AutismKB 2.0

Annotation Detail for ADH7


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Basic Information Top
Gene Symbol:ADH7 ( ADH4 )
Gene Full Name: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Band: 4q23
Quick LinksEntrez ID:131; OMIM: 600086; Uniprot ID:ADH7_HUMAN; ENSEMBL ID: ENSG00000196344; HGNC ID: 256
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-21ethanol degradation II (cytosol)
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
1841Stomach cancer
Desease Name
CARDIOVASCULAR
hypertension
Desease Name
Hypertension
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ADH7 mRNAincreases expression 19933214
C018855 2-tert-butylhydroquinone 2-tert-butylhydroquinone results in increased expression of ADH7 mRNAincreases expression 16014739
D000082 Acetaminophen Acetaminophen affects the expression of ADH7 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADH7 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ADH7 mRNAincreases expression 20713471
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ADH7 mRNAincreases expression 15336504
14729362
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of ADH7 mRNAdecreases expression 19638242
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of ADH7 mRNAincreases expression 14729362
C525593 JK184 JK184 binds to and results in decreased activity of ADH7 proteinaffects binding|decreases activity 19222062
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of ADH7 mRNAincreases expression 20713471
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of ADH7 mRNAdecreases expression 17616710
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of ADH7 mRNAdecreases expression 17681415
18467677
C023036 perfluorooctanoic acid PPARA protein inhibits the reaction [perfluorooctanoic acid results in decreased expression of ADH7 mRNA]decreases expression|decreases reaction 18467677
C006253 pirinixic acid pirinixic acid results in increased expression of ADH7 mRNAincreases expression 18301758
D012172 Retinaldehyde ADH7 protein results in increased chemical synthesis of Retinaldehydeincreases chemical synthesis 17473173
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ADH7 mRNAincreases expression 19933214
18691609
15667827
D014801 Vitamin A ADH7 protein results in increased oxidation of Vitamin Aincreases oxidation 17473173
D014810 Vitamin E Vitamin E results in decreased expression of ADH7 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8414514962 15322242 11752688
MESH:D000015 Abnormalities, Multiple Vitamin A 4.8410992263
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9820127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 11.166695378
MESH:D000236 Adenoma Diethylnitrosamine 11.166695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 11.166695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.2419052882 17620307 16434500 19061943 17162532 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.2416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.2416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9211748828
MESH:D000740 Anemia Vitamin A 8.9216960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.7816960172
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D001249 Asthma Vitamin A 3.3516732791
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4411922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9517474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 1.9517474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 5.5917426644 17377406
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9216050911
MESH:D002277 Carcinoma Methylcholanthrene 8.2810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.2816835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.843084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.8419822196 17162532 19335982 16540662 17173139 16681979 11831363 20727157 20084675 20432363 17978847 19107877 16288022 16698587 17428255 20512989 20007298 18665156 17138121 16830150 19171122 18494052 16807293 18691550 21159647 19383236 19394651 10737359 16779866 20514400 19539802 20101231 3581430 19418558 18785209 18788625 19519916 18056438 18978308 16878318 20935162 18971187 20524982 19052882 18506893 16328049 19701751 18393292 17055752 16502159 19208518 17761372 16935385 20214788 10672840 19919837 3084413 16569478 18210153
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0420419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3516120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.5016936243
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.9117174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 6.9116192471
MESH:D015362 Child Nutrition Disorders Vitamin A 5.4816153327
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2616835633
MESH:D002779 Cholestasis pirinixic acid 8.2119176532
MESH:D002779 Cholestasis Vitamin A 8.2116175620
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1115668235 12621046 15340226 16354765 8697196
MESH:D002972 Cleft Palate Vitamin A 6.1116054864
MESH:D003110 Colonic Neoplasms Vitamin A 3.0416267017 17219422
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin A 3.8910992263
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8919769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.5016506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.0915968718 11743745 12958197 12705907 19085960 16781746 14986274 17906064 16081117 14725611 10915739 14550746 12594235 11739529 16227642 12540782 19923254 11461765 17522070 18071297 16109766 19416960 11421492 16485898 19420014 10663392 11834606 17562736 16177239 19370779 19164858 16393943 15619225 12392966 19739265 11529661 2444490 12153990 11287661 18713872 10774834
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.0919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.7916146918
MESH:C538011 Eales disease Vitamin A 13.129068938
MESH:C538011 Eales disease Vitamin E 13.129068938
MESH:D004480 Ectromelia Vitamin A 5.8216054864
MESH:D004487 Edema perfluorooctanoic acid 11.3617259670 12083418
MESH:D004487 Edema pirinixic acid 11.3612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.3611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9016714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D004938 Esophageal Neoplasms marker/mechanism 18500343
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5916530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.5916704527 15878914 15623463 16510608 15547721 15264214 15150132 15547733 16805852
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Diethylnitrosamine 7.6220387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 7.6219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005327 Fetal Resorption Vitamin A 5.3616054864
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9310962813 14633661
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9320067830
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 15.9220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 15.9210048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin A 15.9210992263 16080930
MESH:D006330 Heart Defects, Congenital Vitamin E 15.9216080930
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 14.393609246
MESH:D006529 Hepatomegaly pirinixic acid 14.3919772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.3912621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin A 6.1516877224 16490937 16863852 17436238 15707848 16292552
MESH:D006548 Hernia, Diaphragmatic Vitamin E 6.1516490937 16863852
MESH:D015658 HIV Infections Vitamin A 3.8116960176
MESH:D006679 HIV Seropositivity Vitamin A 5.5917209195
MESH:D019584 Hot Flashes Vitamin E 3.9714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.058697196 15340226 16354765 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.8016870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.8012083418
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018850075 18670907
MESH:D006986 Hypervitaminosis A Vitamin A 6.1716054864
MESH:D007249 Inflammation Diethylnitrosamine 8.3018785209
MESH:D007249 Inflammation perfluorooctanoic acid 8.3012083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3012200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.2116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6216306350
MESH:D019586 Intracranial Hypertension Vitamin A 5.8215955940
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007674 Kidney Diseases Acetaminophen 5.9215629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 5.9212488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.2516518626
MESH:D007822 Laryngeal Neoplasms marker/mechanism 18500343
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.228812269
MESH:D017880 Limb Deformities, Congenital Vitamin A 4.3016054864
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9619638242 20032147 18522880 18407596 18665156
MESH:D008103 Liver Cirrhosis Vitamin A 6.9616256175
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.7515474484
MESH:D008106 Liver Cirrhosis, Experimental Retinaldehyde 6.7516248980
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 6.7516248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.7516169303
MESH:D008107 Liver Diseases Acetaminophen 6.5911587558 16611625 16610002 12969438 12587719 19784758 19460945 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 6.5917034775
MESH:D008107 Liver Diseases Vitamin A 6.5916175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 5.1416762690
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2216871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.1620195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.162862719 18978307 19427195 20434301 19499222 20118626 12112319 19850985 19690152 19996281 20492335 19090486 10737359 19294768 19642983 19551842 21278145 20583210 21047994 20501860 19426721 19255062 20137499 2422723 19073162 15885732 20405173 18754104 12771043 18648771 21071580 20452335 16942905 20101389 19638242 19254457 21167192 19812893 9163691 15175105 19256749 18977376 19833225 18644402
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 14.1614757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 14.1616377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.1616984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.0918093689 18079962 17942915 18544905 9362446 18775883 3124819 17174075 18253720 19009564 19126423 16267830 18308698 19004024 18164116 2563599 18282651 21159647 16842330 19539802 17854601 19519916
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 14.09598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.0912151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 14.0917113696
MESH:D008171 Lung Diseases Vitamin A 7.7316863852
MESH:D008171 Lung Diseases Vitamin E 7.7316863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.5617053015 18569708 18520028 18816296 20464547 6695378 20135361 20869020 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.5620970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.5615390079 20512841 16271038 6695378 20970405 21163286 16337739 17909032 7750092 10545420 9230183 1399818 11893704
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5619555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 6.5611062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D009062 Mouth Neoplasms marker/mechanism 18500343
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1716381670
MESH:D009101 Multiple Myeloma Vitamin A 4.0416374440
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.569029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7911141357
MESH:D009369 Neoplasms pirinixic acid 4.7917405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D009436 Neural Tube Defects Vitamin A 4.0517400914
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.1220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.949802331
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4116540662
MESH:D010212 Papilloma Hydrogen Peroxide 4.0712065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010610 Pharyngeal Neoplasms marker/mechanism 18500343
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.532563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.6417132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6411399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2017292933
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2015084515
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.7916877224
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012871 Skin Diseases Vitamin A 5.2518709164
MESH:D012871 Skin Diseases Vitamin E 5.2518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.4919755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 13.4912065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.498532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.4916192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3920155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3918456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.3917575124 12958204
MESH:D020521 Stroke Vitamin E 3.5016517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.977505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1717053015
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D014802 Vitamin A Deficiency Vitamin A 5.2616146918 16175781 16960172
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00071 Fatty acid metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00830 Retinol metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24577
    • No data
    Releated disease ID Related disease Name
    PA446879Alcohol-Related Disorders
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA448073ethanol
    PA448073ethanol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB04184 - Acetate Ion Indicators and Reagents
    DB04399 - Cacodylate Ion Herbicides
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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