AutismKB 2.0

Annotation Detail for ADH6


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Basic Information Top
Gene Symbol:ADH6 ( ADH-5 )
Gene Full Name: alcohol dehydrogenase 6 (class V)
Band: 4q23
Quick LinksEntrez ID:130; OMIM: 103735; Uniprot ID:ADH6_HUMAN; ENSEMBL ID: ENSG00000172955; HGNC ID: 255
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-21ethanol degradation II (cytosol)
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CANCER
esophageal cancer
Desease Name
Esophageal cancer
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ADH6 mRNAdecreases expression 17547211
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of ADH6 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ADH6 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ADH6 mRNAdecreases expression 20106945
D002104 Cadmium Cadmium results in decreased expression of ADH6 mRNAdecreases expression 17547211
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of ADH6 mRNAdecreases expression 17547211
D016572 Cyclosporine Cyclosporine results in decreased expression of ADH6 mRNAdecreases expression 20106945
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of ADH6 mRNAdecreases expression 17547211
D004958 Estradiol Estradiol results in decreased expression of ADH6 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ADH6 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.287525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2814514962 11752688 15322242
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3720464547 20127859
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 7.3716033868
MESH:D000230 Adenocarcinoma Estradiol 7.3711473722
MESH:D000236 Adenoma Benzo(a)pyrene 7.206695378
MESH:D000236 Adenoma Dimethylnitrosamine 7.2019555203
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D050197 Atherosclerosis Cadmium 3.7315687053
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7917474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.7919861407 16675129 17289903 12948864 18497071 17018787 14630087 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002277 Carcinoma Dimethylnitrosamine 8.8219555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.8216835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1021507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1016924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9520419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.9516033868
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 16120746 18850075
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7214694615
MESH:D002471 Cell Transformation, Neoplastic Cadmium 11.9517332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.9518566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615340226 8697196 15668235 16354765 12621046
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.7015095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.7014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.6321346803
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 6.638172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.0918566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7816530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.7817016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 3.0319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 9.2112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 18606429 16354765 15340226 8697196
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.0716627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cadmium 15.2916322080 16962696 16226777
MESH:D007674 Kidney Diseases Cadmium Chloride 15.2916962696
MESH:D007674 Kidney Diseases Cyclosporine 15.2910903974 8314463 18776723
MESH:D007674 Kidney Diseases Estradiol 15.2915618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7612371664
MESH:D007680 Kidney Neoplasms Estradiol 7.7615610895
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 3.6217203207 15086199 16009107 16042886 18239293 18567088 17198567 15798949 15577212 15842777 17724770 18210741 16570917 15733078 15793283 15339415 15571005 15366600 15723089 18237412 15744066 15298665 18629640 15138612 14643895 15942678 15504291 15161499 16603200 18371158 15591649 17881167 16169303 17534399 15492853 18637143 17432682 14659978 18364076 16544323 17719030 17640959 14709902 17196135 17036385 15067225 18672772 12925901 15383259 16270385 15081153 12918455 15479170 15369754 14726149 17348192 15864749 17201889 14568256 15763062 18095165 16627068 15099470 17465448 17666798
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6212878042
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.5717457977
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.2115890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.2120195826 21137059
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 11.2115890375 3113478
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.518603461
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 10.511848544 15603536 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5112151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0018816296 20064080 6695378 17053015 20135361 18520028 20869020 20464547 18569708
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 5.0011884234 16061637 19555203
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0011884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6617203775 16891317 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 10.1411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1414600291
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.2614694615
MESH:D010051 Ovarian Neoplasms Estradiol 2.2619401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.6215687053
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11118676 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5917292933
MESH:D011471 Prostatic Neoplasms Cadmium 2.5917075824
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7210029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.5312587719
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.622093021 20155912
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.6216033868
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2317053015
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00071 Fatty acid metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00830 Retinol metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24576
    • No data
    Releated disease ID Related disease Name
    PA446879Alcohol-Related Disorders
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA448073ethanol
    PA448073ethanol
    Drug Bank Top
    No data
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB01048 - Trizivir Anti-HIV Agents;Nucleoside and Nucleotide Reverse Transcriptase Inhibitors;Reverse Transcriptase Inhibitors
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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