AutismKB 2.0

Annotation Detail for TMEM18


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Basic Information Top
Gene Symbol:TMEM18 ( DKFZp434C1714 )
Gene Full Name: transmembrane protein 18
Band: 2p25.3
Quick LinksEntrez ID:129787; OMIM: 613220; Uniprot ID:TMM18_HUMAN; ENSEMBL ID: ENSG00000151353; HGNC ID: 25257
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Body mass index
weight
METABOLIC
Desease Name
Body mass index
Weight
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TMEM18 mRNAincreases expression 18648102
C014347 decitabine decitabine results in decreased expression of TMEM18 mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of TMEM18 mRNA]affects reaction|decreases expression 19363521
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 3.003712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 6.091440618 11289319
MESH:D001943 Breast Neoplasms decitabine 2.5319208741 18320071
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.783581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.867296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6919215824
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.087505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.519022650 19486331
MESH:D003110 Colonic Neoplasms decitabine 2.3917616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1118981723
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.5511298694 8156756 8970840 2524372 14531868 11906362 12868966 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.103621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.067440962 18692083 6679447 6482804 11289319 9653073 8291058 1440618 18289764 9022650 16192314 9328219 18648102
MESH:D004701 Endocrine Gland Neoplasms decitabine 6.1919294695
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.193581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 6.096705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.647505956
MESH:D006258 Head and Neck Neoplasms decitabine 3.8019215824
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.196705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.7015034207
MESH:D007248 Infertility, Male decitabine 3.5117581917
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 6.098074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.406582329
MESH:D007938 Leukemia decitabine 3.2718980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.5518454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4419387464 19010910 18206229 18460780 18704418 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 6.5318055864
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4715034207 9327722
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.801399818 598648 6587162 3712494
MESH:D008223 Lymphoma decitabine 3.7619470736
MESH:D008545 Melanoma decitabine 2.2916505122 17785578
MESH:D009101 Multiple Myeloma decitabine 3.6918172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.6216882708 19010910 19157545 18608210
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.623581430
MESH:D009369 Neoplasms decitabine 2.9117925555 19470736 19116145
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.216679447
MESH:D009765 Obesity marker/mechanism 19079261
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.924026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 6.093988306
MESH:D010051 Ovarian Neoplasms decitabine 2.7619259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 2.9019294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.247296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.546228378
MESH:D055728 Primary Myelofibrosis decitabine 5.4917616702
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.743692021
MESH:D012208 Rhabdomyosarcoma decitabine 5.0119155313
MESH:D013274 Stomach Neoplasms decitabine 2.1119037991
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.541399818 6587162 3712494 6582329 7505956
MESH:D013964 Thyroid Neoplasms decitabine 8.5417967635
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.678074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.6717616700 19087683
MESH:D014604 Uveal Neoplasms decitabine 5.9817785578
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134873089
    • No data
    Releated disease ID Related disease Name
    PA445131Obesity
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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