16011737 12958196 15052691 15996030 17721639 18187930 12609069 15362042 15893842 12741479 18317297 17557913 16097048 15123356 18156304 17714472 16033810 14716496 14716833 15876570 17565644 17823541 15959796 15650968 18395095 17944888
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 19.8016718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 19.8016439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 19.8014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 19.8017823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 19.8015474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 19.8012741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 19.8015980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 19.8018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 19.8012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 19.8016169303
MESH:D008107 Liver Diseases Acetaminophen 8.6619014921 11587558 19460945 16611625 12969438 12587719 19784758 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.6616246199 16964402 15830285 17285989 15720792
MESH:D008107 Liver Diseases Phenytoin 8.6614986274
MESH:D008107 Liver Diseases Sulindac 8.6616867024 14986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.4317185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.4316899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 31.5014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 31.5021137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 31.5019294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 31.5015890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 31.5017045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 31.5020007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 31.5018980244
MESH:D008113 Liver Neoplasms sodium arsenite 31.5015276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 31.5016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 31.5016984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 16.3920377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.3915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 16.3917085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Quercetin 16.3919519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.3912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0915213294
MESH:D008171 Lung Diseases sodium arsenite 6.6819095001
MESH:D008171 Lung Diseases Vitamin E 6.6816863852
MESH:D008175 Lung Neoplasms arsenic trioxide 19.4411798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 19.4418816296 20064080 18569708 18520028 20464547 20869020 17053015 20135361 6695378
MESH:D008175 Lung Neoplasms Dexamethasone 19.4411195469 15824018
MESH:D008175 Lung Neoplasms Doxorubicin 19.4417418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 19.4415246190
MESH:D008175 Lung Neoplasms Quercetin 19.4416280456
MESH:D008175 Lung Neoplasms sodium arsenite 19.4417077188 15276417 19931552 17306315 16712894
MESH:D008175 Lung Neoplasms Sulindac 19.4419359593 15713900
MESH:D008175 Lung Neoplasms Tamoxifen 19.4418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 19.4419555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 19.4411062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4515086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8115166399
MESH:D008223 Lymphoma Diethylstilbestrol 6.9415700306
MESH:D008223 Lymphoma Doxorubicin 6.9416098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.0517654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 8.0514749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2315621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1716002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4219428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 16.5115458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.5111807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 16.5114578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 16.5116827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 16.5119196722 19196723 16827153 14580682 11731420
MESH:D020149 Manganese Poisoning Estradiol 11.4919453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.4919453300
MESH:D008545 Melanoma Doxorubicin 9.0816827129
MESH:D008545 Melanoma Paclitaxel 9.0816342250 12025231 12040289
MESH:D008545 Melanoma sodium arsenite 9.0819082730 16487513
MESH:D008545 Melanoma Sulindac 9.0816642371
MESH:D008545 Melanoma Tamoxifen 9.0812393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2419513568
MESH:D008607 Mental Retardation Phenytoin 3.559212184
MESH:D008654 Mesothelioma Doxorubicin 2.9217638057
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1017261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4416801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1915792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.6716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.6716757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.4517415656
MESH:D009101 Multiple Myeloma arsenic trioxide 10.8319549372 19417148 15949261 11468182 14977855
MESH:D009101 Multiple Myeloma Dexamethasone 10.8315744524 15867202 16118317
MESH:D009101 Multiple Myeloma Paclitaxel 10.8314749477
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.9116882451 16105982
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.919809623
MESH:D009203 Myocardial Infarction Doxorubicin 12.3515857846 19429709
MESH:D009203 Myocardial Infarction Genistein 12.3517141266
MESH:D009203 Myocardial Infarction pirinixic acid 12.3519151258
MESH:D009203 Myocardial Infarction Quercetin 12.3519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 18.1716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 18.1717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 18.1716411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 18.1719207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.1817484760
MESH:D009224 Myotonia Congenita Phenytoin 5.071896199
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6416624393
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.7918259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 8.7915867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.7919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 17.5511141357
MESH:D009369 Neoplasms Diethylstilbestrol 17.5515313581
MESH:D009369 Neoplasms Fluorouracil 17.5518600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 17.5517405874
MESH:D009369 Neoplasms Quercetin 17.5515185748
MESH:D009369 Neoplasms sodium arsenite 17.5511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3420056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6519200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3917289903
MESH:D009401 Nephrosis Doxorubicin 4.4416899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.3518481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.3515640375 16889571
MESH:D009410 Nerve Degeneration Rotenone 3.6217356569 15790535 18619942
MESH:D009421 Nervous System Malformations Diethylstilbestrol 20.8011399458
MESH:D009421 Nervous System Malformations Estradiol 20.8016427766 11399458
MESH:D009421 Nervous System Malformations Genistein 20.8016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.8014600291
MESH:D009436 Neural Tube Defects arsenic trioxide 11.0110525206
MESH:D009436 Neural Tube Defects Phenytoin 11.019118846
MESH:D009436 Neural Tube Defects sodium arsenite 11.0112854658
MESH:D009447 Neuroblastoma Doxorubicin 3.0915555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6118514411
MESH:D019636 Neurodegenerative Diseases Sulindac 7.6116850258 17266991
MESH:D020078 Neurogenic Inflammation Quercetin 4.0517929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2116436463
MESH:D009765 Obesity Dietary Fats 4.1317217161 16723640 20518802 18457598 11836018 19632207 21332399 18674790 20132043
MESH:D009765 Obesity pirinixic acid 4.1320558911
MESH:D010014 Osteolysis Paclitaxel 4.6415867366
MESH:D010018 Osteomalacia Phenytoin 5.0717016548
MESH:D010024 Osteoporosis Genistein 6.8919401787
MESH:D010024 Osteoporosis Isoflavones 6.8916562857
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.1016169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.1019495926
MESH:D012516 Osteosarcoma Doxorubicin 3.8515930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 17.3819769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 17.3819401270
MESH:D010051 Ovarian Neoplasms Genistein 17.3819005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 17.3811161223
MESH:D010051 Ovarian Neoplasms Quercetin 17.3819005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.3817306315 15276417
MESH:D010146 Pain Acetaminophen 9.8916870215
MESH:D010146 Pain Phenytoin 9.8915215642
MESH:D010146 Pain Sulindac 9.893291741
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.3315580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.3316929163 15113037 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Quercetin 11.3316965848
MESH:D010190 Pancreatic Neoplasms Sulindac 11.3311504793 16820089
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D010235 Paraganglioma arsenic trioxide 3.8519927285
MESH:D010300 Parkinson Disease Rotenone 2.8518191903 16140633 19114014 16412576 15451049 11445065 11535288 18619942 19232380
MESH:D020734 Parkinsonian Disorders Rotenone 3.7815795934 18197244 15574749 15927086
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9012520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8117983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3416977796 15687265
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8117638057
MESH:D017689 Polydactyly Phenytoin 4.769212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.1612371664
MESH:D011230 Precancerous Conditions Quercetin 8.1619056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3521297632
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.3017184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.3011399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.3019015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.5918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 5.6619131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 5.6617292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 5.6617136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 5.6615749863 15897917 16868541 16729912 16888761 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 5.6616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 5.6618626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 5.6615256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Isoflavones 5.6617571952 17374662 17219775 16365062
MESH:D011471 Prostatic Neoplasms Paclitaxel 5.6616729912 17172428 17136230 16356831
MESH:D011471 Prostatic Neoplasms Quercetin 5.6617292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 5.6616039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 5.6615067354
MESH:D011471 Prostatic Neoplasms Vitamin E 5.6615084515
MESH:D011472 Prostatitis vinclozolin 4.5918629315
MESH:D011537 Pruritus Ethinyl Estradiol 2.9816919318 15861022
MESH:D019310 Pseudolymphoma Phenytoin 5.201419762 8603615 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7318722050 15538739 16160472 18286688
MESH:D051437 Renal Insufficiency Doxorubicin 3.8917922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2219058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7118379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5118990726
MESH:D012509 Sarcoma Doxorubicin 3.7016767912 18313854 17710206 15625365 17203757 15675481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.2016646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.2014601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4517846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.2016862918
MESH:D012640 Seizures Phenytoin 3.529844417 3691417 19919933 10029267 16876388 15946322 11044598 3137016
MESH:D012871 Skin Diseases Vitamin E 2.3518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.2019755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 12.2015692506
MESH:D012878 Skin Neoplasms sodium arsenite 12.2019524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.2016192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2317203757 16767912 15625365
MESH:D013088 Spermatocele Diethylstilbestrol 18.1216709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 18.1216709447
MESH:D013088 Spermatocele Tamoxifen 18.1216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7019457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5412854658
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.8220235791
MESH:D013272 Stomach Diseases Dexamethasone 3.9815472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.4417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.4420155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 4.4416424979 17172411 18396642 15786421 19015929 17522103 16951190 19084572 17498489 18567086
MESH:D013274 Stomach Neoplasms Paclitaxel 4.4418506536 18396642
MESH:D013276 Stomach Ulcer Dexamethasone 3.2015138204
MESH:D020521 Stroke Vitamin E 3.2516517955
MESH:D024801 Tauopathies Paclitaxel 4.4716930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5612697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.4919014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.4917909728 16010429
MESH:D013978 Tibial Fractures Estradiol 4.3419048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7016280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6215213294
OMIM:254090 ULLRICH CONGENITAL MUSCULAR DYSTROPHY marker/mechanism
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 22.0020435036 12973940 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 22.0017053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 22.0016712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 22.0017653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 22.0016720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 22.0011723127 17306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 22.008653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 2.6710982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 14.2116175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.2116803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.2111813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 14.2616690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 14.2614692618
MESH:D014594 Uterine Neoplasms Sulindac 14.2618645019
MESH:D014605 Uveitis Cyclosporine 10.611336536
MESH:D014605 Uveitis Dexamethasone 10.611336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1016002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.0817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8917334414 16364871 17678736 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9015886252
MESH:D015430 Weight Gain Dietary Fats 3.4516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.0917120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:04974 Protein digestion and absorption
REACT:16888 Signaling by PDGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26729
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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