AutismKB 2.0

Annotation Detail for CMPK2


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Basic Information Top
Gene Symbol:CMPK2 ( TMPK2,TYKi,UMP-CMPK2 )
Gene Full Name: cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
Band: 2p25.2
Quick LinksEntrez ID:129607; OMIM: 611787; Uniprot ID:CMPK2_HUMAN; ENSEMBL ID: ENSG00000134326; HGNC ID: 27015
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY0-166pyrimidine deoxyribonucleotides de novo biosynthesis
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa01100Metabolic pathways
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen results in decreased expression of CMPK2 mRNAdecreases expression 17942131
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CMPK2 mRNAdecreases expression 17942131
20713471
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of CMPK2 mRNAdecreases expression 17942131
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of CMPK2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of CMPK2 mRNAdecreases expression 17942131
D005480 Flurbiprofen Flurbiprofen results in increased expression of CMPK2 mRNAincreases expression 16949054
C006253 pirinixic acid pirinixic acid results in decreased expression of CMPK2 mRNAdecreases expression 18445702
D002762 Cholecalciferol Cholecalciferol results in increased expression of CMPK2 mRNAincreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 5.2910680582
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.3416142846
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816050911 10355542 16124888 15673190 16192424 3786805 18705752 16227642 16011737 15700767 16097048 15721981
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9418788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9419923254 16781746 2444490 12705907 11743745 17522070 12392966 12958197 12153990 10915739 15619225 14550746 19420014 11461765 10774834 11529661 12540782 19416960 18713872 14986274 11739529 11287661 12594235 17906064 16109766 14725611 19164858 11834606 16393943 10663392 16081117 11421492 17562736 16227642 16177239 18071297 16485898 19739265 19370779 19085960 15968718
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.946623471 2869522 7120509 7179309 3786805 6884620 17522070 15998439 15968718 10092053 3732212 11566570 7440962 15027814 16227642 19336974 19085960 4309450 16177239 9327722 10915739 21278145
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.5012795759 61145 17595544 16239168 15959796 19224547 16045604 12631006
MESH:D005234 Fatty Liver Cyclosporine 14.5019224547
MESH:D005234 Fatty Liver pirinixic acid 14.5020131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 9.7118705752
MESH:D005355 Fibrosis Cyclosporine 9.7112639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.3018467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Flurbiprofen 3.8811099482
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.2218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9216943688 11903743 11408273 17334410 16239168 17174718 16221502 17157831 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3817976157 18376398 18279442 18054572 15996030 16248980 18187930 14512876 16192424 18210741 17766677 15370692 16027843 15931870 16011737 18395914 18339082 17805973 12632512 15338365 18263696 18412020 15052691 17869086 12741479 17481882 17900296 17922224 15123356 17698563 17708605 16638106 15876570 16136751 17721639 12389079 12609069 17557913 17631135 18251166 10355542 18472094 17761835 14620537 12667390 12445418 14716833 18006644 18429990 12649538 18156304 17714472 18395095 12632514 18205269 12898905 18420326 15730626 13678700 15925388 17525996 12546737 16033810 15673190 15818738 17823541 18418968 16015684 16097048 18472332 12586293 14716496 12958196 11481614 12445421 14724832 15959796 15650968 17640975 14748882 15362042 16116963 15893842 18277467 20821823 17944888 15057751 18705752 12666154 18481824 18166357 18317297 17565644
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3815474484
MESH:D008107 Liver Diseases Acetaminophen 4.0719460945 12587719 19014921 11587558 19784758 16611625 12969438 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0716246199 16964402 15720792 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1816899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.8419294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.8416377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7512014681 15583823
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618520028 17053015 20464547 20869020 18569708 6695378 18816296 20135361 20064080
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8117292933
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.8117024972
MESH:D011471 Prostatic Neoplasms Flurbiprofen 2.8117409433
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4610029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162382556
    • No data
    Releated disease ID Related disease Name
    PA444987Multiple Sclerosis
    Releated drug ID Related drug Name
    PA450039interferon beta-1b
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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