AutismKB 2.0

Annotation Detail for COL11A1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:COL11A1 ( CO11A1,COLL6,STL2 )
Gene Full Name: collagen, type XI, alpha 1
Band: 1p21.1
Quick LinksEntrez ID:1301; OMIM: 120280; Uniprot ID:COBA1_HUMAN; ENSEMBL ID: ENSG00000060718; HGNC ID: 2186
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05146Amoebiasis
hsa04974Protein digestion and absorption
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
No data
No data
Pathway IDPathway Name
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
protein quantitative trait loci
Desease Name
Protein quantitative trait loci
Desease Name
Marshall syndrome
Stickler syndrome, type II
Lumbar disc herniation, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of COL11A1 mRNAdecreases expression 20406850
C014949 acetylhydrazine acetylhydrazine results in decreased expression of COL11A1 mRNAdecreases expression 15282401
C000188 alachlor alachlor results in increased expression of COL11A1 mRNAincreases expression 12419858
D019386 Alendronate Alendronate affects the expression of COL11A1 mRNAaffects expression 16079270
D000537 Aluminum Oxide Aluminum Oxide results in increased expression of COL11A1 mRNAincreases expression 19464052
D000638 Amiodarone Amiodarone results in increased expression of COL11A1 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of COL11A1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of COL11A1 mRNAdecreases expression 20713471
C031463 beta-glycerophosphoric acid beta-glycerophosphoric acid results in decreased expression of COL11A1 mRNAdecreases expression 17171500
C031463 beta-glycerophosphoric acid Calcitriol promotes the reaction [beta-glycerophosphoric acid results in decreased expression of COL11A1 mRNA]decreases expression|increases reaction 17171500
C031463 beta-glycerophosphoric acid paricalcitol promotes the reaction [beta-glycerophosphoric acid results in decreased expression of COL11A1 mRNA]decreases expression|increases reaction 17171500
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of COL11A1 mRNAincreases expression 17484886
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of COL11A1 mRNAaffects cotreatment|decreases expression 16054899
D004041 Dietary Fats Dietary Fats results in increased expression of COL11A1 mRNAincreases expression 18042831
D002117 Calcitriol Calcitriol promotes the reaction [beta-glycerophosphoric acid results in decreased expression of COL11A1 mRNA]decreases expression|increases reaction 17171500
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of COL11A1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL11A1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of COL11A1 mRNAaffects expression 16079270
C029424 hydrazine hydrazine results in decreased expression of COL11A1 mRNAdecreases expression 15282401
D007052 Ibuprofen Ibuprofen affects the expression of COL11A1 mRNAaffects expression 17070997
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of COL11A1 mRNAaffects cotreatment|decreases expression 16054899
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of COL11A1 mRNAdecreases expression 20713471
D008942 Mitoxantrone COL11A1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C041786 palm oil palm oil results in increased expression of COL11A1 mRNAincreases expression 18042831
C084656 paricalcitol paricalcitol promotes the reaction [beta-glycerophosphoric acid results in decreased expression of COL11A1 mRNA]decreases expression|increases reaction 17171500
D011374 Progesterone Progesterone results in decreased expression of COL11A1 mRNAdecreases expression 18070364
D020849 Raloxifene Raloxifene affects the expression of COL11A1 mRNAaffects expression 16079270
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of COL11A1 mRNAaffects cotreatment|decreases expression 16054899
D013629 Tamoxifen Tamoxifen affects the expression of COL11A1 mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of COL11A1 mRNAaffects expression 16962184
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL11A1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of COL11A1 mRNAincreases expression 15644576
D014192 Trapidil Trapidil affects the reaction [PTH protein affects the expression of COL11A1 mRNA]affects expression|affects reaction 18635661
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6211752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D058186 Acute Kidney Injury Ibuprofen 4.256375363
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.8120127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.8114692618
MESH:D000230 Adenocarcinoma Ibuprofen 6.8110697514
MESH:D000236 Adenoma Benzo(a)pyrene 6.436695378
MESH:D000236 Adenoma Methylcholanthrene 6.4310545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1516835633
MESH:D000382 Agricultural Workers' Diseases alachlor 4.4311874814 14769641
MESH:D000419 Albuminuria Raloxifene 4.3817451421 17308373
MESH:D000544 Alzheimer Disease Ibuprofen 6.5418351690
MESH:D000544 Alzheimer Disease Raloxifene 6.5415800139
MESH:D000544 Alzheimer Disease rosiglitazone 6.5419621015
MESH:D000707 Anaphylaxis Ibuprofen 5.029532969
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8519183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6018057881 18218290 20041841
MESH:D001161 Arteriosclerosis Dietary Fats 9.1615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1611256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.9117659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.9115885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.3211922910
MESH:D001281 Atrial Fibrillation Amiodarone 3.7318651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 8.3619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1117868700
MESH:D001930 Brain Injuries Progesterone 10.2215665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 10.2216580743
MESH:D002545 Brain Ischemia Ibuprofen 4.6515837124
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.5517474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 4.5511237771
MESH:D001943 Breast Neoplasms Dietary Fats 4.5520435547
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.5517474063
MESH:D001943 Breast Neoplasms Progesterone 4.5517614352 15562024 16175315
MESH:D001943 Breast Neoplasms Raloxifene 4.5517261762 17893378 15775269 17440819 17595753 15572757 17952589 15758505 16837676 17049068 17242785 16912660
MESH:D001943 Breast Neoplasms Tamoxifen 4.5519189212 16818667 19221464 17242785 18815881 19059307 17893378 18997820 18351453 20135344 19115204 19066611 19011961 16273361 16202921 19244106 19084267 19155303 19142967 11161223 18855134 20065188 19189210 18821012 18629630 17261762 19487384 18984771 15565566 20005174 16873071 20390343 15668708 20859285 18425577 20544844 21152245 17440819 19288272 17049068 19410462 19289846 19200415 21138602 19103187
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5520435547
MESH:D002100 Cachexia Ibuprofen 5.2415141370
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5616227642 16192424 15673190 16097048 15721981 3786805 15700767 10355542 18705752 16124888 16011737 16050911
MESH:D002277 Carcinoma Methylcholanthrene 7.7410545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2819066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.3616705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.3618788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.3616924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.4620419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.4611237771
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.8417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418670907 16120746 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8215710769 19225199
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2915775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8518974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.426135515
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 6.4216192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7111677210 16105132 17681005 16919318 17110522 15861022 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0115668235 12621046 15340226 16354765 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.3915800139
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4615824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8717141729 14669216
MESH:D019465 Craniofacial Abnormalities marker/mechanism 19638309
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.5517728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5520055451 10048152 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7918551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1419031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9717474826
MESH:D017449 Dermatitis, Allergic Contact alachlor 6.828428444
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.8212438553
MESH:D003920 Diabetes Mellitus rosiglitazone 4.1117446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.3012642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3017107852
MESH:D003928 Diabetic Nephropathies Raloxifene 8.4015920148 17308373 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.4019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2717187935
MESH:D003967 Diarrhea Dexamethasone 3.487237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.4018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.4018218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.4019336974 15027814 15998439 10092053 3786805 10915739 7440962 6884620 6623471 7179309 3732212 4309450 11566570 16177239 7120509 19085960 15968718 17522070 2869522 21278145 16227642 9327722
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.4020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.3818450898 18446180 16133044
MESH:D050171 Dyslipidemias Dietary Fats 3.2918367378
MESH:D004485 Eczema Dexamethasone 4.2412438553
MESH:D004487 Edema Dexamethasone 14.8319703484
MESH:D004487 Edema Raloxifene 14.8315860553
MESH:D004487 Edema rosiglitazone 14.8312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.8312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6716714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 26.3915138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 26.3912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 26.3917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 26.3915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 26.3919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9020544844 19155303 16202921 17893378
MESH:D004715 Endometriosis Ibuprofen 14.2215652904
MESH:D004715 Endometriosis Progesterone 14.2216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.2210568697 9294722
MESH:D019446 Endotoxemia Ibuprofen 4.7411545620
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver Amiodarone 33.8214986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.8261145 15959796 19224547 12795759 17595544 12631006 16045604 16239168
MESH:D005234 Fatty Liver Dietary Fats 33.8219551842 18296743 19004024 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.8215345470
MESH:D005234 Fatty Liver Raloxifene 33.8217473493
MESH:D005234 Fatty Liver rosiglitazone 33.8219196556
MESH:D005234 Fatty Liver Tamoxifen 33.8214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005334 Fever Ibuprofen 4.3916997862
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9519069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7114633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 13.4618705752
MESH:D005355 Fibrosis Dietary Fats 13.4618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.4620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0511294989 10048152
MESH:D006331 Heart Diseases Mitoxantrone 7.5716019553
MESH:D006331 Heart Diseases Raloxifene 7.5711110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3819900420 19110552
MESH:D006529 Hepatomegaly Amiodarone 7.7915265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7916120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.997520565
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8116354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Alendronate 8.0316769263
MESH:D006930 Hyperalgesia rosiglitazone 8.0312083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3016899240
MESH:D006937 Hypercholesterolemia Amiodarone 8.488137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 8.4821332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.4021332399
MESH:D006973 Hypertension Dexamethasone 8.1817042910
MESH:D006973 Hypertension Raloxifene 8.1815787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8615338365
MESH:D006984 Hypertrophy Ibuprofen 4.7716672835
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.2917991464 18020914
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.2118306037
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.6016133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male alachlor 6.5716466525 12948887 17049205
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5717937319
MESH:D007249 Inflammation Dexamethasone 22.448960868 11099482
MESH:D007249 Inflammation Dietary Fats 22.4420412841
MESH:D007249 Inflammation Ibuprofen 22.443291741
MESH:D007249 Inflammation Progesterone 22.4415869954
MESH:D007249 Inflammation rosiglitazone 22.4412083418
MESH:D007249 Inflammation Tamoxifen 22.4419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 22.4412200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.1918457598 11836018
MESH:D007333 Insulin Resistance rosiglitazone 7.1916306350
MESH:C535531 Intervertebral disc disease marker/mechanism
MESH:D007405 Intervertebral Disk Displacement marker/mechanism 17999364
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.2118306037
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.7816705839
MESH:D007680 Kidney Neoplasms Tamoxifen 6.7818625569
MESH:D007889 Leiomyoma Raloxifene 4.2816973256
MESH:D007938 Leukemia alachlor 3.9014769641
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6918172266
MESH:D008064 Lipidoses Amiodarone 7.3815342952 17567588
MESH:D008064 Lipidoses Tamoxifen 7.3817567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.2111903743 17174718 16943688 17157831 11408273 17334410 16239168 21278145 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 6.2118296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4315362042 18210741 18187930 18156304 18339082 17708605 16011737 15673190 12586293 16027843 11481614 17805973 18205269 12546737 12741479 17698563 12958196 12666154 20821823 18006644 15996030 18412020 18317297 15876570 15650968 17761835 15893842 12667390 16116963 12445421 14724832 14620537 17565644 17640975 17631135 12445418 16192424 18279442 12632512 15925388 15052691 17721639 18263696 17557913 15959796 14512876 13678700 15338365 15123356 18472094 17976157 18429990 17766677 15818738 17900296 18418968 18481824 12632514 16033810 14716496 12609069 16248980 17481882 18054572 14748882 17823541 18166357 15730626 12649538 18376398 18420326 15370692 16136751 12389079 15057751 10355542 18395095 12898905 14716833 18251166 18705752 18395914 17869086 16015684 17944888 17525996 16097048 17714472 18472332 16638106 18277467 15931870 17922224
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.4316718785
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 6.4315980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0316246199 17285989 15720792 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4914706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.297678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.2921137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.2919294768
MESH:D008113 Liver Neoplasms Tamoxifen 13.2916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.2916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.976135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.9715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 12.971399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.9712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4117391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.2212587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.2518516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.2820464547 6695378 18520028 20869020 17053015 20064080 18569708 20135361 18816296
MESH:D008175 Lung Neoplasms Dexamethasone 6.2815824018 11195469
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.2816271038 1399818 21163286 20970405 20512841 16337739 7750092 9230183 11893704 15390079 17909032 6695378 10545420
MESH:D008175 Lung Neoplasms Tamoxifen 6.2818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.2811884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5319428831
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 13.1610697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.1611408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 13.1616827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.1611731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.3219453300
MESH:C536025 Marshall syndrome marker/mechanism 9529347
MESH:D008545 Melanoma Tamoxifen 1.8512393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9515990972
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1917261469
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3215863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0216381670
MESH:D009101 Multiple Myeloma alachlor 11.4314769641
MESH:D009101 Multiple Myeloma Dexamethasone 11.4316118317 15867202 15744524
MESH:D009101 Multiple Myeloma Raloxifene 11.4316497877
MESH:D009181 Mycoses Amiodarone 4.6717974566 12754197
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.419809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D009232 Myxoma Raloxifene 5.3216343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.6318551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms Mitoxantrone 4.9916640825
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7719200415 19196722 19189210
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.756375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.2110961664
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0014600291
MESH:D009669 Nose Neoplasms alachlor 4.5911127290 14563481 16698726 16178123 15580706
MESH:D009765 Obesity Dietary Fats 2.2319632207 18457598 20132043 11836018 20518802 17217161 18674790 16723640 21332399
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2316049721
MESH:D010003 Osteoarthritis Ibuprofen 4.007009135
MESH:D010009 Osteochondrodysplasias marker/mechanism 19638309
MESH:D010024 Osteoporosis Alendronate 7.3317882678
MESH:D010024 Osteoporosis Raloxifene 7.3319059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0215758505 17893378 17823083 15579764
MESH:D010051 Ovarian Neoplasms Progesterone 2.4616525653 17393432
MESH:D010146 Pain Ibuprofen 3.753291741
MESH:D010149 Pain, Postoperative Ibuprofen 4.9116678543
MESH:D010190 Pancreatic Neoplasms Ibuprofen 3.4112384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4221297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9611399792 11118676 11222880 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5515572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms Calcitriol 1.9016289102 12479363 15754350 16644109 18247401
MESH:D011471 Prostatic Neoplasms Ibuprofen 1.9017409433
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9016536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9015067354
MESH:D011507 Proteinuria Ibuprofen 4.426375363
MESH:D011537 Pruritus Ethinyl Estradiol 3.0916919318 15861022
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7712832656 11597910 12490602
MESH:D011693 Purpura Raloxifene 5.3215770314
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.8118379247 11700416
MESH:D012135 Respiratory Sounds alachlor 4.7211874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012640 Seizures 2,6-dinitrotoluene 2.3918551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8518724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.1219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7916709447
MESH:D013088 Spermatocele Tamoxifen 10.7916709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.1115862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.1119457130
OMIM:604841 STICKLER SYNDROME, TYPE II marker/mechanism
MESH:D013272 Stomach Diseases Dexamethasone 4.0915472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.552093021 20155912
MESH:D013276 Stomach Ulcer Amiodarone 6.8018087811
MESH:D013276 Stomach Ulcer Dexamethasone 6.8015138204
MESH:D020521 Stroke Raloxifene 3.6416837676
MESH:D013610 Tachycardia Amiodarone 4.0711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9719225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013959 Thyroid Diseases Amiodarone 11.2819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.2812697716
MESH:D013964 Thyroid Neoplasms alachlor 4.108812207
MESH:D013971 Thyrotoxicosis Amiodarone 4.6319584973 18020914
MESH:D013978 Tibial Fractures Raloxifene 4.9819048282
MESH:D016171 Torsades de Pointes Amiodarone 3.9617467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.1916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.1917053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.1917572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.1916712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0910091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0814692618
MESH:D014605 Uveitis Dexamethasone 4.591336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.9619057314
MESH:D054556 Venous Thromboembolism Raloxifene 4.9816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D015430 Weight Gain Dietary Fats 3.5516723640
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:04974 Protein digestion and absorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26702
    • No data
    Releated disease ID Related disease Name
    PA161614136Lumbar Disc Herniation
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved